CN100337674C - Medicine for treating hysteromyoma and its preparation method - Google Patents
Medicine for treating hysteromyoma and its preparation method Download PDFInfo
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- CN100337674C CN100337674C CNB200510018989XA CN200510018989A CN100337674C CN 100337674 C CN100337674 C CN 100337674C CN B200510018989X A CNB200510018989X A CN B200510018989XA CN 200510018989 A CN200510018989 A CN 200510018989A CN 100337674 C CN100337674 C CN 100337674C
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Abstract
The present invention discloses a medicine for treating hysteromyoma, which is prepared from the following raw materials of weight portions: decumbent bugle herb, bittersweet herb, Japanese milkwort herb, coix seed, pummelo peel, tangerine seed and amber. Based on the therapy principles of dispersing stagnated liver qi, reducing fever and activating blood circulation, reducing pathological symptoms and removing blood stasis, the present invention is mainly used for treating the hysteromyoma caused by qi stagnation, blood stasis and stagnated fever. The present invention is a medicine which has the advantages of less toxin and side effect and ideal therapeutic effect and is easy to be accepted by patients.
Description
Technical field
The present invention relates to a kind of medicine and preparation method thereof, especially a kind of medicine for the treatment of hysteromyoma and preparation method thereof.
Background technology
Hysteromyoma has multiple trend, except that therapeutic method of surgery, for the case that still is in the conservative stage state of an illness, needs effective in cure definite endo-medicine in fact, to protect numerous women patient's physical and mental health at present.
Summary of the invention
The object of the present invention is to provide a kind of preparation method for the treatment of endo-medicine and this medicine thereof of hysteromyoma.
Technical scheme of the present invention is: a kind of medicine for the treatment of hysteromyoma, the medicine of this treatment hysteromyoma is made up of the raw material of following weight portion: Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 800-1200, Herba Solani Lyrati 800-1200, Herba Polygalae Japonicae 400-600, Semen Coicis 500-700, Exocarpium Citri Grandis 300-360, Semen Citri Reticulatae 400-600, succinum 80-120.The better prescription of the medicine of this treatment hysteromyoma is to be made up of the raw material of following weight portion: Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 1000, Herba Solani Lyrati 1000, Herba Polygalae Japonicae 500, Semen Coicis 666, Exocarpium Citri Grandis 333, Semen Citri Reticulatae 500, succinum 100.
This a kind of process for producing granula for the treatment of the medicine of hysteromyoma is: is ground into fine powder after the succinum clean dry, crosses 100 mesh sieves, and sterilization, standby, Exocarpium Citri Grandis water vapour distillation volatile oil 20ml, medicinal residues are standby.Semen Coicis is measured 60% ethanol extraction secondaries with 8 times, and each 2 hours, merge alcohol extract, filter, standby.Medicinal residues add 10 times of decoctings with steam distillation medicinal residues and other medical materials and boil secondary, each 2 hours, merge the secondary decoction liquor, filter, being evaporated to relative density is 1.2 (80 ℃ of heat are surveyed), adding ethanol makes and contains the alcohol amount and reach 60%, left standstill 24 hours, and got supernatant and Semen Coicis ethanol extract and merge, reclaim ethanol, and continue to be evaporated to relative density and be 1.20 (80 ℃ of heat are surveyed), spray-dried one-tenth dry powder with auxiliary materials and mixing, adds 60% ethanol and makes soft material as wetting agent, make granule with 14 order ferrum screen clothes, airpillow-dry 3 hours, granulate sprays into volatile oil, airtight, packing promptly.
This a kind of capsule preparation method thereof for the treatment of the medicine of hysteromyoma is: is ground into fine powder after the succinum clean dry, crosses 100 mesh sieves, and sterilization, standby; Exocarpium Citri Grandis water vapour distillation volatile oil 20ml, medicinal residues are standby.Semen Coicis is measured 60% ethanol extraction secondaries with 8 times, and each 2 hours, merge alcohol extract, filter, standby.Medicinal residues add 10 times of decoctings with distillate medicinal residues and other medical materials and boil secondary, each 2 hours, merge the secondary decocting liquid, filter, being evaporated to relative density is 1.2 (80 ℃ of surveys), adds ethanol, and to continue to be evaporated to relative density be 1.2 (80 ℃ of surveys), and spray-dried one-tenth dry powder is used alcohol granulation, drying, granulate sprays into volatile oil, airtight 2 hours, the dress capsule is made 1000, promptly.
