CN100339066C - 稳定的注射液组合物和方法 - Google Patents

稳定的注射液组合物和方法 Download PDF

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Publication number
CN100339066C
CN100339066C CNB008199655A CN00819965A CN100339066C CN 100339066 C CN100339066 C CN 100339066C CN B008199655 A CNB008199655 A CN B008199655A CN 00819965 A CN00819965 A CN 00819965A CN 100339066 C CN100339066 C CN 100339066C
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CN
China
Prior art keywords
particles
glass
sugar
composition according
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB008199655A
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English (en)
Chinese (zh)
Other versions
CN1527699A (zh
Inventor
布鲁斯·约瑟夫·罗泽
阿尔卡迪奥·加西亚德卡斯特罗
詹姆斯·梅基
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cambridge Biostability Ltd
Original Assignee
Cambridge Biostability Ltd
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Filing date
Publication date
Application filed by Cambridge Biostability Ltd filed Critical Cambridge Biostability Ltd
Publication of CN1527699A publication Critical patent/CN1527699A/zh
Application granted granted Critical
Publication of CN100339066C publication Critical patent/CN100339066C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CNB008199655A 2000-10-13 2000-10-13 稳定的注射液组合物和方法 Expired - Fee Related CN100339066C (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2000/028244 WO2002032402A1 (en) 2000-10-13 2000-10-13 Composition and method for stable injectable liquids

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN200510067324A Division CN100594937C (zh) 2000-10-13 2000-10-13 稳定的注射液组合物和方法

Publications (2)

Publication Number Publication Date
CN1527699A CN1527699A (zh) 2004-09-08
CN100339066C true CN100339066C (zh) 2007-09-26

Family

ID=21741883

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB008199655A Expired - Fee Related CN100339066C (zh) 2000-10-13 2000-10-13 稳定的注射液组合物和方法

Country Status (12)

Country Link
EP (1) EP1328255A1 (enExample)
JP (1) JP2004513093A (enExample)
KR (1) KR20030096224A (enExample)
CN (1) CN100339066C (enExample)
AU (2) AU2001211986B2 (enExample)
CA (2) CA2424656C (enExample)
ES (1) ES2337252T3 (enExample)
MX (1) MXPA03003236A (enExample)
NO (1) NO20031706D0 (enExample)
PL (1) PL360052A1 (enExample)
PT (1) PT1452171E (enExample)
WO (1) WO2002032402A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2004037293A1 (ja) * 2002-10-22 2006-02-23 大日本住友製薬株式会社 安定化組成物
JP2007001865A (ja) * 2003-09-16 2007-01-11 Ltt Bio-Pharma Co Ltd 脂溶性薬物封入微粒子、その製造法およびそれを含有する製剤
WO2005099669A1 (en) 2004-04-13 2005-10-27 Cambridge Biostability Limited Liquids containing suspended glass particles
GB0408199D0 (en) * 2004-04-13 2004-05-19 Cambridge Biostability Ltd Liquids containing suspended sugar glass particles
GB2430880A (en) * 2005-10-04 2007-04-11 Cambridge Biostability Ltd Pharmaceutical compositions stabilized in glassy particles
GB0523638D0 (en) * 2005-11-21 2005-12-28 Cambridge Biostability Ltd Pharmaceutical device for the administration of substances to patients
US8946200B2 (en) 2006-11-02 2015-02-03 Southwest Research Institute Pharmaceutically active nanosuspensions
KR101340129B1 (ko) 2008-01-18 2013-12-10 아사히 가세이 파마 가부시키가이샤 안정한 의약 조성물
US8404850B2 (en) 2008-03-13 2013-03-26 Southwest Research Institute Bis-quaternary pyridinium-aldoxime salts and treatment of exposure to cholinesterase inhibitors
US8722706B2 (en) 2008-08-15 2014-05-13 Southwest Research Institute Two phase bioactive formulations of bis-quaternary pyridinium oxime sulfonate salts
US8309134B2 (en) 2008-10-03 2012-11-13 Southwest Research Institute Modified calcium phosphate nanoparticle formation
WO2010146536A1 (en) 2009-06-18 2010-12-23 Koninklijke Philips Electronics N.V. Suspension of particles with drug
WO2011007327A2 (en) 2009-07-16 2011-01-20 Koninklijke Philips Electronics N.V. Suspension for therapeutic use and device for delivering said suspension
ES2362525B8 (es) 2009-10-08 2013-01-03 Azurebio, S.L. Formulación de medicamentos en forma de agujas percutaneas penetrantes.
US9028873B2 (en) 2010-02-08 2015-05-12 Southwest Research Institute Nanoparticles for drug delivery to the central nervous system
US9884498B2 (en) 2014-03-24 2018-02-06 Seiko Epson Corporation Tape printing device and tape printing system
KR20160137543A (ko) * 2014-03-27 2016-11-30 노파르티스 아게 활성 약제 성분의 흡입을 위한 분무-건조되는 수-중-유-중-고체 분산액

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0091313A2 (en) * 1982-04-05 1983-10-12 Alcon Laboratories, Inc. Perfluorohydrocarbons as vehicles for administering drugs
US5620699A (en) * 1990-09-27 1997-04-15 Allergan, Inc. Method for delivering nonaqueous fluorinated drug delivery vehicle suspensions
CN1256626A (zh) * 1997-03-18 2000-06-14 扇形支撑剑桥有限公司 稳定粒子的液体制剂

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3924193A (en) * 1992-03-19 1993-10-21 Allergan, Inc. Compositions comprising a drug delivery vehicle suspended in a nonaqueous fluorinated liquid
US6190701B1 (en) * 1999-03-17 2001-02-20 Peter M. Ronai Composition and method for stable injectable liquids

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0091313A2 (en) * 1982-04-05 1983-10-12 Alcon Laboratories, Inc. Perfluorohydrocarbons as vehicles for administering drugs
US5620699A (en) * 1990-09-27 1997-04-15 Allergan, Inc. Method for delivering nonaqueous fluorinated drug delivery vehicle suspensions
CN1256626A (zh) * 1997-03-18 2000-06-14 扇形支撑剑桥有限公司 稳定粒子的液体制剂

Also Published As

Publication number Publication date
CA2424656A1 (en) 2002-04-25
ES2337252T3 (es) 2010-04-22
NO20031706L (no) 2003-04-11
JP2004513093A (ja) 2004-04-30
CA2689856C (en) 2013-09-24
KR20030096224A (ko) 2003-12-24
AU2001211986B2 (en) 2007-04-26
CA2689856A1 (en) 2002-04-25
EP1328255A1 (en) 2003-07-23
CN1527699A (zh) 2004-09-08
PL360052A1 (en) 2004-09-06
MXPA03003236A (es) 2004-12-03
NO20031706D0 (no) 2003-04-11
WO2002032402A1 (en) 2002-04-25
AU1198601A (en) 2002-04-29
CA2424656C (en) 2010-03-23
PT1452171E (pt) 2010-03-08

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20070926

Termination date: 20111013