CN100364546C - 聚桂醇注射液及其制备方法 - Google Patents
聚桂醇注射液及其制备方法 Download PDFInfo
- Publication number
- CN100364546C CN100364546C CNB2005100960399A CN200510096039A CN100364546C CN 100364546 C CN100364546 C CN 100364546C CN B2005100960399 A CNB2005100960399 A CN B2005100960399A CN 200510096039 A CN200510096039 A CN 200510096039A CN 100364546 C CN100364546 C CN 100364546C
- Authority
- CN
- China
- Prior art keywords
- injection
- lauromacrogol
- ethanol
- test
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000002347 injection Methods 0.000 title claims abstract description 60
- 239000007924 injection Substances 0.000 title claims abstract description 60
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title claims abstract description 45
- 229920002884 Laureth 4 Polymers 0.000 claims abstract description 43
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 23
- 238000002360 preparation method Methods 0.000 claims abstract description 13
- 230000001954 sterilising effect Effects 0.000 claims description 12
- 238000004659 sterilization and disinfection Methods 0.000 claims description 12
- 239000000243 solution Substances 0.000 claims description 10
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 9
- 229930182555 Penicillin Natural products 0.000 claims description 6
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims description 6
- 239000003708 ampul Substances 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 229940049954 penicillin Drugs 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- 239000008215 water for injection Substances 0.000 claims description 6
- OOCCDEMITAIZTP-QPJJXVBHSA-N (E)-cinnamyl alcohol Chemical compound OC\C=C\C1=CC=CC=C1 OOCCDEMITAIZTP-QPJJXVBHSA-N 0.000 claims description 3
- 238000009835 boiling Methods 0.000 claims description 3
- 229910052799 carbon Inorganic materials 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 3
- 238000011049 filling Methods 0.000 claims description 3
- 239000000706 filtrate Substances 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 238000005070 sampling Methods 0.000 claims description 3
- 238000007789 sealing Methods 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 32
- 208000032843 Hemorrhage Diseases 0.000 abstract description 13
- 239000003814 drug Substances 0.000 abstract description 11
- 206010046996 Varicose vein Diseases 0.000 abstract description 10
- 230000000694 effects Effects 0.000 abstract description 10
- 208000027185 varicose disease Diseases 0.000 abstract description 6
- 208000002193 Pain Diseases 0.000 abstract description 5
- 229940079593 drug Drugs 0.000 abstract description 5
- 230000036407 pain Effects 0.000 abstract description 5
- 230000023597 hemostasis Effects 0.000 abstract description 3
- 206010002198 Anaphylactic reaction Diseases 0.000 abstract description 2
- 208000003455 anaphylaxis Diseases 0.000 abstract description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract description 2
- 238000002324 minimally invasive surgery Methods 0.000 abstract description 2
- 230000003444 anaesthetic effect Effects 0.000 abstract 1
- 229940090044 injection Drugs 0.000 description 45
- 238000012360 testing method Methods 0.000 description 30
- 239000002158 endotoxin Substances 0.000 description 19
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 15
- 239000000047 product Substances 0.000 description 13
- 241000239218 Limulus Species 0.000 description 11
- 239000003153 chemical reaction reagent Substances 0.000 description 11
- 230000000740 bleeding effect Effects 0.000 description 9
- 239000000523 sample Substances 0.000 description 9
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- 238000002835 absorbance Methods 0.000 description 6
- 239000013558 reference substance Substances 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 5
