CL2007003784A1 - Compuestos derivados de 1-amino-3-fenilciclopentano, que son agonistas o antagonistas de uno o mas receptores de la familia s1p; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar la esclerosis multiple, artritis reumato - Google Patents
Compuestos derivados de 1-amino-3-fenilciclopentano, que son agonistas o antagonistas de uno o mas receptores de la familia s1p; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar la esclerosis multiple, artritis reumatoInfo
- Publication number
- CL2007003784A1 CL2007003784A1 CL200703784A CL2007003784A CL2007003784A1 CL 2007003784 A1 CL2007003784 A1 CL 2007003784A1 CL 200703784 A CL200703784 A CL 200703784A CL 2007003784 A CL2007003784 A CL 2007003784A CL 2007003784 A1 CL2007003784 A1 CL 2007003784A1
- Authority
- CL
- Chile
- Prior art keywords
- compounds
- phenylcyclopentane
- agonists
- antagonists
- receptors
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 2
- ZNMXRCDHEJJIIK-UHFFFAOYSA-N 3-phenylcyclopentan-1-amine Chemical compound C1C(N)CCC1C1=CC=CC=C1 ZNMXRCDHEJJIIK-UHFFFAOYSA-N 0.000 title 1
- 239000000556 agonist Substances 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 201000006417 multiple sclerosis Diseases 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 206010039073 rheumatoid arthritis Diseases 0.000 title 1
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D231/08—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with oxygen or sulfur atoms directly attached to ring carbon atoms
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/653—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
- C07F9/655345—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US87628806P | 2006-12-21 | 2006-12-21 | |
US87631806P | 2006-12-21 | 2006-12-21 |
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CL2007003784A1 true CL2007003784A1 (es) | 2008-06-27 |
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Family Applications (1)
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CL200703784A CL2007003784A1 (es) | 2006-12-21 | 2007-12-21 | Compuestos derivados de 1-amino-3-fenilciclopentano, que son agonistas o antagonistas de uno o mas receptores de la familia s1p; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar la esclerosis multiple, artritis reumato |
Country Status (19)
Country | Link |
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EP (1) | EP2120575A4 (ja) |
JP (1) | JP2010513532A (ja) |
KR (1) | KR20090095659A (ja) |
AR (1) | AR064650A1 (ja) |
AU (1) | AU2007338700A1 (ja) |
BR (1) | BRPI0720478A2 (ja) |
CA (1) | CA2672727A1 (ja) |
CL (1) | CL2007003784A1 (ja) |
CO (1) | CO6180436A2 (ja) |
CR (1) | CR10872A (ja) |
DO (1) | DOP2009000149A (ja) |
EC (1) | ECSP099435A (ja) |
MX (1) | MX2009006751A (ja) |
NO (1) | NO20092376L (ja) |
PE (1) | PE20081561A1 (ja) |
RU (1) | RU2009128062A (ja) |
TW (1) | TW200838497A (ja) |
UY (1) | UY30829A1 (ja) |
WO (1) | WO2008079382A1 (ja) |
Cited By (1)
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---|---|---|---|---|
US10689373B2 (en) | 2014-02-20 | 2020-06-23 | Takeda Pharmaceutical Company Limited | 1,2-substituted cyclopentanes as orexin receptor antagonists |
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AU2007323557A1 (en) | 2006-11-21 | 2008-05-29 | University Of Virginia Patent Foundation | Benzocycloheptyl analogs having sphingosine 1-phosphate receptor activity |
EP2099741A2 (en) | 2006-11-21 | 2009-09-16 | University Of Virginia Patent Foundation | Hydrindane analogs having sphingosine 1-phosphate receptor agonist activity |
US7956195B2 (en) * | 2006-12-21 | 2011-06-07 | Abbott Laboratories | Process for the preparation and isolation of the individual stereoisomers of 1-amino, 3-substituted phenylcyclopentane-carboxylates |
US8669291B2 (en) | 2007-05-31 | 2014-03-11 | Sunovion Pharmaceuticals Inc. | Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors |
