CN100363038C - Chinese proprietary medicine for treating advanced stage rachitis - Google Patents
Chinese proprietary medicine for treating advanced stage rachitis Download PDFInfo
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- CN100363038C CN100363038C CNB2006100422530A CN200610042253A CN100363038C CN 100363038 C CN100363038 C CN 100363038C CN B2006100422530 A CNB2006100422530 A CN B2006100422530A CN 200610042253 A CN200610042253 A CN 200610042253A CN 100363038 C CN100363038 C CN 100363038C
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Abstract
The present invention discloses a Chinese patent medicine for treating delayed rachitis, which is a medicine made of the following raw materials with proportion by weight by a conventional method: 7 to10 portions of rehmannia, 7 to 10 portions of Chinese yam stir-fried with bran, 3 to 6 portions of cornus officinalis, 3 to 6 portions of schisandra fruits, 3 to 6 portions of wolfberry fruits, 2 to 3 portions of dodder 3 to 6 portions of eucommia bark, 3 to 6 portions of mistletoe, 4 to 6 portions of chaenomeles fruits, 8 to 10 portions of nacre, 15 to 20 portions of keel and 15 to 20 portions of oyster. The medicine of the present invention is mainly suitable for children at the age of 5 to 15, and comprehensively treats the patient by aiming at the characteristics of delayed rachitis; the goal of curing delayed rachitis can be achieved through increase of bone density and blood calcium of patients, obvious relief of pains on joints and legs until disappearance, constitution strengthening, fatigue elimination, sleeping quality improvement, appetite improvement, etc.
Description
Technical field
The present invention relates to medicine, is a kind of Chinese patent medicine for the treatment of delayed rickets.
Background technology
Delayed rickets mostly occurs 5-15 year child, and sickness rate was in rising trend in recent years.Because the early stage clinical manifestation of this disease does not have specificity, so easily fail to pinpoint a disease in diagnosis or mistaken diagnosis.The applicant is devoted to the research treatment of this disease for many years, under the situation that therapeutic scheme in the early stage constantly improves, further raising has been arranged.At present, the treatment of delayed rickets is the simple oral calcium preparation, and this therapeutic effect is not good enough, often takes place to can not get the consequence that effectively treatment causes cacomelia because of primary disease.
Summary of the invention
The objective of the invention is, a kind of Chinese patent medicine for the treatment of delayed rickets is provided, it mainly is applicable to 5-15 year child, at the characteristics Comprehensive Treatment of delayed rickets, raise by bone density and the blood calcium that makes the patient, the pain of joint and lower limb obviously alleviates disappearance to end, body constitution strengthens, the old fatigue that disappears, sleep quality improves, and appetite enhancing etc. reaches the purpose of curing delayed rickets.
The present invention is achieved through the following technical solutions for achieving the above object: a kind of Chinese patent medicine for the treatment of delayed rickets, and it is the medicament that the raw material with following weight ratio is prepared into according to a conventional method, Radix Rehmanniae 7-10 part, Rhizoma Dioscoreae (parched with bran) 7-10 part, Fructus Corni 3-6 part, Fructus Schisandrae Chinensis 3-6 part, Fructus Lycii 3-6 part, Semen Cuscutae 2-3 part, Cortex Eucommiae 3-6 part, Herba Taxilli 3-6 part, Fructus Chaenomelis 4-6 part, Concha Margaritifera 8-10 part, Os Draconis 15-20 part, Concha Ostreae 15-20 part.Described a kind of Chinese patent medicine for the treatment of delayed rickets, it is the medicament that the raw material with following weight ratio is prepared into according to a conventional method, 10 parts of Radix Rehmanniae, 10 parts of Rhizoma Dioscoreae (parched with bran), 6 parts of Fructus Corni, 6 parts of Fructus Schisandrae Chinensis, 6 parts of Fructus Lycii, 3 parts of Semen Cuscutae, 6 parts of the Cortexs Eucommiae, 6 parts of Herba Taxillis, 6 parts of Fructus Chaenomeliss, 10 parts of Concha Margaritiferas, 20 parts of Os Draconis, 20 parts of Concha Ostreaes.
Radix Rehmanniae in the material component of the present invention, Rhizoma Dioscoreae (parched with bran), Fructus Corni, the merit that nourishing kidney replenishing essence, nourishing the liver arresting seminal emission, spleen reinforcing controlling nocturnal emission with astringent drugs are arranged respectively, the Cortex Eucommiae, Fructus Lycii, Herba Taxilli, Semen Cuscutae invigorating the liver and kidney, bone and muscle strengthening, join Fructus Schisandrae Chinensis, Concha Margaritifera, Fructus Chaenomelis, Os Draconis, Concha Ostreae, with sour and astringent arresting sweating, subduing hyperactive YANG to ease mental disorders, all medicines are together with playing kidney-supplementing liver-boosting altogether, the effect of bone and muscle strengthening.
