CL2017002538A1 - Composiciones farmacéuticas para terapias combinadas - Google Patents
Composiciones farmacéuticas para terapias combinadasInfo
- Publication number
- CL2017002538A1 CL2017002538A1 CL2017002538A CL2017002538A CL2017002538A1 CL 2017002538 A1 CL2017002538 A1 CL 2017002538A1 CL 2017002538 A CL2017002538 A CL 2017002538A CL 2017002538 A CL2017002538 A CL 2017002538A CL 2017002538 A1 CL2017002538 A1 CL 2017002538A1
- Authority
- CL
- Chile
- Prior art keywords
- insulin
- blood glucose
- glucose level
- sensitivity
- pharmaceutical compositions
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 238000002648 combination therapy Methods 0.000 title 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 3
- 206010022489 Insulin Resistance Diseases 0.000 abstract 3
- 239000008280 blood Substances 0.000 abstract 3
- 210000004369 blood Anatomy 0.000 abstract 3
- 239000008103 glucose Substances 0.000 abstract 3
- 230000003914 insulin secretion Effects 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940121360 farnesoid X receptor (fxr) agonists Drugs 0.000 abstract 1
- 201000001421 hyperglycemia Diseases 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 abstract 1
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000035945 sensitivity Effects 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562144040P | 2015-04-07 | 2015-04-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2017002538A1 true CL2017002538A1 (es) | 2018-04-20 |
Family
ID=57072872
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2017002538A CL2017002538A1 (es) | 2015-04-07 | 2017-10-06 | Composiciones farmacéuticas para terapias combinadas |
| CL2018001007A CL2018001007A1 (es) | 2015-04-07 | 2018-04-19 | Composiciones farmacéuticas para terapias combinadas (sol. divisional de n° 201702538). |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2018001007A CL2018001007A1 (es) | 2015-04-07 | 2018-04-19 | Composiciones farmacéuticas para terapias combinadas (sol. divisional de n° 201702538). |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US10894054B2 (enExample) |
| EP (1) | EP3280421B1 (enExample) |
| JP (1) | JP6879931B2 (enExample) |
| KR (1) | KR20170132879A (enExample) |
| CN (1) | CN107613986A (enExample) |
| AR (1) | AR104195A1 (enExample) |
| AU (1) | AU2016246524B2 (enExample) |
| BR (1) | BR112017021311A2 (enExample) |
| CA (1) | CA2981507A1 (enExample) |
| CL (2) | CL2017002538A1 (enExample) |
| CO (1) | CO2017010292A2 (enExample) |
| CR (1) | CR20170456A (enExample) |
| EA (1) | EA036757B1 (enExample) |
| EC (1) | ECSP17073004A (enExample) |
| ES (1) | ES2974281T3 (enExample) |
| IL (2) | IL254772A0 (enExample) |
| MA (1) | MA41083A1 (enExample) |
| MX (1) | MX2017012893A (enExample) |
| NI (1) | NI201700121A (enExample) |
| PE (1) | PE20180034A1 (enExample) |
| SM (1) | SMT202400104T1 (enExample) |
| SV (1) | SV2017005539A (enExample) |
| TN (1) | TN2017000426A1 (enExample) |
| TW (1) | TW201642869A (enExample) |
| WO (1) | WO2016164413A1 (enExample) |
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|---|---|---|---|---|
| WO2011140441A2 (en) | 2010-05-06 | 2011-11-10 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
| EP3149156B1 (en) | 2014-05-28 | 2021-02-17 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
| US11584916B2 (en) | 2014-10-17 | 2023-02-21 | Children's Hospital Medical Center | Method of making in vivo human small intestine organoids from pluripotent stem cells |