This a kind of method for preparing tablet thereof for the treatment of the medicine of hysteromyoma is: is ground into fine powder after the succinum clean dry, crosses 100 mesh sieves, and sterilization, standby; Exocarpium Citri Grandis water vapour distillation volatile oil 20ml, medicinal residues are standby.Semen Coicis is measured 60% ethanol extraction secondaries with 8 times, and each 2 hours, merge alcohol extract, filter, standby.Medicinal residues add 10 times of decoctings with distillate medicinal residues and other medical materials and boil secondary, each 2 hours, merge the secondary decocting liquid, filter, being evaporated to relative density is 1.2 (80 ℃ of surveys), adds ethanol, and to continue to be evaporated to relative density be 1.2 (80 ℃ of surveys), and spray-dried one-tenth dry powder is with auxiliary materials and mixing, use alcohol granulation, drying, granulate, spray into volatile oil, airtight 2 hours, tabletting, coating is made 1000, promptly.
The invention has the advantages that: the existing lump in the abdomen of hysteromyoma (lump in the abdomen) Clinical symptoms has the disease of double metrorrhagia, and lump in the abdomen is tangible disease, and lump amasss in abdomen, and localized pain, and this is all relevant with blood stasis.Jing-Yue Complete Works is pointed out: " blood stasis is detained and is done disease, and only the married woman has it.Its card is then or by menstrual period, or by puerperal.All internal injury raw food, or have a cold outward, or susceptible to anger impairing the liver, QI rising in reverse order and blood stays; Or melancholy impairing the spleen, the deficiency of vital energy and stasis; Or a little less than being overworked for a very long period.Gas is weak and also not all right.In always being moved by blood, surplus blood is last clean, and one to some extent against then being detained, and day is amassed and gradually vows with one-tenth disease." this section argumentation of Jing Yue, rounded analysis has been made in the formation of mass formed by blood stasis, very representative in TCM Document.Generally speaking, primary disease is more common in women after the middle age, and this moment, they spent physiology vigorous period, yin and yang imbalance, and QI and blood is lost and is withered, and gasification function weakens, thereby causes and dash through imbalance, and unclean blood agglomeration forms blood stasis in uterus, and with the passing of time just Cheng Jihua disease becomes hysteromyoma.Primary disease forms the several months at least, at most the several years, because knot in the blood stasis is born long-pending transconversion into heat fire for a long time, dashes through failing to keep an appointment and cause, and forcing blood is descending, so the disease that lump in the abdomen is held concurrently metrorrhagia more.Therefore in the determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs of lump in the abdomen, adhere to, when changing the disease dispersing tumor, emphasize to use the method for treatment that cooperates Qinghua stagnant heat in depressed liver-energy dispersing and QI regulating.Consider the primary disease delay with the passing of time, many astringing QIs hematohidrosis deficiency, so unavailable violent medicine send an expedition against to hinder healthy energy, still not according to convention with removing blood stasis or by the high medicine of medicine.
Prescription compatibility of medicines is analyzed: Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.), have another name called ajuga decumbens, bitter sweet cold, go into lung, liver, heart channel, the liver heat removing removing heat from blood is arranged, the function of removing toxic substances and promoting subsidence of swelling, and energy " quench is opened gas " (" book on Chinese herbal medicine is new again "), " disconnected blood stasis and soldier hematochezia " (supplement to the Herbal) has the merit (" Fujian Chinese herbal medicine ") of " clearing away heat-fire, subduing swelling and detoxicating ".Herba Solani Lyrati has another name called Bai Maoteng, and is sweet cold, goes into the liver and gall warp, and its of " book on Chinese herbal medicine " " a main bald malignant boil steam " has removing pathogenic heat from blood and toxic substance from the body, clearing away damp-heat, and the merit of antitumor, " detailed outline " thinks that this medicine can control " inguinal hernia, and clit swells and ache "; This two medicine is our monarch drug.Semen Citri Reticulatae, arduous flat, go into Liver Channel, there is depressed liver-energy dispersing and QI regulating to respect the merit of knot, essentials of Matea Medica is pointed out this product energy " row irritability, the poison that looses of subsiding a swelling "; The energy " dispersing the depressed liver-QI for alleviating pain " of " book on Chinese herbal medicine converges and says ".Herba Polygalae Japonicae, arduous flat, heat-clearing and toxic substances removing, promoting blood circulation and detumescence (Chinese Pharmacopoeia, version