CL2023000191A1 - Inhibidores de factores del complemento y usos de los mismos - Google Patents
Inhibidores de factores del complemento y usos de los mismosInfo
- Publication number
- CL2023000191A1 CL2023000191A1 CL2023000191A CL2023000191A CL2023000191A1 CL 2023000191 A1 CL2023000191 A1 CL 2023000191A1 CL 2023000191 A CL2023000191 A CL 2023000191A CL 2023000191 A CL2023000191 A CL 2023000191A CL 2023000191 A1 CL2023000191 A1 CL 2023000191A1
- Authority
- CL
- Chile
- Prior art keywords
- complement factor
- factor inhibitors
- disclosed
- disease
- compounds
- Prior art date
Links
- 230000000295 complement effect Effects 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 208000030159 metabolic disease Diseases 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/650905—Six-membered rings having the nitrogen atoms in the positions 1 and 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/650905—Six-membered rings having the nitrogen atoms in the positions 1 and 2
- C07F9/650947—Six-membered rings having the nitrogen atoms in the positions 1 and 2 condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Se divulgan compuestos de fórmula I y II y sales farmacéuticamente aceptables de los mismos. También se divulgan métodos para tratar un trastorno neurodegenerativo, una enfermedad inflamatoria, una enfermedad autoinmunitaria, una enfermedad oftalmológica o un trastorno metabólico usando los compuestos divulgados en el presente documento.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063054064P | 2020-07-20 | 2020-07-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2023000191A1 true CL2023000191A1 (es) | 2023-09-08 |
Family
ID=79729495
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2023000191A CL2023000191A1 (es) | 2020-07-20 | 2023-01-19 | Inhibidores de factores del complemento y usos de los mismos |
Country Status (17)
Country | Link |
---|---|
US (2) | US11814404B2 (es) |
EP (1) | EP4185592A1 (es) |
JP (1) | JP2023534974A (es) |
KR (1) | KR20230041758A (es) |
CN (2) | CN116261564A (es) |
AR (1) | AR123011A1 (es) |
AU (1) | AU2021311455A1 (es) |
BR (1) | BR112023001007A2 (es) |
CA (1) | CA3186022A1 (es) |
CL (1) | CL2023000191A1 (es) |
CO (1) | CO2023000683A2 (es) |
IL (1) | IL299840A (es) |
MX (1) | MX2023000919A (es) |
PE (1) | PE20231435A1 (es) |
TW (1) | TW202216168A (es) |
UY (1) | UY39331A (es) |
WO (1) | WO2022020244A1 (es) |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE244234T1 (de) | 1997-04-24 | 2003-07-15 | Ortho Mcneil Pharm Inc | Substituierte imidazole zur behandlung von entzündlichen krankheiten |
EP1971664B1 (en) * | 2006-01-13 | 2015-09-09 | LG Chem, Ltd. | Emitting materials and organic light emitting device using the same |
US8221907B2 (en) | 2007-07-07 | 2012-07-17 | Idemitsu Kosan Co., Ltd. | Chrysene derivative and organic electroluminescent device using the same |
WO2015003146A1 (en) * | 2013-07-03 | 2015-01-08 | Georgetown University | Boronic acid derivatives of resveratrol for activating deacetylase enzymes |
KR101635154B1 (ko) | 2014-08-28 | 2016-06-30 | (주)더블유에스 | 피리딜기가 결합된 트리아진 유도체 및 이를 포함한 유기 전계발광 소자 |
