CL2011001263A1 - Compuestos derivados de pirimidinonas opcionalmente sustituidas; composicion farmaceutica que los comprende; y su uso como inhibidores de fosfodiesterasa 1 (pde1) para el tratamiento de enfermedades que involucran trastornos de la trayectoria intracelular del receptor de dopamina d1 como parkinson, alzheimer, depresion, enfermedad bipolar, hipertension, glaucoma. - Google Patents
Compuestos derivados de pirimidinonas opcionalmente sustituidas; composicion farmaceutica que los comprende; y su uso como inhibidores de fosfodiesterasa 1 (pde1) para el tratamiento de enfermedades que involucran trastornos de la trayectoria intracelular del receptor de dopamina d1 como parkinson, alzheimer, depresion, enfermedad bipolar, hipertension, glaucoma.Info
- Publication number
- CL2011001263A1 CL2011001263A1 CL2011001263A CL2011001263A CL2011001263A1 CL 2011001263 A1 CL2011001263 A1 CL 2011001263A1 CL 2011001263 A CL2011001263 A CL 2011001263A CL 2011001263 A CL2011001263 A CL 2011001263A CL 2011001263 A1 CL2011001263 A1 CL 2011001263A1
- Authority
- CL
- Chile
- Prior art keywords
- glaucoma
- parkinson
- alzheimer
- hypertension
- depression
- Prior art date
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 3
- 208000020925 Bipolar disease Diseases 0.000 title abstract 2
- 208000010412 Glaucoma Diseases 0.000 title abstract 2
- 206010020772 Hypertension Diseases 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title abstract 2
- 239000008194 pharmaceutical composition Chemical class 0.000 title abstract 2
- VTGOHKSTWXHQJK-UHFFFAOYSA-N pyrimidin-2-ol Chemical class OC1=NC=CC=N1 VTGOHKSTWXHQJK-UHFFFAOYSA-N 0.000 title abstract 2
- 101001117086 Dictyostelium discoideum cAMP/cGMP-dependent 3',5'-cAMP/cGMP phosphodiesterase A Proteins 0.000 title 1
- 101100243084 Dictyostelium discoideum pdsA gene Proteins 0.000 title 1
- 102000004076 Dopamine D1 Receptors Human genes 0.000 title 1
- 108090000511 Dopamine D1 Receptors Proteins 0.000 title 1
- 101100243086 Schizosaccharomyces pombe (strain 972 / ATCC 24843) cgs2 gene Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000003834 intracellular effect Effects 0.000 title 1
Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12044208P | 2008-12-06 | 2008-12-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2011001263A1 true CL2011001263A1 (es) | 2011-11-18 |
Family
ID=42233533
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2011001263A CL2011001263A1 (es) | 2008-12-06 | 2011-05-30 | Compuestos derivados de pirimidinonas opcionalmente sustituidas; composicion farmaceutica que los comprende; y su uso como inhibidores de fosfodiesterasa 1 (pde1) para el tratamiento de enfermedades que involucran trastornos de la trayectoria intracelular del receptor de dopamina d1 como parkinson, alzheimer, depresion, enfermedad bipolar, hipertension, glaucoma. |
Country Status (23)
| Country | Link |
|---|---|
| US (4) | US8536159B2 (https=) |
| EP (1) | EP2367429B1 (https=) |
| JP (1) | JP5778582B2 (https=) |
| KR (1) | KR20110095881A (https=) |
| CN (1) | CN102231953A (https=) |
| AU (1) | AU2009322901A1 (https=) |
| BR (1) | BRPI0922348A2 (https=) |
| CA (1) | CA2740391A1 (https=) |
| CL (1) | CL2011001263A1 (https=) |
| CO (1) | CO6390083A2 (https=) |
| CR (1) | CR20110312A (https=) |
| DO (1) | DOP2011000173A (https=) |
| EA (1) | EA201170770A1 (https=) |
| EC (1) | ECSP11011184A (https=) |
| ES (1) | ES2638912T3 (https=) |
| IL (1) | IL213314A0 (https=) |
| MA (1) | MA32938B1 (https=) |
| MX (1) | MX2011005933A (https=) |
| PE (1) | PE20110922A1 (https=) |
| SG (1) | SG171775A1 (https=) |
| TN (1) | TN2011000246A1 (https=) |
| WO (1) | WO2010065149A1 (https=) |
| ZA (1) | ZA201103631B (https=) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006255028B2 (en) | 2005-06-06 | 2012-04-19 | Intra-Cellular Therapies, Inc. | Organic compounds |
| KR20090042227A (ko) | 2006-06-06 | 2009-04-29 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 유기 화합물 |