in 1977) is also controlled metrorrhagia (" Jiangxi medical herbs "), and diseases such as (" Sichuan Chinese medicines ") is collapsed in hemostasis.Exocarpium Citri Grandis, the toil temperature has the merit of regulating qi-flowing for activating stagnancy.Succinum, sweet flat, go into the merit that the heart, liver lung meridian have the broken disease of blood circulation promoting and blood stasis dispelling, more than four medicines be ministerial drug altogether.Semen Coicis, sweet light cold, going into the taste lung meridian has spleen-invigorating stomach-protecting, and inducing diuresis and reducing edema merit is the flavor adjuvant drug.From above data, can find out in the our seven flavor medicine that disconnected blood stasis is arranged more, control clit, main malignant boil, functions such as the diffusing poison of detumescence are stagnated in order to the treatment blood stasis, with the passing of time become the hysteromyoma of disease very to be in step with, and the merit of removing food stagnancy blood stasis dispelling in delaying is arranged.Uterus belongs to liver channel of foot-Jueyin, Gu this warp " it is cloudy to follow clothes, goes in the hair ring external genitals; support lower abdomen ", the external genitalia illness is how relevant with Liver Channel, and all medicine multipotencys are gone into Liver Channel, the row irritability, dispersing the depressed liver-QI for alleviating pain, irritability bar reach that then mechanism of qi is happy, and the capable then blood of gas is also gone, and long-pending elimination is very helpful to the stasis of blood for this.How relatively cold and cool we's medicine is, has the merit of clearing away heat and cooling blood, qi depression to blood stasis caused the heat of inner product, also rather verification.In a word, our seven flavor medicine share, and has depressed liver-energy dispersing and QI regulating, and heat clearing and blood circulation promoting is changed the effect of disease dispersing tumor.Be monarch drug with Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.), Herba Solani Lyrati in the side, the medicine is mild for it, reuses of a specified duration with the nothing else side effect, and to the menorrhagia of stasis of blood heat-transformation or drippingly do not wait disease only, can play the effect of regulating menstruation, the symptom of early stage hysteromyoma and muscular tumor tuberosity are disappeared, thereby reach the purpose of curing or taking a turn for the better.In conjunction with theory of Chinese medical science, we once used the our medicine of self-control to observe 191 examples altogether at the clinical treatment uterine fibroid disease, had obtained obvious curative effects, its total footing: cure 77 examples, account for 43.32%, produce effects 48 examples account for 23.13%, effective 28 examples, account for 19.90%, invalid 28 examples account for 14.66%, total effective rate is 85.34%, and is satisfactory for result.We's attention, with depressed liver-energy dispersing and QI regulating, heat clearing and blood circulation promoting, changing the disease repercussive is the rule of treatment, cures mainly by qi depression to blood stasis, stagnant heat is handed over the hysteromyoma (lump in the abdomen) due to the knot.We's toxic and side effects is little, the patient takes like a shot, the ideal medicine of therapeutic effect.
The specific embodiment
Embodiment 1:
Prescription is: Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 1000g, Herba Solani Lyrati 1000g, Herba Polygalae Japonicae 500g, Semen Coicis 666g, Exocarpium Citri Grandis 333g, Semen Citri Reticulatae 5000g, succinum 100g, soluble starch 200g, dextrin 100g, mannitol 100g, Icing Sugar 100g, steviosin 2g.
Be ground into fine powder after the 100g succinum clean dry, cross 100 mesh sieves, cobalt-60 irradiation, standby, 333g Exocarpium Citri Grandis water vapour distillation volatile oil 20ml, medicinal residues are standby.The 666g Semen Coicis is measured 60% ethanol extraction secondaries with 8 times, and each 2 hours, merge alcohol extract, filter, standby.The Semen Coicis medicinal residues are with Exocarpium Citri Grandis medicinal residues and Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.), Herba Solani Lyrati, Herba Polygalae Japonicae, Semen Citri Reticulatae adds 10 times of decoctings and boils secondary, each 2 hours, merge the secondary decoction liquor, filter, being evaporated to relative density is 1.2 (80 ℃ of heat are surveyed), adding ethanol makes and contains the alcohol amount and reach 60%, left standstill 24 hours, and got supernatant and Semen Coicis ethanol extract and merge, reclaim ethanol, and continue to be evaporated to relative density and be 1.20 (80 ℃ of heat are surveyed), spray-dried one-tenth dry powder is with the adjuvant soluble starch, dextrin, mannitol, Icing Sugar, the steviosin mixing adds 60% ethanol and makes soft material as wetting agent, make granule with 14 order ferrum screen clothes, airpillow-dry 3 hours, granulate sprays into volatile oil, airtight, packing promptly.
