MX2019009063A - Proteinas de fusion del factor ix y procedimientos de preparacion y utilizacion de las mismas. - Google Patents
Proteinas de fusion del factor ix y procedimientos de preparacion y utilizacion de las mismas.Info
- Publication number
- MX2019009063A MX2019009063A MX2019009063A MX2019009063A MX2019009063A MX 2019009063 A MX2019009063 A MX 2019009063A MX 2019009063 A MX2019009063 A MX 2019009063A MX 2019009063 A MX2019009063 A MX 2019009063A MX 2019009063 A MX2019009063 A MX 2019009063A
- Authority
- MX
- Mexico
- Prior art keywords
- fusion proteins
- making
- factor
- methods
- same
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21022—Coagulation factor IXa (3.4.21.22)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/644—Coagulation factor IXa (3.4.21.22)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Abstract
La presente descripción proporciona proteínas de fusión del factor IX (FIX) que comprenden al menos un resto heterólogo, tal como un XTEN. La presente descripción describe además métodos para preparar y utilizar las proteínas de fusión del FIX.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762452826P | 2017-01-31 | 2017-01-31 | |
PCT/US2018/016277 WO2018144623A1 (en) | 2017-01-31 | 2018-01-31 | Factor ix fusion proteins and methods of making and using same |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019009063A true MX2019009063A (es) | 2019-10-21 |
Family
ID=61193175
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019009063A MX2019009063A (es) | 2017-01-31 | 2018-01-31 | Proteinas de fusion del factor ix y procedimientos de preparacion y utilizacion de las mismas. |
Country Status (19)
Country | Link |
---|---|
US (1) | US20210238259A1 (es) |
EP (1) | EP3576762A1 (es) |
JP (1) | JP2020505424A (es) |
KR (1) | KR20190112763A (es) |
CN (1) | CN110831613A (es) |
AR (1) | AR110871A1 (es) |
AU (1) | AU2018215092A1 (es) |
BR (1) | BR112019015569A2 (es) |
CA (1) | CA3051862A1 (es) |
CL (1) | CL2019002155A1 (es) |
CR (1) | CR20190389A (es) |
EA (1) | EA201991768A1 (es) |
IL (1) | IL268234A (es) |
MA (1) | MA47416A (es) |
MX (1) | MX2019009063A (es) |
PH (1) | PH12019501765A1 (es) |
SG (1) | SG11201906788XA (es) |
TW (1) | TW201831521A (es) |
WO (1) | WO2018144623A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112175088B (zh) * | 2019-07-02 | 2023-03-28 | 江苏晟斯生物制药有限公司 | 改进的fix融合蛋白、缀合物及其应用 |
CN113817759B (zh) * | 2020-07-10 | 2023-06-02 | 南京吉迈生物技术有限公司 | 修饰的因子ix、组合物、方法及其在基因治疗中的应用 |
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SG47099A1 (en) | 1991-03-15 | 1998-03-20 | Amgen Boulder Inc | Pegylation of polypeptides |
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US5736137A (en) | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
ATE236987T1 (de) | 1992-11-13 | 2003-04-15 | Idec Pharma Corp | Konsensus-kozak-sequenzen zur säugetier- exprimierung |
US5827690A (en) | 1993-12-20 | 1998-10-27 | Genzyme Transgenics Corporatiion | Transgenic production of antibodies in milk |
GB9524973D0 (en) | 1995-12-06 | 1996-02-07 | Lynxvale Ltd | Viral vectors |
PT981637E (pt) | 1997-03-14 | 2005-09-30 | Biogen Idec Inc | Metodo para integrar genes em sitios especificos em celulas de mamifero atraves de recombinacao homologa e vectores para a realizacao do mesmo |
EP1274720A4 (en) | 2000-04-12 | 2004-08-18 | Human Genome Sciences Inc | ALBUMIN FUSED PROTEINS |
AU2002226028A1 (en) | 2000-11-14 | 2002-05-27 | Board Of Regents, Unversity Of Texas Systems | Mutant human factor ix with an increased resistance to inhibition by heparin |
BR0212035A (pt) | 2001-09-04 | 2004-08-03 | Merck Patent Gmbh | Fator ix modificado |
CA2841097A1 (en) | 2001-12-21 | 2003-07-24 | Human Genome Sciences, Inc. | Albumin and g-csf fusion proteins |
KR101271635B1 (ko) | 2001-12-21 | 2013-06-12 | 휴먼 게놈 사이언시즈, 인코포레이티드 | 알부민 융합 단백질 |
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MX2007005466A (es) | 2004-11-12 | 2007-10-19 | Bayer Healthcare Llc | Modificacion dirigida al sitio del factor viii. |
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-
2018
- 2018-01-31 EA EA201991768A patent/EA201991768A1/ru unknown
- 2018-01-31 MA MA047416A patent/MA47416A/fr unknown
- 2018-01-31 WO PCT/US2018/016277 patent/WO2018144623A1/en unknown
- 2018-01-31 EP EP18704801.2A patent/EP3576762A1/en not_active Ceased
- 2018-01-31 CN CN201880020779.XA patent/CN110831613A/zh active Pending
- 2018-01-31 US US16/478,747 patent/US20210238259A1/en not_active Abandoned
- 2018-01-31 SG SG11201906788XA patent/SG11201906788XA/en unknown
- 2018-01-31 JP JP2019541361A patent/JP2020505424A/ja active Pending
- 2018-01-31 TW TW107103461A patent/TW201831521A/zh unknown
- 2018-01-31 CA CA3051862A patent/CA3051862A1/en active Pending
- 2018-01-31 BR BR112019015569-4A patent/BR112019015569A2/pt unknown
- 2018-01-31 KR KR1020197025194A patent/KR20190112763A/ko not_active Application Discontinuation
- 2018-01-31 AU AU2018215092A patent/AU2018215092A1/en active Pending
- 2018-01-31 AR ARP180100235A patent/AR110871A1/es unknown
- 2018-01-31 CR CR20190389A patent/CR20190389A/es unknown
- 2018-01-31 MX MX2019009063A patent/MX2019009063A/es unknown
-
2019
- 2019-07-23 IL IL268234A patent/IL268234A/en unknown
- 2019-07-30 PH PH12019501765A patent/PH12019501765A1/en unknown
- 2019-07-31 CL CL2019002155A patent/CL2019002155A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
CA3051862A1 (en) | 2018-08-09 |
US20210238259A1 (en) | 2021-08-05 |
CR20190389A (es) | 2019-11-26 |
BR112019015569A2 (pt) | 2020-03-17 |
MA47416A (fr) | 2019-12-11 |
TW201831521A (zh) | 2018-09-01 |
EP3576762A1 (en) | 2019-12-11 |
EA201991768A1 (ru) | 2020-01-22 |
PH12019501765A1 (en) | 2020-03-16 |
WO2018144623A1 (en) | 2018-08-09 |
KR20190112763A (ko) | 2019-10-07 |
IL268234A (en) | 2019-09-26 |
CN110831613A (zh) | 2020-02-21 |
CL2019002155A1 (es) | 2020-02-21 |
AR110871A1 (es) | 2019-05-08 |
JP2020505424A (ja) | 2020-02-20 |
AU2018215092A1 (en) | 2019-08-29 |
SG11201906788XA (en) | 2019-08-27 |
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