CL2021003047A1 - Forma cristalina de bromuro de sofpironio y método para su preparación - Google Patents

Forma cristalina de bromuro de sofpironio y método para su preparación

Info

Publication number
CL2021003047A1
CL2021003047A1 CL2021003047A CL2021003047A CL2021003047A1 CL 2021003047 A1 CL2021003047 A1 CL 2021003047A1 CL 2021003047 A CL2021003047 A CL 2021003047A CL 2021003047 A CL2021003047 A CL 2021003047A CL 2021003047 A1 CL2021003047 A1 CL 2021003047A1
Authority
CL
Chile
Prior art keywords
sophironium
bromide
crystalline form
preparation
diastereomer
Prior art date
Application number
CL2021003047A
Other languages
English (en)
Inventor
Kazuyoshi MARUBAYASHI
Masahito Watanabe
Herbert R Brinkman
Original Assignee
Kaken Pharma Co Ltd
Brickell Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaken Pharma Co Ltd, Brickell Biotech Inc filed Critical Kaken Pharma Co Ltd
Publication of CL2021003047A1 publication Critical patent/CL2021003047A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12Oxygen or sulfur atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/147Saturated compounds having only one carboxyl group and containing —CHO groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrrole Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Se proporciona un cocristal que contiene el diastereómero 1'R y el diastereómero 1'S de bromuro de sofpironio en una relación de 1:3 (Forma CO), una mezcla de cristales (por ejemplo, la Forma B) que contiene la Forma CO y una forma cristalina del diastereómero 1'R (Forma MN), y un método para preparar bromuro de sofpironio, que es adecuado para la fabricación de la mezcla de cristales. La Forma CO y una forma cristalina de bromuro de sofpironio que contiene la Forma CO (por ejemplo, la Forma B) tienen una estabilidad superior sin propiedades higroscópicas y, por consiguiente, pueden usarse preferentemente como materia prima de medicamentos.
CL2021003047A 2019-05-23 2021-11-18 Forma cristalina de bromuro de sofpironio y método para su preparación CL2021003047A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201962851880P 2019-05-23 2019-05-23

Publications (1)

Publication Number Publication Date
CL2021003047A1 true CL2021003047A1 (es) 2022-09-20

Family

ID=72146250

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2021003047A CL2021003047A1 (es) 2019-05-23 2021-11-18 Forma cristalina de bromuro de sofpironio y método para su preparación

Country Status (16)

Country Link
US (3) US20220298108A1 (es)
EP (1) EP3972955A4 (es)
JP (2) JP6748329B1 (es)
KR (1) KR20220011671A (es)
CN (1) CN114008023B (es)
AU (1) AU2020277881A1 (es)
BR (1) BR112021023241A2 (es)
CA (1) CA3139948A1 (es)
CL (1) CL2021003047A1 (es)
CO (1) CO2021017456A2 (es)
IL (1) IL288285A (es)
MX (1) MX2021014163A (es)
SG (1) SG11202111678WA (es)
TW (2) TWI838531B (es)
WO (1) WO2020235665A1 (es)
ZA (1) ZA202109514B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4002383A3 (en) 2020-11-13 2022-08-03 Tokyo Institute of Technology Information processing device, information processing method, recording medium recording information processing program, and information processing system

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7927613B2 (en) * 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
JP5257073B2 (ja) * 2005-11-10 2013-08-07 ボーダー、ニコラス・エス ソフト型抗コリン作動性エステル
US7399861B2 (en) * 2005-11-10 2008-07-15 Bodor Nicholas S Soft anticholinergic esters
MX357741B (es) * 2012-07-06 2018-07-23 Laboratorios Senosiain S A De C V Star Nuevas formas sólidas de inhibidores de fosfodiesterasa tipo 5.
US9512166B2 (en) * 2012-09-05 2016-12-06 Amri Ssci, Llc Cocrystals of progesterone
US20150259283A1 (en) * 2014-03-13 2015-09-17 Brickell Biotech, Inc. Formulation for soft anticholinergic analogs
US10906871B2 (en) * 2016-08-02 2021-02-02 Dermira, Inc. Processes for making, and methods of using, glycopyrronium compounds

Also Published As

Publication number Publication date
WO2020235665A1 (en) 2020-11-26
CA3139948A1 (en) 2020-11-26
US20210395197A1 (en) 2021-12-23
US11566000B2 (en) 2023-01-31
TW202411205A (zh) 2024-03-16
JP2020189856A (ja) 2020-11-26
IL288285A (en) 2022-01-01
EP3972955A4 (en) 2023-07-05
ZA202109514B (en) 2023-12-20
JP2020189839A (ja) 2020-11-26
AU2020277881A1 (en) 2021-12-09
SG11202111678WA (en) 2021-11-29
TWI838531B (zh) 2024-04-11
CN114008023A (zh) 2022-02-01
MX2021014163A (es) 2022-01-04
CO2021017456A2 (es) 2022-01-17
US20220298108A1 (en) 2022-09-22
JP6748329B1 (ja) 2020-08-26
US20210171460A1 (en) 2021-06-10
TW202110796A (zh) 2021-03-16
EP3972955A1 (en) 2022-03-30
BR112021023241A2 (pt) 2022-01-04
KR20220011671A (ko) 2022-01-28
CN114008023B (zh) 2024-02-09
US11584715B2 (en) 2023-02-21

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