CN100490791C - 治疗与新血管生成相关疾病的组合物及方法 - Google Patents

治疗与新血管生成相关疾病的组合物及方法 Download PDF

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Publication number
CN100490791C
CN100490791C CNB018224156A CN01822415A CN100490791C CN 100490791 C CN100490791 C CN 100490791C CN B018224156 A CNB018224156 A CN B018224156A CN 01822415 A CN01822415 A CN 01822415A CN 100490791 C CN100490791 C CN 100490791C
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China
Prior art keywords
gossypol
pharmaceutically acceptable
acceptable salt
neovascularization
medicament
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Expired - Fee Related
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CNB018224156A
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English (en)
Chinese (zh)
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CN1529590A (zh
Inventor
汪建平
汪明中
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Wackvom Ltd
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Wackvom Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/11—Aldehydes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CNB018224156A 2000-12-15 2001-12-14 治疗与新血管生成相关疾病的组合物及方法 Expired - Fee Related CN100490791C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25587600P 2000-12-15 2000-12-15
US60/255,876 2000-12-15

Publications (2)

Publication Number Publication Date
CN1529590A CN1529590A (zh) 2004-09-15
CN100490791C true CN100490791C (zh) 2009-05-27

Family

ID=22970220

Family Applications (1)

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CNB018224156A Expired - Fee Related CN100490791C (zh) 2000-12-15 2001-12-14 治疗与新血管生成相关疾病的组合物及方法

Country Status (7)

Country Link
US (1) US6608107B2 (https=)
EP (1) EP1343487A2 (https=)
JP (1) JP2005502579A (https=)
CN (1) CN100490791C (https=)
AU (1) AU2002230888A1 (https=)
MY (1) MY134562A (https=)
WO (1) WO2002047673A2 (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5385936A (en) 1990-07-12 1995-01-31 The United States Of America As Represented By The Secretary Of The Department Of The Health And Human Services Gossypol acetic acid for the treatment of cancer
CA2417500C (en) * 2000-07-28 2008-11-18 Georgetown University Medical Center Erbb-2 selective small molecule kinase inhibitors
US7432304B2 (en) * 2001-05-30 2008-10-07 The Regents Of The University Of Michigan Small molecule antagonists of Bcl-2 family proteins
AU2002360335A1 (en) 2001-11-01 2003-05-12 The Regents Of The University Of Michigan Small molecule inhibitors targeted at bcl-2
CN100413493C (zh) * 2003-06-11 2008-08-27 中国科学院动物研究所 棉酚及其衍生物在制备治疗骨髓瘤药物中的应用
DE602004012279T3 (de) * 2003-06-25 2010-07-15 The Burnham Institute, La Jolla Katecholderivate zur behandlung von krebs
ES2702607T3 (es) * 2004-01-07 2019-03-04 E L Man Corporation Composición cosmética y método de retardo del crecimiento del vello
EA011218B1 (ru) * 2004-03-25 2009-02-27 Дзе Риджентс Оф Дзе Юниверсити Оф Мичиган Сокристаллы госсипола и их применение
US20110091552A1 (en) * 2007-08-31 2011-04-21 Mccaffrey Tim Use of Bcl Inhibitors for the Treatment of Scarring Caused By Cutaneous Wounds, Burns and Abrasions
WO2009045410A1 (en) * 2007-10-01 2009-04-09 Ascenta Therapeutics, Inc. Process for preparing r-gossypol l-phenylalaninol dienamine
SG10201401549SA (en) 2009-06-22 2014-06-27 Cabot Microelectronics Corp CMP Compositions And Methods For Suppressing Polysilicon Removal Rates
KR101723699B1 (ko) 2009-07-29 2017-04-05 테이진 카세이 가부시키가이샤 폴리카보네이트-폴리디오르가노실록산 공중합체
CN101810577B (zh) * 2010-05-06 2011-09-07 山东大学 治疗肿瘤的棉酚静脉注射脂肪乳剂
CN103467538B (zh) * 2012-05-29 2015-08-19 武汉大学 具有抗艾滋病毒活性的棉酚衍生物及其制备方法
US9750761B2 (en) * 2014-05-21 2017-09-05 University Of Rochester LDH inhibitors as treatment for fibrosis and fibrotic-related disorders
WO2020204161A1 (ja) * 2019-04-04 2020-10-08 日産化学株式会社 細胞外小胞の分泌を促進するための組成物
CN110559449B (zh) * 2019-10-22 2022-09-02 长治医学院 一种聚棉酚前药胶束及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1204510A (zh) * 1997-07-09 1999-01-13 辛国芳 以棉酚或(和)其衍生物为有效成分的药栓及用途
US6114397A (en) * 1990-07-12 2000-09-05 The United States Of America As Represented By The Department Of Health And Human Services Gossypol for the treatment of cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260327A (en) * 1985-10-02 1993-11-09 Sloan-Kettering Institute For Cancer Research Methods for inhibiting the proliferation of brain and hepatic metastases by using lonidamine
US5026726A (en) * 1989-12-11 1991-06-25 The University Of New Mexico Gossylic iminolactones and gossylic lactones and their anti-viral activities
US5936120A (en) * 1997-12-10 1999-08-10 University Of New Mexico Deoxygossylic compounds
US5780675A (en) * 1995-04-28 1998-07-14 The University Of New Mexico Deoxygossylic compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6114397A (en) * 1990-07-12 2000-09-05 The United States Of America As Represented By The Department Of Health And Human Services Gossypol for the treatment of cancer
CN1204510A (zh) * 1997-07-09 1999-01-13 辛国芳 以棉酚或(和)其衍生物为有效成分的药栓及用途

Also Published As

Publication number Publication date
WO2002047673A2 (en) 2002-06-20
US20020137801A1 (en) 2002-09-26
JP2005502579A (ja) 2005-01-27
WO2002047673A3 (en) 2003-01-03
AU2002230888A1 (en) 2002-06-24
US6608107B2 (en) 2003-08-19
CN1529590A (zh) 2004-09-15
MY134562A (en) 2007-12-31
EP1343487A2 (en) 2003-09-17

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