CL2021000942A1 - Anticuerpos anti-npr1 y usos relacionados. - Google Patents
Anticuerpos anti-npr1 y usos relacionados.Info
- Publication number
- CL2021000942A1 CL2021000942A1 CL2021000942A CL2021000942A CL2021000942A1 CL 2021000942 A1 CL2021000942 A1 CL 2021000942A1 CL 2021000942 A CL2021000942 A CL 2021000942A CL 2021000942 A CL2021000942 A CL 2021000942A CL 2021000942 A1 CL2021000942 A1 CL 2021000942A1
- Authority
- CL
- Chile
- Prior art keywords
- npr1
- related uses
- npr1 antibodies
- antibodies
- antigen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2869—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Dermatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862749557P | 2018-10-23 | 2018-10-23 | |
| US201862755720P | 2018-11-05 | 2018-11-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2021000942A1 true CL2021000942A1 (es) | 2022-02-04 |
Family
ID=68732036
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2021000942A CL2021000942A1 (es) | 2018-10-23 | 2021-04-15 | Anticuerpos anti-npr1 y usos relacionados. |
| CL2023001377A CL2023001377A1 (es) | 2018-10-23 | 2023-05-12 | Anticuerpos anti-npr1 y usos de los mismos |
| CL2024000378A CL2024000378A1 (es) | 2018-10-23 | 2024-02-07 | Anticuerpos anti-npr1 y usos de los mismos. |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2023001377A CL2023001377A1 (es) | 2018-10-23 | 2023-05-12 | Anticuerpos anti-npr1 y usos de los mismos |
| CL2024000378A CL2024000378A1 (es) | 2018-10-23 | 2024-02-07 | Anticuerpos anti-npr1 y usos de los mismos. |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US11306148B2 (https=) |
| EP (1) | EP3870612A2 (https=) |
| JP (3) | JP7439076B2 (https=) |
| KR (1) | KR20210082207A (https=) |
| CN (1) | CN112805303B (https=) |
| AU (1) | AU2019368196B2 (https=) |
| CA (1) | CA3115102A1 (https=) |
| CL (3) | CL2021000942A1 (https=) |
| CO (1) | CO2021006663A2 (https=) |
| IL (1) | IL281297B1 (https=) |
| MX (2) | MX2021004284A (https=) |
| MY (1) | MY205168A (https=) |
| PH (1) | PH12021550255A1 (https=) |
| SG (1) | SG11202101037QA (https=) |
| WO (1) | WO2020086406A2 (https=) |
| ZA (1) | ZA202100714B (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY205168A (en) | 2018-10-23 | 2024-10-04 | Regeneron Pharma | Anti-npr1 antibodies and uses thereof |
| EA202193345A1 (ru) | 2019-06-12 | 2022-03-16 | Новартис Аг | Антитела к рецептору-1 натрийуретического пептида и способы их применения |
| EP4259661A1 (en) | 2020-12-14 | 2023-10-18 | Novartis AG | Reversal binding agents for anti-natriuretic peptide receptor 1 (npr1) antibodies and uses thereof |
| US12325752B2 (en) | 2020-12-18 | 2025-06-10 | Regeneron Pharmaceuticals, Inc. | Immunoglobulin proteins that bind to NPR1 agonists |
| US12281161B2 (en) | 2021-07-28 | 2025-04-22 | Trustees Of Boston University | Polypeptides and uses thereof |
| IL311917A (en) | 2021-10-11 | 2024-06-01 | Regeneron Pharma | Methods for Inducing Hemodynamic Change by Administering an Anti-NPR1 Antibody |
| IL313265A (en) | 2021-12-06 | 2024-08-01 | Regeneron Pharma | Antagonistic antibodies against NPR1 and methods of using them |
| WO2023187657A1 (en) | 2022-03-30 | 2023-10-05 | Novartis Ag | Methods of treating disorders using anti-natriuretic peptide receptor 1 (npr1) antibodies |
| WO2024251255A1 (zh) | 2023-06-08 | 2024-12-12 | 江苏恒瑞医药股份有限公司 | 抗npr1抗体及其医药用途 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US20080214437A1 (en) | 2002-09-06 | 2008-09-04 | Mohapatra Shyam S | Methods and compositions for reducing activity of the atrial natriuretic peptide receptor and for treatment of diseases |
