CN106154530A - Microsphere manipulation device based on optical fiber and micro imaging system, fiber fabrication methods - Google Patents
Microsphere manipulation device based on optical fiber and micro imaging system, fiber fabrication methods Download PDFInfo
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- CN106154530A CN106154530A CN201610807824.9A CN201610807824A CN106154530A CN 106154530 A CN106154530 A CN 106154530A CN 201610807824 A CN201610807824 A CN 201610807824A CN 106154530 A CN106154530 A CN 106154530A
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- Prior art keywords
- optical fiber
- microsphere
- fiber
- described optical
- manipulation device
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/32—Micromanipulators structurally combined with microscopes
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
- G02B21/361—Optical details, e.g. image relay to the camera or image sensor
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/24—Coupling light guides
- G02B6/25—Preparing the ends of light guides for coupling, e.g. cutting
Abstract
The invention discloses a kind of microsphere manipulation device based on optical fiber and micro imaging system, microsphere manipulation device includes laser instrument, fiber optic splitter and multiple optical fiber；Multiple described optical fiber at least include two optical fiber being positioned at first plane vertical with microsphere sample place plane and being oppositely arranged centered by microsphere sample；Optical fiber is positioned at the same side of microsphere sample place plane, and has a default angle with microsphere sample place plane, and has the tail end of taper, and the tail end of each optical fiber is just to microsphere sample；Laser instrument is connected with fiber optic splitter, and the outfan of fiber optic splitter is corresponding with optical fiber respectively to be connected.Present invention microsphere based on optical fiber manipulation device and micro imaging system, it is achieved utilize optical beam steering microsphere to move at longitudinal direction, it is possible to the lengthwise position adjusting microsphere arrives optimal imaging point, and then improves image quality.Invention additionally discloses a kind of fiber fabrication methods.
Description
Technical field
The present invention relates to micro-imaging technique field, particularly relate to a kind of microsphere manipulation device based on optical fiber and micro-
Imaging system.The invention still further relates to a kind of fiber fabrication methods.
Background technology
Along with modern biology and the development of material science, in the research of microstructure, imaging resolution is proposed more
Carrying out the highest requirement, scientist wishes to disclose life process and the physical essence of material property from molecular level.
For ordinary optical microscope, owing to being limited by optical diffraction limit, its lateral resolution is limited in
More than 200nm, this is to meet far away requirement for studying deep sub-wavelength structure or cellularity.In order to break through diffraction
The restriction of the limit, scientific research personnel all over the world expands in-depth study to this, and wherein, most typical several method includes being subject to
Swash launch loss microtechnique, Structured Illumination microscopy, random light field reconstruction microscopy, fluorescin photoactivation location technology
Deng, but this several method is mostly based on the subsequent treatment of complex data, there is system complex, expensive, inefficient
Etc. problem, it is impossible to be applied generally.
Super-resolution imaging technology based on microsphere nano coning effect, first by the research team of Univ Manchester UK in
Within 2011, proposing, this technology uses white-light illuminating light source, excites sample to produce evanescent waves, utilizes the microsphere coupling of micron dimension to disappear
Die ripple, and row space of going forward side by side amplifies the virtual image producing amplification, then the virtual image is carried out secondary imaging, obtains the super-resolution of sample surfaces
Micro-image, it is achieved that reach the micro-imaging of far field super-resolution based on white light Both wide field illumination.This technology is tied based on its system
The advantages such as structure is simple, efficiency is high, with low cost are by common concern.
In the art, the distance dependent between width and the microsphere of nanocone is formed based on microsphere.A certain suitably
Distance, the halfwidth degree of nanocone center spot is the narrowest, and the point spread function namely formed is minimum, accordingly at the one-tenth of this position
As resolution is the highest.But technological phase at present, microsphere can not keep suspending in a liquid, and microsphere and sample surfaces are directly to connect
Touch, therefore can not obtain optimal imaging effect.