- 239000003085 diluting agent Substances 0.000 description 5
- 238000011084 recovery Methods 0.000 description 5
- 208000034189 Sclerosis Diseases 0.000 description 4
- 239000013543 active substance Substances 0.000 description 4
- 230000008033 biological extinction Effects 0.000 description 4
- 230000033228 biological regulation Effects 0.000 description 4
- 238000007865 diluting Methods 0.000 description 4
- 238000001990 intravenous administration Methods 0.000 description 4
- 238000010253 intravenous injection Methods 0.000 description 4
- 239000012488 sample solution Substances 0.000 description 4
- 239000012085 test solution Substances 0.000 description 4
- 208000000624 Esophageal and Gastric Varices Diseases 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000013642 negative control Substances 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000005303 weighing Methods 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- KGWDUNBJIMUFAP-KVVVOXFISA-N Ethanolamine Oleate Chemical compound NCCO.CCCCCCCC\C=C/CCCCCCCC(O)=O KGWDUNBJIMUFAP-KVVVOXFISA-N 0.000 description 2
- 206010056091 Varices oesophageal Diseases 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- RXNBDWQDJKUHNH-UHFFFAOYSA-L azane;cobalt(2+);dithiocyanate Chemical compound N.[Co+2].[S-]C#N.[S-]C#N RXNBDWQDJKUHNH-UHFFFAOYSA-L 0.000 description 2
- SVRSEHNKNVARQT-UHFFFAOYSA-N azane;cobalt;thiocyanic acid Chemical compound [NH4+].[Co].[S-]C#N SVRSEHNKNVARQT-UHFFFAOYSA-N 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 239000002027 dichloromethane extract Substances 0.000 description 2
- 208000024170 esophageal varices Diseases 0.000 description 2
- 201000010120 esophageal varix Diseases 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 208000019423 liver disease Diseases 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000013641 positive control Substances 0.000 description 2
- 239000002510 pyrogen Substances 0.000 description 2
- 238000011046 pyrogen test Methods 0.000 description 2
- 239000012088 reference solution Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- UPUIQOIQVMNQAP-UHFFFAOYSA-M sodium;tetradecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCOS([O-])(=O)=O UPUIQOIQVMNQAP-UHFFFAOYSA-M 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 206010008479 Chest Pain Diseases 0.000 description 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 description 1
- GOVWOKSKFSBNGD-UHFFFAOYSA-N Ethopabate Chemical compound CCOC1=CC(NC(C)=O)=CC=C1C(=O)OC GOVWOKSKFSBNGD-UHFFFAOYSA-N 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- 206010017788 Gastric haemorrhage Diseases 0.000 description 1
- 208000012671 Gastrointestinal haemorrhages Diseases 0.000 description 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 108010039491 Ricin Proteins 0.000 description 1
- 208000005718 Stomach Neoplasms Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- OOCCDEMITAIZTP-UHFFFAOYSA-N allylic benzylic alcohol Natural products OCC=CC1=CC=CC=C1 OOCCDEMITAIZTP-UHFFFAOYSA-N 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000007882 cirrhosis Effects 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- 239000003026 cod liver oil Substances 0.000 description 1
- 235000012716 cod liver oil Nutrition 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 201000004101 esophageal cancer Diseases 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 229940031124 ethanolamine oleate Drugs 0.000 description 1
- 229940093501 ethopabate Drugs 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000012847 fine chemical Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 206010017758 gastric cancer Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 201000007270 liver cancer Diseases 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 238000001819 mass spectrum Methods 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 229940083820 other sclerosing agent in atc Drugs 0.000 description 1
