CL2021001573A1 - Anticuerpos anti-muc16 x anti-cd28 biespecíficos y usos de estos. - Google Patents
Anticuerpos anti-muc16 x anti-cd28 biespecíficos y usos de estos.Info
- Publication number
- CL2021001573A1 CL2021001573A1 CL2021001573A CL2021001573A CL2021001573A1 CL 2021001573 A1 CL2021001573 A1 CL 2021001573A1 CL 2021001573 A CL2021001573 A CL 2021001573A CL 2021001573 A CL2021001573 A CL 2021001573A CL 2021001573 A1 CL2021001573 A1 CL 2021001573A1
- Authority
- CL
- Chile
- Prior art keywords
- muc16
- antigen
- antibodies
- binding molecules
- bispecific antigen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
- C07K16/3092—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated mucins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Reproductive Health (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La presente invención proporciona moléculas de fijación al antígeno biespecíficas que comprenden un primer dominio de fijación al antígeno que se fija específicamente a CD28 humana, y un segundo dominio de fijación al antígeno que se fija específicamente a MUC16 humana. En ciertas formas de realización, las moléculas de fijación al antígeno biespecíficas de la presente invención pueden inhibir el crecimiento de tumores que expresan MUC16, tales como tumores de ovario. Los anticuerpos y las moléculas de fijación al antígeno biespecíficas de la invención son útiles para el tratamiento de enfermedades y trastornos en los que una respuesta inmunitaria dirigida regulada de manera ascendente o inducida es conveniente y/o terapéuticamente beneficiosa.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862782142P | 2018-12-19 | 2018-12-19 | |
US201962815861P | 2019-03-08 | 2019-03-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2021001573A1 true CL2021001573A1 (es) | 2021-11-26 |
Family
ID=69182675
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2021001573A CL2021001573A1 (es) | 2018-12-19 | 2021-06-15 | Anticuerpos anti-muc16 x anti-cd28 biespecíficos y usos de estos. |
Country Status (16)
Country | Link |
---|---|
US (2) | US11453721B2 (es) |
EP (1) | EP3898695A1 (es) |
JP (1) | JP2022515611A (es) |
KR (1) | KR20210104758A (es) |
CN (1) | CN113166268A (es) |
AU (1) | AU2019405736A1 (es) |
BR (1) | BR112021010457A2 (es) |
CA (1) | CA3123420A1 (es) |
CL (1) | CL2021001573A1 (es) |
CO (1) | CO2021007077A2 (es) |
IL (1) | IL283493A (es) |
MA (1) | MA54539A (es) |
MX (1) | MX2021006971A (es) |
PH (1) | PH12021551238A1 (es) |
SG (1) | SG11202105948TA (es) |
WO (1) | WO2020132024A1 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3104098A1 (en) * | 2018-06-21 | 2019-12-26 | Regeneron Pharmaceuticals, Inc. | Bispecific anti-psma x anti-cd28 antibodies and uses thereof |
KR20230166150A (ko) | 2020-08-19 | 2023-12-06 | 젠코어 인코포레이티드 | 항-cd28 조성물 |
CN111925990B (zh) * | 2020-09-02 | 2022-08-26 | 北京立康生命科技有限公司 | 一种针对卵巢癌的Anti-MUC16 CAR-T细胞及其制备方法 |
KR20230070259A (ko) * | 2020-09-18 | 2023-05-22 | 리제너론 파마슈티칼스 인코포레이티드 | Cd38 및/또는 cd28에 결합하는 항원 결합 분자, 및 이의 용도 |
KR20230151513A (ko) | 2021-01-11 | 2023-11-01 | 사나 바이오테크놀로지, 인크. | Cd8 표적 바이러스 벡터의 용도 |
WO2022214652A1 (en) | 2021-04-09 | 2022-10-13 | Ose Immunotherapeutics | Scaffold for bifunctioanl molecules comprising pd-1 or cd28 and sirp binding domains |
TW202321457A (zh) | 2021-08-04 | 2023-06-01 | 美商薩那生物科技公司 | 靶向cd4之病毒載體之用途 |
WO2023150518A1 (en) | 2022-02-01 | 2023-08-10 | Sana Biotechnology, Inc. | Cd3-targeted lentiviral vectors and uses thereof |
US20240002544A1 (en) | 2022-03-07 | 2024-01-04 | Novimmune Sa | Cd28 bispecific antibodies for targeted t cell activation |
WO2023174925A1 (en) | 2022-03-14 | 2023-09-21 | Novimmune Sa | Bispecific gpc3xcd28 and gpc3xcd3 antibodies and their combination for targeted killing of gpc3 positive malignant cells |
WO2023193015A1 (en) | 2022-04-01 | 2023-10-05 | Sana Biotechnology, Inc. | Cytokine receptor agonist and viral vector combination therapies |
WO2023198042A1 (zh) * | 2022-04-11 | 2023-10-19 | 江苏恒瑞医药股份有限公司 | 特异性结合egfr和cd28的抗原结合分子及其医药用途 |
