CN100391454C - 氢溴酸右美沙芬和β-环糊精配合物的药物制剂 - Google Patents
氢溴酸右美沙芬和β-环糊精配合物的药物制剂 Download PDFInfo
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Abstract
一种氢溴酸右美沙芬和β-环糊精配合物的药物制剂。将氢溴酸右美沙芬和β-环糊精配合物的药物制剂用于咀嚼片或含片的制药用途。本发明提供以咀嚼片或含片形式服用的氢溴酸右美沙芬和β-环糊精配合物，该产品止咳迅速，见效快，药效稳定，咀嚼15-30分钟见效，吸收好、吸收率可达98%以上，口感好。
Description
所属技术领域
本发明涉及含的氢溴酸右美沙芬药用配合物。
背景技术
氢溴酸右美沙芬为人工合成的非鸦片类中枢性镇咳药，本品功效与可待因相同，而且像可待因一样，亦作用于中枢，提高咳嗽阈。右美沙芬是现有最安全的镇咳药。市场上无需处方即可购得的镇咳制剂中(西药)，大多皆含有此成份药。该药是列入我国国家基本药物目录的基本药物(乙类)。目前，有关该镇咳一类药品较多，如美国药典USP23版，英国药典BP93版及日本药局方JB十二改正版等文献，均有详细报道，上述作法的工艺较为复杂。药物崩解不稳定，吸收较差，生物利用度不高，尤其是服用口感不佳，服药较为困难。
发明内容
本发明的目的在于提供氢溴酸右美沙芬并为咀嚼片口服用可口的药用配合物。
为了达到上述目的本发明采用的技术方案是：将氢溴酸右美沙芬和β-环糊精配合物的药物制剂用于咀嚼片或含片的制药用途。
本发明的优点是：
本发明提供以咀嚼片或含片形式服用的氢溴酸右美沙芬和β-环糊精配合物，该产品止咳迅速，见效快；药效稳定，咀嚼15-30分钟见效，吸收好、吸收率可达98％以上，口感好。
具体实施方式
下面对本发明的实施例作进一步详细的描述。
将氢溴酸右美沙芬和β-环糊精配合物的药物制剂用于咀嚼片或含片的制药用途。
所述的用途在氢溴酸右美沙芬和β-环糊精配合物单剂量单位咀嚼片中或含片中提供5-30毫克，治疗剂量水平的氢溴酸右美沙芬。
实施例1
含氢溴酸右美沙芬包合物
1、将葡萄糖、蔗糖、枸橼酸分别粉碎并过100目筛，羟丙基纤维素临使前用适量水浸泡24小时，制成8％浆液。
2、将氢溴酸右美沙芬溶于适量温水中，加入β-环糊精中混合搅拌4小时后喷雾干燥。
3、将柠檬黄以少量热水溶解后，加入羟丙甲基纤维素浆，使成5％浆液。
4、将β-环糊精包合物于葡萄糖、蔗糖、枸橼酸粉混合均匀，以5％羟丙甲基纤维素(含色素)浆制软材，制粒、干燥，加入硬脂酸镁，均匀喷入橘子香精密闭2小时，取样化验合格后压片即得。
实施例2
含氢溴酸右美沙芬包合物
氢溴酸右美沙芬β-环糊精 138g
葡萄糖 250g
枸橼酸 10g
蔗糖 150g
柠檬黄 0.075g
橘子香精 2g
羟丙基甲基纤维素 0.01g
硬脂酸镁 7g
实施例3
含氢溴酸右美沙芬包合物
氢溴酸右美沙芬β-环糊精 50g
葡萄糖 85g
枸橼酸 3.3g
蔗糖 50g
柠檬黄 0.025g
橘子香精 0.7g
羟丙基甲基纤维素 0.02g
硬脂酸镁 2.3g
实施例4
含氢溴酸右美沙芬包合物
氢溴酸右美沙芬β-环糊精 138g
葡萄糖 250g
枸橼酸 10g
蔗糖 150g
柠檬黄 0.075g
橘子香精 2g
羟丙基甲基纤维素 0.02g
硬脂酸镁 7g。
Claims (2)
1.一种氢溴酸右美沙芬和β-环糊精配合物的药物制剂，其为咀嚼片或者含片，氢溴酸右美沙芬在单剂量单位咀嚼片中或含片中含有5-30毫克，所述的制剂用下述方法制备得到：将葡萄糖、蔗糖、枸橼酸分别粉碎并过100目筛，羟丙基甲基纤维素浆液临使用前用适量水浸泡24小时，制成8％浆液；将氢溴酸右美沙芬溶于适量温水中，加入β-环糊精中混合搅拌4小时后喷雾干燥；将柠檬黄以少量热水溶解后，加入羟丙基甲基纤维素浆液，使成5％浆液；将β-环糊精包合物与上述的葡萄糖、蔗糖、枸橼酸粉混合，以上述5％的羟丙基甲基纤维素浆液制软材，制粒、干燥，加入硬脂酸镁，均匀喷入橘子香精密闭2小时，取样化验合格后压片即得。
2.如权利要求1所述的药物制剂，其中：氢溴酸右美沙芬β-环糊精138克，葡萄糖250克，枸橼酸10克，蔗糖150克，柠檬黄0.075克，橘子香精2克，羟丙基甲基纤维素0.01克和硬脂酸镁7克。
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| Application Number | Priority Date | Filing Date | Title |
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| CNB031325947A CN100391454C (zh) | 2003-09-03 | 2003-09-03 | 氢溴酸右美沙芬和β-环糊精配合物的药物制剂 |
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| CNB031325947A CN100391454C (zh) | 2003-09-03 | 2003-09-03 | 氢溴酸右美沙芬和β-环糊精配合物的药物制剂 |
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| Publication Number | Publication Date |
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| CN1589789A CN1589789A (zh) | 2005-03-09 |
| CN100391454C true CN100391454C (zh) | 2008-06-04 |
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| CNB031325947A Expired - Lifetime CN100391454C (zh) | 2003-09-03 | 2003-09-03 | 氢溴酸右美沙芬和β-环糊精配合物的药物制剂 |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102258489B (zh) * | 2010-05-24 | 2013-06-12 | 重庆医科大学 | 氢溴酸右美沙芬咀嚼胶片剂及其制备方法 |
| CN106539774A (zh) * | 2016-11-01 | 2017-03-29 | 哈尔滨可迪制药有限公司 | 一种氢溴酸右美沙芬口腔崩解片及其制备方法 |
| CN107126421A (zh) * | 2017-04-28 | 2017-09-05 | 北京茗泽中和药物研究有限公司 | 一种氢溴酸右美沙芬咀嚼片 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57156412A (en) * | 1981-03-24 | 1982-09-27 | Kyoritsu Yakuhin Kogyo Kk | Preparation containing dextromethorphan hydrobromide |
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- 2003-09-03 CN CNB031325947A patent/CN100391454C/zh not_active Expired - Lifetime
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57156412A (en) * | 1981-03-24 | 1982-09-27 | Kyoritsu Yakuhin Kogyo Kk | Preparation containing dextromethorphan hydrobromide |
Non-Patent Citations (2)
| Title |
|---|
| 氢溴酸右美沙芬咀嚼片在正常人体内的生物利用度. 吴琳华，樊宏伟.中国药学杂志，第35卷第6期. 2000 |
| 氢溴酸右美沙芬咀嚼片在正常人体内的生物利用度. 吴琳华，樊宏伟.中国药学杂志，第35卷第6期. 2000 * |
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