- 229940025913 polidocanol injection Drugs 0.000 description 1
- -1 polyoxyethylene Polymers 0.000 description 1
- 208000007232 portal hypertension Diseases 0.000 description 1
- 238000011112 process operation Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000013102 re-test Methods 0.000 description 1
- 238000007632 sclerotherapy Methods 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 201000011549 stomach cancer Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 229940126673 western medicines Drugs 0.000 description 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
编号 | 样品含量(标示量)% | 平均值(%) | 相对标准差(%) |
1 | 98.31 | ||
2 | 95.70 | ||
3 | 96.33 | 96.49 | 1.33(RSD) |
4 | 94.97 | ||
5 | 97.13 |
吸收度 | A | 0.170 | 0.370 | 0.559 | 0.787 | 0.984 |
浓度(mg/ml) | C | 0.192 | 0.384 | 0.576 | 0.768 | 0.960 |
编号 | 加入量(mg) | 测得量(mg) | 回收度(%) | 平均回收率(%) | RSD(%) |
6.0 | 6.15 | 102.50 | |||
9.0 | 9.20 | 102.22 | |||
12.0 | 11.72 | 97.67 | 100.89 | 1.82 | |
15.0 | 14.98 | 99.87 | |||
18.0 | 18.27 | 101.50 | |||
21.0 | 21.34 | 101.62 |
样品批号 | 0.0h | 0.5h | 1.0h | 2.0h | 4.0h |
961225 | 100.2% | 100.3% | 98.3% | 91.0% | 36.1% |
970109 | 107.2% | 106.5% | 104.8% | 96.5% | 40.7% |
970110 | 106.5% | 105.8% | 104.4% | 96.5% | 42.6% |
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2005100960399A CN100364546C (zh) | 2005-09-16 | 2005-09-16 | 聚桂醇注射液及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2005100960399A CN100364546C (zh) | 2005-09-16 | 2005-09-16 | 聚桂醇注射液及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1739550A CN1739550A (zh) | 2006-03-01 |
CN100364546C true CN100364546C (zh) | 2008-01-30 |
Family
ID=36092174
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2005100960399A Active CN100364546C (zh) | 2005-09-16 | 2005-09-16 | 聚桂醇注射液及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN100364546C (zh) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102240264A (zh) * | 2011-05-19 | 2011-11-16 | 陕西天宇制药有限公司 | 聚桂醇注射液作为治疗囊肿药物的应用 |
CN102198089A (zh) * | 2011-05-19 | 2011-09-28 | 陕西天宇制药有限公司 | 聚桂醇注射液作为治疗内痔药物的应用 |
CN102836169A (zh) * | 2011-06-24 | 2012-12-26 | 上海方恩医疗用品有限公司 | 一种表面活性剂化学消融剂及制备方法在治疗肿瘤药物中的应用 |
CN103768090B (zh) * | 2014-02-19 | 2015-11-25 | 南通大学附属医院 | 一种介入治疗子宫肌瘤的药物 |
US9351945B1 (en) * | 2015-02-27 | 2016-05-31 | John Daniel Dobak, III | Reduction of adipose tissue |
EP3251654A1 (de) * | 2016-05-30 | 2017-12-06 | Chemische Fabrik Kreussler & Co. Gmbh | Nichtionische tenside zur reduktion von fettgewebe |
CN109646427A (zh) * | 2019-01-28 | 2019-04-19 | 上海上药第生化药业有限公司 | 十四烷基硫酸钠在制备治疗肝脏损伤的药物中的应用 |
CN114159388A (zh) * | 2021-12-17 | 2022-03-11 | 陕西天宇制药有限公司 | 聚桂醇注射液在制备治疗支气管囊肿的药物中的应用 |
CN114306375A (zh) * | 2021-12-17 | 2022-04-12 | 陕西天宇制药有限公司 | 聚桂醇注射液在制备治疗贲门撕裂症的药物中的应用 |
-
2005
- 2005-09-16 CN CNB2005100960399A patent/CN100364546C/zh active Active
Non-Patent Citations (2)
Title |
---|
已批准临床研究的新药(二). 中国新药杂志,第8卷第8期. 1999 * |
药用辅料应用技术. 上海医药工业研究院药物之际研究中心,药物制剂国家工程研究中心,29-32,中国医药科技出版社. 2002 * |
Also Published As
Publication number | Publication date |
---|---|
CN1739550A (zh) | 2006-03-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN100364546C (zh) | 聚桂醇注射液及其制备方法 | |
CN107037146B (zh) | 一种复方木鸡颗粒质量控制的方法 | |
CN117233309A (zh) | 一种多种维生素注射剂杂质的检测方法 | |
JPH01211531A (ja) | フルオロン誘導体を含有する薬剤 | |
CN112666280B (zh) | 一种青黛辐照前后主要成分的测定方法 | |
CN109316474B (zh) | 去铁胺在制备预防和/或治疗肿瘤药物中的应用 | |
CN104706655B (zh) | 注射用环磷腺苷葡胺粉针剂药物组合物和制法 | |
Lorber et al. | Entero-Hepatic Circulation of Bromsulphalein: I. Studies on Man with Special Reference to the Clinical BSP Test | |
CN113876704A (zh) | 一种盐酸表柔比星注射液及其制备方法 | |
EP2902388A1 (en) | Condensation product of theanine derivative and carboxylic acid coumarin derivative, intermediate of the condensation product, method for preparing same, and use thereof | |
