CN100357274C - 二芳基烯炔 - Google Patents
二芳基烯炔 Download PDFInfo
- Publication number
- CN100357274C CN100357274C CNB008151970A CN00815197A CN100357274C CN 100357274 C CN100357274 C CN 100357274C CN B008151970 A CNB008151970 A CN B008151970A CN 00815197 A CN00815197 A CN 00815197A CN 100357274 C CN100357274 C CN 100357274C
- Authority
- CN
- China
- Prior art keywords
- phenyl
- compound
- alkynes
- amylene
- sarkosine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/40—Y being a hydrogen or a carbon atom
- C07C323/41—Y being a hydrogen or an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Confectionery (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Quinoline Compounds (AREA)
- Furan Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43102299A | 1999-11-01 | 1999-11-01 | |
US09/431,022 | 1999-11-01 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1387507A CN1387507A (zh) | 2002-12-25 |
CN100357274C true CN100357274C (zh) | 2007-12-26 |
Family
ID=23710104
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB008151970A Expired - Fee Related CN100357274C (zh) | 1999-11-01 | 2000-11-01 | 二芳基烯炔 |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP1226108A4 (fr) |
JP (1) | JP2003513063A (fr) |
KR (1) | KR100702717B1 (fr) |
CN (1) | CN100357274C (fr) |
AU (1) | AU780922C (fr) |
BG (1) | BG65275B1 (fr) |
BR (1) | BR0015199A (fr) |
CA (1) | CA2387660A1 (fr) |
CZ (1) | CZ20021545A3 (fr) |
EA (1) | EA004602B1 (fr) |
EE (1) | EE05031B1 (fr) |
HR (1) | HRP20020376A2 (fr) |
HU (1) | HUP0203182A3 (fr) |
IL (1) | IL149347A0 (fr) |
MX (1) | MXPA02004354A (fr) |
NO (1) | NO20021936L (fr) |
NZ (1) | NZ529245A (fr) |
PL (1) | PL355425A1 (fr) |
SK (1) | SK6202002A3 (fr) |
UA (1) | UA73749C2 (fr) |
WO (1) | WO2001032602A1 (fr) |
ZA (1) | ZA200203458B (fr) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0456183A2 (fr) * | 1990-05-07 | 1991-11-13 | Shionogi Seiyaku Kabushiki Kaisha | Dérivés spiro de dibenzosuberane |
US5462965A (en) * | 1990-08-13 | 1995-10-31 | Gd Searle & Co. | Use of heterocyclic amino-alcohol compounds for treatment of CNS diseases |
WO1998015542A1 (fr) * | 1996-10-04 | 1998-04-16 | H. Lundbeck A/S | Composes d'acide carboxylique 3-alcoxyisoxazol-4-yl-substitue 2-amino |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE320804T1 (de) * | 1995-12-07 | 2006-04-15 | Daniel C Javitt | Behandlung negativer und kognitiver symptome der schizophrenie mit antagonisten der glycinaufnahme |
PL342818A1 (en) * | 1998-03-06 | 2001-07-02 | Janssen Pharmaceutica Nv | Glycin transport inhibitors |
PL343435A1 (en) * | 1998-03-06 | 2001-08-13 | Janssen Pharmaceutica Nv | Glycine transport inhibitors |
PE20000728A1 (es) * | 1998-06-26 | 2000-08-21 | Cocensys Inc | Heterociclos 4-bencil piperidina alquilsulfoxido y su uso como antagonistas receptores subtipo-selectivo nmda |
US6103743A (en) * | 1999-08-06 | 2000-08-15 | Allelix Neuroscience, Inc. | Unsaturated amino acid derivatives |
-
2000
- 2000-01-11 UA UA2002043703A patent/UA73749C2/uk unknown
- 2000-11-01 EP EP00976775A patent/EP1226108A4/fr not_active Withdrawn
- 2000-11-01 JP JP2001534756A patent/JP2003513063A/ja active Pending
- 2000-11-01 CA CA002387660A patent/CA2387660A1/fr not_active Abandoned
- 2000-11-01 AU AU14507/01A patent/AU780922C/en not_active Ceased
