CL2019002155A1 - Proteínas de fusión del factor ix y procedimientos de preparación y utilización de las mismas. - Google Patents
Proteínas de fusión del factor ix y procedimientos de preparación y utilización de las mismas.Info
- Publication number
- CL2019002155A1 CL2019002155A1 CL2019002155A CL2019002155A CL2019002155A1 CL 2019002155 A1 CL2019002155 A1 CL 2019002155A1 CL 2019002155 A CL2019002155 A CL 2019002155A CL 2019002155 A CL2019002155 A CL 2019002155A CL 2019002155 A1 CL2019002155 A1 CL 2019002155A1
- Authority
- CL
- Chile
- Prior art keywords
- fusion proteins
- factor
- procedures
- preparation
- fix
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/644—Coagulation factor IXa (3.4.21.22)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21022—Coagulation factor IXa (3.4.21.22)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
LA PRESENTE DESCRIPCIÓN PROPORCIONA PROTEÍNAS DE FUSIÓN DEL FACTOR IX (FIX) QUE COMPRENDEN AL MENOS UN RESTO HETERÓLOGO, TAL COMO UN XTEN. LA PRESENTE DESCRIPCIÓN DESCRIBE ADEMÁS MÉTODOS PARA PREPARAR Y UTILIZAR LAS PROTEÍNAS DE FUSIÓN DEL FIX.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762452826P | 2017-01-31 | 2017-01-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2019002155A1 true CL2019002155A1 (es) | 2020-02-21 |
Family
ID=61193175
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2019002155A CL2019002155A1 (es) | 2017-01-31 | 2019-07-31 | Proteínas de fusión del factor ix y procedimientos de preparación y utilización de las mismas. |
Country Status (19)
Country | Link |
---|---|
US (1) | US20210238259A1 (es) |
EP (1) | EP3576762A1 (es) |
JP (1) | JP2020505424A (es) |
KR (1) | KR20190112763A (es) |
CN (1) | CN110831613A (es) |
AR (1) | AR110871A1 (es) |
AU (1) | AU2018215092A1 (es) |
BR (1) | BR112019015569A2 (es) |
CA (1) | CA3051862A1 (es) |
CL (1) | CL2019002155A1 (es) |
CR (1) | CR20190389A (es) |
EA (1) | EA201991768A1 (es) |
IL (1) | IL268234A (es) |
MA (1) | MA47416A (es) |
MX (1) | MX2019009063A (es) |
PH (1) | PH12019501765A1 (es) |
SG (1) | SG11201906788XA (es) |
TW (1) | TW201831521A (es) |
WO (1) | WO2018144623A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112175088B (zh) * | 2019-07-02 | 2023-03-28 | 江苏晟斯生物制药有限公司 | 改进的fix融合蛋白、缀合物及其应用 |
CN113817759B (zh) * | 2020-07-10 | 2023-06-02 | 南京吉迈生物技术有限公司 | 修饰的因子ix、组合物、方法及其在基因治疗中的应用 |
Family Cites Families (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4704362A (en) | 1977-11-08 | 1987-11-03 | Genentech, Inc. | Recombinant cloning vehicle microbial polypeptide expression |
EP0154316B1 (en) | 1984-03-06 | 1989-09-13 | Takeda Chemical Industries, Ltd. | Chemically modified lymphokine and production thereof |
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
ATE74164T1 (de) | 1985-04-22 | 1992-04-15 | Genetics Inst | Herstellung mit hoher leistung des aktivfaktors ix. |
EP0279582A3 (en) | 1987-02-17 | 1989-10-18 | Pharming B.V. | Dna sequences to target proteins to the mammary gland for efficient secretion |
ATE135370T1 (de) | 1988-12-22 | 1996-03-15 | Kirin Amgen Inc | Chemisch modifizierte granulocytenkolonie erregender faktor |
