CN100411629C - 一种缓释型补铁剂的制备方法 - Google Patents
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Classifications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
- Y02A40/81—Aquaculture, e.g. of fish
- Y02A40/818—Alternative feeds for fish, e.g. in aquacultures
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fodder In General (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
本发明公开了一种缓释型的补铁剂及制备方法和用途。它是一种含活性铁的阳离子交换树脂,按重量百分比计,铁在阳离子交换树脂中的含量为1.5~10%。其制备方法是采用二价铁盐与阳离子交换树脂的吸附、离子交换反应,经过滤、干燥、粉碎制成含活性铁的阳离子交换树脂。由于离子交换树脂是一种性能优良的控缓释载体,对所负载的铁具有控缓释作用,从而大大提高了铁的吸收利用率。本发明所制得的缓释型的补铁剂可作为饲料添加剂应用于畜禽、水产动物、牛、羊等的补铁;也可用于制备人类口服补铁和通过给药治疗性的铁来治疗人类疾病的保健品和药物,适用范围广泛。
Description
技术领域
本发明涉及一种缓释型的补铁剂及制备方法和用途。
背景技术
铁是动物必需的一种微量元素,是血红蛋白和肌红蛋白的必需组成成分,并与细胞色素酶、过氧化物酶、过氧化氢酶、乙酰辅酶A、琥珀酸脱氢酶、黄嘌呤氧化酶的活性密切相关。铁参与机体组织内氧的正常运输,直接影响机体的能量和蛋白质代谢,而且还会影响动物体的免疫机能和繁殖性能。常规饲料中的铁含量较高,单从量上讲,已能满足动物需要。但是,植物性饲料中铁的利用率极低,而养殖业的集约化程度越来越高,育种和营养两方面的努力使得畜禽的生长速度大幅度提高。因而,必须人工添加部分铁,才能满足畜禽的需要。人工添加的称为铁添加剂。至今,铁添加剂的发展经历了三个阶段,相应的有三代产品。第一代产品即无机铁:硫酸亚铁、碳酸亚铁、三氧化铁、氯化铁、氯化亚铁等;第二代产品即有机盐铁:乳酸铁、富马酸铁、柠檬酸亚铁、延胡索酸铁等;第三代为蛋白源或氨基酸螯合铁:蛋氨酸螯合铁、苏氨酸螯合铁、甘氨酸铁等。
控缓释系统对药物、农药、肥料、香料的释放部位、速度和方式具有选择性和可控性,可实现目标物的靶向传输和控缓释,提高其利用率和作用效果,控缓释体系的研究和应用将给相关行业带来新的技术革命。控缓释技术的关键是控释载体的选择。离子交换树脂(Ionexchange resin,IER)是一类带有功能基的网状结构的高分子化合物,其结构由三部分组成:不溶性的三维空间网状骨架,连接在骨架上的功能基团和功能基团所带的相反电荷的可交换离子。按照交换基团的性质不同,把离子交换树脂分为六大类:强酸性阳离子交换树脂、弱酸性阳离子交换树脂、强碱性阴离子文换树脂、弱碱性阴离子交换树脂、鳌合性离子交换树脂、两性离子交换树脂、氧化还原性离子交换树脂。根据树脂所带的可交换的离子性质,离子交换树脂大体上分为阳离子交换树脂和阴离子交换树脂,带有酸性功能基(强酸性:磺酸基(-SO3H);弱酸性:羧酸基(-COOH),磷酸基(-PO3H2)等),能与阳离子进行交换的聚合物叫阳离子交换树脂;带有碱性功能基(强碱性:季铵基-N(CH3)3等;弱碱性:伯、仲、叔胺基(-CH2NH2、--CH2NHR,-CH2NR2)等),能与阴离子进行交换的聚合物叫阴离子交换树脂。
根据树脂物理结构的不同,又可以把离子交换树脂分为凝胶型和大孔型树脂两大类。凝胶型树脂是一类外观透明的均相高分子凝胶结构的离子交换树脂,吸水后树脂相内产生微孔,反离子可扩散进由吸水而产生的微孔内进行离子交换。大孔型离子交换树脂的基本特点是在整个树脂内部无论干、湿或收缩、溶胀在水中都存在着比一般凝胶型更多、更大的孔道,因而表面积大,在离子交换过程中,离子容易迁移扩散,交换速度较快。
