CN100491524C - 生产葡糖胺的方法和原料 - Google Patents

生产葡糖胺的方法和原料 Download PDF

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Publication number
CN100491524C
CN100491524C CNB998100870A CN99810087A CN100491524C CN 100491524 C CN100491524 C CN 100491524C CN B998100870 A CNB998100870 A CN B998100870A CN 99810087 A CN99810087 A CN 99810087A CN 100491524 C CN100491524 C CN 100491524C
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China
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glucosamine
phosphate
seq
microorganism
genetic modification
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Expired - Lifetime
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CNB998100870A
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English (en)
Chinese (zh)
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CN1314951A (zh
Inventor
艾伦·贝里
理查德·P·伯林盖姆
詹姆斯·R·米利斯
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DCV Inc
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DCV Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C07H5/06—Aminosugars
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C07H11/04—Phosphates; Phosphites; Polyphosphates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y206/00—Transferases transferring nitrogenous groups (2.6)
    • C12Y206/01—Transaminases (2.6.1)
    • C12Y206/01016—Glutamine-fructose-6-phosphate transaminase (isomerizing) (2.6.1.16), i.e. glucosamine-6-phosphate-synthase

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
CNB998100870A 1998-07-15 1999-07-15 生产葡糖胺的方法和原料 Expired - Lifetime CN100491524C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/115,475 1998-07-15
US09/115,475 US6372457B1 (en) 1997-01-14 1998-07-15 Process and materials for production of glucosamine

Publications (2)

Publication Number Publication Date
CN1314951A CN1314951A (zh) 2001-09-26
CN100491524C true CN100491524C (zh) 2009-05-27

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ID=22361646

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB998100870A Expired - Lifetime CN100491524C (zh) 1998-07-15 1999-07-15 生产葡糖胺的方法和原料

Country Status (9)

Country Link
US (4) US6372457B1 (https=)
EP (1) EP1095158B1 (https=)
JP (2) JP4567887B2 (https=)
CN (1) CN100491524C (https=)
AT (1) ATE414162T1 (https=)
AU (1) AU5102899A (https=)
CA (1) CA2332380C (https=)
DE (1) DE69939901D1 (https=)
WO (1) WO2000004182A1 (https=)

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US20020160459A1 (en) * 1997-01-14 2002-10-31 Alan Berry Process for production of n-glucosamine
US6372457B1 (en) * 1997-01-14 2002-04-16 Arkion Life Sciences Llc Process and materials for production of glucosamine
CA2313836C (en) 2000-03-15 2009-06-09 Cargill, Incorporated Chitosan and method of preparing chitosan
US7923437B2 (en) * 2001-02-16 2011-04-12 Cargill, Incorporated Water soluble β-glucan, glucosamine, and N-acetylglucosamine compositions and methods for making the same
US6693188B2 (en) 2001-08-08 2004-02-17 Cargill Incorporated N-acetyl-D-glucosamine and process for producing N-acetyl-D-glucosamine
US8222232B2 (en) * 2001-02-16 2012-07-17 Cargill, Incorporated Glucosamine and N-acetylglucosamine compositions and methods of making the same fungal biomass
US20020115639A1 (en) 2001-02-16 2002-08-22 Weiyu Fan Glucosamine and method of making glucosamine from microbial blomass
US7816514B2 (en) 2001-02-16 2010-10-19 Cargill, Incorporated Glucosamine and method of making glucosamine from microbial biomass
DE60210772T2 (de) * 2001-07-06 2007-04-12 Degussa Ag Verfahren zur herstellung von l-aminosäuren unter verwendung von stämmen der familie enterobacteriaceae
EP1497335A4 (en) 2002-04-02 2009-08-12 Cargill Inc PREPARATION OF CHITOSAN
KR101035043B1 (ko) * 2002-07-01 2011-05-19 아르키온 라이프 사이언씨즈 엘엘씨 글루코사민 및 ｎ-아세틸글루코사민의 제조를 위한 물질및 공정
PA8576201A1 (es) 2002-07-10 2004-05-26 Pfizer Prod Inc Composicion farmaceutica que tiene una distribucion y potencia uniforme de farmaco
RU2005113312A (ru) * 2002-09-30 2005-10-10 Ачер-Дэниелс-Мидленд Компани (Us) Бесклеточное получение глюкозамина
US20050239173A1 (en) * 2003-12-08 2005-10-27 Cargill, Inc. Production of amino sugars
US20070212764A1 (en) * 2005-01-19 2007-09-13 Ptitsyn Leonid R Method for producing l-amino acids using bacterium of the enterobacteriaceae family
CA2607496C (en) * 2005-05-13 2013-12-10 Nestec S.A. Production of glucosamine from plant species
ES2376114T3 (es) * 2005-05-13 2012-03-09 Nestec S.A. Producción de glucosamina a partir de especies vegetales.
WO2008111507A1 (ja) * 2007-03-09 2008-09-18 Kyowa Hakko Bio Co., Ltd. 改変されたグルコサミン-6-リン酸合成酵素
WO2008119009A2 (en) * 2007-03-27 2008-10-02 University Of Florida Research Foundation, Inc. Materials and methods for efficient alanine production
WO2008144060A2 (en) 2007-05-17 2008-11-27 Tetravitae Bioscience, Inc. Methods and compositions for producing solvents
JP5424604B2 (ja) * 2008-09-30 2014-02-26 協和発酵バイオ株式会社 グルコサミンの製造法
EP2348101B1 (en) 2008-10-20 2016-05-04 CJ CheilJedang Corporation Corynebacterium genus microorganism having ability to produce n-acetyl glucosamine and method for producing n-acetyl glucosamine or glucosamine using same
WO2010123784A2 (en) * 2009-04-24 2010-10-28 New England Biolabs, Inc. Conversion of chitin into n-acetylglucosamine, glucosamine and bioethanol
US20120329135A1 (en) 2011-06-23 2012-12-27 Agrinos AS Process for Making Chitin Derivatives
US10227368B2 (en) 2013-11-05 2019-03-12 Nestec S.A. Generation of glucosamine from plant material
CN104988196A (zh) * 2015-07-30 2015-10-21 安徽丰原发酵技术工程研究有限公司 一种n-乙酰氨基葡萄糖的发酵生产方法
CN107267577A (zh) 2016-04-05 2017-10-20 孙镧 微生物发酵生产n‑乙酰‑d‑氨基葡萄糖和/或d‑氨基葡萄糖盐的方法
WO2017174038A1 (zh) * 2016-04-05 2017-10-12 孙镧 微生物发酵生产n-乙酰-d-氨基葡萄糖和/或d-氨基葡萄糖盐的方法
WO2017174036A1 (zh) * 2016-04-05 2017-10-12 孙镧 微生物发酵生产n-乙酰-d-氨基葡萄糖和/或d-氨基葡萄糖盐的方法
WO2017174040A1 (zh) * 2016-04-05 2017-10-12 孙镧 微生物发酵生产n-乙酰-d-氨基葡萄糖和/或d-氨基葡萄糖盐的方法
CN108070628B (zh) * 2016-11-14 2021-08-24 中国科学院微生物研究所 一种生产氨基葡萄糖的方法
EP3473644A1 (en) * 2017-10-17 2019-04-24 Jennewein Biotechnologie GmbH Fermentative production of n-acetylneuraminic acid
WO2019158541A1 (en) 2018-02-14 2019-08-22 Frieslandcampina Nederland B.V. Nutritional compositions for musculoskeletal support for athletes
CN108410783B (zh) * 2018-05-29 2020-11-03 成都本则生科技有限公司 一种培养大肠杆菌发酵生产氨基葡萄糖的方法
CN110714042A (zh) * 2018-07-13 2020-01-21 中国科学院天津工业生物技术研究所 氨基葡萄糖的酶法制备
CN110577977A (zh) * 2019-10-09 2019-12-17 山东润德生物科技有限公司 大肠杆菌发酵生产氨基葡萄糖的方法
IT202100030935A1 (it) 2021-12-09 2023-06-09 Fidia Farm Spa Compresse comprendenti condroitin solfato, glucosamina cloridrato e vitamina c per il trattamento di danni cartilaginei, tendinei, ossei