HUE030424T2 (en) | 2008-07-23 | 2017-05-29 | Arena Pharm Inc | Substituted 1,2,3,4-tetrahydrocyclopenta [b] indol-3-ylacetic acid derivatives useful in the treatment of autoimmune and inflammatory disorders |
BRPI0917923B1 (pt) | 2008-08-27 | 2022-04-05 | Arena Pharmaceuticals Inc | Derivado de ácido tricíclico substituído, sua composição, seu uso e processo para preparar a referida composição |
EP2344446A4 (en) | 2008-10-17 | 2012-04-04 | Akaal Pharma Pty Ltd | S1P RECEPTOR MODULATORS |
NZ592748A (en) | 2008-10-17 | 2013-01-25 | Akaal Pharma Pty Ltd | 2-Amino-(oxadiazol-3-yl)-benzofuran derivatives and their use as S1P receptor modulators |
AR074061A1 (es) * | 2008-10-31 | 2010-12-22 | Lexicon Pharmaceuticals Inc | Inhibidores de s1p liasa para el tratamiento de la malaria cerebral y formulacion farmaceutica |
AR074062A1 (es) * | 2008-10-31 | 2010-12-22 | Lexicon Pharmaceuticals Inc | Agonistas del receptor s1p para el tratamiento de la malaria cerebral y forma farmaceutica |
JP2012515788A (ja) | 2009-01-23 | 2012-07-12 | ブリストル−マイヤーズ スクイブ カンパニー | 自己免疫疾患および炎症性疾患の処置における、s1pアゴニストとしての置換オキサジアゾール誘導体 |
CN102361868A (zh) | 2009-01-23 | 2012-02-22 | 百时美施贵宝公司 | 作为1-磷酸-鞘氨醇激动剂的吡唑-1,2,4-噁二唑衍生物 |
CN102361867A (zh) | 2009-01-23 | 2012-02-22 | 百时美施贵宝公司 | 在治疗自身免疫疾病和炎性疾病中作为s1p激动剂的取代的噁二唑衍生物 |
US8399451B2 (en) | 2009-08-07 | 2013-03-19 | Bristol-Myers Squibb Company | Heterocyclic compounds |
EP3378854B1 (en) | 2010-01-27 | 2022-12-21 | Arena Pharmaceuticals, Inc. | Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof |
JP2013521301A (ja) | 2010-03-03 | 2013-06-10 | アリーナ ファーマシューティカルズ, インコーポレイテッド | S1p1受容体修飾物質およびその結晶形の調製のためのプロセス |
CN103119038B (zh) | 2010-04-23 | 2016-05-04 | 百时美施贵宝公司 | 作为1-磷酸鞘氨醇1受体激动剂的4-(5-异噁唑基或5-吡唑基-1,2,4-噁二唑基-3-基)扁桃酰胺 |
TW201206893A (en) | 2010-07-09 | 2012-02-16 | Abbott Healthcare Products Bv | Bisaryl (thio) morpholine derivatives as S1P modulators |
TW201643169A (zh) * | 2010-07-09 | 2016-12-16 | 艾伯維股份有限公司 | 作為s1p調節劑的螺-哌啶衍生物 |
TWI522361B (zh) | 2010-07-09 | 2016-02-21 | 艾伯維公司 | 作為s1p調節劑的稠合雜環衍生物 |
WO2012040532A1 (en) | 2010-09-24 | 2012-03-29 | Bristol-Myers Squibb Company | Substituted oxadiazole compounds and their use as s1p1 agonists |
AR085749A1 (es) | 2011-04-01 | 2013-10-23 | Novartis Ag | Formulaciones |
UY35338A (es) * | 2013-02-21 | 2014-08-29 | Bristol Myers Squibb Company Una Corporación Del Estado De Delaware | Compuestos bicíclicos moduladores de la actividad de s1p1 y composiciones farmacéuticas que los contienen |
WO2015009731A2 (en) | 2013-07-15 | 2015-01-22 | The Regents Of The University Of California | Azacyclic constrained analogs of fty720 |
UY36274A (es) | 2014-08-20 | 2016-02-29 | Bristol Myers Squibb Company Una Corporación Del Estado De Delaware | Compuestos bicíclicos sustituidos como agonistas selectivos de la actividad del receptor s1p1 acoplado a la proteína g |
MX2021011472A (es) | 2015-01-06 | 2022-08-17 | Arena Pharm Inc | Metodos de condiciones de tratamiento relacionadas con el receptor s1p1. |
KR102603199B1 (ko) | 2015-06-22 | 2023-11-16 | 아레나 파마슈티칼스, 인크. | S1p1 수용체-관련 장애에서의 사용을 위한 (r)-2-(7-(4-시클로펜틸-3-(트리플루오로메틸)벤질옥시)-1,2,3,4-테트라히드로시클로-펜타[b]인돌-3-일)아세트산 (화합물 1)의 결정성 l-아르기닌 염 |
CA2999177A1 (en) | 2015-09-24 | 2017-03-30 | The Regents Of The University Of California | Synthetic sphingolipid-like molecules, drugs, methods of their synthesis and methods of treatment |
WO2018045149A1 (en) * | 2016-09-02 | 2018-03-08 | Bristol-Myers Squibb Company | Substituted tricyclic heterocyclic compounds |
WO2018151873A1 (en) | 2017-02-16 | 2018-08-23 | Arena Pharmaceuticals, Inc. | Compounds and methods for treatment of primary biliary cholangitis |
CA3053416A1 (en) | 2017-02-16 | 2018-08-23 | Arena Pharmaceuticals, Inc. | Compounds and methods for treatment of inflammatory bowel disease with extra-intestinal manifestations |
