CL2014000606A1 - Combinacion farmaceutica que comprende al compuesto 2-{2-[(2s)-2-metil-2,3-dihidro-1h-indol-1-il]-2-oxoetil}-6-(morfolin-4-il)pirimidin-4-(3h)-ona y al menos un inhibidor de la via de mapk; composicion farmaceutica; kit farmaceutico; su uso en el tratamiento del cancer. - Google Patents
Combinacion farmaceutica que comprende al compuesto 2-{2-[(2s)-2-metil-2,3-dihidro-1h-indol-1-il]-2-oxoetil}-6-(morfolin-4-il)pirimidin-4-(3h)-ona y al menos un inhibidor de la via de mapk; composicion farmaceutica; kit farmaceutico; su uso en el tratamiento del cancer.Info
- Publication number
- CL2014000606A1 CL2014000606A1 CL2014000606A CL2014000606A CL2014000606A1 CL 2014000606 A1 CL2014000606 A1 CL 2014000606A1 CL 2014000606 A CL2014000606 A CL 2014000606A CL 2014000606 A CL2014000606 A CL 2014000606A CL 2014000606 A1 CL2014000606 A1 CL 2014000606A1
- Authority
- CL
- Chile
- Prior art keywords
- pharmaceutical
- oxoethyl
- morpholin
- indol
- pyrimidin
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11306172A EP2570127A1 (en) | 2011-09-16 | 2011-09-16 | Compositions and methods for treating cancer using PI3KB beta inhibitor and MAPK pathway inhibitor, including MEK and RAF inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2014000606A1 true CL2014000606A1 (es) | 2014-11-07 |
Family
ID=46851503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2014000606A CL2014000606A1 (es) | 2011-09-16 | 2014-03-13 | Combinacion farmaceutica que comprende al compuesto 2-{2-[(2s)-2-metil-2,3-dihidro-1h-indol-1-il]-2-oxoetil}-6-(morfolin-4-il)pirimidin-4-(3h)-ona y al menos un inhibidor de la via de mapk; composicion farmaceutica; kit farmaceutico; su uso en el tratamiento del cancer. |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US20140275078A1 (es) |
| EP (2) | EP2570127A1 (es) |
| JP (1) | JP2014530181A (es) |
| KR (1) | KR20140062143A (es) |
| CN (1) | CN103889418A (es) |
| AR (1) | AR087902A1 (es) |
| AU (1) | AU2012307309A1 (es) |
| BR (1) | BR112014005839A2 (es) |
| CA (1) | CA2847091A1 (es) |
| CL (1) | CL2014000606A1 (es) |
| CO (1) | CO6910192A2 (es) |
| CR (1) | CR20140102A (es) |
| DO (1) | DOP2014000046A (es) |
| EA (1) | EA201490638A1 (es) |
| EC (1) | ECSP14013244A (es) |
| GT (1) | GT201400038A (es) |
| IL (1) | IL231212A0 (es) |
| MA (1) | MA35615B1 (es) |
| MX (1) | MX2014003223A (es) |
| NI (1) | NI201400020A (es) |
| PE (1) | PE20141035A1 (es) |
| SG (1) | SG11201400380XA (es) |
| TN (1) | TN2014000086A1 (es) |
| UY (1) | UY34341A (es) |
| WO (1) | WO2013037943A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA38522A1 (fr) | 2013-03-21 | 2017-10-31 | Novartis Ag | Thérapie de combinaison comprenant un inhibiteur de b-raf et un second inhibiteur. |
| BR112015025101A2 (pt) * | 2013-04-05 | 2017-07-18 | Sanofi Sa | composição antitumoral que compreende um inibidor pi3kbeta-seletivo e um inibidor pi3kalfa-seletivo |
| US10111897B2 (en) | 2013-10-03 | 2018-10-30 | Duke University | Compositions and methods for treating cancer with JAK2 activity |
| US10028958B2 (en) | 2014-04-19 | 2018-07-24 | Massachusetts Institute Of Technology | Methods of treating cancer with a combination of selected MEK1/2 and AXL inhibitors |
| JP7300394B2 (ja) | 2017-01-17 | 2023-06-29 | ヘパリジェニックス ゲーエムベーハー | 肝再生の促進又は肝細胞死の低減もしくは予防のためのプロテインキナーゼ阻害 |
| KR101950094B1 (ko) | 2017-07-28 | 2019-02-19 | 이성재 | 보릿대 공예품 제작방법 |
