CN100447603C - Melting and pulling method for manufacturing optical tweezers of parabolic microstructure single fiber - Google Patents
Melting and pulling method for manufacturing optical tweezers of parabolic microstructure single fiber Download PDFInfo
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- CN100447603C CN100447603C CNB2006101510878A CN200610151087A CN100447603C CN 100447603 C CN100447603 C CN 100447603C CN B2006101510878 A CNB2006101510878 A CN B2006101510878A CN 200610151087 A CN200610151087 A CN 200610151087A CN 100447603 C CN100447603 C CN 100447603C
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Abstract
This invention provides one single fiber light nipper melt process method to catch and operate arc micro structure for micro object, wherein, it processes one end of light fiber with arc micro structure light fiber; other end of fiber is coupled to micro light; the laser is reflected from fiber needle to form focus field to form stable three dimensional position well to realize single fiber light nipper.
Description
(1) technical field
The present invention relates to the optical fiber technology field, particularly a kind of parabolic microstructure single fiber optical tweezers and melting and pulling thereof are made method.
(2) background technology
1986 Askin (Opt.Lett.11,288-290,1986) single beam laser introduced high-NA objective formed the three-dimensional optical potential well, realized three dimensions control to fine particle.Realized on the x-y plane with along forming the gradient force potential well on the z direction of principal axis simultaneously with the laser of a branch of strong focusing, thus stable trapped particle.Because this ligh trap only uses beam of laser to form, so claim that this ligh trap is a single beam gradient force ligh trap, the usually said light tweezer of people just.
At present, people's available light tweezer pair cell, organelle and chromosome is caught, sorting, manipulation, crooked cytoskeleton, overcome bacterium rotary power that molecular motor power causes, measure motor albumen acting force, and film system carried out quantitative examination.In addition, optical tweezer technology also can be applicable to fields such as the catching of molecule, arrangement and micro-manufacturing.
Conventional light tweezer instrument all is the laser beam that will send from laser instrument, behind beam expander and dimmer, enter the biological microscope system, assembled the back by bidirectional color beam splitter and high power microcobjective and form the optical focus ligh trap and since the effect of gradient fields ligh trap with the particle capture in the sample near focus.
Bulky based on microscopical conventional light tweezer instrument, the sample one-movement-freedom-degree is little.Owing to it has the characteristic that physical dimension is big and operating distance is short, thereby limited the application of normal optical tweezer, made it be difficult to handle the particulate that is arranged in narrow location (as: deep hole), the also difficult multiple light forceps of realizing is handled.The drawbacks limit that these are intrinsic its application as the little manipulate tools of biomone.The optical fiber optical tweezers technology of new development solves these problems preferably.Utilize two relative single tapered lens single-mode fiber light tweezers of fibre core can catch the polystyrene spheres of micron dimension.But the light tweezer that utilizes two optical fiber to constitute requires the light beam of optical fiber outgoing spatially to aim at, two optical fiber must move simultaneously when mobile, still have inconvenience in the operation.Imagine that easily if can utilize simple optical fiber to constitute the light tweezer, then operation can be more simple, system cost also can reduce greatly.Effect is not enough to offset the gravity of particle but single tapered lensed fiber is to particle trapping, can not realize the 3 D captured of particle.
Canadian R.S.Taylor (Opt.Exp.11 in 2003,2775-2782,2003) etc. the people utilizes the method for corrosion and plated film, made a kind of metallization optical fiber probe point of hollow, utilize the electrostatic attraction and the scattering of light power of needle point to reach balance cleverly, catch and handled the glass granules that is immersed in the water, realized the 3 D captured of particle.But need repeatedly to corrode in this method process, the step complexity, long processing time, and also process need use noxious materials such as hydrofluorite, so processing environment is required high.
(3) summary of the invention
The object of the present invention is to provide a kind of melting and pulling that can be used for small items is carried out 3 D captured and the single fiber optical tweezers handled to make method with parabolic microstructure.
The object of the present invention is achieved like this:
1.1, get the coat of one section optical fiber 1 peeling optical fibre, fibre cladding is cleaned up, be fixed in the groove 3;
1.2, the optical fiber 1 that utilizes 2 pairs of oxyhydrogen flames to be in horizontality heats and impose axial tension, makes optical fiber local softening part gradually by drawing-down, stops heating when the thinnest part of optical fiber reaches 25-35 μ m, simultaneously the stretching of stop slot 3;
1.3, regulate fiber position, to the heating once more of drawing-down part, and stretching optical fiber 1 fast;
1.4, when optical fiber 1 is broken, because capillary effect forms a pair of fine pin 4 of low-light with parabolic shape naturally;
1.5, laser coupled is advanced optical fiber 1, when laser just can form the photo potential trap of stable three-dimensional after 4 outgoing of optical fiber pin at optical fiber pin front end, thereby realize single fiber optical tweezers.