JP3045539B2 (ja) | 1989-02-21 | 2000-05-29 | ワシントン ユニバーシティ | 改変型生殖ホルモン |
US5633076A (en) | 1989-12-01 | 1997-05-27 | Pharming Bv | Method of producing a transgenic bovine or transgenic bovine embryo |
US6552170B1 (en) | 1990-04-06 | 2003-04-22 | Amgen Inc. | PEGylation reagents and compounds formed therewith |
WO1992016221A1 (en) | 1991-03-15 | 1992-10-01 | Synergen, Inc. | Pegylation of polypeptides |
US5846951A (en) | 1991-06-06 | 1998-12-08 | The School Of Pharmacy, University Of London | Pharmaceutical compositions |
IE922437A1 (en) | 1991-07-25 | 1993-01-27 | Idec Pharma Corp | Recombinant antibodies for human therapy |
US5736137A (en) | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
DK0669986T3 (da) | 1992-11-13 | 2003-07-28 | Idec Pharma Corp | Fuldstændigt inaktiverede kozac-sekvenser til ekspression i pattedyr |
US5827690A (en) | 1993-12-20 | 1998-10-27 | Genzyme Transgenics Corporatiion | Transgenic production of antibodies in milk |
GB9524973D0 (en) | 1995-12-06 | 1996-02-07 | Lynxvale Ltd | Viral vectors |
JP4128227B2 (ja) | 1997-03-14 | 2008-07-30 | バイオジェン・アイデック・インコーポレイテッド | 哺乳類細胞内の特定部位に相同組換えによって遺伝子を組み込む方法とそれを実施するためのベクター |
EP2267026A1 (en) | 2000-04-12 | 2010-12-29 | Human Genome Sciences, Inc. | Albumin fusion proteins |
AU2002226028A1 (en) | 2000-11-14 | 2002-05-27 | Board Of Regents, Unversity Of Texas Systems | Mutant human factor ix with an increased resistance to inhibition by heparin |
PL369065A1 (en) | 2001-09-04 | 2005-04-18 | Merck Patent Gmbh | Modified factor ix |
PT1463751E (pt) | 2001-12-21 | 2013-08-26 | Human Genome Sciences Inc | Proteínas de fusão de albumina |
KR101271635B1 (ko) | 2001-12-21 | 2013-06-12 | 휴먼 게놈 사이언시즈, 인코포레이티드 | 알부민 융합 단백질 |
US20080194481A1 (en) | 2001-12-21 | 2008-08-14 | Human Genome Sciences, Inc. | Albumin Fusion Proteins |
EP2371856B1 (en) | 2004-11-12 | 2022-05-18 | Bayer HealthCare LLC | Site-directed modification of FVIII |
MX2008001865A (es) | 2005-08-12 | 2008-04-15 | Human Genome Sciences Inc | Proteinas de fusion de albumina. |
US8048848B2 (en) | 2006-02-03 | 2011-11-01 | Prolor Biotech Ltd. | Long-acting interferons and derivatives thereof and methods thereof |
EP2423307A1 (en) | 2006-06-19 | 2012-02-29 | Catalyst Biosciences, Inc. | Modified coagulation factor IV polypeptides and use thereof for treatment |
US20100254944A1 (en) | 2006-09-14 | 2010-10-07 | Mani Subramanian | Albumin Fusion Proteins |
US7700734B2 (en) | 2007-01-09 | 2010-04-20 | Shu-Wha Lin | Recombinant human factor IX and use thereof |
NZ580670A (en) | 2007-06-21 | 2011-09-30 | Univ Muenchen Tech | Biological active proteins having increased in vivo and/or vitro stability |
CN102026653B (zh) | 2007-10-15 | 2014-06-18 | 北卡罗来纳-查佩尔山大学 | 半衰期延长的人因子ⅸ变体 |
WO2009137254A2 (en) | 2008-04-16 | 2009-11-12 | Bayer Healthcare Llc | Modified factor ix polypeptides and uses thereof |
CA2721362A1 (en) | 2008-04-16 | 2009-11-19 | Bayer Healthcare Llc | Site-directed modification of factor ix |
TWI573806B (zh) | 2008-04-17 | 2017-03-11 | 巴克斯歐塔公司 | 生物活性胜肽 |
