CL2009000651A1 - Forma anhidra ii, forma hemi pentahidrato y forma solvato metanol de la sal del acido lactico 4-amino-5-fluoro-3-[5-(4-metil piperazin-1-il)1h-benzimidazol-2-il]quinolin-2-(1h)-ona; composición farmacéutica que las comprende; y uso para tratar enfermedades que inhiben la actividad de vegfr2 y fgfr3, tales como cáncer. - Google Patents

Forma anhidra ii, forma hemi pentahidrato y forma solvato metanol de la sal del acido lactico 4-amino-5-fluoro-3-[5-(4-metil piperazin-1-il)1h-benzimidazol-2-il]quinolin-2-(1h)-ona; composición farmacéutica que las comprende; y uso para tratar enfermedades que inhiben la actividad de vegfr2 y fgfr3, tales como cáncer.

Info

Publication number
CL2009000651A1
CL2009000651A1 CL2009000651A CL2009000651A CL2009000651A1 CL 2009000651 A1 CL2009000651 A1 CL 2009000651A1 CL 2009000651 A CL2009000651 A CL 2009000651A CL 2009000651 A CL2009000651 A CL 2009000651A CL 2009000651 A1 CL2009000651 A1 CL 2009000651A1
Authority
CL
Chile
Prior art keywords
cancer
benzimidazol
quinolin
fluoro
amino
Prior art date
Application number
CL2009000651A
Other languages
English (en)
Spanish (es)
Inventor
Frank Stowasser
Danielle Giron
Philippe Piechon
Andreas Schreiner
Walter Hammerschmidt
Johanne Polasek
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40622140&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2009000651(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CL2009000651A1 publication Critical patent/CL2009000651A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CL2009000651A 2008-03-19 2009-03-18 Forma anhidra ii, forma hemi pentahidrato y forma solvato metanol de la sal del acido lactico 4-amino-5-fluoro-3-[5-(4-metil piperazin-1-il)1h-benzimidazol-2-il]quinolin-2-(1h)-ona; composición farmacéutica que las comprende; y uso para tratar enfermedades que inhiben la actividad de vegfr2 y fgfr3, tales como cáncer. CL2009000651A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3774608P 2008-03-19 2008-03-19

Publications (1)

Publication Number Publication Date
CL2009000651A1 true CL2009000651A1 (es) 2010-07-19

Family

ID=40622140

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2009000651A CL2009000651A1 (es) 2008-03-19 2009-03-18 Forma anhidra ii, forma hemi pentahidrato y forma solvato metanol de la sal del acido lactico 4-amino-5-fluoro-3-[5-(4-metil piperazin-1-il)1h-benzimidazol-2-il]quinolin-2-(1h)-ona; composición farmacéutica que las comprende; y uso para tratar enfermedades que inhiben la actividad de vegfr2 y fgfr3, tales como cáncer.

Country Status (24)