The present invention lacks the calcium that causes at the patient VitD of delayed rickets especially, in the time of the phosphorus metabolism obstacle, also relevant with the intake deficiency of trace element zinc, in material component of the present invention, add Os Draconis, Concha Ostreae, Concha Margaritifera, they are except that containing a large amount of calcium carbonate, also contain several amino acids and trace element, so that the present invention is different from the treatment of replenishing the calcium merely in the existing Therapeutic Method, medicament of the present invention is by regulating function, the enhancing body resistance, increase VitD calcium, the absorption of zinc and multiple nutrients material, finally reach and improve symptom, supplement the nutrients, delayed rickets is carried out the purpose for the treatment of both the principal and secondary aspects of a disease.
The present invention proves through clinical use: little, the instant effect of side effect, effect is lasting.Clinical 235 examples of the present invention, obvious effective rate is 67.1%, and total effective rate is 96.7%, and curative effect obviously is better than precious male capsule product.Oral medicament of the present invention is after one week, and the pain of patient joint and lower limb obviously alleviates, and the transference cure person reaches 82.5% after one month, and after pain disappeared, sleep quality improved.The obvious improving appetite of 2 week back patients of taking medicine, appetite increases, and body constitution strengthens, and banishes the feeling of languor.After taking medicine one month, what blood calcium recovered normal value reaches 91.7%, and after taking medicine 2 months, what bone density reached normal value reaches 89.6%.The The acute toxicity tests of medicament of the present invention: by maximum permission administration concentration (0.67g/ml) and maximum administration volume (0.4ml/10g) i.g. mice, three times on the one, the visible activity of mice slightly reduces after the administration, does not see other tangible toxic reaction to occur, does not occur dead.Thereafter observe 7d continuously, mice behavioral activity, the mental status, defecation, quilt hair, secretions etc. show no obvious abnormalities none death; Put to death and cut open inspection part mice in 7d, main organs such as the perusal heart, liver, spleen, lung, kidney do not see that naked eyes are as seen unusual, therefore, medicament of the present invention to the maximum tolerated dose of mice i.g. administration on the one greater than 80.4g/kg.Conclusion (of pressure testing) is: the present invention is by maximum permission administration concentration (0.67g/ml) and maximum administration volume (0.4ml/10g) mice i.g. administration, three times on the one, do not see that any tangible toxic reaction appears in mice, therefore medicament of the present invention maximum tolerated dose on the one is greater than 80.4g/kg, this dosage is about clinical child 160.8 times with dosage, shows that thus clinical practice of the present invention is safe.
Produce effects criterion of the present invention is: treat a month clinical symptom disappearance, it is normal that blood biochemistry index recovers, and bone density improves a standard deviation.Effectively criterion is: treat a month clinical symptom relief, and 2 months transference cures, blood is biochemical to recover normal, and bone density improves a standard deviation.Chinese patent medicine dosage form of the present invention is a capsule, also can be electuary or tablet, all makes according to a conventional method.
The specific embodiment
Chinese patent medicine of the present invention, the raw material of its weight ratio can have various embodiments:
1, Radix Rehmanniae 10g, Rhizoma Dioscoreae (parched with bran) 10g, Fructus Corni 6g, Fructus Schisandrae Chinensis 6g, Fructus Lycii 6g, Semen Cuscutae 3g, Cortex Eucommiae 6g, Herba Taxilli 6g, Fructus Chaenomelis 6g, Concha Margaritifera 10g, Os Draconis 20g, Concha Ostreae 20g.
2, Radix Rehmanniae 7g, Rhizoma Dioscoreae (parched with bran) 7g, Fructus Corni 3g, Fructus Schisandrae Chinensis 3g, Fructus Lycii 3g, Semen Cuscutae 2g, Cortex Eucommiae 3g, Herba Taxilli 3g, Fructus Chaenomelis 4g, Concha Margaritifera 8g, Os Draconis 15g, Concha Ostreae 15g.
3, Radix Rehmanniae 8g, Rhizoma Dioscoreae (parched with bran) 8g, Fructus Corni 5g, Fructus Schisandrae Chinensis 5g, Fructus Lycii 5g, Semen Cuscutae 2g, Cortex Eucommiae 5g, Herba Taxilli 5g, Fructus Chaenomelis 5g, Concha Margaritifera 9g, Os Draconis 16g, Concha Ostreae 16g.
4, Radix Rehmanniae 9g, Rhizoma Dioscoreae (parched with bran) 9g, Fructus Corni 4g, Fructus Schisandrae Chinensis 4g, Fructus Lycii 4g, Semen Cuscutae 3g, Cortex Eucommiae 4g, Herba Taxilli 4g, Fructus Chaenomelis 6g, Concha Margaritifera 10g, Os Draconis 18g, Concha Ostreae 18g.
Model case:
1, Zhang Xiaoming, the man, 10 years old, the gonalgia 4 years, the gonalgia appearred in infant repeatedly from 6 years old, do not have obvious inducement, nearly 1 year sx mostly occurs at night or night, can not fall asleep when serious or hypnalgia is waken up, pain relief after massage or the hot compress, mistaken diagnosis once is arthritis, growing pain, it is invalid to take Drug therapy such as aspirin.Outdoor activities are few, monophagia, appetite can, no liver, kidney illness.
