CL2016003214A1 - Derivados de la indolizina como inhibidores de las fosfoinositido-3 quinasas - Google Patents

Derivados de la indolizina como inhibidores de las fosfoinositido-3 quinasas

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Publication number
CL2016003214A1
CL2016003214A1 CL2016003214A CL2016003214A CL2016003214A1 CL 2016003214 A1 CL2016003214 A1 CL 2016003214A1 CL 2016003214 A CL2016003214 A CL 2016003214A CL 2016003214 A CL2016003214 A CL 2016003214A CL 2016003214 A1 CL2016003214 A1 CL 2016003214A1
Authority
CL
Chile
Prior art keywords
phosphoinositide
kinase inhibitors
indolizine derivatives
indolizine
derivatives
Prior art date
Application number
CL2016003214A
Other languages
English (en)
Spanish (es)
Inventor
Matteo Biagetti
Anna Maria Capelli
Alessandro Accetta
Matilde Guala
Michele Retini
Original Assignee
Chiesi Farm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farm Spa filed Critical Chiesi Farm Spa
Publication of CL2016003214A1 publication Critical patent/CL2016003214A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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CL2016003214A 2014-06-17 2016-12-14 Derivados de la indolizina como inhibidores de las fosfoinositido-3 quinasas CL2016003214A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP14172764 2014-06-17

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CL2016003214A1 true CL2016003214A1 (es) 2017-06-23

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CL2016003214A CL2016003214A1 (es) 2014-06-17 2016-12-14 Derivados de la indolizina como inhibidores de las fosfoinositido-3 quinasas

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US (1) US9527869B2 (cg-RX-API-DMAC7.html)
EP (1) EP3157920B1 (cg-RX-API-DMAC7.html)
JP (1) JP6730200B2 (cg-RX-API-DMAC7.html)
KR (1) KR102420322B1 (cg-RX-API-DMAC7.html)
CN (1) CN106661019B (cg-RX-API-DMAC7.html)
AR (1) AR100879A1 (cg-RX-API-DMAC7.html)
AU (1) AU2015276264B2 (cg-RX-API-DMAC7.html)
BR (1) BR112016028845B1 (cg-RX-API-DMAC7.html)
CA (1) CA2952287C (cg-RX-API-DMAC7.html)
CL (1) CL2016003214A1 (cg-RX-API-DMAC7.html)
EA (1) EA031409B1 (cg-RX-API-DMAC7.html)
ES (1) ES2750791T3 (cg-RX-API-DMAC7.html)
GE (1) GEP20186938B (cg-RX-API-DMAC7.html)
IL (1) IL249554A0 (cg-RX-API-DMAC7.html)
MX (1) MX373129B (cg-RX-API-DMAC7.html)
PE (1) PE20170303A1 (cg-RX-API-DMAC7.html)
PH (1) PH12016502291A1 (cg-RX-API-DMAC7.html)
PL (1) PL3157920T3 (cg-RX-API-DMAC7.html)
SG (1) SG11201610473QA (cg-RX-API-DMAC7.html)
TN (1) TN2016000555A1 (cg-RX-API-DMAC7.html)
TW (1) TW201625611A (cg-RX-API-DMAC7.html)
WO (1) WO2015193263A1 (cg-RX-API-DMAC7.html)
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KR102280614B1 (ko) 2013-03-15 2021-07-21 글로벌 블러드 테라퓨틱스, 인크. 헤모글로빈 조정을 위한 화합물 및 이의 용도
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
KR101815193B1 (ko) * 2015-12-29 2018-01-30 (주)스파크바이오파마 PPARγ 인산화 저해제 및 이를 포함하는 약학적 조성물
JP2019501979A (ja) * 2016-01-15 2019-01-24 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ， Ｉｎｃ． Ｅａａｔ２活性化剤としてのピリダジン誘導体
EP3411375B1 (en) * 2016-02-04 2020-08-05 Chiesi Farmaceutici S.p.A. Pyrazole derivatives as phosphoinositide 3-kinases inhibitors
KR20190129851A (ko) 2017-03-16 2019-11-20 지앙수 헨그루이 메디슨 컴퍼니 리미티드 헤테로아릴[4,3-c]피리미딘-5-아민 유도체, 이의 제조 방법 및 이의 의학적 용도
CN108129480A (zh) * 2018-03-11 2018-06-08 赵艳阳 一种含芳杂环亚甲基吲嗪衍生物的制备方法
WO2019236625A1 (en) * 2018-06-04 2019-12-12 Ohio State Innovation Foundation Eaat2 activators and methods of using thereof
SI3947384T1 (sl) * 2019-04-04 2024-03-29 Chiesi Farmaceutici S.P.A. Izokromenski derivati kot inhibitorji fosfoinozitid 3-kinaz
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