WO2024026377A1 (en) | 2022-07-27 | 2024-02-01 | Sana Biotechnology, Inc. | Methods of transduction using a viral vector and inhibitors of antiviral restriction factors |
WO2024040195A1 (en) | 2022-08-17 | 2024-02-22 | Capstan Therapeutics, Inc. | Conditioning for in vivo immune cell engineering |
WO2024084052A1 (en) | 2022-10-21 | 2024-04-25 | Novimmune Sa | Pd-l1xcd28 bispecific antibodies for immune checkpoint-dependent t cell activation |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
DK0590058T3 (da) | 1991-06-14 | 2004-03-29 | Genentech Inc | Humaniseret heregulin-antistof |
US20040116675A1 (en) | 2001-12-14 | 2004-06-17 | Tso J. Jun | Silenced anti-cd28 antibodies and use thereof |
JP5848861B2 (ja) | 2004-04-20 | 2016-01-27 | ジェンマブ エー/エスGenmab A/S | Cd20に対するヒトモノクローナル抗体 |
SI2041177T1 (sl) | 2006-06-02 | 2012-03-30 | Regeneron Pharma | Visoko afinitetna protitelesa za humani IL receptor |
RS59001B1 (sr) | 2010-02-08 | 2019-08-30 | Regeneron Pharma | Miš sa zajedničkim lakim lancem |
US20150203591A1 (en) | 2012-08-02 | 2015-07-23 | Regeneron Pharmaceuticals, Inc. | Mutivalent antigen-binding proteins |
US9682143B2 (en) * | 2012-08-14 | 2017-06-20 | Ibc Pharmaceuticals, Inc. | Combination therapy for inducing immune response to disease |
JOP20200236A1 (ar) | 2012-09-21 | 2017-06-16 | Regeneron Pharma | الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها |
WO2015036606A1 (en) * | 2013-09-16 | 2015-03-19 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Bi- or multispecific polypeptides binding immune effector cell surface antigens and hbv antigens for treating hbv infections and associated conditions |
TWI681969B (zh) | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對pd-1的人類抗體 |
WO2016019969A1 (en) * | 2014-08-08 | 2016-02-11 | Ludwig-Maximilians-Universität München | Subcutaneously administered bispecific antibodies for use in the treatment of cancer |
SI3353212T1 (sl) | 2015-09-23 | 2022-01-31 | Regeneron Pharmaceuticals, Inc., | Optimizirana bispecifična protitelesa proti-CD3 in njihove uporabe |
JP7078609B2 (ja) | 2016-09-23 | 2022-05-31 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 抗steap2抗体、抗体-薬物複合体、およびsteap2とcd3を結合する二重特異性抗原結合分子、ならびにそれらの使用 |
PL3515946T3 (pl) | 2016-09-23 | 2022-11-07 | Regeneron Pharmaceuticals, Inc. | Przeciwciała anty-muc16 (mucyna 16) |
-
2019
- 2019-12-18 MX MX2021006971A patent/MX2021006971A/es unknown
- 2019-12-18 EP EP19839545.1A patent/EP3898695A1/en active Pending
- 2019-12-18 AU AU2019405736A patent/AU2019405736A1/en active Pending
- 2019-12-18 JP JP2021535639A patent/JP2022515611A/ja active Pending
- 2019-12-18 KR KR1020217021119A patent/KR20210104758A/ko unknown
- 2019-12-18 CN CN201980080509.2A patent/CN113166268A/zh active Pending
- 2019-12-18 WO PCT/US2019/067109 patent/WO2020132024A1/en active Application Filing
- 2019-12-18 SG SG11202105948TA patent/SG11202105948TA/en unknown
- 2019-12-18 CA CA3123420A patent/CA3123420A1/en active Pending
- 2019-12-18 BR BR112021010457-7A patent/BR112021010457A2/pt unknown
- 2019-12-18 US US16/719,273 patent/US11453721B2/en active Active
- 2019-12-18 MA MA054539A patent/MA54539A/fr unknown
-
2021
- 2021-05-27 IL IL283493A patent/IL283493A/en unknown
- 2021-05-28 CO CONC2021/0007077A patent/CO2021007077A2/es unknown
- 2021-05-28 PH PH12021551238A patent/PH12021551238A1/en unknown
- 2021-06-15 CL CL2021001573A patent/CL2021001573A1/es unknown
-
2022
- 2022-08-17 US US17/890,078 patent/US20230279113A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
SG11202105948TA (en) | 2021-07-29 |
US20230279113A1 (en) | 2023-09-07 |
US20200199233A1 (en) | 2020-06-25 |
AU2019405736A1 (en) | 2021-06-24 |
MA54539A (fr) | 2021-10-27 |
KR20210104758A (ko) | 2021-08-25 |
MX2021006971A (es) | 2021-07-15 |
CN113166268A (zh) | 2021-07-23 |
BR112021010457A2 (pt) | 2021-08-24 |
US11453721B2 (en) | 2022-09-27 |
CA3123420A1 (en) | 2020-06-25 |
PH12021551238A1 (en) | 2021-12-13 |
EP3898695A1 (en) | 2021-10-27 |
WO2020132024A1 (en) | 2020-06-25 |
IL283493A (en) | 2021-07-29 |
JP2022515611A (ja) | 2022-02-21 |
CO2021007077A2 (es) | 2021-06-10 |
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