Summary of the invention
It is an object of the invention to provide a kind of microsphere manipulation device based on optical fiber and micro imaging system, it is achieved utilize light
Bundle is handled microsphere and is moved at longitudinal direction, it is possible to the lengthwise position adjusting microsphere arrives optimal imaging point, and then improves into picture element
Amount.The present invention also provides for a kind of fiber fabrication methods.
For achieving the above object, the present invention provides following technical scheme:
A kind of microsphere manipulation device based on optical fiber, including laser instrument, fiber optic splitter and multiple optical fiber；
Multiple described optical fiber at least include being positioned at first plane vertical with microsphere sample place plane and with microsphere sample
Two the described optical fiber being oppositely arranged centered by product；
Described optical fiber is positioned at the same side of described microsphere sample place plane, and has default with microsphere sample place plane
Angle, and there is the tail end of taper, the tail end of each described optical fiber is just to described microsphere sample；
Described laser instrument is connected with described fiber optic splitter, the outfan of described fiber optic splitter respectively with described optical fiber pair
Should connect.
Alternatively, multiple described optical fiber also include being positioned at second plane vertical with microsphere sample place plane and with micro-
Two the described optical fiber being oppositely arranged centered by ball sample.
Alternatively, also including micrometric displacement bench board, described optical fiber is fixed by described micrometric displacement bench board, and described micrometric displacement is grasped
Vertical platform and the angle scalable of microsphere sample place plane.
Alternatively, the glass capillary being arranged on described optical fiber with described micrometric displacement bench board fixed area is also included.
Alternatively, described laser instrument is the power adjustable humorous formula laser instrument of a length of 980nm of output light-wave.
Alternatively, also include that another outfan with described fiber optic splitter is connected, for detecting the light merit of luminous power
Rate meter.
A kind of micro imaging system, including:
Including object lens and the optical microscope of eyepiece；
Microsphere manipulation device as above, wherein, multiple optical fiber of described microsphere manipulation device are correspondingly arranged at respectively
Object stage sample area；
The photoelectric imaging device arranged in the eyepiece side of described optical microscope；
The computer being connected with described photoelectric imaging device.
A kind of fiber fabrication methods, including:
In the central region of simple optical fiber, the protective layer of optical fiber one section is divested；
The two ends of described optical fiber are fixed, the section divesting protective layer is heated, applies at the two ends of described optical fiber simultaneously
Axial tension, until being broken by described optical fiber, one end that described optical fiber is broken is as tail end.
Alternatively, the described protective layer by optical fiber one section also includes after divesting: use alcohol swab to divesting protective layer
The covering of fiber segment be carried out；
Described described optical fiber is broken after also include: use alcohol swab to formed optical fiber tail-end be carried out.
Alternatively, the described two ends by described optical fiber are fixed, and specifically include: being separately fixed at the two ends of described optical fiber can
In the V-groove of movement；
Described the two ends of described optical fiber apply axial tension, specifically include: by described V-groove to described optical fiber two
End applies axial tension.
By technique scheme it can be seen that microsphere manipulation device based on optical fiber provided by the present invention and micro-imaging
System, described microsphere manipulation device includes that laser instrument, fiber optic splitter and multiple optical fiber, multiple described optical fiber at least include being positioned at
Two optical fiber being oppositely arranged in the first plane vertical with microsphere sample place plane and centered by microsphere sample, optical fiber with
Microsphere sample place plane has a default angle, and has the tail end of taper, and the tail end of each optical fiber is just to microsphere sample.Optical fiber
Output illumination is mapped to microsphere sample, is mainly subject to the scattering force along direction of beam propagation and gradient at optical trap medium microsphere
Power (highest energy density points is pointed in its direction).The optical fiber output light action that relative two are obliquely installed, in microsphere, can produce
Raw two gradient forces and two scattering forces, be therefore subject to by two gradient forces of balance, two scattering forces and microsphere other
Form power such as gravity, buoyancy, can handle microsphere and move at longitudinal direction.