Embodiment 2:
Prescription is: Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 1665g, Herba Solani Lyrati 1665g, Herba Polygalae Japonicae 832.5g, Semen Coicis 1110g, Exocarpium Citri Grandis 555g, Semen Citri Reticulatae 832.5g, succinum 166.5g, starch 150g.
Technology:
Be ground into fine powder after the succinum clean dry, cross 100 mesh sieves, sterilization, standby; Exocarpium Citri Grandis water vapour distillation volatile oil 20ml, medicinal residues are standby.Semen Coicis is measured 60% ethanol extraction secondaries with 8 times, and each 2 hours, merge alcohol extract, filter, standby.The Semen Coicis medicinal residues add 10 times of decoctings with Exocarpium Citri Grandis medicinal residues and Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.), Herba Solani Lyrati, Herba Polygalae Japonicae, Semen Citri Reticulatae and boil secondary, each 2 hours, merge the secondary decocting liquid, filter, being evaporated to relative density is 1.2 (80 ℃ of surveys), adds ethanol, and to continue to be evaporated to relative density be 1.2 (80 ℃ of surveys), and spray-dried one-tenth dry powder is with the starch mixing, use alcohol granulation, drying, granulate, spray into volatile oil, airtight 2 hours, the dress capsule, make 1000, promptly.
Embodiment 3:
Prescription: Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 1665g, Herba Solani Lyrati 1665g, Herba Polygalae Japonicae 832.5g, Semen Coicis 1110g, Exocarpium Citri Grandis 555g, Semen Citri Reticulatae 832.5g, succinum 166.5g, starch 100g, L-hydroxypropyl cellulose 50g, crospolyvinylpyrrolidone 10g.
Technology:
Be ground into fine powder after the succinum clean dry, cross 100 mesh sieves, sterilization, standby; Exocarpium Citri Grandis water vapour distillation volatile oil 20ml, medicinal residues are standby.Semen Coicis is measured 60% ethanol extraction secondaries with 8 times, and each 2 hours, merge alcohol extract, filter, standby.The Semen Coicis medicinal residues add 10 times of decoctings with Exocarpium Citri Grandis medicinal residues and Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.), Herba Solani Lyrati, Herba Polygalae Japonicae, Semen Citri Reticulatae and boil secondary, each 2 hours, merge the secondary decocting liquid, filter, being evaporated to relative density is 1.2 (80 ℃ of surveys), adds ethanol, and to continue to be evaporated to relative density be 1.2 (80 ℃ of surveys), and spray-dried one-tenth dry powder is with auxiliary materials and mixing, use alcohol granulation, drying, granulate, spray into volatile oil, airtight 2 hours, tabletting, coating is made 1000, promptly.
Claims (5)
1, a kind of medicine for the treatment of hysteromyoma, it is characterized in that making effective ingredient raw material of Chinese medicine consist of:
The white pod 800-1200 of Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 800-1200 Herba Polygalae Japonicae 400-600
Semen Coicis 500-700 Exocarpium Citri Grandis 300-360 Semen Citri Reticulatae 400-600
Succinum 80-120.
2, a kind of medicine for the treatment of hysteromyoma according to claim 1 is characterized in that the raw material of Chinese medicine of making effective ingredient consists of: Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 1000 Herba Solani Lyratis 1000 Herba Polygalae Japonicae 500 Semen Coiciss 666 Exocarpium Citri Grandises 333 Semen Citri Reticulataes 500 succinums 100.
3, a kind of medicine for the treatment of hysteromyoma according to claim 1 and 2, it is characterized in that: the process for producing granula of the medicine of treatment hysteromyoma is: be ground into fine powder after the succinum clean dry, cross 100 mesh sieves, sterilization, standby, Exocarpium Citri Grandis water vapour distillation volatile oil 20ml, medicinal residues are standby; Semen Coicis is measured 60% ethanol extraction secondaries with 8 times, and each 2 hours, merge alcohol extract, filter, standby; The Semen Coicis medicinal residues are with Exocarpium Citri Grandis medicinal residues and Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.), Herba Solani Lyrati, Herba Polygalae Japonicae, Semen Citri Reticulatae adds 10 times of decoctings and boils secondary, each 2 hours, merge the secondary decoction liquor, filter, being evaporated to 80 ℃ of heat survey relative densities is 1.2, adding ethanol makes and contains the alcohol amount and reach 60%, left standstill 24 hours, and got supernatant and Semen Coicis ethanol extract and merge, reclaim ethanol, and continuing to be evaporated to 80 ℃ of heat, to survey relative densities be 1.20, spray-dried one-tenth dry powder with auxiliary materials and mixing, adds 60% ethanol and makes soft material as wetting agent, make granule with 14 order ferrum screen clothes, airpillow-dry 3 hours, granulate sprays into volatile oil, airtight, packing promptly.