Check: development nutrition is good, and the breastbone form is normal, and double knee joint does not have redness, tenderness, and limbs do not have deformity, bone density 0.372g/cm
2, blood calcium 2.01mmol/L, P 0.74mmol/L, ALP 458u/L, the knee joint anterioposterior and lateral film shows bone trabecula slightly disorderly, fuzzy in epiphysis end calcification preparation band, bone trabecula is sparse.Obey medicament of the present invention, knee joint bone density 0.421g/cm during a check in month
2, blood calcium 2.52mmol/L, ALP187u/L, the gonalgia obviously alleviates, and continues to take medicine, two months pain disappears, it is normal that the X line recovers.After treatment three totally months, bone density increases to 0.498g/cm
2, near normal value 0.562 ± 0.055 level.
2, Chen Shu, the woman, 8 years old, hyperhidrosis, skelalgia, weak, suffered from respiratory tract infection 2 years repeatedly.Infant was perspired many in nearly 2 years, and irrelevant with temperature, night very, ankle joint pain appears behind the aggravating activities, but spontaneous remission after the rest, fatiguability, weak, the back of falling asleep is how moving, easily awake, suffered from sense or bronchitis in average every month once, easily fidgety, outdoor activities are few, since the childhood monophagia, appetite is poor, no Liver and kidney illness.
Check: physically well develop, nutrition is normal, and the thorax shape is normal, existing obvious rachitic rosary, and two ankle joint do not have redness, tenderness, and limbs do not have deformity.Bone density 0.35g/cm
2, blood calcium 1.89mmol/L, P1.43mmol/L, ALP312u/L.Carpal joint palm bit slice shows that postponing appears in the epiphyseal nucleus center, and bone density reduces.Obey medicament of the present invention, the check bone density rose to 0.399g/cm in one month
2, blood calcium 2.35mmol/L, ALP145u/L, hyperhidrosis, skelalgia disappear, appetite increases.Continue to take medicine.Bone density 0.435g/cm during check in two months
2, the X line shows that bone density improves, epiphyseal nucleus increases to normally.Rachitic rosary disappears substantially, and muscle power obviously strengthens, and movable increasing also do not have skelalgia after climbing the mountain, and emotion is clearly better, and sleeps, and observes and does not suffer from respiratory tract infection during 6 months.
Claims (2)
1. Chinese patent medicine for the treatment of delayed rickets is characterized in that: it is the medicament that the raw material with following weight ratio is prepared into according to a conventional method, Radix Rehmanniae 7-10 part, Rhizoma Dioscoreae (parched with bran) 7-10 part, Fructus Corni 3-6 part, Fructus Schisandrae Chinensis 3-6 part, Fructus Lycii 3-6 part, Semen Cuscutae 2-3 part, Cortex Eucommiae 3-6 part, Herba Taxilli 3-6 part, Fructus Chaenomelis 4-6 part, Concha Margaritifera 8-10 part, Os Draconis 15-20 part, Concha Ostreae 15-20 part.
2. a kind of Chinese patent medicine for the treatment of delayed rickets according to claim 1 is characterized in that: it is the medicament that the raw material with following weight ratio is prepared into according to a conventional method, 10 parts of Radix Rehmanniae, 10 parts of Rhizoma Dioscoreae (parched with bran), 6 parts of Fructus Corni, 6 parts of Fructus Schisandrae Chinensis, 6 parts of Fructus Lycii, 3 parts of Semen Cuscutae, 6 parts of the Cortexs Eucommiae, 6 parts of Herba Taxillis, 6 parts of Fructus Chaenomeliss, 10 parts of Concha Margaritiferas, 20 parts of Os Draconis, 20 parts of Concha Ostreaes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100422530A CN100363038C (en) | 2006-02-13 | 2006-02-13 | Chinese proprietary medicine for treating advanced stage rachitis |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100422530A CN100363038C (en) | 2006-02-13 | 2006-02-13 | Chinese proprietary medicine for treating advanced stage rachitis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1843449A CN1843449A (en) | 2006-10-11 |
| CN100363038C true CN100363038C (en) | 2008-01-23 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB2006100422530A Expired - Fee Related CN100363038C (en) | 2006-02-13 | 2006-02-13 | Chinese proprietary medicine for treating advanced stage rachitis |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105596722A (en) * | 2015-12-25 | 2016-05-25 | 薛学明 | Medicine for treating rickets and preparation method of medicine |
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- 2006-02-13 CN CNB2006100422530A patent/CN100363038C/en not_active Expired - Fee Related
Non-Patent Citations (2)
| Title |
|---|
| 中华人民共和国卫生部药品标准 中药成方制剂 第十二册. 中华人民共和国卫生部药典委员会，87. 1997 * |
| 补肾健骨散治疗晚发性佝偻病57例疗效观察. 刘亚玲，刘秀芳，陈运华，王伯祥，陈学美.现代中西医结合杂志，第12卷第10期. 2003 * |
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| Publication number | Publication date |
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| CN1843449A (en) | 2006-10-11 |
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