EP2268807A2 (en) | 2008-04-21 | 2011-01-05 | Novo Nordisk A/S | Hyperglycosylated human coagulation factor ix |
US8680050B2 (en) | 2009-02-03 | 2014-03-25 | Amunix Operating Inc. | Growth hormone polypeptides fused to extended recombinant polypeptides and methods of making and using same |
EP2393828B1 (en) | 2009-02-03 | 2016-10-12 | Amunix Operating Inc. | Extended recombinant polypeptides and compositions comprising same |
US8703717B2 (en) | 2009-02-03 | 2014-04-22 | Amunix Operating Inc. | Growth hormone polypeptides and methods of making and using same |
EP2440228B8 (en) | 2009-06-08 | 2023-02-22 | Amunix Operating Inc. | Glucose-regulating polypeptides and methods of making and using same |
MX354555B (es) | 2009-06-08 | 2018-03-09 | Amunix Operating Inc | Polipeptidos de la hormona de crecimiento y metodos de preparacion y su uso. |
WO2011028229A1 (en) | 2009-08-24 | 2011-03-10 | Amunix Operating Inc. | Coagulation factor ix compositions and methods of making and using same |
WO2011028344A2 (en) | 2009-08-25 | 2011-03-10 | Amunix Operating Inc. | Interleukin-1 receptor antagonist compositions and methods of making and using same |
EP4382170A2 (en) | 2009-12-06 | 2024-06-12 | Bioverativ Therapeutics Inc. | Factor viii-fc chimeric and hybrid polypeptides, and methods of use thereof |
AU2011274423B2 (en) | 2010-07-09 | 2016-02-11 | Bioverativ Therapeutics Inc. | Chimeric clotting factors |
MX356527B (es) | 2010-07-09 | 2018-06-01 | Bioverativ Therapeutics Inc | Polipeptidos de factor ix y metodos para usarlos. |
EP3508573A1 (en) | 2010-07-09 | 2019-07-10 | Bioverativ Therapeutics Inc. | Systems for factor viii processing and methods thereof |
LT2882450T (lt) | 2012-07-11 | 2020-03-25 | Bioverativ Therapeutics Inc. | Faktoriaus viii komplekso su xten ir von vilebrando faktoriumi baltymas ir jo panaudojimas |
US10548953B2 (en) | 2013-08-14 | 2020-02-04 | Bioverativ Therapeutics Inc. | Factor VIII-XTEN fusions and uses thereof |
EP3331608A4 (en) * | 2015-08-03 | 2019-05-01 | Bioverativ Therapeutics Inc. | FUSION XI FUSION PROTEINS AND METHODS OF MAKING AND USING THE SAME |
-
2018
- 2018-01-31 MX MX2019009063A patent/MX2019009063A/es unknown
- 2018-01-31 AR ARP180100235A patent/AR110871A1/es unknown
- 2018-01-31 US US16/478,747 patent/US20210238259A1/en not_active Abandoned
- 2018-01-31 CN CN201880020779.XA patent/CN110831613A/zh active Pending
- 2018-01-31 JP JP2019541361A patent/JP2020505424A/ja active Pending
- 2018-01-31 TW TW107103461A patent/TW201831521A/zh unknown
- 2018-01-31 EP EP18704801.2A patent/EP3576762A1/en not_active Ceased
- 2018-01-31 BR BR112019015569-4A patent/BR112019015569A2/pt unknown
- 2018-01-31 KR KR1020197025194A patent/KR20190112763A/ko not_active Application Discontinuation
- 2018-01-31 AU AU2018215092A patent/AU2018215092A1/en active Pending
- 2018-01-31 WO PCT/US2018/016277 patent/WO2018144623A1/en unknown
- 2018-01-31 SG SG11201906788XA patent/SG11201906788XA/en unknown
- 2018-01-31 MA MA047416A patent/MA47416A/fr unknown
- 2018-01-31 CA CA3051862A patent/CA3051862A1/en active Pending
- 2018-01-31 CR CR20190389A patent/CR20190389A/es unknown
