CL2007002678A1 - Composicion que comprende a) un primer agente seleccionado de loratadina, bifonazol, sertralina, ritonavir y atorvastatina, entre otros; y b) un segundo agente seleccionado de amprenavir, nevirapina y rosiglitazona, entre otros; kit farmaceutico, uti - Google Patents

Composicion que comprende a) un primer agente seleccionado de loratadina, bifonazol, sertralina, ritonavir y atorvastatina, entre otros; y b) un segundo agente seleccionado de amprenavir, nevirapina y rosiglitazona, entre otros; kit farmaceutico, uti

Info

Publication number
CL2007002678A1
CL2007002678A1 CL200702678A CL2007002678A CL2007002678A1 CL 2007002678 A1 CL2007002678 A1 CL 2007002678A1 CL 200702678 A CL200702678 A CL 200702678A CL 2007002678 A CL2007002678 A CL 2007002678A CL 2007002678 A1 CL2007002678 A1 CL 2007002678A1
Authority
CL
Chile
Prior art keywords
selected agent
sertralina
rosiglitazona
nevirapina
loratadina
Prior art date
Application number
CL200702678A
Other languages
English (en)
Inventor
M Johansen Christopher M Lisa
Original Assignee
Combinatorx Singapore Pte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Combinatorx Singapore Pte Ltd filed Critical Combinatorx Singapore Pte Ltd
Publication of CL2007002678A1 publication Critical patent/CL2007002678A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CL200702678A 2006-09-14 2007-09-14 Composicion que comprende a) un primer agente seleccionado de loratadina, bifonazol, sertralina, ritonavir y atorvastatina, entre otros; y b) un segundo agente seleccionado de amprenavir, nevirapina y rosiglitazona, entre otros; kit farmaceutico, uti CL2007002678A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84446306P 2006-09-14 2006-09-14
US87406106P 2006-12-11 2006-12-11

Publications (1)

Publication Number Publication Date
CL2007002678A1 true CL2007002678A1 (es) 2008-03-28

Family

ID=39184352

Family Applications (1)

Application Number Title Priority Date Filing Date
CL200702678A CL2007002678A1 (es) 2006-09-14 2007-09-14 Composicion que comprende a) un primer agente seleccionado de loratadina, bifonazol, sertralina, ritonavir y atorvastatina, entre otros; y b) un segundo agente seleccionado de amprenavir, nevirapina y rosiglitazona, entre otros; kit farmaceutico, uti

Country Status (5)

Country Link
US (1) US20080161324A1 (es)
AR (1) AR062794A1 (es)
CL (1) CL2007002678A1 (es)
TW (1) TW200831112A (es)
WO (1) WO2008033466A2 (es)