Therefore, present invention microsphere based on optical fiber manipulation device and micro imaging system, it is achieved utilize optical beam steering microsphere
Move at longitudinal direction, it is possible to the lengthwise position adjusting microsphere arrives optimal imaging point, and then improves image quality.
Accompanying drawing explanation
In order to be illustrated more clearly that the embodiment of the present invention or technical scheme of the prior art, below will be to embodiment or existing
In having technology to describe, the required accompanying drawing used is briefly described, it should be apparent that, the accompanying drawing in describing below is only this
Some embodiments of invention, for those of ordinary skill in the art, on the premise of not paying creative work, it is also possible to
Other accompanying drawing is obtained according to these accompanying drawings.
In a kind of based on optical fiber the microsphere manipulation device that Fig. 1 provides for the embodiment of the present invention, optical fiber arranges schematic diagram；
The flow chart of a kind of fiber fabrication methods that Fig. 2 provides for the embodiment of the present invention；
The schematic diagram of a kind of micro imaging system that Fig. 3 provides for the embodiment of the present invention.
Detailed description of the invention
For the technical scheme making those skilled in the art be more fully understood that in the present invention, real below in conjunction with the present invention
Execute the accompanying drawing in example, the technical scheme in the embodiment of the present invention is clearly and completely described, it is clear that described enforcement
Example is only a part of embodiment of the present invention rather than whole embodiments.Based on the embodiment in the present invention, this area is common
The every other embodiment that technical staff is obtained under not making creative work premise, all should belong to present invention protection
Scope.
The embodiment of the present invention provides a kind of microsphere manipulation device based on optical fiber, including laser instrument, fiber optic splitter and many
Individual optical fiber；
Multiple described optical fiber at least include being positioned at first plane vertical with microsphere sample place plane and with microsphere sample
Two the described optical fiber being oppositely arranged centered by product；
Described optical fiber is positioned at the same side of described microsphere sample place plane, and has default with microsphere sample place plane
Angle, and there is the tail end of taper, the tail end of each described optical fiber is just to described microsphere sample；
Described laser instrument is connected with described fiber optic splitter, the outfan of described fiber optic splitter respectively with described optical fiber pair
Should connect.
It can be seen that the present embodiment microsphere based on optical fiber manipulation device, it is applied to the micro imaging system of microsphere application
In, including laser instrument, fiber optic splitter and multiple optical fiber, multiple described optical fiber at least include being positioned at and microsphere sample place plane
Two optical fiber in the first vertical plane and being oppositely arranged centered by microsphere sample, optical fiber and microsphere sample place plane tool
Having a default angle, and have the tail end of taper, the tail end of each optical fiber is just to microsphere sample.Optical fiber output illumination is mapped to microsphere sample
Product, at optical trap medium microsphere mainly by along the scattering force of direction of beam propagation and gradient force, (its direction is pointed to the highest
Energy density point).The optical fiber output light action that relative two are obliquely installed, in microsphere, can produce two gradient forces and two
Scattering force, other form power such as gravity, buoyancy being therefore subject to by two gradient forces of balance, two scattering forces and microsphere,
Microsphere can be handled move at longitudinal direction.
Therefore, present invention microsphere based on optical fiber manipulation device realizes utilizing optical beam steering microsphere to move at longitudinal direction,
The lengthwise position that can adjust microsphere arrives optimal imaging point, and then improves image quality.
Below the set-up mode of optical fiber in the present embodiment microsphere manipulation device is described in detail.
Referring to Fig. 1, the present embodiment microsphere manipulation device, multiple described optical fiber at least include being positioned at and microsphere sample place
Two optical fiber 1 in the first plane that plane is vertical, said two optical fiber 1 is oppositely arranged centered by microsphere sample, Mei Yiguang
Fine 1 tail end 100 with taper, just to microsphere sample, is mapped to medium microsphere by optical fiber output illumination, handles microsphere and moves
Dynamic.
