CL2012001479A1 - Compuestos derivados de azabiciclo[3.1.0]hex-2-ilo, inhibidores de acetilcolinesterasa; compuestos intermediarios; composicion farmaceutica; utiles en el tratamiento de trastornos del sueño, tal como narcolepsia, hipersomnias, somnolencias diurnas. - Google Patents
Compuestos derivados de azabiciclo[3.1.0]hex-2-ilo, inhibidores de acetilcolinesterasa; compuestos intermediarios; composicion farmaceutica; utiles en el tratamiento de trastornos del sueño, tal como narcolepsia, hipersomnias, somnolencias diurnas.Info
- Publication number
- CL2012001479A1 CL2012001479A1 CL2012001479A CL2012001479A CL2012001479A1 CL 2012001479 A1 CL2012001479 A1 CL 2012001479A1 CL 2012001479 A CL2012001479 A CL 2012001479A CL 2012001479 A CL2012001479 A CL 2012001479A CL 2012001479 A1 CL2012001479 A1 CL 2012001479A1
- Authority
- CL
- Chile
- Prior art keywords
- azabicyclo
- hex
- useful
- treatment
- compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- -1 hex-2-yl Chemical class 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 208000007590 Disorders of Excessive Somnolence Diseases 0.000 title 2
- 206010041349 Somnolence Diseases 0.000 title 1
- 239000000544 cholinesterase inhibitor Chemical class 0.000 title 1
- 201000003631 narcolepsy Diseases 0.000 title 1
- 208000019116 sleep disease Diseases 0.000 title 1
- 206010019196 Head injury Diseases 0.000 abstract 1
- 230000032683 aging Effects 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 230000001149 cognitive effect Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0905953A FR2953521B1 (fr) | 2009-12-09 | 2009-12-09 | Nouveaux derives azabicyclo[3.1.0]hex-2-yl, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2012001479A1 true CL2012001479A1 (es) | 2013-02-08 |
Family
ID=42711699
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2012001479A CL2012001479A1 (es) | 2009-12-09 | 2012-06-06 | Compuestos derivados de azabiciclo[3.1.0]hex-2-ilo, inhibidores de acetilcolinesterasa; compuestos intermediarios; composicion farmaceutica; utiles en el tratamiento de trastornos del sueño, tal como narcolepsia, hipersomnias, somnolencias diurnas. |
Country Status (32)
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015032966A1 (en) * | 2013-09-09 | 2015-03-12 | Sanofi | An h3 receptor antagonist combined with a cholinesterase inhibitor for use in the treatment of alzheimer's disease |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2866647B1 (fr) * | 2004-02-20 | 2006-10-27 | Servier Lab | Nouveaux derives azabicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| GB0507680D0 (en) * | 2005-04-15 | 2005-05-25 | Glaxo Group Ltd | Compounds |
| JP2009517434A (ja) * | 2005-11-30 | 2009-04-30 | エフ．ホフマン−ラ ロシュ アーゲー | ５−置換インドール−２−カルボキサミド誘導体 |
-
2009
- 2009-12-09 FR FR0905953A patent/FR2953521B1/fr not_active Expired - Fee Related
-
2010
- 2010-12-01 UY UY0001033072A patent/UY33072A/es unknown
- 2010-12-03 TW TW099142190A patent/TW201200499A/zh unknown
- 2010-12-06 AR ARP100104484A patent/AR079265A1/es not_active Application Discontinuation
- 2010-12-07 SA SA110320011A patent/SA110320011B1/ar unknown
- 2010-12-08 JP JP2012542591A patent/JP2013513589A/ja not_active Ceased
- 2010-12-08 EA EA201200849A patent/EA201200849A1/ru unknown
- 2010-12-08 AP AP2012006352A patent/AP2012006352A0/xx unknown
- 2010-12-08 MA MA34932A patent/MA33882B1/fr unknown
- 2010-12-08 AU AU2010329762A patent/AU2010329762B2/en not_active Ceased
- 2010-12-08 PH PH1/2012/501053A patent/PH12012501053A1/en unknown
- 2010-12-08 BR BR112012013666A patent/BR112012013666A2/pt not_active IP Right Cessation
- 2010-12-08 GE GEAP201012774A patent/GEP20156227B/en unknown
- 2010-12-08 PE PE2012000722A patent/PE20121475A1/es not_active Application Discontinuation
- 2010-12-08 CA CA2782469A patent/CA2782469C/fr not_active Expired - Fee Related
