CN100444883C - Anshenjiannaocong granule and its compounding process - Google Patents
Anshenjiannaocong granule and its compounding process Download PDFInfo
- Publication number
- CN100444883C CN100444883C CNB2006100132627A CN200610013262A CN100444883C CN 100444883 C CN100444883 C CN 100444883C CN B2006100132627 A CNB2006100132627 A CN B2006100132627A CN 200610013262 A CN200610013262 A CN 200610013262A CN 100444883 C CN100444883 C CN 100444883C
- Authority
- CN
- China
- Prior art keywords
- radix
- brain
- rhizoma
- tranquilizing
- mind
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention relates to a granule for tranquilizing mind and aiding digestion and a preparing method thereof. The granule for tranquilizing mind and aiding digestion is composed of 26 flavors of traditional Chinese medicine of top quality. Firstly, bitter cardamon, grassleaved sweetflag rhizome, Indian bread with hostwood, gastrodia tubers, ledebouriella roots, angelica, bupleurum roots, caulis polygoni multiflori, bombyx batryticatus and chaenomeles fruits are pulverized into fine powder, and sieved by a sieve with 120 meshes for standby; sieved raw decoction dregs are decocted with hooked uncaria, pseudostellaria roots, albizia flowers, giant typhonium tubers, arisaema with bile, phlogoptie, bamboo shavings, centipedes, scorpios, nacre, cicada sloughs, keels, oysters, oldenlandia and buck grass for three times by adding water, and filtrate is extracted for standby; then, the extracted filtrate is boiled and condensed to paste form; finally, ray medicine powder is added, mixed, dried and milled to make small particles, the small particles are packaged into bags after irradiated and sterilized by cobalt 60, and the weight of each bag is eight grams. The granule for tranquilizing mind and aiding digestion performs the functions of brain invigoration, tranquilization, intelligence cultivation, hyperactive liver suppression, wind elimination, spirit tranquilization, obstinate phlegm elimination, convulsion relief and tic stop, and has good curative effect on Gilles de la Tourettes syndrome, minimal brain dysfunction, all kinds of epilepsy, neurasthenia, memory decline, hypophrenia and dreamful sleep with strange dreams.
Description
Technical field:
The invention belongs to a kind of nourishing the brain and tranquilizing the mind preparation, particularly relate to a kind of nourishing the brain and tranquilizing the mind electuary and compound method thereof for the treatment of coprolalia syndrome, hyperkinetic syndrome, various epilepsy, neurasthenia, torsion spasm, children's's cerebral hypoplasia, dementia, mental retardation, hypomnesis, distractibility, mental maladjustment disease, blaming dream more night.
Background technology:
As everyone knows, coprolalia syndrome children's morbidity is for seeing more, its clinical manifestation such as extremity twitch, twitch, tremble, tetanic, shaking, make eyes etc.Pathogenesis is that wind-phlegm is tied mutually, because of the normal operation that expectorant can block people's bromhidrosis, blood, meridians, and blockage of main and collateral channels, QI-blood circulation is not smooth, and then the normal physiological function of human five internal organs's six internal organs also takes place against disorderly thereupon, so pertinacious disease is many because of expectorant rises, strange illness is many is given birth to by wind.Before 18 years old, function and nervous system all are in the period of development, in case ailment said due to cold or exposure, the evil body of invading of expectorant, to bring out this disease, usually, the patient is many to bring out this disease by following reason, and, cord around neck impaired as congenital defect such as nausea, in utero prominent frightened the and impairing fetus-QI of anoxia or anemia of pregnant woman, essence are impairment of the kidney and are lost; Or patient's disorder of emotion is as learning anxiety, quick-witted injured initiation liver-wind stirring up internally; Long-time electron radiation; The incidence wound; Monophagia or have a liking for food extremely in the life; Inherited genetic factors; Drug intoxication etc.At present, both at home and abroad multiselect suppresses relief of symptoms with Western medicine such as chlorpromazine, kappa rice piperazine, haloperidol, Tai Bili, trihexyphenidyl, in case drug withdrawal, clinical symptoms increases the weight of on the contrary, simultaneously, big as the slurred speech of side effect, sialorrhea, eyes are stared blankly, nerve problems, bradykinesia and drowsiness etc., also selecting for use Chinese herbal medicine to decoct takes and acupuncture and moxibustion therapy, main contrary treatment lung, soothing the liver accent spleen are controlled kidney water and are set about, curative effect is still undesirable, especially in preparation, add sugar and make adjuvant, had a strong impact on therapeutic efficiency.
Summary of the invention:
Main purpose of the present invention be to overcome above deficiency and provide a kind of invigorating brain and relieving mental uneasiness Fructus Alpiniae Oxyphyllae, suppressing the hyperactive liver and subsiding YANG dispel the wind, calm the nerves soul, the pertinacious phlegm of dispelling, arresting convulsion epilepsy, end and twitching.Treatment coprolalia syndrome, hyperkinetic syndrome, various epilepsy, neurasthenia, blame the nourishing the brain and tranquilizing the mind electuary and the compound method thereof of dream night more.
The technical solution adopted for the present invention to solve the technical problems is: be following weight proportion crude drug and extracts of bulk drugs in this electuary constituent:
Fructus Alpiniae Oxyphyllae 95g-115g, Rhizoma Acori Graminei 95g-115g, Poria cum Radix Pini 60g-80g,
Rhizoma Gastrodiae 60g-80g, Ramulus Uncariae Cum Uncis 60g-80g, Radix Saposhnikoviae 60g-80g,
Radix Pseudostellariae 95g-115g, Radix Angelicae Sinensis 60g-80g, Radix Bupleuri 60g-80g,
Caulis Polygoni Multiflori 95g-115g, Flos Albiziae 95g-115g, Rhizoma Typhonii 60g-80g,
Arisaema Cum Bile 60g-80g, Lapis Micae Aureus 130g-150g, Caulis Bambusae In Taenia 95g-115g,
Scolopendra 25g-45g, Scorpio 32-52g, Bombyx Batryticatus 60g-80g,
Concha Margaritifera 130g-150g, Periostracum Cicadae 60g-80g, Pheretima 53g-73g,
Os Draconis 95g-115g, Concha Ostreae 95g-115g, Herba Hedyotidis Diffusae 130g-150g,
Fructus Chaenomelis 60g-80g, Herba Lycopodii 95g-115g.
