CL2008001559A1 - Compuestos heterociclos que contienen al menos un atomo de nitrogeno, moduladores de gamma secretasa; composiciones farmaceuticas que los comprenden; uso de los compuestos en la preparacion de medicamentos para tratar trastornos del sistema nervioso central, tal como alzheimer; y kit que incluye a la composicion farmaceutica. - Google Patents
Compuestos heterociclos que contienen al menos un atomo de nitrogeno, moduladores de gamma secretasa; composiciones farmaceuticas que los comprenden; uso de los compuestos en la preparacion de medicamentos para tratar trastornos del sistema nervioso central, tal como alzheimer; y kit que incluye a la composicion farmaceutica.Info
- Publication number
- CL2008001559A1 CL2008001559A1 CL2008001559A CL2008001559A CL2008001559A1 CL 2008001559 A1 CL2008001559 A1 CL 2008001559A1 CL 2008001559 A CL2008001559 A CL 2008001559A CL 2008001559 A CL2008001559 A CL 2008001559A CL 2008001559 A1 CL2008001559 A1 CL 2008001559A1
- Authority
- CL
- Chile
- Prior art keywords
- compounds
- alzheimer
- medicaments
- kit
- preparation
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000008194 pharmaceutical composition Chemical group 0.000 title abstract 3
- VHNYOQKVZQVBLC-RTCGXNAVSA-N (4r,7e,9as)-7-[[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]methylidene]-4-(3,4,5-trifluorophenyl)-1,3,4,8,9,9a-hexahydropyrido[2,1-c][1,4]oxazin-6-one Chemical group C1([C@@H]2COC[C@@H]3CC\C(C(N32)=O)=C/C=2C=C(C(=CC=2)N2C=C(C)N=C2)OC)=CC(F)=C(F)C(F)=C1 VHNYOQKVZQVBLC-RTCGXNAVSA-N 0.000 title abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 title abstract 2
- 229940124648 γ-Secretase Modulator Drugs 0.000 title abstract 2
- 210000003169 central nervous system Anatomy 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 125000000623 heterocyclic group Chemical group 0.000 title 1
- 125000004433 nitrogen atom Chemical group N* 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Compuestos derivados de heterociclos nitrogenados, moduladores de gamma secretasa; composición farmacéutica que comprende a dichos compuestos; y su uso para tratar Alzheimer.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US94139607P | 2007-06-01 | 2007-06-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2008001559A1 true CL2008001559A1 (es) | 2008-12-05 |
Family
ID=40130388
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2008001559A CL2008001559A1 (es) | 2007-06-01 | 2008-05-29 | Compuestos heterociclos que contienen al menos un atomo de nitrogeno, moduladores de gamma secretasa; composiciones farmaceuticas que los comprenden; uso de los compuestos en la preparacion de medicamentos para tratar trastornos del sistema nervioso central, tal como alzheimer; y kit que incluye a la composicion farmaceutica. |
Country Status (18)
Country | Link |
---|---|
US (1) | US8580956B2 (es) |
EP (1) | EP2164852A2 (es) |
JP (1) | JP2010529014A (es) |
KR (1) | KR20100021633A (es) |
CN (1) | CN101932578A (es) |
AR (1) | AR066151A1 (es) |
AU (1) | AU2008263206A1 (es) |
BR (1) | BRPI0812491A2 (es) |
CA (1) | CA2689930A1 (es) |
CL (1) | CL2008001559A1 (es) |
CO (1) | CO6241125A2 (es) |
EC (1) | ECSP099773A (es) |
IL (1) | IL202316A0 (es) |
MX (1) | MX2009013130A (es) |
PE (1) | PE20090319A1 (es) |
RU (1) | RU2009148865A (es) |
TW (1) | TW200904422A (es) |
WO (1) | WO2008153792A2 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2152695A2 (en) | 2007-06-01 | 2010-02-17 | Schering Corporation | Gamma secretase modulators |
WO2010054067A1 (en) * | 2008-11-06 | 2010-05-14 | Schering Corporation | Gamma secretase modulators |
EP2691393B1 (en) | 2011-03-31 | 2016-09-14 | Pfizer Inc | Novel bicyclic pyridinones |