| US20040101920A1 (en) | 2002-11-01 | 2004-05-27 | Czeslaw Radziejewski | Modification assisted profiling (MAP) methodology |
| WO2005103081A2 (en) | 2004-04-20 | 2005-11-03 | Genmab A/S | Human monoclonal antibodies against cd20 |
| US8257740B1 (en) | 2011-08-15 | 2012-09-04 | Gp Medical, Inc. | Pharmaceutical composition of nanoparticles |
| US8246995B2 (en) | 2005-05-10 | 2012-08-21 | The Board Of Trustees Of The Leland Stanford Junior University | Hydrophobic nanotubes and nanoparticles as transporters for the delivery of drugs into cells |
| ES2398076T3 (es) | 2006-06-02 | 2013-03-13 | Regeneron Pharmaceuticals, Inc. | Anticuerpos de alta afinidad contra el receptor de IL-6 humano |
| EP2162464A1 (en) * | 2007-06-06 | 2010-03-17 | Boehringer Ingelheim International GmbH | Natriuretic fusion proteins |
| US9090695B2 (en) * | 2008-12-03 | 2015-07-28 | Morphosys Ag | Antibodies for guanylyl cyclase receptors |
| JP5816170B2 (ja) | 2009-06-26 | 2015-11-18 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 天然の免疫グロブリン形式を有する容易に単離される二重特異性抗体 |
| CN102482715A (zh) | 2009-07-13 | 2012-05-30 | 霍夫曼-拉罗奇有限公司 | 用于癌症治疗的诊断方法和组合物 |
| SI2501817T2 (sl) | 2010-02-08 | 2021-09-30 | Regeneron Pharmaceuticals, Inc. | Miš z navadno lahko verigo |
| US10184942B2 (en) | 2011-03-17 | 2019-01-22 | University Of South Florida | Natriuretic peptide receptor as a biomarker for diagnosis and prognosis of cancer |
| US9451770B2 (en) | 2012-06-08 | 2016-09-27 | Charles Despres | Method of activating immune response in plants |
| TWI682941B (zh) | 2013-02-01 | 2020-01-21 | 美商再生元醫藥公司 | 含嵌合恆定區之抗體 |
| AR097306A1 (es) | 2013-08-20 | 2016-03-02 | Merck Sharp & Dohme | Modulación de la inmunidad tumoral |
| WO2016131943A1 (en) | 2015-02-20 | 2016-08-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of obesity and complications arising therefrom including type 2 diabetes |
| WO2017209553A2 (ko) | 2016-06-03 | 2017-12-07 | 사회복지법인 삼성생명공익재단 | 환자 유래 세포를 이용한 항체 스크리닝 방법 |
| US20190248888A1 (en) * | 2016-10-20 | 2019-08-15 | Regeneron Pharmaceuticals, Inc. | Methods of lowering blood glucose levels |
| US20190135804A1 (en) | 2017-11-03 | 2019-05-09 | The United States Of America,As Represented By The Secretary,Department Of Health And Human Services | Compositions and methods for the inhibition of pruritus |
| MY205168A (en) | 2018-10-23 | 2024-10-04 | Regeneron Pharma | Anti-npr1 antibodies and uses thereof |
| EP3898700A1 (en) | 2018-12-18 | 2021-10-27 | Novartis AG | Reversal binding agents for anti-factor xi/xia antibodies and uses thereof |
| EA202193345A1 (ru) | 2019-06-12 | 2022-03-16 | Новартис Аг | Антитела к рецептору-1 натрийуретического пептида и способы их применения |
| EP4259661A1 (en) | 2020-12-14 | 2023-10-18 | Novartis AG | Reversal binding agents for anti-natriuretic peptide receptor 1 (npr1) antibodies and uses thereof |
| US12325752B2 (en) | 2020-12-18 | 2025-06-10 | Regeneron Pharmaceuticals, Inc. | Immunoglobulin proteins that bind to NPR1 agonists |
| IL313265A (en) | 2021-12-06 | 2024-08-01 | Regeneron Pharma | Antagonistic antibodies against NPR1 and methods of using them |
-
2019
- 2019-10-18 MY MYPI2021001138A patent/MY205168A/en unknown
- 2019-10-18 JP JP2021522004A patent/JP7439076B2/ja active Active
- 2019-10-18 WO PCT/US2019/057033 patent/WO2020086406A2/en not_active Ceased
- 2019-10-18 US US16/657,000 patent/US11306148B2/en active Active
- 2019-10-18 MX MX2021004284A patent/MX2021004284A/es unknown
- 2019-10-18 CA CA3115102A patent/CA3115102A1/en active Pending