- 2010-12-08 EP EP10799080A patent/EP2509947A1/fr not_active Withdrawn
- 2010-12-08 UA UAA201208178A patent/UA102950C2/ru unknown
- 2010-12-08 SG SG2012038931A patent/SG181082A1/en unknown
- 2010-12-08 CN CN2010800559947A patent/CN102652127A/zh active Pending
- 2010-12-08 US US13/514,796 patent/US20120283245A1/en not_active Abandoned
- 2010-12-08 WO PCT/FR2010/000823 patent/WO2011070253A1/fr not_active Ceased
- 2010-12-08 MX MX2012006578A patent/MX2012006578A/es active IP Right Grant
- 2010-12-08 KR KR1020127017843A patent/KR20120102763A/ko not_active Ceased
- 2010-12-08 IN IN4966DEN2012 patent/IN2012DN04966A/en unknown
-
2012
- 2012-05-28 TN TNP2012000267A patent/TN2012000267A1/fr unknown
- 2012-05-29 CR CR20120286A patent/CR20120286A/es unknown
- 2012-05-30 ZA ZA2012/03943A patent/ZA201203943B/en unknown
- 2012-06-05 EC ECSP12011950 patent/ECSP12011950A/es unknown
- 2012-06-06 CL CL2012001479A patent/CL2012001479A1/es unknown
- 2012-06-06 CO CO12095636A patent/CO6541535A2/es unknown
- 2012-06-07 CU CU20120091A patent/CU20120091A7/es unknown
- 2012-06-07 NI NI201200099A patent/NI201200099A/es unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| UY32968A (es) | Compuestos heterocíclicos fusionados como moduladores del receptor de orexina | |
| GT201300165A (es) | Compuestos y su uso como inhibidores de bace | |
| MX2020012825A (es) | Compuestos multiciclicos y metodos de uso de los mismos. | |
| ECSP11011051A (es) | Nuevos compuestos 578 | |
| UY32967A (es) | Compuestos heterocíclicos fusionados como moduladores del receptor de la orexina | |
| IN2014DN09805A (enExample) | ||
| ECSP12011908A (es) | OCTAHIDROPIRROLO[3,4-c]PIRROLOS DISUSTITUIDOS COMO | |
| WO2010127152A3 (en) | Compounds and compositions as microsomal prostaglandin e synthase-1 inhibitors | |
| JO3199B1 (ar) | مركبات 5- فلورو-1h- بيرازولوبيريدينات مستبدلة واستخدامها | |
| EA201100138A1 (ru) | 4-феноксиметилпиперидины в качестве модуляторов активности gpr119 | |
| MY171091A (en) | Inhibitors of b-secretase | |
| BRPI0909040A8 (pt) | Derivados de azetidina e ciclobutano, seus usos, e composição | |
| AU2012253757A8 (en) | Partially saturated tricyclic compounds and methods of making and using same | |
| CR20130580A (es) | Spiro-[1,3]-oxacinas y spiro-[1,4]-oxacepinas como inhibidores de bace1 y/o bace2 | |
| CL2015000096A1 (es) | Compuestos derivados de 4-metil-2,3,5,9,9b-pentaaza-ciclopenta[a]naftalenos, inhibidores de fosfodiestearasa 2 y/o 10; composicion farmaceutica; y su uso para prevencion o tratamiento de enfermedades del sistema nervioso, como deficiencia cognitiva, demencia, trastornos de ansiedad, enf. de alzheimer, enf. de parkinson, otros | |
| MX2012004078A (es) | Compuestos y composiciones como moduladores de la actividad de gpr119. | |
| MD4583B1 (ro) | Piridinone biciclice noi | |
| MX2011013032A (es) | Inhibidores de fosfatidilinositol 3-cinasa. | |
| UY32837A (es) | Uso de la 4-aminopiridina para mejorar el deterioro cognitivo en pacientes con desmielinizacion y otros estados del sistema nervioso | |
| TN2011000595A1 (en) | Substituted piperidines | |
| CL2012002259A1 (es) | Forma cristalina de 4-{(1s,2s)-2-[84-ciclobutilpiperazin-1-il-carbonil]ciclopropil}benzamida; composicion farmacéutica; y su uso para tratar enfermedades tales como esquizofrenia, narcolepsia, somnolencia diurna excesiva, obesidad, trastornos por deficit de atencion con hiperactividad, dolor, entre otras. | |
| MX342119B (es) | 2-oxi-quinolin-3-carboxamidas sustituidas como moduladores de kcnq2/3. | |
| TN2011000596A1 (en) | Substituted piperidines | |
| WO2011014520A3 (en) | Compounds and compositions as modulators of gpr119 activity | |
| MX2015005733A (es) | Compuestos triciclicos para usarse en el tratamiento y/o control de obesidad. |