The present invention can also adopt following technical measures: be following weight proportion crude drug and extracts of bulk drugs in this granule best constituent:
Fructus Alpiniae Oxyphyllae 105g, Rhizoma Acori Graminei 105g, Poria cum Radix Pini 70g, Rhizoma Gastrodiae 70g, Ramulus Uncariae Cum Uncis 70g,
Radix Saposhnikoviae 70g, Radix Pseudostellariae 105g, Radix Angelicae Sinensis 70g, Radix Bupleuri 70g, Caulis Polygoni Multiflori 105g,
Flos Albiziae 105g, Rhizoma Typhonii 70g, Arisaema Cum Bile 70g, Lapis Micae Aureus 140g, Caulis Bambusae In Taenia 105g,
Scolopendra 35g, Scorpio 42g, Bombyx Batryticatus 70g, Concha Margaritifera 140g, Periostracum Cicadae 70g,
Pheretima 63g, Os Draconis 105g, Concha Ostreae 105g, Herba Hedyotidis Diffusae 140g,
Fructus Chaenomelis 70g, Herba Lycopodii 105g.
The compounding method of nourishing the brain and tranquilizing the mind electuary, it comprises following operation:
Select superior Chinese herbal medicine by weight,
1., preparation fine powder: Fructus Alpiniae Oxyphyllae 95g-115g, Rhizoma Acori Graminei 95g-115g, Poria cum Radix Pini 60g-80g, Rhizoma Gastrodiae 60g-80g, Radix Saposhnikoviae 60g-80g, Radix Angelicae Sinensis 60g-80g, Radix Bupleuri 60g-80g, Caulis Polygoni Multiflori 95g-115g, Bombyx Batryticatus 60g-80g, Fructus Chaenomelis 60g-80g are selected, rinsing, dry, are ground into fine powder, after 120 mesh sieves sieve, standby again;
2., preparation Chinese medicine extract:
A, decocting in water extracts: crude drug slag after will sieving and Ramulus Uncariae Cum Uncis 60g-80g, Radix Pseudostellariae 95g-115g, Flos Albiziae 95g-115g, Rhizoma Typhonii 60g-80g, Arisaema Cum Bile 60g-80g, Lapis Micae Aureus 130g-150g, Caulis Bambusae In Taenia 95g-115g, Scolopendra 25g-45g, Scorpio 32-52g, Concha Margaritifera 130g-150g, Periostracum Cicadae 60g-80g, Pheretima 53g-73g, Os Draconis 95g-115g, Concha Ostreae 95g-115g, Herba Hedyotidis Diffusae 130g-150g, Herba Lycopodii 95g-115g adds decocting three times, each amount of water is respectively 8 times of total dose, 6 times and 4 times, decocting time was respectively 2 hours, 1 hour and 1 hour, it extracts temperature is 90 ℃-100 ℃, collects filtrate for later use;
B, concentrated:
Three times extraction filtrate is mixed, again decocting in water is extracted filtrate and be concentrated into paste, make them in the time of 65 ℃-90 ℃, relative density is 1.2g/ml-1.3g/ml;
C, be mixed into finished product: extract at the decocting in water that is concentrated into paste and add the crude drug powder in the filtrate, abundant mix homogeneously, dry, pulverize, grind after, make fine particle, with being distributed into pouch behind cobalt 60 illumination-based disinfections, every bag 8 restrains.
Advantage and good effect that the present invention has are: invigorating brain and relieving mental uneasiness Fructus Alpiniae Oxyphyllae, suppressing the hyperactive liver and subsiding YANG dispel the wind, calm the nerves soul, the pertinacious phlegm of dispelling, arresting convulsion epilepsy, end and twitching.Have no side effect, than Chinese herbal medicine decoction take with easy to carry, refining instant, the saving of labor saves time again, do not have sugar, clear and bright, good effect in the preparation, can effectively treat diseases such as coprolalia syndrome, hyperkinetic syndrome, various epilepsy, torsion spasm, children's's cerebral hypoplasia, dementia, mental retardation, hypomnesis, distractibility, mental maladjustment disease, neurasthenia, insomnia headache and many strange dreams at night.
The specific embodiment:
For further understanding summary of the invention characteristics of the present invention and effect following examples for example now, be described in detail as follows.
Embodiment 1:
Comprise following weight proportion crude drug and extracts of bulk drugs in this granule best constituent:
Fructus Alpiniae Oxyphyllae 105g, Rhizoma Acori Graminei 105g, Poria cum Radix Pini 70g, Rhizoma Gastrodiae 70g, Ramulus Uncariae Cum Uncis 70g,
Radix Saposhnikoviae 70g, Radix Pseudostellariae 105g, Radix Angelicae Sinensis 70g, Radix Bupleuri 70g, Caulis Polygoni Multiflori 105g,
Flos Albiziae 105g, Rhizoma Typhonii 70g, Arisaema Cum Bile 70g, Lapis Micae Aureus 140g, Caulis Bambusae In Taenia 105g,
Scolopendra 35g, Scorpio 42g, Bombyx Batryticatus 70g, Concha Margaritifera 140g, Periostracum Cicadae 70g,
Pheretima 63g, Os Draconis 105g, Concha Ostreae 105g, Herba Hedyotidis Diffusae 140g,
Fructus Chaenomelis 70g, Herba Lycopodii 105g.