| AU2016229982B2 (en) | 2015-03-09 | 2020-06-18 | Intekrin Therapeutics, Inc. | Methods for the treatment of nonalcoholic fatty liver disease and/or lipodystrophy |
| US11267861B2 (en) | 2016-04-19 | 2022-03-08 | Ureka Sarl | Peptide-oligourea foldamer compounds and methods of their use |
| CN116790476A (zh) | 2016-05-05 | 2023-09-22 | 儿童医院医疗中心 | 用于体外制造胃底组织的方法和与其相关的组合物 |
| KR102546194B1 (ko) * | 2016-11-04 | 2023-06-21 | 칠드런즈 호스피탈 메디칼 센터 | 간 유사 장기 조성물 및 이를 제조 및 사용하는 방법 |
| KR102558606B1 (ko) | 2016-12-05 | 2023-07-26 | 칠드런즈 호스피탈 메디칼 센터 | 결장 유사장기 및 이를 제조 및 사용하는 방법 |
| JP2020515639A (ja) | 2017-04-03 | 2020-05-28 | コヒラス・バイオサイエンシズ・インコーポレイテッド | 進行性核上性麻痺の処置のためのＰＰＡＲγアゴニスト |
| WO2018191673A1 (en) | 2017-04-14 | 2018-10-18 | Children's Hospital Medical Center | Multi donor stem cell compositions and methods of making same |
| EP3694603A4 (en) | 2017-10-10 | 2021-07-14 | Children's Hospital Medical Center | ESOPHAGUS TISSUE AND / OR ORGANOID COMPOSITIONS AND METHOD FOR MANUFACTURING THEREOF |
| EP3727394A4 (en) | 2017-12-21 | 2021-09-08 | Children's Hospital Medical Center | DIGITALIZED HUMAN ORGANOIDS AND METHOD OF USING THEREOF |
| JP2021522247A (ja) * | 2018-04-24 | 2021-08-30 | ピーエイチ・ファーマ・カンパニー・リミテッドＰｈ Ｐｈａｒｍａ Ｃｏ．， Ｌｔｄ． | 肝疾患における好中球エラスターゼ阻害薬の使用 |
| JP7506657B2 (ja) | 2018-07-26 | 2024-06-26 | チルドレンズ ホスピタル メディカル センター | 肝胆膵組織およびその作製方法 |
| GB201812382D0 (en) | 2018-07-30 | 2018-09-12 | Nzp Uk Ltd | Compounds |
| US12428622B2 (en) | 2018-09-12 | 2025-09-30 | Children's Hospital Medical Center | Organoid compositions for the production of hematopoietic stem cells and derivatives thereof |
| WO2020081766A1 (en) * | 2018-10-18 | 2020-04-23 | Avolynt | Use of sglt2 inhibitors to treat primary sclerosing cholangitis |
| AU2019384074B2 (en) | 2018-11-20 | 2025-04-10 | Sparrow Pharmaceuticals, Inc. | Methods for administering corticosteroids |
| WO2020108830A1 (en) * | 2018-11-30 | 2020-06-04 | Ureka Sarl | Peptide-oligourea foldamer compounds and methods of their use |
| AU2020247991A1 (en) * | 2019-03-26 | 2021-10-21 | Intercept Pharmaceuticals, Inc. | Methods of diagnosis and treatment of liver diseases using obeticholic acid |
| US20220288054A1 (en) * | 2019-04-04 | 2022-09-15 | Coherus Biosciences, Inc. | Compositions and methods to treat non-alcoholic fatty liver diseases (nafld) |
| JP7610533B2 (ja) | 2019-05-31 | 2025-01-08 | チルドレンズ ホスピタル メディカル センター | 造血幹細胞の生成および拡大方法 |
| WO2021029656A1 (ko) * | 2019-08-14 | 2021-02-18 | 주식회사 바이오톡스텍 | 하이드로퀴논 유도체, 및 오베티콜릭산을 포함하는 비알콜성 지방간염의 예방 또는 치료용 약학조성물 |
| EP4277630A1 (en) * | 2021-01-14 | 2023-11-22 | ENYO Pharma | Method for treating chronic kidney diseases |
| WO2023225507A1 (en) * | 2022-05-16 | 2023-11-23 | Sparrow Pharmaceuticals, Inc. | Methods and compositions for treating glucocorticoid excess |
| CA3250533A1 (en) | 2022-05-16 | 2023-11-23 | Sparrow Pharmaceuticals, Inc. | METHODS AND COMPOSITIONS FOR TREATING EXCESS GLUCOCORTICOIDS |
| WO2023240204A2 (en) * | 2022-06-08 | 2023-12-14 | Kojin Therapeutics, Inc. | Methods and compositions for initiating, regulating, and modulating weight loss and therapeutic applications thereof |
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| WO2012106581A1 (en) * | 2011-02-03 | 2012-08-09 | The University Of Chicago | Fxr inhibitor, bile acid sequestrant as combination therapy for cholesterol reduction |
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| EA030152B1 (ru) | 2013-05-14 | 2018-06-29 | Интерсепт Фармасьютикалз, Инк | 11-гидроксилпроизводные желчных кислот и их аминокислотные конъюгаты в качестве модуляторов фарнезоидных х-рецепторов |