Families Citing this family (141)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008535862A (ja) 2005-04-08 2008-09-04 キメリクス，インコーポレイテッド ポックスウイルス感染の治療のための化合物、組成物および方法
US20070003608A1 (en) * 2005-04-08 2007-01-04 Almond Merrick R Compounds, compositions and methods for the treatment of viral infections and other medical disorders
DK2056675T3 (en) 2006-10-12 2019-04-23 Galera Labs Llc Methods for treating oral mucositis
CL2008000070A1 (es) * 2007-01-17 2008-07-25 Lg Life Sciences Ltd Monosal del acido maleico (3-[({1-[(2-amino-9h-purin-9-il)metil]ciclopropil}oxi)metil]-8,8-dimetil-3,7-dioxo-2,4,6-trioxa-3 lambda 5-fosfanon-1-il-pivalato; composicion farmaceutica que comprende a dicha monosal; y uso para el tratamiento del virus h
US7981930B2 (en) * 2007-03-13 2011-07-19 Adamas Pharmaceuticals, Inc. Compositions and kits for treating influenza
US8003314B2 (en) 2007-04-16 2011-08-23 Diagnostic Hybrids, Inc. Methods for direct fluorescent antibody virus detection in liquids
JP5547069B2 (ja) * 2007-08-03 2014-07-09 バイオトロン リミテッド Ｃ型肝炎抗ウイルス組成物および方法
WO2009033725A1 (en) * 2007-09-11 2009-03-19 Mondobiotech Laboratories Ag Use of human neuropeptide as a therapeutic agent
EP2200611A4 (en) * 2007-09-14 2010-09-22 Biogen Idec Inc COMPOSITIONS AND METHODS FOR TREATING PROGRESSIVE MULTIFOCAL LEUCOENCEPHALEPATHY (PML)
US9149463B2 (en) 2007-09-18 2015-10-06 The Board Of Trustees Of The Leland Standford Junior University Methods and compositions of treating a Flaviviridae family viral infection
US9101628B2 (en) 2007-09-18 2015-08-11 The Board Of Trustees Of The Leland Stanford Junior University Methods and composition of treating a flaviviridae family viral infection
US8895598B2 (en) 2007-09-18 2014-11-25 The Board Of Trustees Of The Leland Stanford Junior University Methods of treating a flaviviridae family viral infection, compositions for treating a flaviviridae family viral infection, and screening assays for identifying compositions for treating a flaviviridae family viral infection
US8940730B2 (en) 2007-09-18 2015-01-27 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions of treating a Flaviviridae family viral infection
WO2009067225A2 (en) * 2007-11-20 2009-05-28 Concert Pharmaceuticals, Inc. Boceprevir derivatives for the treatment of hcv infections
WO2009094190A2 (en) * 2008-01-25 2009-07-30 Chimerix, Inc. Methods of treating viral infections
DE102008010362A1 (de) * 2008-02-18 2009-08-20 Florian Prof. Dr. Lang Sgk1 als therapeutisches und diagnostisches Target für virale Erkrankungen
US7935817B2 (en) * 2008-03-31 2011-05-03 Apotex Pharmachem Inc. Salt form and cocrystals of adefovir dipivoxil and processes for preparation thereof
PT2280973E (pt) 2008-04-23 2013-02-04 Gilead Sciences Inc Análogos de carba-nucleósido para tratamento antiviral
US20110110891A1 (en) * 2008-05-09 2011-05-12 Melanie Ott Methods of Treating Hepatitis C Virus Infection
JP2011530519A (ja) * 2008-08-06 2011-12-22 サイクローン・ファーマシューティカルズ・インコーポレイテッド 免疫調節化合物を用いたｃ型肝炎の治療または予防の方法
WO2010021681A2 (en) * 2008-08-18 2010-02-25 Combinatorx (Singapore) Pte. Ltd. Compositions and methods for treatment of viral diseases
WO2010020676A1 (en) * 2008-08-20 2010-02-25 Vib Vzw The use of topoisomerase type i inhibitors to treat viral infections
US9034863B2 (en) 2008-09-02 2015-05-19 The Board Of Trustees Of The University Of Illinois Compositions and methods for inhibiting entry of a hepatic virus
