CL2014000606A1 - Combinacion farmaceutica que comprende al compuesto 2-{2-[(2s)-2-metil-2,3-dihidro-1h-indol-1-il]-2-oxoetil}-6-(morfolin-4-il)pirimidin-4-(3h)-ona y al menos un inhibidor de la via de mapk; composicion farmaceutica; kit farmaceutico; su uso en el tratamiento del cancer. - Google Patents
Combinacion farmaceutica que comprende al compuesto 2-{2-[(2s)-2-metil-2,3-dihidro-1h-indol-1-il]-2-oxoetil}-6-(morfolin-4-il)pirimidin-4-(3h)-ona y al menos un inhibidor de la via de mapk; composicion farmaceutica; kit farmaceutico; su uso en el tratamiento del cancer.Info
- Publication number
- CL2014000606A1 CL2014000606A1 CL2014000606A CL2014000606A CL2014000606A1 CL 2014000606 A1 CL2014000606 A1 CL 2014000606A1 CL 2014000606 A CL2014000606 A CL 2014000606A CL 2014000606 A CL2014000606 A CL 2014000606A CL 2014000606 A1 CL2014000606 A1 CL 2014000606A1
- Authority
- CL
- Chile
- Prior art keywords
- pharmaceutical
- oxoethyl
- morpholin
- indol
- pyrimidin
- Prior art date
Links
- UAXHPOBBKRWJGA-ZDUSSCGKSA-N 2-[2-[(2s)-2-methyl-2,3-dihydroindol-1-yl]-2-oxoethyl]-6-morpholin-4-yl-1h-pyrimidin-4-one Chemical compound C([C@@H]1C)C2=CC=CC=C2N1C(=O)CC(NC(=O)C=1)=NC=1N1CCOCC1 UAXHPOBBKRWJGA-ZDUSSCGKSA-N 0.000 title 1
- 101150024075 Mapk1 gene Proteins 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000037361 pathway Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11306172A EP2570127A1 (en) | 2011-09-16 | 2011-09-16 | Compositions and methods for treating cancer using PI3KB beta inhibitor and MAPK pathway inhibitor, including MEK and RAF inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2014000606A1 true CL2014000606A1 (es) | 2014-11-07 |
Family
ID=46851503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2014000606A CL2014000606A1 (es) | 2011-09-16 | 2014-03-13 | Combinacion farmaceutica que comprende al compuesto 2-{2-[(2s)-2-metil-2,3-dihidro-1h-indol-1-il]-2-oxoetil}-6-(morfolin-4-il)pirimidin-4-(3h)-ona y al menos un inhibidor de la via de mapk; composicion farmaceutica; kit farmaceutico; su uso en el tratamiento del cancer. |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US20140275078A1 (enExample) |
| EP (2) | EP2570127A1 (enExample) |
| JP (1) | JP2014530181A (enExample) |
| KR (1) | KR20140062143A (enExample) |
| CN (1) | CN103889418A (enExample) |
| AR (1) | AR087902A1 (enExample) |
| AU (1) | AU2012307309A1 (enExample) |
| BR (1) | BR112014005839A2 (enExample) |
| CA (1) | CA2847091A1 (enExample) |
| CL (1) | CL2014000606A1 (enExample) |
| CO (1) | CO6910192A2 (enExample) |
| CR (1) | CR20140102A (enExample) |
| DO (1) | DOP2014000046A (enExample) |
| EA (1) | EA201490638A1 (enExample) |
| EC (1) | ECSP14013244A (enExample) |
| GT (1) | GT201400038A (enExample) |
| IL (1) | IL231212A0 (enExample) |
| MA (1) | MA35615B1 (enExample) |
| MX (1) | MX2014003223A (enExample) |
| NI (1) | NI201400020A (enExample) |
| PE (1) | PE20141035A1 (enExample) |
| PH (1) | PH12014500536A1 (enExample) |
| SG (1) | SG11201400380XA (enExample) |
| TN (1) | TN2014000086A1 (enExample) |
| UY (1) | UY34341A (enExample) |
| WO (1) | WO2013037943A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY181085A (en) * | 2013-03-21 | 2020-12-17 | Novartis Ag | Combination therapy |
| CN105163736A (zh) * | 2013-04-05 | 2015-12-16 | 赛诺菲 | 包含PI3Kβ选择性抑制剂和PI3Kα选择性抑制剂的抗肿瘤组合物 |
| WO2015051252A1 (en) * | 2013-10-03 | 2015-04-09 | Duke University | Compositions and methods for treating cancer with jak2 activity |
| US10028958B2 (en) | 2014-04-19 | 2018-07-24 | Massachusetts Institute Of Technology | Methods of treating cancer with a combination of selected MEK1/2 and AXL inhibitors |
| ES2928773T3 (es) | 2017-01-17 | 2022-11-22 | Heparegenix Gmbh | Inhibidores de proteína cinasas para fomentar la regeneración hepática o reducir o prevenir la muerte de hepatocitos |