| WO2008063505A1 (en) * | 2006-11-13 | 2008-05-29 | Intra-Cellular Therapies, Inc. | Organic compounds |
| WO2008070095A1 (en) | 2006-12-05 | 2008-06-12 | Intra-Cellular Therapies, Inc. | Novel uses |
| KR20120012831A (ko) | 2007-12-06 | 2012-02-10 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 유기 화합물 |
| EP2240028B1 (en) * | 2007-12-06 | 2016-07-20 | Intra-Cellular Therapies, Inc. | Pyrazolopyrimidine-4,6-dione derivatives and their use as pharmaceutical |
| KR20110103949A (ko) * | 2008-12-06 | 2011-09-21 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 유기 화합물 |
| BRPI0922809A2 (pt) | 2008-12-06 | 2018-05-29 | Intracellular Therapies Inc | compostos orgânicos |
| JP5778582B2 (ja) * | 2008-12-06 | 2015-09-16 | イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． | 有機化合物 |
| MA32942B1 (fr) | 2008-12-06 | 2012-01-02 | Intra Cellular Therapies Inc | Composes organiques |
| EP2367431B1 (en) | 2008-12-06 | 2015-08-05 | Intra-Cellular Therapies, Inc. | Organic compounds |
| EP2367430B1 (en) | 2008-12-06 | 2014-08-13 | Intra-Cellular Therapies, Inc. | Organic compounds |
| WO2010098839A1 (en) | 2009-02-25 | 2010-09-02 | Intra-Cellular Therapies, Inc. | Pde 1 inhibitors for ophthalmic disorders |
| JP2012526810A (ja) | 2009-05-13 | 2012-11-01 | イントラ−セルラー・セラピーズ・インコーポレイテッド | 有機化合物 |
| WO2011043816A1 (en) * | 2009-10-08 | 2011-04-14 | Intra-Cellular Therapies, Inc. | Phosphodiesterase 1-targeting tracers and methods |
| WO2011153136A1 (en) | 2010-05-31 | 2011-12-08 | Intra-Cellular Therapies, Inc. | Organic compounds |
| WO2011153135A1 (en) | 2010-05-31 | 2011-12-08 | Intra-Cellular Therapies, Inc. | Organic compounds |
| TW201206937A (en) | 2010-05-31 | 2012-02-16 | Intra Cellular Therapies Inc | Organic compounds |
| EP2576551A4 (en) | 2010-05-31 | 2014-04-16 | Intra Cellular Therapies Inc | ORGANIC CONNECTIONS |
| JP6051210B2 (ja) * | 2011-06-10 | 2016-12-27 | イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． | 有機化合物 |
| US8633178B2 (en) | 2011-11-23 | 2014-01-21 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| CA2877146C (en) | 2012-06-18 | 2020-10-20 | Dart Neuroscience (Cayman) Ltd | Substituted thiophene- and furan-fused azolopyrimidine-5-(6h)-one compounds |
| AR091507A1 (es) | 2012-06-21 | 2015-02-11 | Intra Cellular Therapies Inc | SALES DE (6aR,9aS)-5,6a,7,8,9,9a-HEXAHIDRO-5-METIL-3-(FENILAMINO)-2-((4-(6-FLUOROPIRIDIN-2-IL)FENIL)METIL)-CICLOPENT[4,5]IMIDAZO[1,2-a]PIRAZOLO[4,3-e]PIRIMIDIN-4(2H)-ONA |
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| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
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- 2009-12-07 ES ES09830744.0T patent/ES2638912T3/es active Active
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- 2009-12-07 SG SG2011036589A patent/SG171775A1/en unknown
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Also Published As
| Publication number | Publication date |
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| JP5778582B2 (ja) | 2015-09-16 |
| AU2009322901A1 (en) | 2010-06-10 |
| MX2011005933A (es) | 2011-12-16 |
| ECSP11011184A (es) | 2011-10-31 |
| CA2740391A1 (en) | 2010-06-10 |
| EP2367429A4 (en) | 2012-06-06 |
| US20110245214A1 (en) | 2011-10-06 |
| EP2367429B1 (en) | 2017-06-07 |
| BRPI0922348A2 (pt) | 2015-08-11 |
| US20150038474A1 (en) | 2015-02-05 |
| KR20110095881A (ko) | 2011-08-25 |
| PE20110922A1 (es) | 2012-01-22 |
| EA201170770A1 (ru) | 2012-02-28 |
| US20140005155A1 (en) | 2014-01-02 |
| JP2012510993A (ja) | 2012-05-17 |
| US20160083390A1 (en) | 2016-03-24 |
| CR20110312A (es) | 2011-10-28 |
| MA32938B1 (fr) | 2012-01-02 |
| TN2011000246A1 (en) | 2012-12-17 |
| DOP2011000173A (es) | 2011-10-31 |
| US8536159B2 (en) | 2013-09-17 |
| SG171775A1 (en) | 2011-07-28 |
| CO6390083A2 (es) | 2012-02-29 |
| IL213314A0 (en) | 2011-07-31 |
| CN102231953A (zh) | 2011-11-02 |
| ZA201103631B (en) | 2013-05-29 |
| EP2367429A1 (en) | 2011-09-28 |
| ES2638912T3 (es) | 2017-10-24 |
| WO2010065149A1 (en) | 2010-06-10 |
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