Its compounding method comprises following operation: select superior Chinese herbal medicine by weight,
1., preparation fine powder: with Fructus Alpiniae Oxyphyllae 105g, Rhizoma Acori Graminei 105g, Poria cum Radix Pini 70g, Rhizoma Gastrodiae 70g, Radix Saposhnikoviae 70g, Radix Angelicae Sinensis 70g, Radix Bupleuri 70g, Caulis Polygoni Multiflori 105g, Bombyx Batryticatus 70g, Fructus Chaenomelis 70g, this 10 flavor medicine is selected, rinsing, is dried, is ground into fine powder, after 120 mesh sieves sieve, standby again;
2., preparation Chinese medicine extract:
A, decocting in water extract: crude drug slag after will sieving and Ramulus Uncariae Cum Uncis 70g, Radix Pseudostellariae 105g, Flos Albiziae 105g, Rhizoma Typhonii 70g, Arisaema Cum Bile 70g, Lapis Micae Aureus 140g, Caulis Bambusae In Taenia 105g, Scolopendra 35g, Scorpio 42g, Concha Margaritifera 140g, Periostracum Cicadae 70g, Pheretima 63g, Os Draconis 105g, Concha Ostreae 105g, Herba Hedyotidis Diffusae 140g, Herba Lycopodii 105g, this 16 flavor medicine decocts with water three times, each amount of water is respectively 8 times, 6 times and 4 times of total dose, decocting time was respectively 2 hours, 1 hour and 1 hour, it extracts temperature is 90 ℃-100 ℃, all collects filtrate for later use at every turn;
B, concentrated:
Three times extraction filtrate is mixed, again decocting in water is extracted filtrate and be concentrated into paste, make them in the time of 65 ℃-90 ℃, relative density is 1.2g/ml-1.3g/ml;
C, be mixed into finished product: extract at the decocting in water that is concentrated into paste and add the crude drug powder in the filtrate, abundant mix homogeneously, dry, pulverize, grind after, make fine particle, with being distributed into pouch behind cobalt 60 illumination-based disinfections, every bag 8 restrains.
Instructions of taking is as follows: oral, every day 2-3 time, each 8 the gram or follow the doctor's advice.The period in a medicine preventing cold, fasting Folium Allii tuberosi, Herba Coriandri, Fructus Foeniculi.
Its advantage is: invigorating brain and relieving mental uneasiness Fructus Alpiniae Oxyphyllae, suppressing the hyperactive liver and subsiding YANG dispel the wind, calm the nerves soul, the pertinacious phlegm of dispelling, arresting convulsion epilepsy, end and twitching.Have no side effect, than Chinese herbal medicine decoction take with easy to carry, refining instant, the saving of labor saves time again, do not have sugar, clear and bright, good effect in the preparation, can effectively treat diseases such as coprolalia syndrome, hyperkinetic syndrome, various epilepsy, torsion spasm, children's's cerebral hypoplasia, dementia, mental retardation, hypomnesis, distractibility, mental maladjustment disease, neurasthenia, insomnia headache and many strange dreams at night.
Embodiment 2:
Comprise following weight proportion crude drug and extracts of bulk drugs in this electuary constituent:
Fructus Alpiniae Oxyphyllae 95g, Rhizoma Acori Graminei Poria cum Radix Pini 95g 60g, Rhizoma Gastrodiae 60g, Ramulus Uncariae Cum Uncis 60g,
Radix Saposhnikoviae 60g, Radix Pseudostellariae 95g, Radix Angelicae Sinensis 60g, Radix Bupleuri 60g, Caulis Polygoni Multiflori 95g,
Flos Albiziae 95g, Rhizoma Typhonii 60g, Arisaema Cum Bile 60g, Lapis Micae Aureus 130g, Caulis Bambusae In Taenia 95g,
Scolopendra 25g, Scorpio 32g, Bombyx Batryticatus 60g, Concha Margaritifera 130g, Periostracum Cicadae 60g,
Pheretima 53g, Os Draconis (life) 95g, Concha Ostreae (life) 95g, Herba Hedyotidis Diffusae 130g,
Fructus Chaenomelis 60g, Herba Lycopodii 95g.
Compounding method, instructions of taking and advantage and embodiment 1 according to above weight proportion crude drug and extracts of bulk drugs are identical.
Embodiment 3:
Comprise following weight proportion crude drug and extracts of bulk drugs in this electuary constituent:
Fructus Alpiniae Oxyphyllae 115g, Rhizoma Acori Graminei 115g, Poria cum Radix Pini 80g, Rhizoma Gastrodiae 80g, Ramulus Uncariae Cum Uncis 80g,
Radix Saposhnikoviae 80g, Radix Pseudostellariae 115g, Radix Angelicae Sinensis 80g, Radix Bupleuri 80g, Caulis Polygoni Multiflori 115g,
Flos Albiziae 115g, Rhizoma Typhonii 80g, Arisaema Cum Bile 80g, Lapis Micae Aureus 150g, Caulis Bambusae In Taenia 115g,
Scolopendra 45g, Scorpio 52g, Bombyx Batryticatus 80g, Concha Margaritifera 150g, Periostracum Cicadae 80g,
Pheretima 73g, Os Draconis (life) 115g, Concha Ostreae (life) 115g, Herba Hedyotidis Diffusae 150g,
Fructus Chaenomelis 80g, Herba Lycopodii 115g.
Compounding method, instructions of taking and advantage and embodiment 1 according to above weight proportion crude drug and extracts of bulk drugs are identical.
Through the medical science pharmacopeia as can be known, the main component that contains of this nourishing the brain and tranquilizing the mind electuary is:
(1), Fructus Alpiniae Oxyphyllae: acrid in the mouth, temperature.Return spleen, kidney channel.Effect: warming the spleen is opened and is taken the photograph saliva, the solid Tianjin of warming the kidney reducing urination.
(2), Rhizoma Acori Graminei: acrid in the mouth, temperature.GUIXIN, stomach warp.Effect: resuscitation inducing and mind tranquilizing, removing dampness to restore normal function of the stomach.
(3), Poria cum Radix Pini: sweet in the mouth, light, flat.GUIXIN, spleen, kidney channel.Effect: promoting diuresis to eliminate damp pathogen, spleen invigorating, calm the nerves.
(4), Rhizoma Gastrodiae: sweet in the mouth, flat.Return Liver Channel.Effect: endogenous wind stopping relieving convulsion, suppressing the hyperactive liver and subsiding YANG.
(5), Radix Saposhnikoviae: acrid in the mouth, sweet, tepor.Return bladder, liver, spleen channel.Effect: expelling pathogenic wind from the body surface, win wet, pain relieving, spasmolytic.
(6), Radix Angelicae Sinensis: sweet in the mouth, suffering, temperature.Return liver, the heart, spleen channel.Effect: enrich blood, invigorate blood circulation, pain relieving, intestine moistening.