Country Link
US (1) US8563556B2 (enExample)
EP (1) EP2257544B1 (enExample)
JP (1) JP2011515370A (enExample)
KR (1) KR20100137517A (enExample)
CN (1) CN101970425B (enExample)
AR (1) AR070924A1 (enExample)
AU (1) AU2009227003B2 (enExample)
BR (1) BRPI0909762A2 (enExample)
CA (1) CA2718076A1 (enExample)
CL (1) CL2009000651A1 (enExample)
CO (1) CO6321253A2 (enExample)
EC (1) ECSP10010555A (enExample)
IL (1) IL208020A0 (enExample)
MA (1) MA32230B1 (enExample)
MX (1) MX2010010152A (enExample)
MY (1) MY150554A (enExample)
NZ (2) NZ600887A (enExample)
PE (1) PE20091628A1 (enExample)
PH (2) PH12012502568A1 (enExample)
RU (1) RU2497820C2 (enExample)
SG (1) SG188919A1 (enExample)
TW (1) TWI426072B (enExample)
WO (1) WO2009115562A2 (enExample)
ZA (1) ZA201006263B (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
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PE20091628A1 (es) 2008-03-19 2009-11-19 Novartis Ag Formas cristalinas y dos formas solvatadas de sales de acido lactico de 4-amino-5-fluoro-3-[5-(4-metilpiperazin-1-il)-1h-benzimidazol-2-il]quinolin-2(1h)-ona
SG184311A1 (en) 2010-04-16 2012-11-29 Novartis Ag Combination of organic compounds
CA2793779A1 (en) 2010-04-16 2011-10-20 Novartis Ag Organic compound for use in the treatment of liver cancer
AR081776A1 (es) * 2010-06-30 2012-10-17 Novartis Ag Composiciones farmaceuticas que comprenden monohidrato de lactato de 4-amino-5-fluoro-3-[6-(4-metil-piperazin-1-il)-1h-bencimidazol-2-il]-1h-quinolin-2-ona, proceso para la produccion de la composicion
CN103429759A (zh) 2011-03-17 2013-12-04 诺华股份有限公司 Fgfr及其配体作为hr阳性对象中乳腺癌的生物标记
SG194445A1 (en) 2011-05-19 2013-12-30 Novartis Ag Method for treating adenoid cystic carcinoma
IN2014DN02060A (enExample) 2011-09-15 2015-05-15 Novartis Ag
WO2013063003A1 (en) 2011-10-28 2013-05-02 Novartis Ag Method of treating gastrointestinal stromal tumors
JP2015505562A (ja) 2012-01-31 2015-02-23 ノバルティス アーゲー Ｒｔｋ阻害剤と抗エストロゲン剤との組合せ、およびがん治療のためのその使用
AU2013289175A1 (en) 2012-07-11 2015-01-22 Novartis Ag Method of treating gastrointestinal stromal tumors
WO2014058785A1 (en) 2012-10-10 2014-04-17 Novartis Ag Combination therapy
EP2764866A1 (en) 2013-02-07 2014-08-13 IP Gesellschaft für Management mbH Inhibitors of nedd8-activating enzyme
JOP20200094A1 (ar) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc جزيئات جسم مضاد لـ pd-1 واستخداماتها
JOP20200096A1 (ar) 2014-01-31 2017-06-16 Children’S Medical Center Corp جزيئات جسم مضاد لـ tim-3 واستخداماتها
KR102442436B1 (ko) 2014-03-14 2022-09-15 노파르티스 아게 Lag-3에 대한 항체 분자 및 그의 용도
MA41044A (fr) 2014-10-08 2017-08-15 Novartis Ag Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer
EA201790834A1 (ru) 2014-10-14 2018-01-31 Новартис Аг Молекулы антител к pd-l1 и их применение
WO2016100882A1 (en) 2014-12-19 2016-06-23 Novartis Ag Combination therapies
EA035817B1 (ru) 2015-03-10 2020-08-14 Адуро Байотек, Инк. Композиции и способы для активации сигналинга, зависимого от "гена стимулятора интерферона"
US20180222982A1 (en) 2015-07-29 2018-08-09 Novartis Ag Combination therapies comprising antibody molecules to pd-1
ES2878188T3 (es) 2015-07-29 2021-11-18 Novartis Ag Terapias de combinación que comprenden moléculas de anticuerpos contra LAG-3
EP3316902A1 (en) 2015-07-29 2018-05-09 Novartis AG Combination therapies comprising antibody molecules to tim-3
MA43186B1 (fr) 2015-11-03 2022-03-31 Janssen Biotech Inc Anticorps se liant spécifiquement à pd-1 et leurs utilisations
WO2017106656A1 (en) 2015-12-17 2017-06-22 Novartis Ag Antibody molecules to pd-1 and uses thereof
WO2018009466A1 (en) 2016-07-05 2018-01-11 Aduro Biotech, Inc. Locked nucleic acid cyclic dinucleotide compounds and uses thereof
UY37695A (es) 2017-04-28 2018-11-30 Novartis Ag Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo
US12398209B2 (en) 2018-01-22 2025-08-26 Janssen Biotech, Inc. Methods of treating cancers with antagonistic anti-PD-1 antibodies