KR102233296B1 (ko) * | 2014-11-18 | 2021-03-29 | 덕산네오룩스 주식회사 | 유기전기 소자용 화합물, 이를 이용한 유기전기소자 및 그 전자 장치 |
AR103397A1 (es) * | 2015-01-13 | 2017-05-10 | Syngenta Participations Ag | Oxoborazoles microbicidas |
CN114984016A (zh) | 2015-03-13 | 2022-09-02 | 雷斯韦洛吉克斯公司 | 用于治疗补体相关疾病之组合物及治疗方法 |
KR101981245B1 (ko) | 2015-10-27 | 2019-05-22 | 주식회사 엘지화학 | 고리 화합물 및 이를 포함하는 유기 발광 소자 |
KR101806464B1 (ko) | 2015-11-19 | 2017-12-07 | (주)랩토 | 피리딜기가 결합된 피리미딘 유도체 및 이를 이용한 유기 전계 발광 소자 |
CN111683935B (zh) | 2018-06-11 | 2023-09-29 | 株式会社Lg化学 | 杂环化合物及包含其的有机发光器件 |
WO2020032428A1 (ko) * | 2018-08-09 | 2020-02-13 | 덕산네오룩스 주식회사 | 유기전기 소자용 화합물을 포함하는 유기전기소자 및 그 전자 장치 |
CN109574910B (zh) * | 2018-12-19 | 2021-07-02 | 山西大学 | 一种咔唑衍生物mcab及其制备方法和应用 |
CN111087387B (zh) | 2019-12-26 | 2022-04-29 | 厦门天马微电子有限公司 | 一种有机化合物、显示面板及显示装置 |
CN111423390A (zh) | 2020-03-30 | 2020-07-17 | 北京燕化集联光电技术有限公司 | 一种新型结构化合物及其应用 |
CN111662309B (zh) | 2020-07-10 | 2021-11-09 | 北京燕化集联光电技术有限公司 | 一种多杂环结构化合物及其应用 |
CN113045585A (zh) | 2021-03-16 | 2021-06-29 | 吉林奥来德光电材料股份有限公司 | 一种有机稠环化合物及其制备方法和应用 |
-
2021
- 2021-07-19 WO PCT/US2021/042198 patent/WO2022020244A1/en active Application Filing
- 2021-07-19 KR KR1020237005805A patent/KR20230041758A/ko unknown
- 2021-07-19 AR ARP210102028A patent/AR123011A1/es unknown
- 2021-07-19 MX MX2023000919A patent/MX2023000919A/es unknown
- 2021-07-19 US US17/379,334 patent/US11814404B2/en active Active
- 2021-07-19 CN CN202180059041.6A patent/CN116261564A/zh active Pending
- 2021-07-19 BR BR112023001007A patent/BR112023001007A2/pt unknown
- 2021-07-19 PE PE2023000109A patent/PE20231435A1/es unknown
- 2021-07-19 AU AU2021311455A patent/AU2021311455A1/en active Pending
- 2021-07-19 IL IL299840A patent/IL299840A/en unknown
- 2021-07-19 EP EP21845924.6A patent/EP4185592A1/en active Pending
- 2021-07-19 CA CA3186022A patent/CA3186022A1/en active Pending
- 2021-07-19 JP JP2023503413A patent/JP2023534974A/ja active Pending
- 2021-07-19 CN CN202310870524.5A patent/CN116947903A/zh active Pending
- 2021-07-20 UY UY0001039331A patent/UY39331A/es unknown
- 2021-07-20 TW TW110126637A patent/TW202216168A/zh unknown
-
2023
- 2023-01-19 CL CL2023000191A patent/CL2023000191A1/es unknown
- 2023-01-20 CO CONC2023/0000683A patent/CO2023000683A2/es unknown
- 2023-10-04 US US18/376,526 patent/US20240109920A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
MX2023000919A (es) | 2023-04-19 |
IL299840A (en) | 2023-03-01 |
CA3186022A1 (en) | 2022-01-27 |
CN116947903A (zh) | 2023-10-27 |
US20220048930A1 (en) | 2022-02-17 |
TW202216168A (zh) | 2022-05-01 |
JP2023534974A (ja) | 2023-08-15 |
UY39331A (es) | 2022-02-25 |
PE20231435A1 (es) | 2023-09-14 |
AU2021311455A1 (en) | 2023-02-16 |
US20240109920A1 (en) | 2024-04-04 |
WO2022020244A1 (en) | 2022-01-27 |
US11814404B2 (en) | 2023-11-14 |
KR20230041758A (ko) | 2023-03-24 |
EP4185592A1 (en) | 2023-05-31 |
AR123011A1 (es) | 2022-10-19 |
CN116261564A (zh) | 2023-06-13 |
BR112023001007A2 (pt) | 2023-03-28 |
CO2023000683A2 (es) | 2023-01-26 |
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