Optical fiber 1 and microsphere sample place plane have default angle theta, by regulation angle, θ, can regulate microsphere by power
Direction and the size of each component.
In another kind of embodiment, it is flat that multiple described optical fiber also include being positioned at second vertical with microsphere sample place plane
Two optical fiber being oppositely arranged in face and centered by microsphere sample, optical fiber and microsphere sample place plane have default angle.
By being positioned at the first plane and the optical fiber of the second plane, microsphere sample can be more accurately controlled and move at longitudinal direction,
Control microsphere lengthwise position and arrive optimal imaging point.The angle of its first plane and the second plane can be arranged flexibly, it is preferred that
Described first plane is vertically arranged with described second plane.
The present embodiment optical fiber has the tail end of taper, can be made the optical energy density of fiber-optic output by the tail end of taper
Being greatly improved, output has the output beam of high intensity gradient distribution, can control gradient force that microsphere is subject to and scattering force
Size and Orientation.A kind of fiber fabrication methods provided the present embodiment below is described in detail, and refer to Fig. 2, this enforcement
Example fiber fabrication methods includes step:
S1: in the central region of simple optical fiber, the protective layer of optical fiber one section is divested.
Concrete, it is possible to use optical fiber wire stripper, the protective layer of a section of simple optical fiber central region is divested.Enter one
Step can use the covering of the alcohol swab fiber segment to divesting protective layer to be carried out, and cleans up.
S2: fixed at the two ends of described optical fiber, heats the section divesting protective layer, executes at the two ends of described optical fiber simultaneously
Adding axial tension, until being broken by described optical fiber, one end that described optical fiber is broken is as tail end.
Concrete, can be by the two ends of described optical fiber be separately fixed in moveable V-groove, by described optical fiber
Two ends are fixed.Then the section using oxyhydrogen flame that optical fiber divests protective layer heats, and meanwhile, passes through V-type at optical fiber two ends
Groove applies axial tension to the two ends of described optical fiber, until being broken by optical fiber, one end that optical fiber is broken is as tail end.And further
Use alcohol swab that the optical fiber tail-end formed is carried out.
Microsphere manipulation device described in the present embodiment, refers to Fig. 3, and fiber optic splitter 3 is connected with laser instrument 2, its output
End is corresponding with optical fiber respectively to be connected.In the present embodiment, optical fiber 1 preferably employs single-mode fiber, and in order to make the output light of laser instrument
Can be coupled into efficiently in single-mode fiber, laser instrument 2 outfan exports with single-mode fiber.Further, since need in water
Medium microsphere is handled, therefore for reducing the water loss to laser light source power, it is preferred to use a length of 980nm of output light-wave
Power adjustable humorous formula laser instrument.
Described microsphere manipulation device also includes that micrometric displacement bench board 4, optical fiber 1 are fixed by micrometric displacement bench board 4, scalable light
Fine 1 in the horizontal direction or longitudinal direction displacement.Described micrometric displacement bench board 4 also has angle regulating function, micrometric displacement bench board
With the angle scalable of microsphere sample place plane, thus regulate the angle of optical fiber 1 and microsphere sample place plane.Incline at optical fiber
After rake angle determines, can relatively accurately control optical fiber by micrometric displacement bench board 4 and in the horizontal direction or move on longitudinal direction
Dynamic, to adjust microsphere lengthwise position in a liquid.
Preferably, in order to reduce optical fiber rigidity low generation Bending Influence microsphere handle precision, can optical fiber 1 and microbit
Move bench board 4 fixed area and glass capillary 6 is set, glass capillary 6 on the outer set of optical fiber 1, increase its rigidity.