- 2018-01-31 EA EA201991768A patent/EA201991768A1/ru unknown
-
2019
- 2019-07-23 IL IL268234A patent/IL268234A/en unknown
- 2019-07-30 PH PH12019501765A patent/PH12019501765A1/en unknown
- 2019-07-31 CL CL2019002155A patent/CL2019002155A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
MA47416A (fr) | 2019-12-11 |
WO2018144623A1 (en) | 2018-08-09 |
CR20190389A (es) | 2019-11-26 |
AR110871A1 (es) | 2019-05-08 |
BR112019015569A2 (pt) | 2020-03-17 |
MX2019009063A (es) | 2019-10-21 |
EA201991768A1 (ru) | 2020-01-22 |
AU2018215092A1 (en) | 2019-08-29 |
CA3051862A1 (en) | 2018-08-09 |
TW201831521A (zh) | 2018-09-01 |
IL268234A (en) | 2019-09-26 |
KR20190112763A (ko) | 2019-10-07 |
US20210238259A1 (en) | 2021-08-05 |
SG11201906788XA (en) | 2019-08-27 |
JP2020505424A (ja) | 2020-02-20 |
PH12019501765A1 (en) | 2020-03-16 |
CN110831613A (zh) | 2020-02-21 |
EP3576762A1 (en) | 2019-12-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CL2018000302A1 (es) | Proteínas de fusión de factor ix y métodos para producirlas y utilizarlas | |
CO2020006900A2 (es) | Medios y método para preparar vectores virales y usos de los mismos | |
CO2019003154A2 (es) | Anticuerpos anti-pd-1 y sus usos | |
CO2018005369A2 (es) | Inhibidores triazol de acc y usos de los mismos | |
BR112018067368A2 (pt) | terapia de combinação com anticorpos anti-cd73 | |
CL2018000358A1 (es) | Proteínas de fusión de gitrl y usos de las mismas | |
BR112017003414A2 (pt) | composições compreendendo caseína e métodos para produzir as mesmas | |
CR20160141A (es) | Formulaciones de anticuerpos anti-pdl1 | |
MX2019007021A (es) | Anticuerpos il-11ra. | |
DOP2018000258A (es) | Anticuerpos anti-cd40 y sus usos | |
CR20150482A (es) | Anticuerpos e inmunoconjugados anti-b7-h4 | |
BR112017009374A2 (pt) | ?composições de ramnolipídeo de baixa viscosidade concentradas? | |
UY34617A (es) | Composiciones veterinarias orales parasiticidas que comprenden agentes activos de acción sistémica, métodos y usos de las mismas | |
BR112017025711A2 (pt) | ?composições, processo para preparação de siloxanos modificados por poliéter e uso das composições inovadoras? | |
CL2017001227A1 (es) | Ganado lechero híbrido y sistemas para maximizar la ventaja híbrida. | |
CL2019002251A1 (es) | Anticuerpos contra triptasa, composiciones de estos y usos de estos. | |
BR112018001814A2 (pt) | unidade móvel de produção de implante | |
CY1122644T1 (el) | Πρωτεϊνες συντηξης tatk-cdkl5, συνθεσεις, φαρμακοτεχνικες μορφες και η χρηση αυτων | |
BR112017009792A2 (pt) | anticorpos anti-pdgf-b e métodos de uso | |
BR112017014598A2 (pt) | métodos e usos para hidrólise de queratina | |
CO2017010621A2 (es) | Compuestos bicíclicos fusionados para el tratamiento de enfermedades | |
UY35463A (es) | Formulaciones de polipéptido fc-factor ix. | |
CL2019002155A1 (es) | Proteínas de fusión del factor ix y procedimientos de preparación y utilización de las mismas. | |
MX2017009180A (es) | Biomateriales de nanocelulosa sintetizada bacterialmente y de fases múltiples, y método para producirlos. | |
BR112018077458A2 (pt) | proteases aspárticas |