| KR101950094B1 (ko) | 2017-07-28 | 2019-02-19 | 이성재 | 보릿대 공예품 제작방법 |
| CN113440616A (zh) * | 2020-03-25 | 2021-09-28 | 上海科州药物研发有限公司 | Ras或raf突变型癌症的联合疗法 |
| CN120204228A (zh) * | 2025-04-17 | 2025-06-27 | 重庆医科大学附属第一医院 | 化合物或其盐在制备癌症治疗药物中的用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60330227D1 (de) | 2002-03-13 | 2010-01-07 | Array Biopharma Inc | N3-alkylierte benzimidazol-derivate als mek-hemmer |
| PT1893612E (pt) | 2005-06-22 | 2011-11-21 | Plexxikon Inc | Derivados de pirrolo [2,3-b]piridina como inibidores de proteína quinase |
| FR2951169B1 (fr) * | 2009-10-09 | 2011-12-02 | Sanofi Aventis | Nouveaux derives de (6-oxo-1,6-dihydro-pyrimidin-2-yl)-amide, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) |
| NZ597579A (en) | 2009-07-02 | 2013-06-28 | Sanofi Sa | Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors |
-
2011
- 2011-09-16 EP EP11306172A patent/EP2570127A1/en not_active Ceased
-
2012
- 2012-09-14 CN CN201280051036.1A patent/CN103889418A/zh active Pending
- 2012-09-14 MX MX2014003223A patent/MX2014003223A/es not_active Application Discontinuation
- 2012-09-14 KR KR1020147009655A patent/KR20140062143A/ko not_active Withdrawn
- 2012-09-14 PH PH1/2014/500536A patent/PH12014500536A1/en unknown
- 2012-09-14 WO PCT/EP2012/068072 patent/WO2013037943A1/en not_active Ceased
- 2012-09-14 SG SG11201400380XA patent/SG11201400380XA/en unknown
- 2012-09-14 AU AU2012307309A patent/AU2012307309A1/en not_active Abandoned
- 2012-09-14 BR BR112014005839A patent/BR112014005839A2/pt not_active IP Right Cessation
- 2012-09-14 EA EA201490638A patent/EA201490638A1/ru unknown
- 2012-09-14 PE PE2014000346A patent/PE20141035A1/es not_active Application Discontinuation
- 2012-09-14 US US14/343,935 patent/US20140275078A1/en not_active Abandoned
- 2012-09-14 JP JP2014530237A patent/JP2014530181A/ja not_active Abandoned
- 2012-09-14 EP EP12759137.8A patent/EP2755653A1/en not_active Withdrawn
- 2012-09-14 CA CA2847091A patent/CA2847091A1/en not_active Abandoned
- 2012-09-17 AR ARP120103421A patent/AR087902A1/es unknown
- 2012-09-17 UY UY0001034341A patent/UY34341A/es not_active Application Discontinuation
-
2014
- 2014-02-27 IL IL231212A patent/IL231212A0/en unknown
- 2014-02-27 CR CR20140102A patent/CR20140102A/es unknown
- 2014-02-28 TN TNP2014000086A patent/TN2014000086A1/en unknown
- 2014-03-03 GT GT201400038A patent/GT201400038A/es unknown
- 2014-03-04 DO DO2014000046A patent/DOP2014000046A/es unknown
- 2014-03-13 CL CL2014000606A patent/CL2014000606A1/es unknown
- 2014-03-14 CO CO14055689A patent/CO6910192A2/es unknown
- 2014-03-14 NI NI201400020A patent/NI201400020A/es unknown
- 2014-03-14 EC ECSP14013244 patent/ECSP14013244A/es unknown
- 2014-04-10 MA MA36908A patent/MA35615B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SG11201400380XA (en) | 2014-04-28 |
| MX2014003223A (es) | 2014-06-05 |
| TN2014000086A1 (en) | 2015-07-01 |
| CA2847091A1 (en) | 2013-03-21 |
| MA35615B1 (fr) | 2014-11-01 |
| ECSP14013244A (es) | 2014-07-31 |
| AU2012307309A1 (en) | 2014-04-03 |
| DOP2014000046A (es) | 2014-07-15 |
| PH12014500536A1 (en) | 2019-08-07 |
| GT201400038A (es) | 2014-12-16 |
| US20140275078A1 (en) | 2014-09-18 |
| KR20140062143A (ko) | 2014-05-22 |
| IL231212A0 (en) | 2014-04-30 |
| PE20141035A1 (es) | 2014-09-04 |
| CO6910192A2 (es) | 2014-03-31 |
| WO2013037943A1 (en) | 2013-03-21 |
| EP2755653A1 (en) | 2014-07-23 |
| EA201490638A1 (ru) | 2014-08-29 |
| EP2570127A1 (en) | 2013-03-20 |
| UY34341A (es) | 2013-04-05 |
| WO2013037943A8 (en) | 2013-07-18 |
| CR20140102A (es) | 2014-05-07 |
| CN103889418A (zh) | 2014-06-25 |
| BR112014005839A2 (pt) | 2017-03-28 |
| AR087902A1 (es) | 2014-04-23 |
| JP2014530181A (ja) | 2014-11-17 |
| NI201400020A (es) | 2014-04-23 |
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