(7), Radix Bupleuri: bitter in the mouth, suffering, be slightly cold.GUIXIN envelope, liver, three warmers, gallbladder meridian.Effect: reducing fever by reconciliation, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.
(8), Arisaema Cum Bile: bitter in the mouth, cold.Return lung, Liver Channel.Effect: removing heat-phlegm, relieving convulsion arresting convulsion.
(9), Rhizoma Typhonii: acrid in the mouth, sweet, warm; Poisonous.Return stomach, spleen channel.Effect: drying dampness to eliminate phlegm, expelling wind and relieving convulsion, detoxicating and resolving stagnation of pathogens.
(10), Lapis Micae Aureus: sweet in the mouth, salty, flat.Return lung, Liver Channel.Effect: expectorant is long-pending, suppressing the hyperactive liver Town is frightened.
(11), Bombyx Batryticatus: salty in the mouth, suffering, flat.Return liver, lung meridian.Effect: endogenous wind stopping relieving convulsion, wind-expelling pain-stopping, detoxicating and resolving stagnation of pathogens.
(12), Fructus Chaenomelis: sour in the mouth, temperature.Return liver, spleen channel.Effect: relaxing muscles and tendons and activating QI and blood in the collateral, removing dampness to restore normal function of the stomach.
The auxiliary element that this nourishing the brain and tranquilizing the mind electuary contains is:
(1), Ramulus Uncariae Cum Uncis: sweet in the mouth, little flat.Return liver, pericardium channel.Effect: endogenous wind stopping relieving convulsion, heat clearing away suppressing the hyperactive liver.
(2), Radix Pseudostellariae: sweet in the mouth, little hardship, flat.Return spleen, lung meridian.Effect: tonifying QI to produce body fluid.
(3), Caulis Polygoni Multiflori: sweet in the mouth, flat.GUIXIN, Liver Channel.Effect: tranquilizing by nourishing the heart, collateral dredging dispel the wind.
(4), Flos Albiziae: sweet in the mouth, flat.GUIXIN, Liver Channel.Effect: the resolving depression of calming the nerves.
(5), Caulis Bambusae In Taenia: sweet in the mouth, be slightly cold.Return lung, stomach, gallbladder meridian.Effect: removing heat-phlegm, relieve restlessness and prevent vomiting.
(6), Scolopendra: acrid in the mouth, temperature; Poisonous.Return Liver Channel.Effect: endogenous wind stopping relieving convulsion, detoxicating and resolving stagnation of pathogens, removing obstruction in the collateral to relieve pain.
(7), Scorpio: acrid in the mouth, flat, poisonous.Return Liver Channel.Effect: endogenous wind stopping relieving convulsion, detoxicating and resolving stagnation of pathogens, removing obstruction in the collateral to relieve pain.
(8), Concha Margaritifera: salty in the mouth, cold.Return liver, heart channel.Effect: suppressing the hyperactive liver and subsiding YANG, liver heat removing and eyesight improving.
(9), Periostracum Cicadae: sweet in the mouth, cold.Return lung, Liver Channel.Effect: dispelling wind heat, rash, improving acuity of vision and removing nebula, endogenous wind stopping relieving convulsion.
(10), Pheretima: salty in the mouth, cold.Return liver, spleen, urinary bladder channel.Effect: clearing heat for calming endogenous wind, relieving asthma, collateral dredging, diuresis.
(11), Os Draconis: sweet in the mouth, puckery, be slightly cold.GUIXIN, Liver Channel.Effect: suppressing the hyperactive liver and subsiding YANG, tranquillizing and allaying excitement, convergence are astringent or styptic treatment for spontaneous sweating.
(12), Concha Ostreae: salty in the mouth, be slightly cold.Return liver, kidney channel.Effect: suppressing the hyperactive liver and subsiding YANG, hard masses softening and resolving, convergence are astringent or styptic treatment for spontaneous sweating.
(13), Herba Hedyotidis Diffusae: mildly bitter flavor, sweet, cold.Return stomach, large intestine, small intestine meridian.Effect: heat clearing away, dampness removing, detoxifcation, eliminating carbuncle.
(14), Herba Lycopodii: bitter in the mouth, suffering, temperature.Return Liver Channel.Effect: wind-damp dispelling, relaxing muscles and tendons and activating QI and blood in the collateral.
Its clinical case 15 examples are asked for an interview attached sheet.
Attached sheet:
Clinical place: village waterborne, Tianjin hospital.
1. burnt * *, man, 10 years old, Kowloon people, certain primary school student.
Before 5 years; the unknown reason of patient occurs that the involuntary twisting of cervical region, the probe action that protracts, head do not stop to rock layback, shrug, clap hands, make eyes, ears are twitched and abdominal part is twitched; took multiple Chinese and western drugs treatment once; but the commentaries on classics of not getting better; the back is to my institute's treatment; take the nourishing the brain and tranquilizing the mind electuary; behind the two weeks; above clinical symptoms all has alleviating in various degree, after continuing to take 3 months, and various symptom complete obiterations; in order to consolidate curative effect; append again take 1 month after, stop the treatment, follow up a case by regular visits to 1 year not the recurrence.
Cui * *, man, 17 years old, Shijiazhuang City people, certain middle school student.
Before 10 years, the unknown reason of patient the discontinuity that extremity can not automatic control occurs and twitches, when twitching outbreak, difficulty in walking is also made faces, is hanged one's tongue out in astonishment, often the words with oneself bite, multiple Western medicine such as oral haloperidol is treated for many years, does not all feel any better, and the obscene words phenomenon of not automatic control appears again in the patient in therapeutic process.The back is to my institute's diagnosis and treatment, and take the nourishing the brain and tranquilizing the mind electuary, after 1 month, patient's obscene words phenomenon disappears substantially, other symptom still is interrupted outbreak, after continuing to take 3 months, above symptom disappears substantially, append again take 3 months after, the clinical symptoms complete obiteration, can orthobiosis and study, now stopped treatment is followed up a case by regular visits to not recurrence in 1 year.
Sieve * *, the man, 38 years old, the workman, unmarried, people from Shanxi.