| EA036404B1 (ru) | 2015-02-06 | 2020-11-06 | Интерсепт Фармасьютикалз, Инк. | Фармацевтические композиции для комбинированной терапии |
-
2016
- 2016-04-06 EA EA201792203A patent/EA036757B1/ru unknown
- 2016-04-06 SM SM20240104T patent/SMT202400104T1/it unknown
- 2016-04-06 CA CA2981507A patent/CA2981507A1/en not_active Abandoned
- 2016-04-06 EP EP16777168.2A patent/EP3280421B1/en active Active
- 2016-04-06 JP JP2017553131A patent/JP6879931B2/ja active Active
- 2016-04-06 MX MX2017012893A patent/MX2017012893A/es unknown
- 2016-04-06 MA MA41083A patent/MA41083A1/fr unknown
- 2016-04-06 CN CN201680029144.7A patent/CN107613986A/zh active Pending
- 2016-04-06 TN TNP/2017/000426A patent/TN2017000426A1/en unknown
- 2016-04-06 PE PE2017001987A patent/PE20180034A1/es unknown
- 2016-04-06 CR CR20170456A patent/CR20170456A/es unknown
- 2016-04-06 WO PCT/US2016/026146 patent/WO2016164413A1/en not_active Ceased
- 2016-04-06 BR BR112017021311A patent/BR112017021311A2/pt not_active IP Right Cessation
- 2016-04-06 KR KR1020177031857A patent/KR20170132879A/ko not_active Ceased
- 2016-04-06 ES ES16777168T patent/ES2974281T3/es active Active
- 2016-04-06 US US15/564,799 patent/US10894054B2/en active Active
- 2016-04-06 AU AU2016246524A patent/AU2016246524B2/en not_active Ceased
- 2016-04-07 TW TW105110879A patent/TW201642869A/zh unknown
- 2016-04-07 AR ARP160100929A patent/AR104195A1/es unknown
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2017
- 2017-09-28 IL IL254772A patent/IL254772A0/en unknown
- 2017-10-05 NI NI201700121A patent/NI201700121A/es unknown
- 2017-10-05 SV SV2017005539A patent/SV2017005539A/es unknown
- 2017-10-06 CL CL2017002538A patent/CL2017002538A1/es unknown
- 2017-10-10 CO CONC2017/0010292A patent/CO2017010292A2/es unknown
- 2017-11-01 EC ECIEPI201773004A patent/ECSP17073004A/es unknown
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2018
- 2018-04-19 CL CL2018001007A patent/CL2018001007A1/es unknown
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2019
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Also Published As
| Publication number | Publication date |
|---|---|
| US10894054B2 (en) | 2021-01-19 |
| JP6879931B2 (ja) | 2021-06-02 |
| CA2981507A1 (en) | 2016-10-13 |
| CR20170456A (es) | 2018-06-13 |
| WO2016164413A1 (en) | 2016-10-13 |
| US20180117065A1 (en) | 2018-05-03 |
| NI201700121A (es) | 2018-01-10 |
| CN107613986A (zh) | 2018-01-19 |
| ES2974281T3 (es) | 2024-06-26 |
| CL2018001007A1 (es) | 2018-06-15 |
| IL268316B (en) | 2022-02-01 |
| MX2017012893A (es) | 2018-01-15 |
| KR20170132879A (ko) | 2017-12-04 |
| TN2017000426A1 (en) | 2019-04-12 |
| IL254772A0 (en) | 2017-12-31 |
| ECSP17073004A (es) | 2018-02-28 |
| EP3280421A4 (en) | 2019-08-28 |
| EP3280421B1 (en) | 2023-12-27 |
| IL268316A (en) | 2019-09-26 |
| CO2017010292A2 (es) | 2018-01-05 |
| TW201642869A (zh) | 2016-12-16 |
| EP3280421A1 (en) | 2018-02-14 |
| PE20180034A1 (es) | 2018-01-09 |
| JP2018510900A (ja) | 2018-04-19 |
| EA201792203A1 (ru) | 2018-02-28 |
| BR112017021311A2 (pt) | 2018-06-26 |
| AU2016246524A1 (en) | 2017-10-26 |
| AU2016246524B2 (en) | 2021-04-01 |
| AR104195A1 (es) | 2017-07-05 |
| SV2017005539A (es) | 2019-01-18 |
| MA41083A1 (fr) | 2018-05-31 |
| SMT202400104T1 (it) | 2024-05-14 |
| EA036757B1 (ru) | 2020-12-17 |
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