离子交换树脂的全名称由分类名称、骨架(或基团)名称、基本名称排列组成。离子交换树脂的型号名称是根据结构不同而定的,由三位阿拉伯数字组成:第一位数字代表产品的分类,第二位数字代表骨架结构的差异,第三位数字为顺序号,用以区别基团、交联剂等。凡大孔型离子交换树脂,在型号前加,-D表示:凝胶型离子交换树脂,在型号后用“×”联接阿拉伯数字表示。其中,分类代号有0,1,2,3,4,5,6,相应代表强酸型、弱酸型、强碱型、弱碱型、螯合型、两性及氧化还原型离子交换树脂。骨架代号有0,1,2,3等,分别代表苯乙烯系、丙烯酸系、酚醛系、环氧系等。
离子交换树脂长期以来应用于分析化学医药的分离和纯化纯水制备及近期用于环境保护血液净化等领域。自1956年首次提出离子交换树脂作为药物载体用于延缓药物释放以来,利用离子交换技术来延缓药物释放的报道不断增加,并已进入实用性阶段。离子交换树脂作为药物载体具有多种优良特性,目前其在控释、透皮给药、定位给药、速溶、离子导入透皮、鼻腔、局部给药和掩盖药物苦味等方而的应用都有很深入的研究,有些产品已经上市。离子交换树脂主要在胃肠道中控制药物释放,即离子交换树脂控释给药系统(Ion-Exchange ResinControlled Drag Delivery System,IERCDDS),与其他给药系统相比,IERCDDS的主要特点是药物的释放不依赖于胃肠道内的pH值、酶活性、温度以及胃肠道液的体积,由于胃肠道液中的离子种类及其强度维持相对恒定,故药物在体内可以恒定速率释放。
发明内容
本发明的目的是提供一种缓释型的补铁剂及制备方法和用途。
缓释型的补铁剂是采用二价铁盐与阳离子交换树脂经吸附、离子交换反应制备而成的一种含活性铁的阳离子交换树脂,按重量百分比计,铁在阳离子交换树脂中的含量为1.5~10%。
缓释型的补铁剂的制备方法,包括以下步骤:
1)将阳离子交换树脂置于树脂体积1~2倍的0.5~2mol/L盐酸溶液浸泡2~5小时,放尽酸液后用水漂洗至中性;
2)将含铁量为阳离子交换树脂重量1.5~10%的二价铁盐,预先配置成0.1~2.0mol/L的水溶液,于搅拌下缓慢加入步骤1)的树脂中,检测并调节反应液的pH值为3.0~6.0,室温反应5~10小时;
3)检测步骤2)反应液的pH值,用碱性溶液调节,使反应液pH值为7.5~8.5;水洗3~5次,过滤或离心脱水;
4)将步骤3)所得的滤饼在低于70℃下烘干、粉碎,得到缓释型的补铁剂。
本发明所述的铁盐为氯化亚铁、硝酸亚铁或硫酸亚铁。本发明所述的碱性溶液为浓度为0.5~5moL/L的氢氧化钠、氢氧化钾、碳酸钠、碳酸钾、碳酸氢钠或碳酸氢钾的水溶液。
缓释型的补铁剂用作畜禽、水产动物、牛、羊补铁饲料添加剂。
缓释型的补铁剂用作制备人类口服补铁和通过给药治疗性的铁来治疗人类疾病的保健品和药物。
本发明的优点是:
(1)利用阳离子交换树脂可与阳离子起交换作用的特点,将铁负载到阳离子交换树脂中,实施方法简便,适宜工业化生产,成本较低。
(2)由于离子交换树脂是一种性能优良的控缓释载体,对所负载的铁具有控缓释作用,从而大大提高了铁的吸收利用率。
(3)本发明所制得的缓释型的补铁剂可作为饲料添加剂应用于畜禽、水产动物、牛、羊等的补铁;也可用于制备人类口服补铁和通过给药治疗性的铁来治疗人类疾病的保健品和药物,适用范围广泛。
(4)本发明的缓释型的补铁剂易于与饲料混合,形成均匀分散系,使用方便。
具体实施方式
阳离子交换树脂包括强酸性阳离子交换树脂和弱酸性阳离子交换树脂。阳离子交换树脂为带有酸性功能基,包括强酸性(磺酸基,-SO3H)和弱酸性(羧酸基-COOH,磷酸基-PO3H2)功能基,能与阳离子进行交换的聚合物。根据树脂物理结构的不同,阳离子交换树脂可以为凝胶型或大孔型树脂。阳离子交换树脂骨架为苯乙烯系或者丙烯酸系。
实施例1