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1105367A (zh) * 1993-11-12 1995-07-19 田边制药株式会社 葡糖胺衍生物及该衍生物和其合成中间体的制备方法
CN1137799A (zh) * 1993-11-17 1996-12-11 实验室奥姆公司 葡糖胺二糖类、其制备方法和用途、以及含有这些二糖的药物组合物
CN1153820A (zh) * 1995-10-27 1997-07-09 宝酒造株式会社 编码内-β-N-乙酰基葡糖胺的酶的基因

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2769992B2 (ja) * 1995-04-25 1998-06-25 工業技術院長 グルコサミン−６−ホスフェートデアミナーゼ
US5998173A (en) * 1996-02-20 1999-12-07 The University Of Bristish Columbia Process for producing N-acetyl-D-glucosamine
JP2824508B2 (ja) * 1996-03-04 1998-11-11 工業技術院長 Ｎ−アセチルグルコサミン６−リン酸デアセチラーゼ
US20020160459A1 (en) * 1997-01-14 2002-10-31 Alan Berry Process for production of n-glucosamine
US6372457B1 (en) * 1997-01-14 2002-04-16 Arkion Life Sciences Llc Process and materials for production of glucosamine

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1105367A (zh) * 1993-11-12 1995-07-19 田边制药株式会社 葡糖胺衍生物及该衍生物和其合成中间体的制备方法
CN1137799A (zh) * 1993-11-17 1996-12-11 实验室奥姆公司 葡糖胺二糖类、其制备方法和用途、以及含有这些二糖的药物组合物
CN1153820A (zh) * 1995-10-27 1997-07-09 宝酒造株式会社 编码内-β-N-乙酰基葡糖胺的酶的基因

Also Published As

Publication number Publication date
US6372457B1 (en) 2002-04-16
JP2002520067A (ja) 2002-07-09
CA2332380A1 (en) 2000-01-27
US20030044939A1 (en) 2003-03-06
ATE414162T1 (de) 2008-11-15
WO2000004182A1 (en) 2000-01-27
AU5102899A (en) 2000-02-07
CA2332380C (en) 2010-11-02
JP4567887B2 (ja) 2010-10-20
EP1095158A4 (en) 2005-03-02
DE69939901D1 (de) 2008-12-24
US20060094085A1 (en) 2006-05-04
EP1095158B1 (en) 2008-11-12
CN1314951A (zh) 2001-09-26
JP2010166934A (ja) 2010-08-05
US20090017520A1 (en) 2009-01-15
EP1095158A1 (en) 2001-05-02

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Granted publication date: 20090527