UA110688C2 (uk) | 2012-09-21 | 2016-01-25 | Пфайзер Інк. | Біциклічні піридинони |
JP6628805B2 (ja) | 2015-02-03 | 2020-01-15 | ファイザー・インク | 新規シクロプロパベンゾフラニルピリドピラジンジオン |
AR114237A1 (es) * | 2018-02-01 | 2020-08-05 | Japan Tobacco Inc | Compuesto de amida heterocíclica que contiene nitrógeno y su uso farmacéutico |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0646115B1 (en) | 1991-03-28 | 2003-01-22 | Eisai Co., Ltd. | Heterocyclic-cyclic amine derivatives |
WO2004071431A2 (en) | 2003-02-05 | 2004-08-26 | Myriad Genetics, Inc. | Method and composition for treating neurodegenerative disorders |
BRPI0410348A (pt) | 2003-05-14 | 2006-05-30 | Torreypines Therapeutics Inc | compostos e usos dos mesmos na modulação de amilóide-beta |
KR20060040676A (ko) | 2003-07-11 | 2006-05-10 | 미리어드 제네틱스, 인크. | 알츠하이머병을 치료하기 위한 약제학적 방법, 투약 방법및 제형 |
US20070293538A1 (en) | 2004-04-13 | 2007-12-20 | Myriad Genetics, Incorporated | Pharmaceutical Composition And Methods For Treating Neurodegenerative Disorders |
CA2567223A1 (en) | 2004-05-19 | 2005-11-24 | Boehringer Ingelheim International Gmbh | Treatment of diseases associated with altered level of amyloid beta peptides |
TWI335816B (en) | 2004-05-26 | 2011-01-11 | Eisai R&D Man Co Ltd | Cinnamide compound |
EP1650183A1 (en) | 2004-10-21 | 2006-04-26 | Cellzome Ag | (Benzyloxy-biphenyl) acetic acids and derivatives thereof and their use in therapy |
US20070117839A1 (en) | 2005-11-24 | 2007-05-24 | Eisai R&D Management Co., Ltd. | Two cyclic cinnamide compound |
KR20080069221A (ko) | 2005-11-24 | 2008-07-25 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 모르폴린 타입의 신나미드 화합물 |
-
2008
- 2008-05-28 PE PE2008000911A patent/PE20090319A1/es not_active Application Discontinuation
- 2008-05-28 KR KR1020097027039A patent/KR20100021633A/ko not_active Application Discontinuation
- 2008-05-28 RU RU2009148865/04A patent/RU2009148865A/ru unknown
- 2008-05-28 CN CN2008801013158A patent/CN101932578A/zh active Pending
- 2008-05-28 JP JP2010510315A patent/JP2010529014A/ja not_active Withdrawn
- 2008-05-28 MX MX2009013130A patent/MX2009013130A/es unknown
- 2008-05-28 WO PCT/US2008/006733 patent/WO2008153792A2/en active Application Filing
- 2008-05-28 AU AU2008263206A patent/AU2008263206A1/en not_active Abandoned
- 2008-05-28 CA CA2689930A patent/CA2689930A1/en not_active Abandoned
- 2008-05-28 US US12/600,910 patent/US8580956B2/en not_active Expired - Fee Related
- 2008-05-28 EP EP08767901A patent/EP2164852A2/en not_active Withdrawn
- 2008-05-28 BR BRPI0812491-4A2A patent/BRPI0812491A2/pt not_active Application Discontinuation
- 2008-05-28 AR ARP080102243A patent/AR066151A1/es not_active Application Discontinuation
- 2008-05-29 CL CL2008001559A patent/CL2008001559A1/es unknown
- 2008-05-29 TW TW097119966A patent/TW200904422A/zh unknown
-
2009
- 2009-11-24 IL IL202316A patent/IL202316A0/en unknown
- 2009-11-30 EC EC2009009773A patent/ECSP099773A/es unknown
- 2009-12-01 CO CO09137088A patent/CO6241125A2/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
ECSP099773A (es) | 2009-12-28 |
US20100255005A1 (en) | 2010-10-07 |
US8580956B2 (en) | 2013-11-12 |
KR20100021633A (ko) | 2010-02-25 |
CA2689930A1 (en) | 2008-12-18 |
MX2009013130A (es) | 2010-01-15 |
AU2008263206A1 (en) | 2008-12-18 |
BRPI0812491A2 (pt) | 2014-12-02 |
RU2009148865A (ru) | 2011-07-20 |
CO6241125A2 (es) | 2011-01-20 |
JP2010529014A (ja) | 2010-08-26 |
WO2008153792A2 (en) | 2008-12-18 |
CN101932578A (zh) | 2010-12-29 |
AR066151A1 (es) | 2009-07-29 |
IL202316A0 (en) | 2010-06-30 |
PE20090319A1 (es) | 2009-03-27 |
EP2164852A2 (en) | 2010-03-24 |
AU2008263206A2 (en) | 2010-01-21 |
WO2008153792A3 (en) | 2009-05-07 |
TW200904422A (en) | 2009-02-01 |
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