CN107167541A (zh) | 测定大鼠血浆生物样品中的DTPA‑Zn的方法 | |
CN1830465A (zh) | 香丹注射液及其制备方法 | |
CN113599379A (zh) | 蝗虫内生真菌次级代谢产物的新用途 | |
CN103897010A (zh) | 一种用于治疗银屑病的组合物及制备方法 | |
CN102525910B (zh) | 盐酸戊乙奎醚注射液的制备工艺 | |
KR20230136233A (ko) | 봉술 오일 중 세스퀴테르펜계 화합물 부작용을 평가하는 방법 | |
CN103159710B (zh) | 用于抗病毒的十氢萘衍生物 | |
CN110208397A (zh) | 一种同时测定土霉素氟尼辛注射液中两种主药含量的高效液相色谱法 | |
CN100336557C (zh) | 一种生长抑素的水溶液制剂、其制备方法及应用 | |
CN111808051A (zh) | 一种新化合物及其在制备治疗骨折药物中的用途 | |
CN103893234B (zh) | 一种红花注射液、制备方法及含量测定方法 | |
CN104971040B (zh) | 一种甲磺酸非诺多泮注射液及其制备方法 | |
CN114441659B (zh) | 检测更昔洛韦眼用凝胶中更昔洛韦和有关物质的方法 | |
CN114767627B (zh) | 一种乳酸环丙沙星氯化钠注射液的制备方法 | |
CN111504933B (zh) | 一种分析检测抗艾滋病新药的方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Polycinnamic alcohol injection and its prepn Effective date of registration: 20111122 Granted publication date: 20080130 Pledgee: Bank of Xi'an Limited by Share Ltd. South Second Ring branch Pledgor: SHAANXI TIANYU PHARMACEUTICAL Co.,Ltd. Registration number: 2011990000445 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20121220 Granted publication date: 20080130 Pledgee: Bank of Xi'an Limited by Share Ltd. South Second Ring branch Pledgor: SHAANXI TIANYU PHARMACEUTICAL Co.,Ltd. Registration number: 2011990000445 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Polycinnamic alcohol injection and its prepn Effective date of registration: 20121220 Granted publication date: 20080130 Pledgee: Bank of Xi'an Limited by Share Ltd. South Second Ring branch Pledgor: SHAANXI TIANYU PHARMACEUTICAL Co.,Ltd. Registration number: 2012990000821 |
|
PLDC | Enforcement, change and cancellation of contracts on pledge of patent right or utility model | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20131209 Granted publication date: 20080130 Pledgee: Bank of Xi'an Limited by Share Ltd. South Second Ring branch Pledgor: SHAANXI TIANYU PHARMACEUTICAL Co.,Ltd. Registration number: 2012990000821 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Polycinnamic alcohol injection and its prepn Effective date of registration: 20131209 Granted publication date: 20080130 Pledgee: Bank of Xi'an Limited by Share Ltd. South Second Ring branch Pledgor: SHAANXI TIANYU PHARMACEUTICAL Co.,Ltd. Registration number: 2013990000949 |
|
PLDC | Enforcement, change and cancellation of contracts on pledge of patent right or utility model | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20141216 Granted publication date: 20080130 Pledgee: Bank of Xi'an Limited by Share Ltd. South Second Ring branch Pledgor: SHAANXI TIANYU PHARMACEUTICAL Co.,Ltd. Registration number: 2013990000949 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Polycinnamic alcohol injection and its prepn Effective date of registration: 20141217 Granted publication date: 20080130 Pledgee: Bank of Xi'an Limited by Share Ltd. South Second Ring branch Pledgor: SHAANXI TIANYU PHARMACEUTICAL Co.,Ltd. Registration number: 2014990001085 |
|
PLDC | Enforcement, change and cancellation of contracts on pledge of patent right or utility model | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20151228 Granted publication date: 20080130 Pledgee: Bank of Xi'an Limited by Share Ltd. South Second Ring branch Pledgor: SHAANXI TIANYU PHARMACEUTICAL Co.,Ltd. Registration number: 2014990001085 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Polycinnamic alcohol injection and its prepn Effective date of registration: 20151229 Granted publication date: 20080130 Pledgee: Bank of Xi'an Limited by Share Ltd. South Second Ring branch Pledgor: SHAANXI TIANYU PHARMACEUTICAL Co.,Ltd. Registration number: 2015990001188 |
|