KR101891051B1 (ko) * | 2018-01-29 | 2018-08-31 | 주식회사 세종바이오메드 | 스핑고신-1-포스페이트 유사체 및 이의 합성 방법 |
EP3847158A1 (en) | 2018-09-06 | 2021-07-14 | Arena Pharmaceuticals, Inc. | Compounds useful in the treatment of autoimmune and inflammatory disorders |
US11034669B2 (en) | 2018-11-30 | 2021-06-15 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
CN110808093A (zh) * | 2019-09-16 | 2020-02-18 | 中山大学孙逸仙纪念医院 | 一种放射性脑病临床预后的预测模型及其构建方法 |
CA3159378A1 (en) | 2019-10-31 | 2021-05-06 | ESCAPE Bio, Inc. | Solid forms of an s1p-receptor modulator |
CN117007818B (zh) * | 2023-08-04 | 2024-04-09 | 徐州医科大学科技园发展有限公司 | S1pr1作为靶点在开发或制备用于预防慢性疼痛相关记忆损伤疾病的药物中的应用 |
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JP3333510B2 (ja) * | 1991-10-02 | 2002-10-15 | スミスクライン・ビーチャム・コーポレイション | 抗アレルギー、抗炎症および腫瘍壊死因子抑制活性を有するシクロペンタンおよびシクロペンテン誘導体 |
US5314896A (en) * | 1991-11-20 | 1994-05-24 | Warner-Lambert Company | 1,3-substituted cycloalkenes and cycloalkanes as central nervous system agents |
JP2008530135A (ja) * | 2005-02-14 | 2008-08-07 | ユニバーシティ オブ バージニア パテント ファンデーション | アミノ基およびフェニル基で置換されたシクロアルカンならびに5員の複素環を含むスフィンゴシン=1−リン酸アゴニスト |
EP1991535A1 (en) * | 2006-02-21 | 2008-11-19 | University Of Virginia Patent Foundation | Phenyl-cycloalkyl and phenyl-heterocyclic derivatives as sip receptor agonists |
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2007
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- 2007-12-21 WO PCT/US2007/026263 patent/WO2008079382A1/en active Search and Examination
- 2007-12-21 UY UY30829A patent/UY30829A1/es not_active Application Discontinuation
- 2007-12-21 CL CL200703784A patent/CL2007003784A1/es unknown
- 2007-12-21 RU RU2009128062/04A patent/RU2009128062A/ru not_active Application Discontinuation
- 2007-12-21 AU AU2007338700A patent/AU2007338700A1/en not_active Abandoned
- 2007-12-21 TW TW096149594A patent/TW200838497A/zh unknown
- 2007-12-21 JP JP2009542960A patent/JP2010513532A/ja not_active Withdrawn
- 2007-12-21 CA CA002672727A patent/CA2672727A1/en not_active Abandoned
- 2007-12-21 AR ARP070105818A patent/AR064650A1/es not_active Application Discontinuation
- 2007-12-21 BR BRPI0720478-7A patent/BRPI0720478A2/pt not_active Application Discontinuation
- 2007-12-21 EP EP07863237A patent/EP2120575A4/en not_active Withdrawn
- 2007-12-21 KR KR1020097015385A patent/KR20090095659A/ko not_active Application Discontinuation
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2008
- 2008-01-02 PE PE2008000051A patent/PE20081561A1/es not_active Application Discontinuation
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2009
- 2009-06-02 CO CO09056803A patent/CO6180436A2/es not_active Application Discontinuation
- 2009-06-15 EC EC2009009435A patent/ECSP099435A/es unknown
- 2009-06-19 CR CR10872A patent/CR10872A/es not_active Application Discontinuation
- 2009-06-19 DO DO2009000149A patent/DOP2009000149A/es unknown
- 2009-06-22 NO NO20092376A patent/NO20092376L/no not_active Application Discontinuation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10689373B2 (en) | 2014-02-20 | 2020-06-23 | Takeda Pharmaceutical Company Limited | 1,2-substituted cyclopentanes as orexin receptor antagonists |
Also Published As
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UY30829A1 (es) | 2008-07-31 |
RU2009128062A (ru) | 2011-01-27 |
KR20090095659A (ko) | 2009-09-09 |
AR064650A1 (es) | 2009-04-15 |
EP2120575A1 (en) | 2009-11-25 |
NO20092376L (no) | 2009-06-22 |
MX2009006751A (es) | 2009-06-30 |
DOP2009000149A (es) | 2010-05-15 |
EP2120575A4 (en) | 2011-04-27 |
PE20081561A1 (es) | 2008-10-30 |
CO6180436A2 (es) | 2010-07-19 |
AU2007338700A1 (en) | 2008-07-03 |
ECSP099435A (es) | 2009-07-31 |
JP2010513532A (ja) | 2010-04-30 |
CA2672727A1 (en) | 2008-07-03 |
BRPI0720478A2 (pt) | 2014-01-14 |
WO2008079382A1 (en) | 2008-07-03 |
TW200838497A (en) | 2008-10-01 |
CR10872A (es) | 2009-07-23 |
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