CL2020003074A1 - Inhibidores de la vía de respuesta al estrés integrada. - Google Patents
Inhibidores de la vía de respuesta al estrés integrada.Info
- Publication number
- CL2020003074A1 CL2020003074A1 CL2020003074A CL2020003074A CL2020003074A1 CL 2020003074 A1 CL2020003074 A1 CL 2020003074A1 CL 2020003074 A CL2020003074 A CL 2020003074A CL 2020003074 A CL2020003074 A CL 2020003074A CL 2020003074 A1 CL2020003074 A1 CL 2020003074A1
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- CL
- Chile
- Prior art keywords
- inhibitors
- stress response
- integrated stress
- response pathway
- pathway
- Prior art date
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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Abstract
La presente descripción se refiere generalmente a agentes terapéuticos que pueden ser útiles como inhibidores de la vía de respuesta al estrés integrada (ISR).
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US201862681071P | 2018-06-05 | 2018-06-05 |
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BR112020011914A2 (pt) | 2017-12-13 | 2020-11-24 | Praxis Biotech LLC | inibidores de via de resposta de tensão integrada |
JP2022536663A (ja) | 2019-06-12 | 2022-08-18 | プラクシス バイオテック エルエルシー | 統合的ストレス応答経路のモジュレーター |
IL296220A (en) | 2020-03-11 | 2022-11-01 | Evotec Int Gmbh | Modulators for an integrated stress response pathway |
KR20230110510A (ko) | 2020-10-22 | 2023-07-24 | 에보텍 인터내셔널 게엠베하 | 통합 스트레스 반응 경로의 조절제 |
JP2023546224A (ja) | 2020-10-22 | 2023-11-01 | エヴォテック・インターナショナル・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 統合ストレス応答経路のモジュレーター |
WO2022084448A1 (en) | 2020-10-22 | 2022-04-28 | Evotec International Gmbh | Modulators of the integrated stress response pathway |
EP4001917A1 (en) | 2020-11-12 | 2022-05-25 | Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts | Inhibitors for use in treating liver disorders |
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2019
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2020
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2021
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CN112912082A (zh) | 2021-06-04 |
AU2019282253A1 (en) | 2020-11-26 |
US20220071966A1 (en) | 2022-03-10 |
US11166942B2 (en) | 2021-11-09 |
CA3100715A1 (en) | 2019-12-12 |
IL279151A (en) | 2021-01-31 |
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