| CN113440616A (zh) * | 2020-03-25 | 2021-09-28 | 上海科州药物研发有限公司 | Ras或raf突变型癌症的联合疗法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100984613B1 (ko) | 2002-03-13 | 2010-09-30 | 어레이 바이오파마 인크. | Ｍｅｋ 억제제로서의 ｎ3 알킬화 벤즈이미다졸 유도체 |
| PL1893612T3 (pl) | 2005-06-22 | 2012-01-31 | Plexxikon Inc | Pochodne pirolo-[2,3-b]pirydyny jako inhibitory kinazy białkowej |
| NZ597579A (en) | 2009-07-02 | 2013-06-28 | Sanofi Sa | Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors |
| FR2951169B1 (fr) * | 2009-10-09 | 2011-12-02 | Sanofi Aventis | Nouveaux derives de (6-oxo-1,6-dihydro-pyrimidin-2-yl)-amide, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) |
-
2011
- 2011-09-16 EP EP11306172A patent/EP2570127A1/en not_active Ceased
-
2012
- 2012-09-14 CA CA2847091A patent/CA2847091A1/en not_active Abandoned
- 2012-09-14 EA EA201490638A patent/EA201490638A1/ru unknown
- 2012-09-14 PE PE2014000346A patent/PE20141035A1/es not_active Application Discontinuation
- 2012-09-14 WO PCT/EP2012/068072 patent/WO2013037943A1/en active Application Filing
- 2012-09-14 KR KR1020147009655A patent/KR20140062143A/ko not_active Application Discontinuation
- 2012-09-14 SG SG11201400380XA patent/SG11201400380XA/en unknown
- 2012-09-14 JP JP2014530237A patent/JP2014530181A/ja not_active Abandoned
- 2012-09-14 US US14/343,935 patent/US20140275078A1/en not_active Abandoned
- 2012-09-14 CN CN201280051036.1A patent/CN103889418A/zh active Pending
- 2012-09-14 EP EP12759137.8A patent/EP2755653A1/en not_active Withdrawn
- 2012-09-14 BR BR112014005839A patent/BR112014005839A2/pt not_active IP Right Cessation
- 2012-09-14 AU AU2012307309A patent/AU2012307309A1/en not_active Abandoned
- 2012-09-14 MX MX2014003223A patent/MX2014003223A/es not_active Application Discontinuation
- 2012-09-17 AR ARP120103421A patent/AR087902A1/es unknown
- 2012-09-17 UY UY0001034341A patent/UY34341A/es not_active Application Discontinuation
-
2014
- 2014-02-27 IL IL231212A patent/IL231212A0/en unknown
- 2014-02-27 CR CR20140102A patent/CR20140102A/es unknown
- 2014-02-28 TN TNP2014000086A patent/TN2014000086A1/en unknown
- 2014-03-03 GT GT201400038A patent/GT201400038A/es unknown
- 2014-03-04 DO DO2014000046A patent/DOP2014000046A/es unknown
- 2014-03-13 CL CL2014000606A patent/CL2014000606A1/es unknown
- 2014-03-14 NI NI201400020A patent/NI201400020A/es unknown
- 2014-03-14 EC ECSP14013244 patent/ECSP14013244A/es unknown
- 2014-03-14 CO CO14055689A patent/CO6910192A2/es unknown
- 2014-04-10 MA MA36908A patent/MA35615B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR112014005839A2 (pt) | 2017-03-28 |
| WO2013037943A1 (en) | 2013-03-21 |
| IL231212A0 (en) | 2014-04-30 |
| SG11201400380XA (en) | 2014-04-28 |
| EP2570127A1 (en) | 2013-03-20 |
| DOP2014000046A (es) | 2014-07-15 |
| CR20140102A (es) | 2014-05-07 |
| NI201400020A (es) | 2014-04-23 |
| MA35615B1 (fr) | 2014-11-01 |
| KR20140062143A (ko) | 2014-05-22 |
| EA201490638A1 (ru) | 2014-08-29 |
| TN2014000086A1 (en) | 2015-07-01 |
| AU2012307309A1 (en) | 2014-04-03 |
| CO6910192A2 (es) | 2014-03-31 |
| MX2014003223A (es) | 2014-06-05 |
| ECSP14013244A (es) | 2014-07-31 |
| UY34341A (es) | 2013-04-05 |
| CN103889418A (zh) | 2014-06-25 |
| EP2755653A1 (en) | 2014-07-23 |
| CA2847091A1 (en) | 2013-03-21 |
| GT201400038A (es) | 2014-12-16 |
| US20140275078A1 (en) | 2014-09-18 |
| JP2014530181A (ja) | 2014-11-17 |
| PE20141035A1 (es) | 2014-09-04 |
| AR087902A1 (es) | 2014-04-23 |
| WO2013037943A8 (en) | 2013-07-18 |
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