The present invention also has some technical characterictics like this:
1, the described coat 25-35mm that utilizes optical fiber wire-stripping pliers peeling optical fibre in the middle of optical fiber 1 cleans up fibre cladding with alcohol and ether mixed liquor;
2, described groove 3 is V-type groove movably;
3, the described optical fiber pin 4 parabolic shape optical fiber end structure that is micron dimension;
4, described optical fiber 1 has single parabolic microstructure;
5, described optical fiber 1 is single-mode fiber;
6, described optical fiber 1 is multimode optical fiber.
The present invention at first utilizes oxyhydrogen flame that the optical fiber that is in horizontality is heated and imposes axial tension, makes optical fiber local softening part gradually by drawing-down, reach certain size after, stop heating and stretch.The adjusting fiber position, the drawing-down part just is in the oxyhydrogen flame edge in the middle of making, to the heating once more of middle drawing-down part, and quick stretching optical fiber, when optical fiber is broken, because capillary effect forms a pair of fine pin of low-light with parabolic shape naturally.
Ultimate principle of the present invention is that the particle that is in the light field is subjected to two kinds of basic light pressures---along the scattering force of incident beam direction with along the gradient force of intensity gradient direction.The gradient force that forms when light field is greater than its scattering force with when absorbing the power that produces, to the active gradient force of particulate with particle capture near beam focus, form the ligh trap that produces by the optical gradient field.
For the particle of determining, the with a tight waist of light field is the key factor that can light field form potential well, can utilize the method for parsing accurately to describe light field influence with a tight waist based on the light tweezer theory of ray model, then can not form the photo potential trap when gauss light beam waist is big.Conclusion is got up, and very little with a tight waist and bigger beam divergence angle must be arranged, and could produce enough strong gradient force, with particle-stabilised being strapped in the photo potential trap.
Fig. 4 in the accompanying drawing-5 is the emergent light field distribution of the single fiber optical tweezers of parabolic structure, adopts BPM (beam propagation method) to carry out simulation calculation, is taken into and penetrates optical wavelength 0.98 μ m, and surrounding medium is a water, refractive index 1.33, optical fiber pin refractive index 1.46.
From Fig. 4-5 as can be seen, laser is after the single fiber optical tweezers outgoing of parabolic structure, form a minimum light field with a tight waist at optical fiber needle tip place, this light field decays rapidly along optical propagation direction, also shows the Gradient distribution characteristic of rapid decay simultaneously on the direction of propagating perpendicular to light.As shown in Figure 6, the small items 5 that is opposite to wherein from this light field with very little beam radius and big Gradient distribution characteristic produces certain gradient force, this gradient force points to the strength of light, and be enough to offset the gravity of light scattering power and object, small items can be caught and is constrained near the optical fiber pin front end.
The present invention has following characteristics:
(1) the present invention utilizes molten pull technology processing optical fiber optical tweezers, and equipment is simple, and processing conditions is not had specific (special) requirements;
(2) optical fiber of making single fiber optical tweezers is not had specific (special) requirements, can be for single-mode fiber, multimode optical fiber a kind of;
(3) the present invention utilizes the single fiber pin to constitute the light tweezer, and is simple in structure, need not external optical system;
(4) single fiber optical tweezers of the present invention's making adopts standard fiber to make, and is with low cost, and convenient with the light source coupling, and the communication mode of light source is not had specific (special) requirements;
(5) the ligh trap manoeuvrable of the single fiber optical tweezers formation of the present invention's making, captive sample can move freely, and the little control system of light tweezer is simply suitable;
(6) single fiber optical tweezers of the present invention's making can be deep into any position, sample chamber, has improved range of application greatly.
The present invention utilizes above-mentioned method, molten the drawing of one end of one section optical fiber is processed into the optical fiber pin with parabolic microstructure, with laser coupled in the other end of optical fiber, the light field that converges that laser forms at optical fiber pin front end after the outgoing of optical fiber pin less than 1 micron waist spot diameter, can form stable three-dimensional light potential well, thereby realize single fiber optical tweezers.The present invention can be used for carrying out 3 D captured and manipulation to small items, wherein, realization is when the optical fiber pin moves to the 3 D captured and manipulation of medium microsphere, the particle of being caught also moves thereupon, when a plurality of optical fiber pins act on particulate, particulate can be with optical fiber pin position, light intensity, between the logical light time, the difference of moving direction, realizes maneuverability patterns such as rotation, stretching, handing-over.