Preferably, the outfan at described fiber optic splitter 3 can be connected to detect the light power meter 5 of luminous power, logical
Cross the output of light power meter 5 detection laser 2.If manipulation device arranges two optical fiber 1, described fiber optic splitter 3 can be adopted
With 1 × 3 fiber optic splitter, two outfan is connected with the optical fiber of both sides, another output termination light power meter 5.
The present embodiment microsphere based on optical fiber manipulation device, is applied in the micro imaging system of microsphere application, utilizes light
Fine output beam acts on the microsphere in liquid, and the opposite sides at microsphere sample arranges two and handles optical fiber, optical fiber and level
Mask has angle to be obliquely installed, it is possible to achieve handles microsphere and moves in a longitudinal direction.The longitudinal direction of microsphere in liquid can be adjusted
Position, to arrive optimal imaging point, reaches optimal imaging resolution and optimal imaging contrast, and then improves image quality.This
Embodiment microsphere manipulation device simple in construction, workable, low cost, efficiency is high, it is possible to obtains universal and is widely applied.
Accordingly, the embodiment of the present invention also provides for a kind of micro imaging system, and referring to Fig. 3, Fig. 3 is the embodiment of the present invention
The schematic diagram of a kind of micro imaging system provided, described micro imaging system includes:
Optical microscope 7 including object lens and eyepiece；
Microsphere manipulation device as above, wherein, multiple optical fiber of described microsphere manipulation device are correspondingly arranged at respectively
Object stage sample area；
The photoelectric imaging device 8 arranged in the eyepiece side of described optical microscope；
The computer 9 being connected with described photoelectric imaging device.
Formed the picture of sample by optical microscope 7, photoelectric imaging device 8, output shows to computer 9.Described
Photoelectric imaging device 8 specifically can use CCD camera.
Described micro imaging system also include micrometric displacement bench board 4, glass capillary 6, laser instrument 2, fiber optic splitter 3 with
And light power meter 5, concrete functions and set-up mode all refer to described in embodiment content.
When in actual applications sample is carried out micro-imaging observation, first divide in optical microscope 7 object stage sample area
Optical fiber 1 is not set, is fixed by micrometric displacement bench board 4 respectively；The outfan of laser instrument 2 is connected with fiber optic splitter 3, fiber beam splitting
One output termination light power meter 5 of device 3, additionally outfan connects optical fiber 1 respectively.After optical fiber is fixed, sample is placed on
On object stage 10, instil on sample several suspensions containing microsphere, and microsphere can use the silicon oxide pellets (n of a diameter of 5 μm
=1.46).Relative to the optical fiber output beam of position, microsphere is handled by both sides, microsphere can be handled and move at longitudinal direction
Dynamic, adjust its lengthwise position.Through optical microscope 7 and CCD camera 8, computer 9 is arrived in the picture output of sample.By suitably regulation
Distance between microsphere and sample obtains the position of optimal imaging point, thus obtains the figure of optimum resolution and image contrast
Picture.
Above to a kind of microsphere manipulation device based on optical fiber provided by the present invention and micro imaging system, optical fiber fabrication
Method is described in detail.Principle and the embodiment of the present invention are set forth by specific case used herein, with
The explanation of upper embodiment is only intended to help to understand method and the core concept thereof of the present invention.It should be pointed out that, and this technology is led
For the those of ordinary skill in territory, under the premise without departing from the principles of the invention, it is also possible to the present invention is carried out some improvement and
Modifying, these improve and modify in the protection domain also falling into the claims in the present invention.
Claims (10)
1. a microsphere manipulation device based on optical fiber, it is characterised in that include laser instrument, fiber optic splitter and multiple optical fiber；
Multiple described optical fiber at least include being positioned at first plane vertical with microsphere sample place plane and with microsphere sample are
Two described optical fiber that center is oppositely arranged；
Described optical fiber is positioned at the same side of described microsphere sample place plane, and has default folder with microsphere sample place plane
Angle, and there is the tail end of taper, the tail end of each described optical fiber is just to described microsphere sample；
Described laser instrument is connected with described fiber optic splitter, and the outfan of described fiber optic splitter is corresponding with described optical fiber respectively to be connected
Connect.
