WO2010127152A3 - Compounds and compositions as microsomal prostaglandin e synthase-1 inhibitors - Google Patents

Compounds and compositions as microsomal prostaglandin e synthase-1 inhibitors Download PDF

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Publication number
WO2010127152A3
WO2010127152A3 PCT/US2010/033022 US2010033022W WO2010127152A3 WO 2010127152 A3 WO2010127152 A3 WO 2010127152A3 US 2010033022 W US2010033022 W US 2010033022W WO 2010127152 A3 WO2010127152 A3 WO 2010127152A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
inhibitors
compositions
synthase
microsomal prostaglandin
Prior art date
Application number
PCT/US2010/033022
Other languages
French (fr)
Other versions
WO2010127152A2 (en
Inventor
Donatella Chianelli
Valentina Molteni
Pamela A. Albaugh
Ha-Soon Choi
Jon Loren
Zhicheng Wang
Pranab Mishra
Original Assignee
Irm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Irm Llc filed Critical Irm Llc
Publication of WO2010127152A2 publication Critical patent/WO2010127152A2/en
Publication of WO2010127152A3 publication Critical patent/WO2010127152A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Provided herein are compounds, and pharmaceutical compositions comprising such compounds, wherein the compounds are inhibitors of mPGES-1 activity. Also provided herein are methods of using such compounds and composition to treat or prevent diseases or disorders associated with the activity of mPGES-1.
PCT/US2010/033022 2009-04-29 2010-04-29 Compounds and compositions as microsomal prostaglandin e synthase-1 inhibitors WO2010127152A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17379509P 2009-04-29 2009-04-29
US61/173,795 2009-04-29

Publications (2)

Publication Number Publication Date
WO2010127152A2 WO2010127152A2 (en) 2010-11-04
WO2010127152A3 true WO2010127152A3 (en) 2011-09-29

Family

ID=42272690

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/033022 WO2010127152A2 (en) 2009-04-29 2010-04-29 Compounds and compositions as microsomal prostaglandin e synthase-1 inhibitors

Country Status (1)

Country Link
WO (1) WO2010127152A2 (en)

Families Citing this family (19)

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US9447049B2 (en) 2010-03-01 2016-09-20 University Of Tennessee Research Foundation Compounds for treatment of cancer
EP2330894B8 (en) 2008-09-03 2017-04-19 BioMarin Pharmaceutical Inc. Compositions including 6-aminohexanoic acid derivatives as hdac inhibitors
CA2785204C (en) * 2010-01-07 2016-01-05 Selexagen Therapeutics, Inc. Hedgehog inhibitors
WO2011123609A1 (en) * 2010-03-31 2011-10-06 Glaxo Group Limited Imidazolyl-imidazoles as kinase inhibitors
AR084174A1 (en) 2010-12-21 2013-04-24 Lilly Co Eli IMIDAZOL-2-BENZAMIDA COMPOUNDS USEFUL FOR THE TREATMENT OF OSTEOARTRITIS AND A PHARMACEUTICAL COMPOSITION
US10059723B2 (en) 2011-02-28 2018-08-28 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
US8957066B2 (en) 2011-02-28 2015-02-17 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
AU2012223509B2 (en) 2011-02-28 2016-11-10 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
AR086254A1 (en) 2011-05-26 2013-11-27 Lilly Co Eli USEFUL IMIDAZOL DERIVATIVES FOR THE TREATMENT OF ARTHRITIS
JP2015503505A (en) * 2011-12-23 2015-02-02 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Heteroaryl and uses thereof
US9056874B2 (en) 2012-05-04 2015-06-16 Novartis Ag Complement pathway modulators and uses thereof
WO2013170770A1 (en) * 2012-05-16 2013-11-21 上海医药集团股份有限公司 Acetylene derivatives having antitumor activity
WO2013186089A2 (en) 2012-06-14 2013-12-19 Basf Se Pesticidal methods using substituted 3-pyridyl thiazole compounds and derivatives for combating animal pests
US9475806B2 (en) 2013-03-14 2016-10-25 Novartis Ag Complement factor B inhibitors and uses there of
ES2680224T3 (en) 2013-03-15 2018-09-05 Biomarin Pharmaceutical Inc. HDAC inhibitors
EP3089963A1 (en) 2013-10-30 2016-11-09 Novartis AG 2-benzyl-benzimidazole complement factor b inhibitors and uses thereof
CA2935280A1 (en) * 2014-01-21 2015-07-30 F. Hoffmann-La Roche Ag Imidazoles for the treatment and prophylaxis of respiratory syncytial virus infection
ES2963906T3 (en) 2017-11-22 2024-04-03 Khondrion Ip B V Compounds as MPGES-1 inhibitors
WO2024041555A1 (en) * 2022-08-24 2024-02-29 Insilico Medicine Ip Limited Methods of manufacturing kinase inhibitors

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005123673A1 (en) * 2004-06-18 2005-12-29 Biolipox Ab Indoles useful in the treatment of inflammation
US20070208017A1 (en) * 2004-12-17 2007-09-06 Anh Chau 2-(Phenyl or heterocyclic)-1H-phenantrho[9,10-d]imidazoles as mPGES-1 inhibitors
WO2008084218A1 (en) * 2007-01-12 2008-07-17 Boehringer Ingelheim International Gmbh Benzazole derivatives for the treatment of inflammations
WO2008139161A1 (en) * 2007-05-10 2008-11-20 Sareum Limited Oxazole tyrosine kinase inhibitors

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005123673A1 (en) * 2004-06-18 2005-12-29 Biolipox Ab Indoles useful in the treatment of inflammation
US20070208017A1 (en) * 2004-12-17 2007-09-06 Anh Chau 2-(Phenyl or heterocyclic)-1H-phenantrho[9,10-d]imidazoles as mPGES-1 inhibitors
WO2008084218A1 (en) * 2007-01-12 2008-07-17 Boehringer Ingelheim International Gmbh Benzazole derivatives for the treatment of inflammations
WO2008139161A1 (en) * 2007-05-10 2008-11-20 Sareum Limited Oxazole tyrosine kinase inhibitors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ST. LAURANT DR ET AL: "Preparation of 5-substituted 2-(2-alkyl/aryl-1H-imidazol-4-yl)oxazoles and 5-substituted 2-(2-alkyl/arylthiazol-4-yl)oxazoles by utilizing 5-substituted 2-(2-bromo-1,1-diethoxyethyl)oxazole as a synthon", SYNTHESIS, no. 9, 25 March 2009 (2009-03-25), pages 1445 - 1458, XP002589898 *
TANAKA ET AL: "Studies on antiplatelet agents i. Synthesis and platelet inhibitory activity of 5-alkyl-2-aryl-4-pyridylimidazoles", CHEMICAL AND PHARMACEUTICAL BULLETIN, vol. 40, no. 12, 1 January 1992 (1992-01-01), pages 3206 - 3213, XP002651273 *

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