(4) description of drawings
Fig. 1 draws the optical fiber synoptic diagram for adding hot melt by oxyhydrogen flame;
Fig. 2 forms the parabolic structure synoptic diagram for optical fiber;
The local enlarged diagram of optical fiber pin when Fig. 3 forms para-curve for Fig. 2 optical fiber;
Fig. 4-5 is the emergent light field pattern of single fiber optical tweezers;
Fig. 6 is the single fiber optical tweezers synoptic diagram;
Fig. 7 constitutes the optical optical tweezers system synoptic diagram for utilizing single fiber optical tweezers;
Fig. 8 utilizes single fiber optical tweezers to realize the mobile synoptic diagram of small items.
(5) embodiment
The invention will be further described below in conjunction with embodiment and accompanying drawing:
Embodiment 1: the making of parabolic microstructure single fiber optical tweezers.
In conjunction with Fig. 1-3, concrete making step is:
1. get one section optical fiber, utilize the coat 30mm of optical fiber wire-stripping pliers peeling optical fibre therebetween, fibre cladding is cleaned up with alcohol and ether mixed liquor;
2. optical fiber is fixed on movably in the V-type groove, utilize electrode the optical fiber that is in horizontality to be heated by discharge, discharge current is elected 20mA as, control V-type groove is with the speed stretching fiber of 25 μ m/s in the time of heating, make optical fiber local softening part gradually by drawing-down, after the thinnest part of optical fiber reaches 30 μ m, stop electrode discharge;
3. by oxyhydrogen flame middle drawing-down part is heated once more, and with the quick stretching optical fiber of the speed of 2cm/s, when optical fiber is broken, because capillary effect forms a pair of fine pin of low-light with parabolic shape naturally;
4. laser coupled is advanced optical fiber, when laser just can form stable three-dimensional light potential well at optical fiber pin front end after the outgoing of optical fiber pin, thereby realize the parabolic microstructure single fiber optical tweezers.
In conjunction with Fig. 4-5, the emergent light field distribution of single fiber optical tweezers adopts BPM (beam propagation method) to carry out simulation calculation, is taken into and penetrates optical wavelength 0.98 μ m, and surrounding medium is a water, refractive index 1.33, optical fiber pin refractive index 1.46,2 ω among Fig. 4
0≈ 1 μ m.The ω that is with a tight waist among Fig. 6
0
Embodiment 2: the making of parabolic microstructure single fiber optical tweezers.
In conjunction with Fig. 1-3, concrete making step is:
1. get one section optical fiber, utilize the coat 35mm of optical fiber wire-stripping pliers peeling optical fibre therebetween, fibre cladding is cleaned up with alcohol and ether mixed liquor;
2. optical fiber is fixed on movably in the V-type groove, utilize electrode the optical fiber that is in horizontality to be heated by discharge, discharge current is elected 20mA as, control V-type groove is with the speed stretching fiber of 25 μ m/s in the time of heating, make optical fiber local softening part gradually by drawing-down, after the thinnest part of optical fiber reaches 25 μ m, stop electrode discharge;
3. by oxyhydrogen flame middle drawing-down part is heated once more, and with the quick stretching optical fiber of the speed of 2cm/s, when optical fiber is broken, because capillary effect forms a pair of fine pin of low-light with parabolic shape naturally;
4. laser coupled is advanced optical fiber, when laser just can form stable three-dimensional light potential well at optical fiber pin front end after the outgoing of optical fiber pin, thereby realize the parabolic microstructure single fiber optical tweezers.
Embodiment 3: utilize the parabolic microstructure single fiber optical tweezers to realize the carrying of small items.
In conjunction with Fig. 7, light source 6 uses the laser instrument of wavelength X=980nm.The light that light source 6 sends is to be divided into two bundles behind 95: 5 the fiber coupler 7 through a splitting ratio, and wherein a branch of as power detection 8, another bundle is transferred to parabolic microstructure single fiber optical tweezers 4 by optical fiber 1.Behind the parabolic microstructure single fiber optical tweezers 4 usefulness water pipe precautions, but be installed on the mechanical adjustment frame 9 of a three-dimensional translating, one dimension rotation, can regulate insertion position, insertion depth and the insertion angle of optical fiber in sample cell 10 by this mechanical adjustment frame.Sample cell 10 places on the objective table 11 of an inverted biologic microscope, and image is imaged on the CCD14 by micro objective 13 through an infrared fileter 12 backs and gathers.
With microscopical objective table 11 sample 5 is moved in the visuals field, will regulate the single fiber optical tweezers 4 that inserts angle then and move into visual fields, and make it and sample to be caught is in same plane, single fiber optical tweezers is shifted near sample 5 and regulate luminous power and can realize catching.Sample will no longer move with microscope stage 11 behind the acquisition success.As shown in Figure 8, at initial position I, sample 5 is caught by single fiber optical tweezers 4, when single fiber optical tweezers 4 moved, sample 5 also left sample cell 10 bottoms thereupon and moves to position II, III successively, when arriving target location IV, reduce the luminous power of light source 6, sample 5 is released.