- 2000-11-01 WO PCT/US2000/030074 patent/WO2001032602A1/fr active IP Right Grant
- 2000-11-01 KR KR1020027005593A patent/KR100702717B1/ko not_active IP Right Cessation
- 2000-11-01 PL PL00355425A patent/PL355425A1/xx not_active IP Right Cessation
- 2000-11-01 MX MXPA02004354A patent/MXPA02004354A/es active IP Right Grant
- 2000-11-01 HU HU0203182A patent/HUP0203182A3/hu unknown
- 2000-11-01 SK SK620-2002A patent/SK6202002A3/sk unknown
- 2000-11-01 NZ NZ529245A patent/NZ529245A/en active Application Filing
- 2000-11-01 EA EA200200521A patent/EA004602B1/ru not_active IP Right Cessation
- 2000-11-01 CN CNB008151970A patent/CN100357274C/zh not_active Expired - Fee Related
- 2000-11-01 BR BR0015199-8A patent/BR0015199A/pt not_active Application Discontinuation
- 2000-11-01 IL IL14934700A patent/IL149347A0/xx unknown
- 2000-11-01 EE EEP200200229A patent/EE05031B1/xx not_active IP Right Cessation
- 2000-11-01 CZ CZ20021545A patent/CZ20021545A3/cs unknown
-
2002
- 2002-04-24 NO NO20021936A patent/NO20021936L/no not_active Application Discontinuation
- 2002-04-29 HR HR20020376A patent/HRP20020376A2/hr not_active Application Discontinuation
- 2002-04-30 BG BG106671A patent/BG65275B1/bg unknown
- 2002-04-30 ZA ZA200203458A patent/ZA200203458B/xx unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0456183A2 (fr) * | 1990-05-07 | 1991-11-13 | Shionogi Seiyaku Kabushiki Kaisha | Dérivés spiro de dibenzosuberane |
US5462965A (en) * | 1990-08-13 | 1995-10-31 | Gd Searle & Co. | Use of heterocyclic amino-alcohol compounds for treatment of CNS diseases |
WO1998015542A1 (fr) * | 1996-10-04 | 1998-04-16 | H. Lundbeck A/S | Composes d'acide carboxylique 3-alcoxyisoxazol-4-yl-substitue 2-amino |
Also Published As
Publication number | Publication date |
---|---|
MXPA02004354A (es) | 2003-10-06 |
CA2387660A1 (fr) | 2001-05-10 |
NO20021936D0 (no) | 2002-04-24 |
EA200200521A1 (ru) | 2002-10-31 |
HUP0203182A3 (en) | 2003-04-28 |
PL355425A1 (en) | 2004-04-19 |
EP1226108A4 (fr) | 2004-06-16 |
SK6202002A3 (en) | 2002-10-08 |
WO2001032602A1 (fr) | 2001-05-10 |
CN1387507A (zh) | 2002-12-25 |
EP1226108A1 (fr) | 2002-07-31 |
AU1450701A (en) | 2001-05-14 |
KR100702717B1 (ko) | 2007-04-03 |
BG106671A (en) | 2003-02-28 |
JP2003513063A (ja) | 2003-04-08 |
BG65275B1 (bg) | 2007-11-30 |
UA73749C2 (en) | 2005-09-15 |
AU780922C (en) | 2005-10-20 |
HUP0203182A2 (hu) | 2003-01-28 |
IL149347A0 (en) | 2002-11-10 |
CZ20021545A3 (cs) | 2002-10-16 |
EE200200229A (et) | 2003-06-16 |
ZA200203458B (en) | 2003-10-29 |
BR0015199A (pt) | 2002-07-09 |
KR20020060961A (ko) | 2002-07-19 |
EE05031B1 (et) | 2008-06-16 |
NZ529245A (en) | 2005-09-30 |
AU780922B2 (en) | 2005-04-28 |
EA004602B1 (ru) | 2004-06-24 |
NO20021936L (no) | 2002-07-01 |
HRP20020376A2 (en) | 2004-02-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: NPS PHARMACEUTICALS, INC. Free format text: FORMER OWNER: NPS ALLELIX CORP. Effective date: 20080912 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20080912 Address after: new jersey Patentee after: NPS Pharmaceuticals, Inc. Address before: Ontario, Canada Patentee before: NPS Allelix Corp. |
|
C17 | Cessation of patent right | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20071226 Termination date: 20101101 |