CN100497386C - 非功能性p2x7受体的抗体及其应用 - Google Patents

非功能性p2x7受体的抗体及其应用 Download PDF

Info

Publication number
CN100497386C
CN100497386C CNB028214331A CN02821433A CN100497386C CN 100497386 C CN100497386 C CN 100497386C CN B028214331 A CNB028214331 A CN B028214331A CN 02821433 A CN02821433 A CN 02821433A CN 100497386 C CN100497386 C CN 100497386C
Authority
CN
China
Prior art keywords
antibody
functional
acceptor
probe
receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB028214331A
Other languages
English (en)
Chinese (zh)
Other versions
CN1625565A (zh
Inventor
安格斯·吉德利-贝尔德
朱莉安·亚历山大·巴登
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biosceptre International Ltd
Original Assignee
Intreat Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AUPR7431A external-priority patent/AUPR743101A0/en
Priority claimed from AUPR7430A external-priority patent/AUPR743001A0/en
Priority claimed from PCT/AU2002/000061 external-priority patent/WO2002057306A1/en
Application filed by Intreat Pty Ltd filed Critical Intreat Pty Ltd
Publication of CN1625565A publication Critical patent/CN1625565A/zh
Application granted granted Critical
Publication of CN100497386C publication Critical patent/CN100497386C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CNB028214331A 2001-09-03 2002-09-03 非功能性p2x7受体的抗体及其应用 Expired - Lifetime CN100497386C (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
AUPR7431 2001-09-03
AUPR7431A AUPR743101A0 (en) 2001-09-03 2001-09-03 A cancer therapeutic
AUPR7430 2001-09-03
AUPR7430A AUPR743001A0 (en) 2001-09-03 2001-09-03 Diagnosis and treatment of irritable bowel syndrome
AUPCT/AU02/00061 2002-01-17
PCT/AU2002/000061 WO2002057306A1 (en) 2001-01-17 2002-01-17 Antibodies to non-functional p2x7 receptor diagnosis and treatment of cancers and other conditions

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN2008102142942A Division CN101445555B (zh) 2001-09-03 2002-09-03 非功能性p2x7受体的抗体,癌症及其它疾病的诊断和治疗

Publications (2)

Publication Number Publication Date
CN1625565A CN1625565A (zh) 2005-06-08
CN100497386C true CN100497386C (zh) 2009-06-10

Family

ID=41706691

Family Applications (2)

Application Number Title Priority Date Filing Date
CNB028214331A Expired - Lifetime CN100497386C (zh) 2001-09-03 2002-09-03 非功能性p2x7受体的抗体及其应用
CN2008102142942A Expired - Lifetime CN101445555B (zh) 2001-09-03 2002-09-03 非功能性p2x7受体的抗体,癌症及其它疾病的诊断和治疗

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN2008102142942A Expired - Lifetime CN101445555B (zh) 2001-09-03 2002-09-03 非功能性p2x7受体的抗体,癌症及其它疾病的诊断和治疗

Country Status (9)