CA2735811A1 (en) * 2008-09-02 2010-03-11 Susan L. Uprichard Compositions and methods for inhibiting entry of a hepatic virus
JP2012503619A (ja) 2008-09-26 2012-02-09 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル Ｈｃｖ感染に対する抗ウイルス治療のための標的としての宿主細胞キナーゼ
EP2361242B1 (en) 2008-10-17 2018-08-01 Oryzon Genomics, S.A. Oxidase inhibitors and their use
CN101747258B (zh) * 2008-12-04 2013-12-25 中国人民解放军军事医学科学院毒物药物研究所 N-[(3aR，4R，4aR，5aS，6S，6aS)-1，3-二氧代-3，3a，4，4a，5，5a，6，6a-八氢-4，6-亚乙烯基环丙烷[f]异氮杂茚-2(1H)-基]-4-(三氟甲基)苯甲酰胺一水合物及其医药用途
WO2010084160A1 (en) 2009-01-21 2010-07-29 Oryzon Genomics S.A. Phenylcyclopropylamine derivatives and their medical use
US8475804B2 (en) * 2009-02-20 2013-07-02 U.S. Army Medical Research And Material Command Compositions and methods for treatment of filovirus-mediated diseases
US8975389B2 (en) 2009-03-02 2015-03-10 Alnylam Pharmaceuticals, Inc. Nucleic acid chemical modifications
CN102448458B (zh) 2009-03-18 2015-07-22 小利兰·斯坦福大学理事会 治疗黄病毒科病毒感染的方法和组合物
LT2421527T (lt) * 2009-04-25 2018-09-10 F. Hoffmann-La Roche Ag Farmakokinetinių savybių pagerinimo būdai
SG10201402281WA (en) 2009-05-12 2014-07-30 Romark Lab Lc Haloalkyl heteroaryl benzamide compounds
BRPI1014322A2 (pt) * 2009-06-26 2015-08-25 Romark Lab Lc Método para tratar infecção, e para interromper ou evitar a produção de partículas virais infecciosas, combinação, e, composição farmacêutica.
WO2011003071A1 (en) * 2009-07-02 2011-01-06 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Methods of modulating hepatitis c virus infection
EP2641906B1 (en) 2009-07-08 2015-04-22 Dermira (Canada), Inc. Tofa analogs useful in treating dermatological disorders or conditions
WO2011011519A1 (en) 2009-07-21 2011-01-27 Chimerix, Inc. Compounds, compositions and methods for treating ocular conditions
WO2011035225A1 (en) * 2009-09-21 2011-03-24 President And Fellows Of Harvard College Synergistic combination therapy
CA2773773C (en) 2009-09-21 2019-04-23 Gilead Sciences, Inc. Processes and intermediates for the preparation of 1'-substituted carba-nucleoside analogs
MX338041B (es) 2009-09-25 2016-03-30 Oryzon Genomics Sa Inhibidores de demetilasa-1 especificos de lisina y su uso.
EP2486002B1 (en) 2009-10-09 2019-03-27 Oryzon Genomics, S.A. Substituted heteroaryl- and aryl- cyclopropylamine acetamides and their use
US8653025B2 (en) * 2010-01-27 2014-02-18 AB Pharma Ltd. Polyheterocyclic compounds highly potent as HCV inhibitors
DK2534150T3 (en) 2010-02-12 2017-06-12 Chimerix Inc METHODS OF TREATING VIRUS INFECTION
US9186337B2 (en) 2010-02-24 2015-11-17 Oryzon Genomics S.A. Lysine demethylase inhibitors for diseases and disorders associated with Hepadnaviridae
US9616058B2 (en) 2010-02-24 2017-04-11 Oryzon Genomics, S.A. Potent selective LSD1 inhibitors and dual LSD1/MAO-B inhibitors for antiviral use
CN102188698B (zh) * 2010-03-08 2014-10-01 上海南方模式生物科技发展有限公司 核糖核酸酶和青蒿素的联用
WO2011123621A2 (en) 2010-04-01 2011-10-06 Alnylam Pharmaceuticals Inc. 2' and 5' modified monomers and oligonucleotides
MX2012012111A (es) 2010-04-19 2013-05-30 Oryzon Genomics Sa Inhibidores de demetilasa-1 especifica de lisina y su uso.
US9278135B2 (en) 2010-04-26 2016-03-08 Chimerix Inc. Methods of treating retroviral infections and related dosage regimes
BR112013001267A2 (pt) 2010-07-19 2016-05-17 Gilead Sciences Inc métodos para a preparação de pró-fármacos de fosforamidato diasteromericamente puro