Private prosecution is in the time of 6 years old, fall down accidentally from the second floor balcony, cause the incidence damage, and excessively frighten, behind the about wheat harvesting period, one day time-out early, the involuntary twisting of cervical region promptly appears, and protract probe action and double swerve of cervical region every now and then, sometimes with making eyes, dehisce to blow, when writing, can not pat desktop to automatic control, and unconscious the tearing to pieces again of the thing that will finish writing write, write again and torn with hands, before scurry layback in the process of walking, often fall down, psychentonia, timid, emotion is extremely unstable, over year, its clinical symptoms is changeable, behind one group of transference cure surplus in the of 30, another group symptom occurs again in succession, or on the basis of another group symptom, increase new symptom again and together occur, successively take multiple Chinese-western medicine preparation, as haloperidol, Tai Bili, trihexyphenidyl etc. and Chinese herbal medicine decoction, acupuncture, the acupuncture point bury the treatment equal curative effect average, institute going to a doctor to me in the back, is diagnosed as coprolalia syndrome, selects for use the nourishing the brain and tranquilizing the mind electuary after oral 2 months at once, above symptom all has alleviating and disappear in various degree, continue to take 1 year again after 3 months, its clinical symptoms complete obiteration can operate as normal and life, stop treatment, follow up a case by regular visits to not recurrence in a year.
Jiang * *, man, 15 years old, Chinese American, middle school student.
Before 8 years, trunk appears in the unknown reason of patient, extremity discontinuity is not autonomous, twitch in not automatic control ground, twisting, and make eyes, alarm nose, shrug, the squatting motion of variable interval during walking, when hearing the tap water flowing water sound, fear very much, and making above sx, how tame abroad hospitalize is more than 2 years, all inefficacy, multiple Western medicine such as haloperidol have been taken after coming back home, treatments such as trihexyphenidyl, and take Chinese herbal medicine decoction and acupuncture and moxibustion therapy more than a year, bad during its clinical symptoms fashion, the back is to my institute's treatment, all Therapeutic Method more than stopping using, select for use the nourishing the brain and tranquilizing the mind electuary after oral 3 months, patient has no longer feared to hear tap water flowing water sound, extremity, trunk is twitched the symptom basic controlling and is lived.After continuing again to take 4 months, clinical symptoms disappears substantially.Idol has and makes eyes when occurring, append again take 2 months after, clinical symptoms complete obiteration, and stopped treatment.
Lee *, woman, 14 years old, people from Chengdu, Sichuan, middle school student.
Before 9 years, making eyes appears in the unknown reason of patient, and not automatic control of cervical region, involuntary about the twisting, whenever behind the walking certain hour, suddenly stop, turn-taking behind the 3-5 circle in the original place, walking again, emotional lability, irritated irritability is sent to variable interval the sound of " " again, and it is surplus once to take medicines such as Tai Bili, trihexyphenidyl, acupuncture and massage therapy 3 years, its clinical symptoms is not felt any better, on the contrary aggravation.To my institute's diagnosis and treatment, stop above Therapeutic Method at once, select the nourishing the brain and tranquilizing the mind electuary for use, after taking 1 month, the sound of " " of independently not sending disappears substantially, but other symptoms are not all felt any better, after continuing to take 3 months, no matter the transference cure of turn-taking is on the spot in the process of walking walked and how long is not also reaccessed, and still has and twists phenomenon about cervical region, for the after treatment effect, after continuing again to take 3 months, except that idol has the sound of pharyngeal " " of sending other symptom complete obiterations.Can learn normally and live, thus stopped treatment.Following up a case by regular visits to 1 year other symptom does not all occur.
6. all * *, man, 9 years old, people from Beijing, primary school student.
Before 4 years, the unknown reason of patient occurs not independently, the looking smug or conceited of not automatic control, sway one's hips swing one's arm, the eyes eyeball rotates once in a while and turns over eye, hospital is diagnosed as coprolalia syndrome, once used western medicines such as haloperidol more than 2 years, clinical symptoms is not only alleviated above on the contrary symptom and is alternately occurred, and aggravation.Stop using Western medicine gradually, and take the nourishing the brain and tranquilizing the mind electuary after 2 months to my institute's treatment in the back, its clinical symptoms is most of to disappear, but also can occur once in a while looking smug or conceited, turn over a phenomenon, after continuing to take 3 months, not recurrence in 1 year is followed up a case by regular visits in symptom complete obiteration, and stopped treatment.
The king * *, man, 12 years old, people from Tianjin, primary school's five classmans.
Before 6 years, the unknown reason of patient occurs not independently, the face of not automatic control are twitched, shrug swing one's arm, come back, kick, stamp one's foot, emotional lability and irritated irritability, hospital is diagnosed as coprolalia syndrome, once used western medicines such as haloperidol, trihexyphenidyl more than a year, clinical symptoms is not felt any better, and the side effect after occurring taking medicine, long-term sialorrhea is more than, the dull nothing of eyes is refreshing.The back is to the treatment of my institute, all Western medicine of stopping using, take nourishing the brain and tranquilizing the mind electuary two weeks after, its clinical symptoms disappears substantially, after continued again to take 3 months, the clinical symptoms complete obiteration is in order to consolidate curative effect, append again and take recovery from illness after 1 month, and stop treatment, follow up a case by regular visits to not recurrence in a year.
Lee * *, woman, 15 years old, Canadian nationality Chinese, middle school student.
Before 9 years, in cat fever headache recovery from illness, behind half wheat harvesting period, involuntary occur both shoulders shrug one's shoulders, look smug or conceited, make eyes, hang one's tongue out in astonishment, sometimes in gait processes not independently, not automatic control after the original place is stopped 2-3 minute, walking forward again, hospital treatment is more than 2 years, the clothes Western medicine is not quite clear, the back is gone back to China and is continued treatment, press the coprolalia syndrome treatment, and take Western medicine and Chinese herbal medicine decoctions such as haloperidol, Tai Bili and cooperate acupuncture and moxibustion therapy more than a year, clinical symptoms is not felt any better, and the time and the phenomenon of making a scene appears.The back is to my institute's treatment, Western medicine such as inactive at once haloperidol, Tai Bili, select oral nourishing the brain and tranquilizing the mind electuary treatment for use, after 10 days, the symptom of making a scene disappears substantially, other symptom still exists, after continuing to take 5 months, above symptom disappears substantially, appends again and takes recovery from illness after 2 months, and stop to treat go back to Canada, do not follow up a case by regular visits to.