Device the most according to claim 1, it is characterised in that multiple described optical fiber also include being positioned at and microsphere sample place
Two the described optical fiber in the second plane that plane is vertical and being oppositely arranged centered by microsphere sample.
Device the most according to claim 1, it is characterised in that also include micrometric displacement bench board, described optical fiber is by described micro-
Displacement bench board is fixed, described micrometric displacement bench board and the angle scalable of microsphere sample place plane.
Device the most according to claim 3, it is characterised in that also include that being arranged on described optical fiber handles with described micrometric displacement
The glass capillary of platform fixed area.
Device the most according to claim 1, it is characterised in that described laser instrument is the power of a length of 980nm of output light-wave
Tunable laser instrument.
Device the most according to claim 1, it is characterised in that also include that another outfan with described fiber optic splitter is even
That connect, for detecting the light power meter of luminous power.
7. a micro imaging system, it is characterised in that including:
Including object lens and the optical microscope of eyepiece；
Microsphere manipulation device as described in any one of claim 1-6, wherein, multiple optical fiber of described microsphere manipulation device are respectively
It is correspondingly arranged at object stage sample area；
The photoelectric imaging device arranged in the eyepiece side of described optical microscope；
The computer being connected with described photoelectric imaging device.
8. a fiber fabrication methods, it is characterised in that including:
In the central region of simple optical fiber, the protective layer of optical fiber one section is divested；
The two ends of described optical fiber are fixed, the section divesting protective layer is heated, applies axially at the two ends of described optical fiber simultaneously
Pulling force, until being broken by described optical fiber, one end that described optical fiber is broken is as tail end.
Manufacture method the most according to claim 8, it is characterised in that after the described protective layer by optical fiber one section divests
Also include: use the covering of the alcohol swab fiber segment to divesting protective layer to be carried out；
Described described optical fiber is broken after also include: use alcohol swab to formed optical fiber tail-end be carried out.
Manufacture method the most according to claim 8, it is characterised in that the described two ends by described optical fiber are fixed, and specifically wrap
Include: the two ends of described optical fiber are separately fixed in moveable V-groove；
Described in the two ends of described optical fiber applying axial tension, specifically include: by described V-groove, the two ends of described optical fiber are executed
Add axial tension.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610807824.9A CN106154530A (en) | 2016-09-07 | 2016-09-07 | Microsphere manipulation device based on optical fiber and micro imaging system, fiber fabrication methods |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610807824.9A CN106154530A (en) | 2016-09-07 | 2016-09-07 | Microsphere manipulation device based on optical fiber and micro imaging system, fiber fabrication methods |
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| CN201610807824.9A Pending CN106154530A (en) | 2016-09-07 | 2016-09-07 | Microsphere manipulation device based on optical fiber and micro imaging system, fiber fabrication methods |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109269980A (en) * | 2018-10-16 | 2019-01-25 | 中国科学院光电技术研究所 | One kind being based on monochromatic light tweezer medium microsphere high-resolution optical detection method |
| CN109324406A (en) * | 2018-11-14 | 2019-02-12 | 暨南大学 | Plant living body cell capture and control device and its method based on optical fiber probe |
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| CN1963583A (en) * | 2006-12-01 | 2007-05-16 | 哈尔滨工程大学 | Melting and pulling method for manufacturing optical tweezers of parabolic microstructure single fiber |
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| US20040037493A1 (en) * | 2002-08-23 | 2004-02-26 | Asia Pacific Microsystems, Inc. | Optical signal processing apparatus based on movable tilted reflection mirror |
| CN1963583A (en) * | 2006-12-01 | 2007-05-16 | 哈尔滨工程大学 | Melting and pulling method for manufacturing optical tweezers of parabolic microstructure single fiber |
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