SG186830A1 (en) 2010-07-22 2013-02-28 Gilead Sciences Inc Methods and compounds for treating paramyxoviridae virus infections
CN102335171B (zh) * 2010-07-27 2013-09-11 中国农业科学院上海兽医研究所 一类n-(2-噻唑)苯甲酰胺衍生物的应用
RS57331B1 (sr) 2010-07-29 2018-08-31 Oryzon Genomics Sa Inhibitori demetilaze za lsd1 zasnovani na arilciklopropilaminu i njihova medicinska upotreba
US9006449B2 (en) 2010-07-29 2015-04-14 Oryzon Genomics, S.A. Cyclopropylamine derivatives useful as LSD1 inhibitors
PE20140608A1 (es) 2010-09-22 2014-06-12 Alios Biopharma Inc Analogos de nucleotidos sustituidos
US20120082719A1 (en) * 2010-10-05 2012-04-05 Sam Poon Ang Compositions For Treating Chronic Viral Infections
US9061966B2 (en) 2010-10-08 2015-06-23 Oryzon Genomics S.A. Cyclopropylamine inhibitors of oxidases
WO2012072713A2 (en) 2010-11-30 2012-06-07 Oryzon Genomics, S.A. Lysine demethylase inhibitors for diseases and disorders associated with flaviviridae
WO2012096655A1 (en) * 2011-01-11 2012-07-19 Sam Poon Ang Compositions for treating chronic viral infections
US8569255B2 (en) 2011-02-02 2013-10-29 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of National Defence Post-exposure therapy of influenza A infections
EP3981395A1 (en) 2011-02-08 2022-04-13 Oryzon Genomics, S.A. Lysine demethylase inhibitors for myeloproliferative disorders
RU2478397C2 (ru) * 2011-02-09 2013-04-10 Государственное образовательное учреждение высшего профессионального образования "Уральская государственная медицинская академия Федерального агентства по здравоохранению и социальному развитию" (ГОУ ВПО УГМА Росздрава) Способ лечения врожденного гепатита в у детей первого года жизни
US9221760B2 (en) 2011-05-09 2015-12-29 Van Andel Research Institute Autophagy inhibitors
WO2012154944A2 (en) * 2011-05-10 2012-11-15 Stc.Unm Methods of treating autophagy-associated disorders and related pharmaceutical compositions, diagnostics, screening techniques and kits
WO2013006795A2 (en) 2011-07-07 2013-01-10 Humanitas International Foundation Antiviral compositions and methods of their use
US8871756B2 (en) * 2011-08-11 2014-10-28 Hoffmann-La Roche Inc. Compounds for the treatment and prophylaxis of Respiratory Syncytial Virus disease
US9149483B2 (en) 2011-09-26 2015-10-06 Galera Labs, Llc Methods for treatment of diseases
PE20141692A1 (es) 2011-10-20 2014-11-08 Oryzon Genomics Sa Compuestos de (hetero) aril ciclopropilamina como inhibidores de lsd1
CN107266345B (zh) 2011-10-20 2021-08-17 奥瑞泽恩基因组学股份有限公司 作为lsd1抑制剂的(杂)芳基环丙胺化合物
US8492386B2 (en) 2011-10-21 2013-07-23 Abbvie Inc. Methods for treating HCV
CN104383541A (zh) 2011-10-21 2015-03-04 艾伯维公司 用于治疗hcv的包含至少两种直接抗病毒剂和利巴韦林但无干扰素的方法
US8466159B2 (en) 2011-10-21 2013-06-18 Abbvie Inc. Methods for treating HCV
DK2583680T1 (da) 2011-10-21 2015-01-19 Abbvie Inc Mono (PSI-7977) eller kombinationsbehandling af DAA til anvendelse ved behandling af HCV
CN105030797B (zh) * 2011-10-25 2018-10-23 中国农业科学院上海兽医研究所 一类抗乙型脑炎病毒感染的组合物及其应用
CN102423488B (zh) * 2011-11-23 2013-07-10 石家庄中硕药业集团有限公司 一种治疗带状疱疹的药物组合物
EP2794630A4 (en) 2011-12-22 2015-04-01 Alios Biopharma Inc SUBSTITUTED PHOSPHORTHIOAT NUCLEOTIDE ANALOGUE
WO2013142159A1 (en) * 2012-03-21 2013-09-26 Alios Biopharma, Inc. Pharmaceutical combinations comprising a thionucleotide analog
NZ631601A (en) 2012-03-21 2016-06-24 Alios Biopharma Inc Solid forms of a thiophosphoramidate nucleotide prodrug