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60132937T2 (de) 2000-09-11 2009-02-12 Novartis Vaccines and Diagnostics, Inc., Emeryville Verfahren zur Herstellung von Benzimidazol-2-yl -Chinolinonderivaten
AU2003288899B2 (en) 2002-08-23 2009-09-03 Novartis Vaccines And Diagnostics, Inc. Benzimidazole quinolinones and uses thereof
US7825132B2 (en) 2002-08-23 2010-11-02 Novartis Vaccines And Diagnostics, Inc. Inhibition of FGFR3 and treatment of multiple myeloma
US20050256157A1 (en) 2002-08-23 2005-11-17 Chiron Corporation Combination therapy with CHK1 inhibitors
CN100377709C (zh) * 2002-11-13 2008-04-02 希龙公司 受体酪氨酸激酶抑制剂的制药用途及相关检测方法
AU2003290699B2 (en) 2002-11-13 2009-08-27 Novartis Vaccines And Diagnostics, Inc. Methods of treating cancer and related methods
MXPA06004194A (es) * 2003-11-07 2006-06-28 Chiron Corp Inhibicion de fgfr3 y tratamiento de mieloma multiple.
RU2377988C2 (ru) * 2004-02-20 2010-01-10 Новартис Вэксинес Энд Дайэгностикс, Инк. Модуляция воспалительных и метастатических процессов
WO2006081445A2 (en) * 2005-01-27 2006-08-03 Novartis Vaccines And Diagnostics Inc. Treatment of metastasized tumors
KR101368519B1 (ko) * 2005-05-23 2014-02-27 노파르티스 아게 결정형 및 기타 형태의 4-아미노-5-플루오로-3-［6-(4-메틸피페라진-1-일)-1ｈ-벤즈이미다졸-2-일］-1ｈ-퀴놀린-2-온 락트산염
PL1957074T3 (pl) * 2005-11-29 2014-08-29 Novartis Ag Preparaty chinolinonów
US8268834B2 (en) 2008-03-19 2012-09-18 Novartis Ag Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme
PE20091628A1 (es) 2008-03-19 2009-11-19 Novartis Ag Formas cristalinas y dos formas solvatadas de sales de acido lactico de 4-amino-5-fluoro-3-[5-(4-metilpiperazin-1-il)-1h-benzimidazol-2-il]quinolin-2(1h)-ona

Also Published As

Publication number Publication date
PH12012502569A1 (en) 2015-09-21
WO2009115562A2 (en) 2009-09-24
ECSP10010555A (es) 2010-11-30
PE20091628A1 (es) 2009-11-19
HK1147492A1 (en) 2011-08-12
BRPI0909762A2 (pt) 2018-04-03
EP2257544B1 (en) 2014-12-03
ZA201006263B (en) 2011-05-25
SG188919A1 (en) 2013-04-30
US8563556B2 (en) 2013-10-22
PH12012502568A1 (en) 2014-10-27
NZ587829A (en) 2012-08-31
IL208020A0 (en) 2010-12-30
KR20100137517A (ko) 2010-12-30
CA2718076A1 (en) 2009-09-24
NZ600887A (en) 2013-10-25
AU2009227003B2 (en) 2013-03-14
AU2009227003A1 (en) 2009-09-24
MX2010010152A (es) 2010-10-25
AR070924A1 (es) 2010-05-12
RU2497820C2 (ru) 2013-11-10
CN101970425A (zh) 2011-02-09
RU2010142396A (ru) 2012-04-27
MY150554A (en) 2014-01-30
US20110021536A1 (en) 2011-01-27
CN101970425B (zh) 2014-04-16
JP2011515370A (ja) 2011-05-19
TW201000463A (en) 2010-01-01
TWI426072B (zh) 2014-02-11
EP2257544A2 (en) 2010-12-08
WO2009115562A3 (en) 2009-11-26
CO6321253A2 (es) 2011-09-20
MA32230B1 (fr) 2011-04-01

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