CN100393713C - 用于治疗疼痛的治疗剂 - Google Patents

用于治疗疼痛的治疗剂 Download PDF

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Publication number
CN100393713C
CN100393713C CNB03825297XA CN03825297A CN100393713C CN 100393713 C CN100393713 C CN 100393713C CN B03825297X A CNB03825297X A CN B03825297XA CN 03825297 A CN03825297 A CN 03825297A CN 100393713 C CN100393713 C CN 100393713C
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another embodiment
alkyl
phenyl
group
halogen
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Expired - Fee Related
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CN1701071A (zh
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孙群
周晓明
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Euro Celtique SA
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Euro Celtique SA
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    • C07—ORGANIC CHEMISTRY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Otolaryngology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Nutrition Science (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNB03825297XA 2002-09-24 2003-09-24 用于治疗疼痛的治疗剂 Expired - Fee Related CN100393713C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41284702P 2002-09-24 2002-09-24
US60/412,847 2002-09-24

Publications (2)

Publication Number Publication Date
CN1701071A CN1701071A (zh) 2005-11-23
CN100393713C true CN100393713C (zh) 2008-06-11

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US (4) US7157462B2 (US07737148-20100615-C00077.png)
EP (2) EP1810970B8 (US07737148-20100615-C00077.png)
JP (1) JP4560610B2 (US07737148-20100615-C00077.png)
KR (1) KR20050052514A (US07737148-20100615-C00077.png)
CN (1) CN100393713C (US07737148-20100615-C00077.png)
AT (2) ATE356817T1 (US07737148-20100615-C00077.png)
AU (1) AU2003272685A1 (US07737148-20100615-C00077.png)
BR (1) BR0314699A (US07737148-20100615-C00077.png)
CA (1) CA2500113C (US07737148-20100615-C00077.png)
CY (1) CY1106634T1 (US07737148-20100615-C00077.png)
DE (2) DE60332562D1 (US07737148-20100615-C00077.png)
DK (1) DK1562936T3 (US07737148-20100615-C00077.png)
ES (1) ES2285170T3 (US07737148-20100615-C00077.png)
HK (1) HK1083216A1 (US07737148-20100615-C00077.png)
MX (1) MXPA05003302A (US07737148-20100615-C00077.png)
NZ (1) NZ539205A (US07737148-20100615-C00077.png)
PT (1) PT1562936E (US07737148-20100615-C00077.png)
SI (1) SI1562936T1 (US07737148-20100615-C00077.png)
WO (1) WO2004029031A2 (US07737148-20100615-C00077.png)
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CN1832935A (zh) * 2003-08-01 2006-09-13 欧洲凯尔特公司 用于治疗疼痛的治疗药
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US20080153845A1 (en) * 2006-10-27 2008-06-26 Redpoint Bio Corporation Trpv1 antagonists and uses thereof
DK2142529T3 (da) 2007-04-27 2014-02-10 Purdue Pharma Lp Trpv1-antagonister og anvendelser deraf
WO2009052377A1 (en) * 2007-10-18 2009-04-23 Harry Fisch Treatment of migraine headaches using antiestrogens
JP5643112B2 (ja) 2008-01-28 2014-12-17 アモーレパシフィック コーポレイションＡｍｏｒｅｐａｃｉｆｉｃ Ｃｏｒｐｏｒａｔｉｏｎ バニロイド受容体としての新規化合物、その異性体または薬剤学的に許容し得る塩、及びこれを含有する医薬組成物
KR101621444B1 (ko) 2008-07-02 2016-05-19 (주)아모레퍼시픽 바닐로이드 수용체 길항제로 작용하는 신규 화합물, 이의 이성질체 또는 이의 약제학적으로 허용 가능한 염, 및 이를 포함하는 약학 조성물
MY171866A (en) 2008-07-08 2019-11-05 Incyte Holdings Corp 1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase
TWI510241B (zh) 2010-02-18 2015-12-01 Vtv Therapeutice Llc 苯基－雜芳基衍生物及其使用方法
WO2011162409A1 (en) 2010-06-22 2011-12-29 Shionogi & Co., Ltd. Compounds having trpv1 antagonistic activity and uses thereof
US9156830B2 (en) 2011-05-17 2015-10-13 Shionogi & Co., Ltd. Heterocyclic compounds
CA2837178C (en) 2011-06-22 2016-09-20 Purdue Pharma L.P. Trpv1 antagonists including dihydroxy substituent and uses thereof
PL3066085T3 (pl) 2013-11-08 2020-11-02 Incyte Holdings Corporation Sposób syntezy inhibitora 2,3-dioksygenazy indoloaminowej
CA2937365C (en) 2016-03-29 2018-09-18 F. Hoffmann-La Roche Ag Granulate formulation of 5-methyl-1-phenyl-2-(1h)-pyridone and method of making the same
JP2019522032A (ja) 2016-07-29 2019-08-08 ヤンセン ファーマシューティカ エヌ．ベー． 前立腺癌の治療方法
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