9. shut out * *, man, 13 years old, the big Hongkong people in Tianjin, pupil.
Before 8 years, after a body temperature is 39.8 ℃ of cat fever recoveries from illness, looking smug or conceited, hanging one's tongue out in astonishment of not automatic control appears, in case living environment change, the patient not independently, mouthful the spitting of not automatic control, and the sound of roaring of sending frequently, psychentonia, dysphoria and be forced to stop school work.Successively to how tame hospital therapy, all by the coprolalia syndrome treatment, and take haloperidol, oryzanol, Western medicine such as stable, and cooperate and take several different methods such as Chinese herbal medicine decoction, acupuncture, the ear acupoint overlay and treat, more than totally four years, curative effect is very little.Institute going to a doctor to me in the back, selects oral nourishing the brain and tranquilizing the mind electuary treatment for use, after 20 days, patient's spirit emotion is more preceding stable, and after living environment changed, no longer mouth was spat, the sound of roaring disappears substantially, but other symptom is not still felt any better, and after continuing to take 5 months, above symptom disappears substantially, in order to consolidate curative effect, append again and take recovery from illness after 5 months, and stop treatment, follow up a case by regular visits to not recurrence in a year.
Horse * *, man, 15 years old, people from Daqing, Heilongjiang Province, middle school student.
Before 8 years, two lower limb occur and independently do not twitch, usually can not automatic control fall down during walking, and occur two upper limb gradually and raise involuntary rocking high aloft, or both hands clapping hands of autonomous not automatic control not.Head shakes incessantly simultaneously, sometimes send the sound of shouting strangely in the mouth, sway one's hips sometimes, when taking food whenever as animal, often bowls and chopsticks are pushed on ground, or not automatic control strike with the hand and hit own head, or the hair of oneself pulled up puts into mouth and chew food, along with the development of the state of an illness, often be regardless of occasion and send the speech that is difficult to pleasant obscene words, how tame hospitalize 3 years be surplus in the locality, and the how tame hospitalize in the other places again gives haloperidol, Tai Bili, trihexyphenidyl, vitamin B by twitching the obscene words syndrome
1Oryzanol, multiple Western medicine such as chlorpromazine and multiple Chinese herbal medicine decoction treatment are for many years, all curative effect is average, institute go to a doctor to me in the back, inactive at once Western medicine preparation, take the treatment of nourishing the brain and tranquilizing the mind electuary, behind the first quarter moon, patient does not fall down in the process of walking again, the symptom that hands held high rocks in the air also obviously alleviates, but other symptom is not still felt any better, and continues medication treatment after 3 months, and its clinical symptoms mostly disappears, but still have the cry of interruption and occur the obscene words phenomenon once in a while, append take 6 months after, its clinical symptoms complete obiteration, and can orthobiosis and study, and stopped treatment is followed up a case by regular visits to not recurrence in a year.
11. Zhao *, woman, 20 years old, Jining, Shandong Province county peasant.
(readme) father and mother are very tight to oneself supervisor since the childhood, and learning pressure is big, and it is absent minded to occur study in the time of 9 years old, little trick is many, nictation, Zhou E Yang eyebrow, look side ways, loll lick lip, turn one's head, bend over, verbigeration etc. not independently, the performance of not automatic control.Arrive national various big hospital 10 years all by the coprolalia syndrome diagnosis and treatment more, give Western medicine such as haloperidol, trihexyphenidyl, also carried out massage and psychotherapy, curative effect is average.The back is diagnosed as coprolalia syndrome to my institute's diagnosis and treatment, stops above treatment, selects the nourishing the brain and tranquilizing the mind electuary at once for use, after 1 month, nictation, Zhou E Yang eyebrow, strabismus do not occur again, but other symptoms still alternately occur, after continuing to take 3 months, above symptom all disappears, stopped treatment.Followed up a case by regular visits to the phenomenon of turning one's head by chance 1 year.
12. the king * *, woman, 11 years old, the big Hongkong people in Tianjin, primary school student.
(Dai Shu) parental discord is often quarreled, divorce before 6 years, divorce after half a year, to murmur to oneself appears in daughter, makes eyes, spitting ptysis, the performance of clearing one's throat is to the various big hospital diagnosis and treatment, all treat by coprolalia syndrome, for many years, all oral stable, sulpiride, bad during period in a medicine state of an illness fashion, after carry out psychotherapy, poor effect again.The back also is diagnosed as coprolalia syndrome to my institute's treatment, gradually stops above medicine, allows father and mother give child a good family atmosphere, oral nourishing the brain and tranquilizing the mind electuary, and after two months, the above symptom of patient all disappears stopped treatment.Follow up a case by regular visits to not recurrence in a year.
13. the hole * *, 12 years old, Harbin City, Heilongjiang Province people from city, pupil.
(Dai Shu) in the time of five years old, be fascinated by dozen electronic game machine, after 1 year, just appear nictation, turn over eye, after alternately occur again opening one's mouth to stuck out one's tongue, grit one's teeth, shrug, press the coprolalia syndrome treatment for many years, all oral haloperidol, the stable Western medicine that waits, period in a medicine takes a turn for the better, a drug withdrawal, and the state of an illness increases the weight of on the contrary, the back is to my institute's treatment, be diagnosed as coprolalia syndrome, gradually stop above medicine, stop console gaming, oral Anshenjiannaocong granule is after one month, nictation, turn over eye and take a turn for the better, but all the other symptoms still do not feel any better, after took again 1 month, open one's mouth to stuck out one's tongue, grit one's teeth, the transference cure of shrugging, but idol has nictation, turn over a phenomenon, continued to take 2 months, above symptom complete obiteration, stopped treatment is followed up a case by regular visits to not recurrence in a year.