4, a kind of medicine for the treatment of hysteromyoma according to claim 1 and 2 is characterized in that: the capsule preparation method thereof of the medicine of treatment hysteromyoma is: be ground into fine powder after the succinum clean dry, cross 100 mesh sieves, and sterilization, standby; Exocarpium Citri Grandis water vapour distillation volatile oil 20ml, medicinal residues are standby; Semen Coicis is measured 60%C alcohol extraction secondaries with 8 times, and each 2 hours, merge alcohol extract, filter, standby; The Semen Coicis medicinal residues add 10 times of decoctings with Exocarpium Citri Grandis medicinal residues and Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.), Herba Solani Lyrati, Herba Polygalae Japonicae, Semen Citri Reticulatae and boil secondary, each 2 hours, merge the secondary decocting liquid, filter, being evaporated to 80 ℃ of survey relative densities is 1.2, adds ethanol, and continuing to be evaporated to 80 ℃, to survey relative densities be 1.2, and spray-dried one-tenth dry powder is used alcohol granulation, drying, granulate sprays into volatile oil, airtight 2 hours, the dress capsule is made 1000, promptly.
5, a kind of medicine for the treatment of hysteromyoma according to claim 1 and 2 is characterized in that: the method for preparing tablet thereof of the medicine of treatment hysteromyoma is: be ground into fine powder after the succinum clean dry, cross 100 mesh sieves, and sterilization, standby; Exocarpium Citri Grandis water vapour distillation volatile oil 20ml, medicinal residues are standby; Semen Coicis is measured 60% ethanol extraction secondary with 8 companions, and each 2 hours, merge alcohol extract, filter, standby; The Semen Coicis medicinal residues add 10 times of decoctings with Exocarpium Citri Grandis medicinal residues and Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.), Herba Solani Lyrati, Herba Polygalae Japonicae, Semen Citri Reticulatae and boil secondary, each 2 hours, merge the secondary decocting liquid, filter, being evaporated to 80 ℃ of survey relative densities is 1.2, adds ethanol, and continuing to be evaporated to 80 ℃, to survey relative densities be 1.2, and spray-dried one-tenth dry powder is with auxiliary materials and mixing, use alcohol granulation, drying, granulate, spray into volatile oil, airtight 2 hours, tabletting, or coating, make 1000, promptly.
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| CNB200510018989XA CN100337674C (en) | 2005-06-24 | 2005-06-24 | Medicine for treating hysteromyoma and its preparation method |
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| CNB200510018989XA CN100337674C (en) | 2005-06-24 | 2005-06-24 | Medicine for treating hysteromyoma and its preparation method |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102526550A (en) * | 2012-03-20 | 2012-07-04 | 江西南昌济生制药厂 | Preparation method for traditional Chinese medicine for resisting cyclomastopathy |
| CN102908582B (en) * | 2012-09-18 | 2013-11-13 | 郭敬春 | Traditional Chinese medicine composition for treating blood stasis type abdominal mass for women and preparation method thereof |
| CN104208332A (en) * | 2014-08-22 | 2014-12-17 | 烟台瑞智生物医药科技有限公司 | Traditional Chinese medicine for treating damp-heat stagnation type abdominal mass |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1356125A (en) * | 2001-10-11 | 2002-07-03 | 刘伟东 | Medicine for treating tumor |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1356125A (en) * | 2001-10-11 | 2002-07-03 | 刘伟东 | Medicine for treating tumor |
Non-Patent Citations (1)
| Title |
|---|
| 肌瘤消颗粒对子宫肌瘤模型大鼠干预作用的研究 韩立民，中医药学刊，第22卷第6期 2004 * |
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Address after: 330115 No. 125, Zhou Ji Sheng Road, Beijiao, Nanchang, Jiangxi Patentee after: Jiangxi Nanchang Jisheng Pharmaceutical Co., Ltd. Address before: 330115 No. 125, Zhou Ji Sheng Road, Beijiao, Nanchang, Jiangxi Patentee before: Jisheng Pharmaceutical Factory, Nanchang, Jiangxi |
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