PLDC | Enforcement, change and cancellation of contracts on pledge of patent right or utility model | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20170112 Granted publication date: 20080130 Pledgee: Bank of Xi'an Limited by Share Ltd. South Second Ring branch Pledgor: SHAANXI TIANYU PHARMACEUTICAL Co.,Ltd. Registration number: 2015990001188 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Polycinnamic alcohol injection and its prepn Effective date of registration: 20170112 Granted publication date: 20080130 Pledgee: Bank of Xi'an Limited by Share Ltd. South Second Ring branch Pledgor: SHAANXI TIANYU PHARMACEUTICAL Co.,Ltd. Registration number: 2017990000029 |
|
PLDC | Enforcement, change and cancellation of contracts on pledge of patent right or utility model | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20171025 Granted publication date: 20080130 Pledgee: Bank of Xi'an Limited by Share Ltd. South Second Ring branch Pledgor: SHAANXI TIANYU PHARMACEUTICAL Co.,Ltd. Registration number: 2017990000029 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Polycinnamic alcohol injection and its prepn Effective date of registration: 20180124 Granted publication date: 20080130 Pledgee: Bank of Xi'an Limited by Share Ltd. Xi'an Qujiang branch Pledgor: SHAANXI TIANYU PHARMACEUTICAL Co.,Ltd. Registration number: 2018610000013 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20181210 Granted publication date: 20080130 Pledgee: Bank of Xi'an Limited by Share Ltd. Xi'an Qujiang branch Pledgor: SHAANXI TIANYU PHARMACEUTICAL Co.,Ltd. Registration number: 2018610000013 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Polycinnamic alcohol injection and its prepn Effective date of registration: 20181212 Granted publication date: 20080130 Pledgee: Ankang Finance and Credit Financing Guarantee Co.,Ltd. Xi'an Branch Pledgor: SHAANXI TIANYU PHARMACEUTICAL Co.,Ltd. Registration number: 2018610000216 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20191219 Granted publication date: 20080130 Pledgee: Ankang Finance and Credit Financing Guarantee Co.,Ltd. Xi'an Branch Pledgor: SHAANXI TIANYU PHARMACEUTICAL Co.,Ltd. Registration number: 2018610000216 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Polycinnamic alcohol injection and its prepn Effective date of registration: 20200420 Granted publication date: 20080130 Pledgee: Xi'an innovation financing Company limited by guarantee Pledgor: SHAANXI TIANYU PHARMACEUTICAL Co.,Ltd. Registration number: Y2020990000339 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20210401 Granted publication date: 20080130 Pledgee: Xi'an innovation financing Company limited by guarantee Pledgor: SHAANXI TIANYU PHARMACEUTICAL Co.,Ltd. Registration number: Y2020990000339 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Lauryl alcohol injection and its preparation Effective date of registration: 20210401 Granted publication date: 20080130 Pledgee: Xi'an innovation financing Company limited by guarantee Pledgor: SHAANXI TIANYU PHARMACEUTICAL Co.,Ltd. Registration number: Y2021990000295 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20220608 Granted publication date: 20080130 Pledgee: Xi'an innovation financing Company limited by guarantee Pledgor: SHAANXI TIANYU PHARMACEUTICAL Co.,Ltd. Registration number: Y2021990000295 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Polylauryl alcohol injection and its preparation method Effective date of registration: 20220614 Granted publication date: 20080130 Pledgee: Xi'an Science and Technology Financial Service Center Co.,Ltd. Pledgor: SHAANXI TIANYU PHARMACEUTICAL Co.,Ltd. Registration number: Y2022610000312 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20230706 Granted publication date: 20080130 Pledgee: Xi'an Science and Technology Financial Service Center Co.,Ltd. Pledgor: SHAANXI TIANYU PHARMACEUTICAL Co.,Ltd. Registration number: Y2022610000312 |