1)将市售的001×7强酸性苯乙烯系阳离子交换树脂(本产品相当于美国:AmberrliteIR-120 Dowex-50,西德:Lewatit-100,日本:DiaonSK-1),置于与树脂等体积的0.5mol/L盐酸溶液浸泡5小时,放尽酸液后用水漂洗至中性;
2)将含铁量为阳离子交换树脂重量1.5%的氯化亚铁,预先配置成0.1mol/L的水溶液,于搅拌下缓慢加入步骤1)的树脂中,检测并调节反应液的pH值为3.0,室温反应5小时;
3)检测步骤2)反应液的pH值,用浓度为0.5moL/L的氢氧化钠水溶液调节,使反应液pH值为7.5;水洗3次,过滤脱水;
4)将步骤3)所得的滤饼在低于70℃下烘干、粉碎,得到缓释型的补铁剂。按重量百分比计,铁在阳离子交换树脂中的含量为1.5%。
实施例2
1)将市售的D001大孔强酸性苯乙烯系阳离子交换树脂(本产品相当于美国:Amberlite200,西德:Lewaitet-SP120),置于树脂体积2倍的2mol/L盐酸溶液浸泡2小时,放尽酸液后用水漂洗至中性;
2)将含铁量为阳离子交换树脂重量10%的硝酸亚铁,预先配置成2.0mol/L的水溶液,于搅拌下缓慢加入步骤1)的树脂中,检测并调节反应液的pH值为6.0,室温反应10小时;
3)检测步骤2)反应液的pH值,用浓度为5moL/L的氢氧化钾水溶液调节,使反应液pH值为8.5;水洗5次,离心脱水;
4)将步骤3)所得的滤饼在低于70℃下烘干、粉碎,得到缓释型的补铁剂。按重量百分比计,铁在阳离子交换树脂中的含量为10%。
实施例3
1)将市售的D113大孔弱酸性丙烯酸系阳离子交换树脂(本产品相当于德国:LewatitCNP-80,美国:AmberliteIRC-84),置于树脂体积1.5倍的1mol/L盐酸溶液浸泡3小时,放尽酸液后用水漂洗至中性;
2)将含铁量为阳离子交换树脂重量5.0%的硫酸亚铁,预先配置成1.0mol/L的水溶液,于搅拌下缓慢加入步骤1)的树脂中,检测并调节反应液的pH值为5.0,室温反应6小时;
3)检测步骤2)反应液的pH值,用浓度为1mol/L的碳酸钠水溶液调节,使反应液pH值为8.0;水洗4次,过滤脱水;
4)将步骤3)所得的滤饼在低于70℃下烘干、粉碎,得到缓释型的补铁剂。按重量百分比计,铁在阳离子交换树脂中的含量为5.0%。
Claims (3)
1. 一种缓释型的补铁剂的制备方法,其特征在于方法的步骤如下:
1)将阳离子交换树脂置于树脂体积1~2倍的0.5~2mol/L盐酸溶液浸泡2~5小时,放尽酸液后用水漂洗至中性;
2)将含铁量为阳离子交换树脂重量1.5~10%的二价铁盐,预先配置成0.1~2.0mol/L的水溶液,于搅拌下缓慢加入步骤1)的树脂中,检测并调节反应液的pH值为3.0~6.0,室温反应5~10小时;
3)检测步骤2)反应液的pH值,用碱性溶液调节,使反应液pH值为7.5~8.5;水洗3~5次,过滤或离心脱水;
4)将步骤3)所得的滤饼在低于70℃下烘干、粉碎,得到缓释型的补铁剂。
2. 根据权利要求1所述的一种缓释型的补铁剂的制备方法,其特征在于所述的铁盐为氯化亚铁、硝酸亚铁或硫酸亚铁。
3. 根据权利要求1所述的一种缓释型的补铁剂的制备方法,其特征在于所述的碱性溶液为浓度为0.5~5moL/L的氢氧化钠、氢氧化钾、碳酸钠、碳酸钾、碳酸氢钠或碳酸氢钾的水溶液。
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CN1546008A (zh) * | 2003-12-02 | 2004-11-17 | 沈阳药科大学 | 盐酸氨溴索液体缓释制剂及其制备方法 |
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CN1618427A (zh) * | 2003-11-21 | 2005-05-25 | 沈阳药科大学 | 阿昔洛韦药物树脂生物粘附缓释液体制剂及其制备方法 |
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