Country Link
JP (1) JP4467973B2 (https=)
CN (2) CN100497386C (https=)
AU (1) AU2002322192B2 (https=)
CA (1) CA2459348C (https=)
MY (1) MY142283A (https=)
NZ (2) NZ565994A (https=)
TW (1) TWI329648B (https=)
WO (1) WO2003020762A1 (https=)
ZA (1) ZA200402630B (https=)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1360203B1 (en) 2001-01-17 2008-12-24 Intreat Pty Limited Antibodies to non-functional p 2 x 7 receptor diagnosis and treatment of cancers and other conditions
WO2004053426A1 (en) * 2002-12-05 2004-06-24 Kla-Tencor Technologies Corporation Apparatus and methods for detecting overlay errors using scatterometry
WO2004090097A2 (en) 2003-04-03 2004-10-21 Bristol-Myers Squibb Company Polynucleotide encoding a novel human p2x7 splice variant, hbmyp2x7v
US8124730B1 (en) 2004-04-02 2012-02-28 Bristol-Myers Squibb Company Polynucleotide encoding a novel human P2X7 splice variant, HBMYP2X7v
US7767789B2 (en) * 2005-06-02 2010-08-03 University Hopitals of Cleveland Truncated proteins as cancer markers
WO2008043146A1 (en) * 2006-10-10 2008-04-17 Biosceptre International Limited Antibodies against non functional p2x7 receptor
JP2010505426A (ja) * 2006-10-10 2010-02-25 バイオスセプター インターナショナル リミテッド 非機能性ｐ２ｘ７受容体に対する抗体を産生するハイブリドーマ
AU2008299594B2 (en) * 2007-09-14 2013-10-03 Biosceptre International Limited Purinergic (P2X) receptors in extra-cellular body fluid
AU2013238152B2 (en) * 2007-09-14 2015-09-24 Biosceptre International Limited Purinergic (P2X) receptors in extra-cellular body fluid
AU2008299593B2 (en) 2007-09-14 2013-04-18 Biosceptre International Limited Novel P2X7 epitopes
BRPI0915367B8 (pt) 2008-07-04 2021-05-25 Biosceptre International Ltd peptídeo anti-p2x7
CN101469352B (zh) * 2008-08-29 2011-12-21 苏州福英基因科技有限公司 一种早期子宫癌原位杂交检测试剂盒
ES2904911T3 (es) * 2009-08-20 2022-04-06 Biosceptre Aust Pty Ltd Anticuerpos anti-receptor P2X7 y fragmentos de los mismos
JP5992831B2 (ja) * 2009-12-24 2016-09-14 バイオセプター・（オーストラリア）・ピーティーワイ・リミテッド 非機能性オリゴマーｐ２ｘ７受容体に対する抗体
CN106310245A (zh) * 2010-09-10 2017-01-11 生物权威(澳大利亚)有限责任公司 陪伴动物治疗
US9566318B2 (en) * 2011-07-01 2017-02-14 Biosceptre (Aust) Pty Ltd Combination therapy
EP2990800A1 (en) * 2014-08-29 2016-03-02 Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol Neprilysin as heartfailure (HF) prognostic marker
EP3347474B1 (en) 2015-09-11 2020-11-04 Biosceptre (UK) Limited Chimeric antigen receptors and uses thereof
CN109862883A (zh) * 2016-10-21 2019-06-07 生物权威（英国）有限公司 细胞毒性颗粒
EP3797164A4 (en) 2018-05-21 2022-03-02 Biosceptre (Aust) Pty Ltd CHIMERIC ANTIGEN RECEPTORS WITH MODIFIED LINKER DOMAINS AND THEIR USES
CN110054691B (zh) * 2019-05-09 2021-09-07 潍坊医学院 一种抗人p2rx7单克隆抗体的杂交瘤细胞系
JP2024513485A (ja) * 2021-04-08 2024-03-25 バイオセプター （オースト） プロプライエタリー・リミテッド 免疫細胞活性を制御する方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6133434A (en) * 1997-04-28 2000-10-17 Glaxo Group Limited Purinergic receptor
EP1360203B1 (en) * 2001-01-17 2008-12-24 Intreat Pty Limited Antibodies to non-functional p 2 x 7 receptor diagnosis and treatment of cancers and other conditions

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
a single nucleotide polymorphism is associated with loss of function of the monocyte P2X7 receptor. Wiley等.Blood,Vol.96 . 2000
a single nucleotide polymorphism is associated with loss of function of the monocyte P2X7 receptor. Wiley等.Blood,Vol.96. 2000 *
Blockade of human P2X7 receptor function with a monoclonal antibody. Buell G等.Blood,Vol.82 No.10. 1998
Blockade of human P2X7 receptor function with a monoclonal antibody. Buell G等.Blood,Vol.82 No.10. 1998 *
localisation of P2X5 and P2X7 receptors by immunohistochemistry in rat stratified squamous epithelia. Groschel-Stewart U等.Cell Tissue Research,Vol.296 No.3. 1999

Also Published As

Publication number Publication date
CN1625565A (zh) 2005-06-08
MY142283A (en) 2010-11-15
CA2459348C (en) 2013-06-18
NZ549019A (en) 2008-05-30
TWI329648B (en) 2010-09-01
ZA200402630B (en) 2005-06-29
CN101445555B (zh) 2013-07-03
CA2459348A1 (en) 2003-03-13
JP4467973B2 (ja) 2010-05-26
JP2005513416A (ja) 2005-05-12
CN101445555A (zh) 2009-06-03
WO2003020762A1 (en) 2003-03-13
AU2002322192B2 (en) 2008-05-01
NZ565994A (en) 2010-02-26

Similar Documents

Publication Publication Date Title
CN100497386C (zh) 非功能性p2x7受体的抗体及其应用
US10450380B2 (en) Polypeptide immunogen for generating an antibody to non-functional P2X7 receptor
JP2004528286A5 (https=)
AU2002322192A1 (en) Antibodies to non-functional P2X7receptor, diagnosis and treatment of cancers and other conditions
HK1123311B (en) Diagnosis and treatment of cancers and other conditions
HK1138013B (en) Antibodies to non-functional p2x7 receptor diagnosis and treatment of cancers and other conditions

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
ASS Succession or assignment of patent right

Owner name: BIOSCEPTRE INTERNATIONAL LIMITED

Free format text: FORMER OWNER: INTREAT PTY LTD.

Effective date: 20110915

C41 Transfer of patent application or patent right or utility model
TR01 Transfer of patent right

Effective date of registration: 20110915

Address after: New South Wales, Australia

Patentee after: BIOSCEPTRE INTERNATIONAL Ltd.

Address before: New South Wales, Australia

Patentee before: Intreat Pty Ltd.

CX01 Expiry of patent term

Granted publication date: 20090610

CX01 Expiry of patent term