- 2019-10-18 KR KR1020217015469A patent/KR20210082207A/ko active Pending
- 2019-10-18 EP EP19812875.3A patent/EP3870612A2/en active Pending
- 2019-10-18 SG SG11202101037QA patent/SG11202101037QA/en unknown
- 2019-10-18 AU AU2019368196A patent/AU2019368196B2/en active Active
- 2019-10-18 CN CN201980065187.4A patent/CN112805303B/zh active Active
-
2021
- 2021-02-02 ZA ZA2021/00714A patent/ZA202100714B/en unknown
- 2021-02-03 PH PH12021550255A patent/PH12021550255A1/en unknown
- 2021-03-07 IL IL281297A patent/IL281297B1/en unknown
- 2021-04-14 MX MX2024011444A patent/MX2024011444A/es unknown
- 2021-04-15 CL CL2021000942A patent/CL2021000942A1/es unknown
- 2021-05-21 CO CONC2021/0006663A patent/CO2021006663A2/es unknown
-
2022
- 2022-03-10 US US17/692,084 patent/US11820826B2/en active Active
-
2023
- 2023-05-12 CL CL2023001377A patent/CL2023001377A1/es unknown
- 2023-10-11 US US18/485,241 patent/US20240059780A1/en not_active Abandoned
-
2024
- 2024-02-07 CL CL2024000378A patent/CL2024000378A1/es unknown
- 2024-02-13 JP JP2024019151A patent/JP7713051B2/ja active Active
- 2024-05-31 US US18/680,910 patent/US20240309103A1/en active Pending
-
2025
- 2025-07-10 JP JP2025116272A patent/JP2025148445A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CL2021000942A1 (es) | Anticuerpos anti-npr1 y usos relacionados. | |
| PE20211217A1 (es) | Anticuerpos estabilizadores de trem2 | |
| UY37928A (es) | Anticuerpos anti-cd38 y métodos de uso | |
| SA521420953B1 (ar) | بروتين ربط مولد ضد مضاد لـمولد ضد ظهاري ذو 6 أغشية انتقالية من البروستاتا 1 | |
| CL2018002490A1 (es) | Anticuerpos anti-cd3, anticuerpos anti-cd123 y anticuerpos biespecíficos que se unen específicamente a cd3 y/o cd123. (divisional solicitud 201701866) | |
| EA202090247A1 (ru) | Антитела против cd166 и их применения | |
| AR111362A1 (es) | Anticuerpos anti-ilt4 y fragmentos de unión a antígeno | |
| BR112019000770A2 (pt) | proteínas de ligação semelhantes a anticorpos biespecíficos que se ligam especificamente às cd3 e cd123 | |
| AR101846A1 (es) | Anticuerpos anti-cll-1 e inmunoconjugados | |
| PE20180480A1 (es) | Anticuerpos de factor xi y metodos de uso | |
| PE20181046A1 (es) | Anticuerpos anti-tigit y metodos de uso | |
| ES2676023T3 (es) | Polipéptidos de IL-22 y proteínas de fusión de IL-22 Fc y métodos de uso | |
| CU20180135A7 (es) | Anticuerpos monoclonales aislados que compiten por la unión a tau con el anticuerpo 3d6 | |
| EA201892522A1 (ru) | Днк-моноклональные антитела, нацеленные на молекулы контрольных точек | |
| CO2021014153A2 (es) | Anticuerpo monoclonal que se une específicamente a gitr | |
| HRP20240704T1 (hr) | Postupci za predviđanje korisnosti neoantigena za imunoterapiju | |
| AR128031A1 (es) | Anticuerpos agonistas anti-ltbr y anticuerpos biespecíficos que los comprenden | |
| JOP20200215A1 (ar) | الأجسام المضادة لـ PHF-Tau المضاد واستخداماتها | |
| CL2018003072A1 (es) | Anticuerpos anti-basigin humanizados y uso de los mismos. | |
| MX2021015356A (es) | Anticuerpos y fragmentos de anticuerpos anti-epcam condicionalmente activos, sus inmunoconjugados y usos de estos. | |
| EA201790341A1 (ru) | Анти-ск8 антитела для применения в лечении рака | |
| BR112022005410A2 (pt) | Métodos e composições compreendendo um anticorpo monoclonal anti-ctla4 com proteínas de célula hospedeira reduzidas e estabilidade de polissorbato 80 aumentada | |
| CL2021001104A1 (es) | Anticuerpo monoclonal que se une específicamente al antígeno cd20 | |
| UY37752A (es) | Proteínas de unión al antígeno anti-jagged1 | |
| BR112022004570A2 (pt) | Terapia de combinação com anticorpos entpd2 e cd73 |