Claims (4)
1. the melting and pulling of a parabolic microstructure single fiber optical tweezers is made method, and concrete making step is:
1.1, get one section optical fiber (1), the coat of the centre of peeling optical fibre cleans up fibre cladding;
1.2, the two ends of optical fiber are separately fixed at movably in the V-type groove (3), utilize oxyhydrogen flame (2) that the centre of the optical fiber (1) that is in horizontality is heated and optical fiber is imposed axial tension by the V-type groove, make optical fiber local softening part gradually by drawing-down, when the thinnest part of optical fiber reaches 25-35 μ m, stop heating, stop the stretching of V-type groove (3) simultaneously;
1.3, regulate fiber position, make the drawing-down part just be in the oxyhydrogen flame edge, to the heating once more of drawing-down part, and stretching optical fiber (1) fast;
1.4, optical fiber (1) is when being broken, because capillary effect forms a pair of fine pin (4) of low-light with parabolic shape naturally;
1.5, laser coupled is advanced optical fiber (1), when laser just can form the photo potential trap of stable three-dimensional at the fine pin front end of low-light after fine pin (4) outgoing from low-light, thus the realization single fiber optical tweezers.
2. the melting and pulling of parabolic microstructure single fiber optical tweezers according to claim 1 is made method, it is characterized in that: in step 1.1, utilize the coat 25-35mm of the centre of optical fiber wire-stripping pliers peeling optical fibre, fibre cladding is cleaned up with alcohol and ether mixed liquor.
3. the melting and pulling of parabolic microstructure single fiber optical tweezers according to claim 1 is made method, it is characterized in that described optical fiber (1) is single-mode fiber.
4. the melting and pulling of parabolic microstructure single fiber optical tweezers according to claim 1 is made method, it is characterized in that described optical fiber (1) is multimode optical fiber.
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| JP5342674B1 (en) * | 2012-05-27 | 2013-11-13 | 株式会社石原産業 | Diameter-reducing optical fiber, manufacturing method and manufacturing apparatus |
| CN102922131B (en) * | 2012-11-16 | 2014-12-10 | 厦门大学 | Optical fiber microsphere preparation device |
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| CN106154531A (en) * | 2016-09-07 | 2016-11-23 | 中国科学院长春光学精密机械与物理研究所 | Microsphere manipulation device based on optical fiber and micro imaging system, fiber fabrication methods |
| CN106154530A (en) * | 2016-09-07 | 2016-11-23 | 中国科学院长春光学精密机械与物理研究所 | Microsphere manipulation device based on optical fiber and micro imaging system, fiber fabrication methods |
| CN107245431A (en) * | 2017-08-04 | 2017-10-13 | 重庆三峡医药高等专科学校 | A kind of microinjection device precisely injected for cell drug and its operating method |
| CN110411490B (en) * | 2019-07-31 | 2021-01-19 | 华中科技大学 | Optical fiber type wearable human body motion sensor |
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| CN111261312A (en) * | 2020-01-18 | 2020-06-09 | 江苏锐精光电研究院有限公司 | Micro optical tweezers device and method based on self-focusing lens pair |
| CN113219581B (en) * | 2020-11-24 | 2022-07-29 | 桂林电子科技大学 | Single-fiber-core beak-shaped optical fiber tweezers with sorting function and preparation method thereof |
| CN114815090A (en) * | 2022-04-25 | 2022-07-29 | 暨南大学 | Preparation method, focusing method and focusing device of optical fiber microprobe |
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| CN1510694A (en) * | 2002-12-23 | 2004-07-07 | 中国科学技术大学 | Fibre-optical probe with excellent vibration characteristic and producing method thereof |
| JP2004325222A (en) * | 2003-04-24 | 2004-11-18 | Seikoh Giken Co Ltd | Manufacturing method of optical fiber probe |
| CN1794359A (en) * | 2005-12-26 | 2006-06-28 | 西安交通大学 | Scanning electrochemical and optical microscope probe and its preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1510694A (en) * | 2002-12-23 | 2004-07-07 | 中国科学技术大学 | Fibre-optical probe with excellent vibration characteristic and producing method thereof |
| JP2004325222A (en) * | 2003-04-24 | 2004-11-18 | Seikoh Giken Co Ltd | Manufacturing method of optical fiber probe |
| CN1794359A (en) * | 2005-12-26 | 2006-06-28 | 西安交通大学 | Scanning electrochemical and optical microscope probe and its preparation method |
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