14. Bai, man, 5 years old, people from Tianjin.
(Dai Shu) its father performance of being arranged nictation, turning one's head, its infant in the time of 4 years old unknown cause appear nictation, after occur again dehiscing, draw the abdomen, kicking, arrive each hospital's regulation immediately, press coprolalia syndrome and treat half a year, oral haloperidol takes a turn for the better, and a drug withdrawal is recurred again, the back is to my institute's treatment, be diagnosed as coprolalia syndrome, gradually stop above medicine, oral nourishing the brain and tranquilizing the mind electuary is after one month, dehisce, draw the abdomen, kick and do not occur again, but still have phenomenon nictation, continued to take 1 month, above transference cure, stopped treatment is followed up a case by regular visits to not recurrence in a year.
15. Liu * *, man, 52 years old, people from Tianjin, workman.
Readme, in the time of 16 years old, to shake the head appear in unknown cause, facial strange resemble, touch hair, unconscious grunt, after occur again stretching out one's hand, kicking, sleep disorder, above action alternately occurs over more than 30 year, the front and back treatment is pressed the coprolalia syndrome treatment, oral haloperidol, trihexyphenidyl and New type of S SRI class Western medicine for many years, and cooperating Therapeutic Method such as acupuncture, massage, curative effect is average.The back is diagnosed as coprolalia syndrome to the treatment of my institute, withdraws above medicine, stops above Therapeutic Method, and oral nourishing the brain and tranquilizing the mind electuary is after 3 months, grunt and shake the head, the facial strange disappearance that resembles, continue to take half a year, idol has strange elephant of face, all the other symptom complete obiterations.Do not follow up a case by regular visits to.
Claims (3)
1, a kind of nourishing the brain and tranquilizing the mind electuary, it is characterized in that: the weight proportion of crude drug is:
Fructus Alpiniae Oxyphyllae 95g-115g, Rhizoma Acori Graminei 95g-115g, Poria cum Radix Pini 60g-80g,
Rhizoma Gastrodiae 60g-80g, Ramulus Uncariae Cum Uncis 60g-80g, Radix Saposhnikoviae 60g-80g,
Radix Pseudostellariae 95g-115g, Radix Angelicae Sinensis 60g-80g, Radix Bupleuri 60g-80g,
Caulis Polygoni Multiflori 95g-115g, Flos Albiziae 95g-115g, Rhizoma Typhonii 60g-80g,
Arisaema Cum Bile 60g-80g, Lapis Micae Aureus 130g-150g, Caulis Bambusae In Taenia 95g-115g,
Scolopendra 25g-45g, Scorpio 32-52g, Bombyx Batryticatus 60g-80g,
Concha Margaritifera 130g-150g, Periostracum Cicadae 60g-80g, Pheretima 53g-73g,
Os Draconis 95g-115g, Concha Ostreae 95g-115g, Herba Hedyotidis Diffusae 130g-150g,
Fructus Chaenomelis 60g-80g, Herba Lycopodii 95g-115g.
2, nourishing the brain and tranquilizing the mind electuary according to claim 1, it is characterized in that: the weight proportion of crude drug is:
Fructus Alpiniae Oxyphyllae 105g, Rhizoma Acori Graminei 105g, Poria cum Radix Pini 70g, Rhizoma Gastrodiae 70g, Ramulus Uncariae Cum Uncis 70g,
Radix Saposhnikoviae 70g, Radix Pseudostellariae 105g, Radix Angelicae Sinensis 70g, Radix Bupleuri 70g, Caulis Polygoni Multiflori 105g,
Flos Albiziae 105g, Rhizoma Typhonii 70g, Arisaema Cum Bile 70g, Lapis Micae Aureus 140g, Caulis Bambusae In Taenia 105g,
Scolopendra 35g, Scorpio 42g, Bombyx Batryticatus 70g, Concha Margaritifera 140g, Periostracum Cicadae 70g,
Pheretima 63g, Os Draconis 105g, Concha Ostreae 105g, Herba Hedyotidis Diffusae 140g,
Fructus Chaenomelis 70g, Herba Lycopodii 105g.
3, the compounding method of nourishing the brain and tranquilizing the mind electuary is characterized in that: it comprises following operation:
Select superior Chinese herbal medicine by weight,
1., preparation fine powder: Fructus Alpiniae Oxyphyllae 95g-115g, Rhizoma Acori Graminei 95g-115g, Poria cum Radix Pini 60g-80g, Rhizoma Gastrodiae 60g-80g, Radix Saposhnikoviae 60g-80g, Radix Angelicae Sinensis 60g-80g, Radix Bupleuri 60g-80g, Caulis Polygoni Multiflori 95g-115g, Bombyx Batryticatus 60g-80g, Fructus Chaenomelis 60g-80g are selected, rinsing, dry, are ground into fine powder, after 120 mesh sieves sieve, standby again;
2., preparation Chinese medicine extract:
A, decocting in water extracts: crude drug slag after will sieving and Ramulus Uncariae Cum Uncis 60g-80g, Radix Pseudostellariae 95g-115g, Flos Albiziae 95g-115g, Rhizoma Typhonii 60g-80g, Arisaema Cum Bile 60g-80g, Lapis Micae Aureus 130g-150g, Caulis Bambusae In Taenia 95g-115g, Scolopendra 25g-45g, Scorpio 32-52g, Concha Margaritifera 130g-150g, Periostracum Cicadae 60g-80g, Pheretima 53g-73g, Os Draconis 95g-115g, Concha Ostreae 95g-115g, Herba Hedyotidis Diffusae 130g-150g, Herba Lycopodii 95g-115g adds decocting three times, each amount of water is respectively 8 times of total dose, 6 times and 4 times, decocting time was respectively 2 hours, 1 hour and 1 hour, it extracts temperature is 90 ℃-100 ℃, collects filtrate for later use;
B, concentrated:
Three times extraction filtrate is mixed, again decocting in water is extracted filtrate and be concentrated into paste, make them in the time of 65 ℃-90 ℃, relative density is 1.2g/ml-1.3g/ml;
C, be mixed into finished product: extract at the decocting in water that is concentrated into paste and add the crude drug powder in the filtrate, abundant mix homogeneously, dry, pulverize, grind after, make fine particle, with being distributed into pouch behind cobalt 60 illumination-based disinfections, every bag 8 restrains.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100132627A CN100444883C (en) | 2006-03-10 | 2006-03-10 | Anshenjiannaocong granule and its compounding process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100132627A CN100444883C (en) | 2006-03-10 | 2006-03-10 | Anshenjiannaocong granule and its compounding process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1857579A CN1857579A (en) | 2006-11-08 |
| CN100444883C true CN100444883C (en) | 2008-12-24 |
Family
ID=37296567
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2006100132627A Expired - Fee Related CN100444883C (en) | 2006-03-10 | 2006-03-10 | Anshenjiannaocong granule and its compounding process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100444883C (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101905005A (en) * | 2009-06-04 | 2010-12-08 | 赵怀谦 | Formula of traditional Chinese medicine for treating epilepsy |
| CN102988905B (en) * | 2012-12-28 | 2014-09-17 | 青岛华仁技术孵化器有限公司 | Traditional Chinese medicine preparation for treating epilepsia and preparation method thereof |
| CN103316255A (en) * | 2013-07-16 | 2013-09-25 | 冯宇伟 | Children health-care product and its preparation method |
| CN103860912B (en) * | 2014-03-10 | 2016-11-16 | 朱增伟 | One treats neurasthenic Chinese medicine composition |
| CN104352818A (en) * | 2014-11-21 | 2015-02-18 | 郝建国 | Traditional Chinese medicine composition for treating atelencephalia and preparation method thereof |
| CN104524464A (en) * | 2014-12-30 | 2015-04-22 | 陈淑娟 | Traditional Chinese medicine preparation for treating hyperactivity and preparation method of traditional Chinese medicine preparation |
| CN104623315A (en) * | 2015-02-11 | 2015-05-20 | 郭如英 | Blood-nourishing yin-replenishing medicine for treating mental retardation and preparation method of medicine |
| CN105055830A (en) * | 2015-08-11 | 2015-11-18 | 宁同波 | Medicine for treating epilepsy after cerebral trauma |
| CN105233050A (en) * | 2015-11-06 | 2016-01-13 | 黄秋丽 | Traditional Chinese medicinal composition for treating neurasthenia, and preparation method thereof |
| CN105343549A (en) * | 2015-11-14 | 2016-02-24 | 薛学明 | Pharmaceutical for treating childhood mental retardation and its preparation method |
| CN116898929A (en) * | 2023-07-21 | 2023-10-20 | 大彭世纪科技有限公司 | Nerve-soothing brain-nourishing health-care soup |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1061552C (en) * | 1997-10-28 | 2001-02-07 | 董国良 | Epilepsy recovering pill and preparing process thereof |
| CN1228079C (en) * | 2003-12-29 | 2005-11-23 | 西安中医脑病医院 | Oral medicine for treating child restless syndrome |
-
2006
- 2006-03-10 CN CNB2006100132627A patent/CN100444883C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1061552C (en) * | 1997-10-28 | 2001-02-07 | 董国良 | Epilepsy recovering pill and preparing process thereof |
| CN1228079C (en) * | 2003-12-29 | 2005-11-23 | 西安中医脑病医院 | Oral medicine for treating child restless syndrome |
Non-Patent Citations (2)
| Title |
|---|
| 近十年儿童多动综合征中西医诊治概况. 林红，马霞.中国中西医结合学会第七届精神疾病学术讨论会论文汇编. 2002 |
| 近十年儿童多动综合征中西医诊治概况. 林红，马霞.中国中西医结合学会第七届精神疾病学术讨论会论文汇编. 2002 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1857579A (en) | 2006-11-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100444883C (en) | Anshenjiannaocong granule and its compounding process | |
| CN103520572B (en) | A kind of Chinese medicine composition being used for the treatment of atopic dermatitis and preparation method thereof | |
| CN103405728B (en) | A kind of Chinese medicine composition for the treatment of climacteric syndrome and preparation method thereof | |
| CN103638250B (en) | One treats prosopoplegic Chinese medicine preparation and preparation method thereof | |
| CN101301459B (en) | Medicated pillow | |
| CN104013868B (en) | Traditional Chinese medicine composition for treating chronic obstructive pulmonary disease and preparation method thereof | |
| CN104069474A (en) | Traditional Chinese medicine composition for treating seborrheic alopecia and preparation method thereof | |
| CN105288208A (en) | Traditional Chinese medicine composition for treating acute optic neuritis | |
| CN104771602A (en) | Medicine for treating facioplegia and preparation method thereof | |
| CN104274754A (en) | Traditional Chinese medicine composition for treating infantile enuresis and preparation method of traditional Chinese medicine composition | |
| CN104127702A (en) | Traditional Chinese medicine preparation for treating acute optic neuritis, as well as preparation method thereof | |
| CN103495072B (en) | Traditional Chinese medicine composition treating bronchiectasia disease and preparation method thereof | |
| CN101422584A (en) | Multifunctional health-care medicine bag and production method thereof | |
| CN104147460A (en) | Traditional Chinese medicinal preparation for treating Parkinson's disease and preparation method thereof | |
| CN102949633B (en) | Traditional Chinese medicine combination for treating constipation | |
| CN103549072B (en) | Vital energy-benefiting brain-boosting tea and preparation method thereof | |
| CN101249245A (en) | Medicament for curing esophagus cancer and cardiac cancer | |
| CN104689283A (en) | Medicine for treatment of spleen insufficiency damp-aggregating type chloasma and preparation method thereof | |
| CN110292622A (en) | A kind of Chinese medicine composition and preparation method thereof for treating meningioma | |
| CN105434922A (en) | Preparation for treating facial paralysis and preparation method thereof | |
| CN101317989B (en) | Pure traditional Chinese medicine medicament composition for treating white plague | |
| CN106421113A (en) | Traditional Chinese medicinal composition for prevention and external treatment of insomnia and using method of traditional Chinese medicinal composition | |
| CN105770773A (en) | Traditional Chinese medicinal preparation for treating adult mild brain disturbance and preparation method of traditional Chinese medicinal preparation | |
| CN105343394A (en) | Traditional Chinese medicine composition for treating hypertension | |
| CN104162038A (en) | Traditional Chinese medicine composition for treating neonatal seizures and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20081224 Termination date: 20120310 |