WO2013142157A1 (en) * 2012-03-22 2013-09-26 Alios Biopharma, Inc. Pharmaceutical combinations comprising a thionucleotide analog
CN102626404B (zh) * 2012-03-22 2013-07-17 华东理工大学 二咖啡酰基奎尼酸类化合物的用途
MY151083A (en) * 2012-03-30 2014-04-04 Univ Malaya Antiviral composition against flavivirus
BR112014026158A2 (pt) 2012-04-18 2017-06-27 Hadasit Med Res Service métodos e composições para o tratamento de infecções virais
WO2013159243A1 (en) * 2012-04-25 2013-10-31 National Institute Of Biological Sciences, Beijing Compositions and uses of functional receptor for hbv/hdv virus
US20150164858A1 (en) * 2012-05-22 2015-06-18 King Abdullah University Of Science And Technology Combination comprising parthenolide for use in the treatment of alzheimer's disease and other neurodegenerative disorders
US20140066438A1 (en) * 2012-08-29 2014-03-06 Academia Sinica Dopamine receptor d2 antagonist for prevention and treatment of flavivirus infection
WO2014052836A2 (en) 2012-09-27 2014-04-03 Dunman Paul M Methods and compositions for treating infection
WO2014062621A1 (en) * 2012-10-15 2014-04-24 Stc.Unm Treatment of autophagy-based disorders and related pharmaceutical compositions, diagnostic and screening assays and kits
WO2014074604A2 (en) * 2012-11-08 2014-05-15 National Health Research Institutes Combination therapy for hepatitis c virus infection
WO2014127378A2 (en) * 2013-02-18 2014-08-21 Spring Bank Pharmaceuticals, Inc. Design of short oligonucleotides as vaccine adjuvants and therapeutic agents
WO2014164667A1 (en) * 2013-03-11 2014-10-09 Georgetown University Dengue and west nile virus protease inhibitors
WO2014169355A1 (en) * 2013-04-16 2014-10-23 Monash University Method of viral inhibition
CN104109112B (zh) * 2013-04-19 2017-02-08 北京勤邦生物技术有限公司 赛庚啶半抗原、人工抗原和抗体及其制备方法和应用
CN103720684B (zh) * 2013-12-11 2015-10-21 武汉威立得生物医药有限公司 盐酸双环胺在制备治疗或预防流感病毒感染药物中的应用
US9919034B2 (en) 2014-03-28 2018-03-20 Tamir Biotechnology, Inc. Methods of treating and prophylactically protecting mammalian patients infected by viruses classified in Baltimore group V
EP3125891A4 (en) * 2014-03-31 2017-08-09 Mirx Pharmaceuticals, LLC Novel hdmx inhibitors and their use for cancer treatment
US10835598B2 (en) 2014-08-18 2020-11-17 Orgenesis Inc. Prophylactic protection against viral infections, particularly HIV
MY171137A (en) * 2014-09-11 2019-09-27 Univ Sains Malaysia Thioguanine derivatives
WO2016061210A2 (en) * 2014-10-14 2016-04-21 The Trustees Of Columbia University In The City Of New York Novel viruses found in rattus norvegicus and uses thereof
TWI687432B (zh) 2014-10-29 2020-03-11 美商基利科學股份有限公司 絲狀病毒科病毒感染之治療
EP3307238A1 (en) 2015-06-15 2018-04-18 Tamir Biotechnology, Inc. Pharmaceuticals for treatment of viral infections of the eye
US20180140620A1 (en) 2015-06-15 2018-05-24 Newsouth Innovations Pty Limited Pharmaceutical Combinations of Organo-Arsenoxide Compounds and mTOR Inhibitors
LT3785717T (lt) 2015-09-16 2022-04-11 Gilead Sciences, Inc. Coronaviridae infekcijų gydymo būdai
FR3041529A1 (fr) * 2015-09-24 2017-03-31 Inst De Rech Pour Le Dev (Ird) Compositions utiles pour le traitement des arboviroses
US10071062B2 (en) * 2015-12-08 2018-09-11 Cipla Limited Methods for the treatment of hepatitis C
US9763901B2 (en) 2015-12-09 2017-09-19 Cipla Limited Treatment of hepatitis C using histone deacetylase inhibitors
WO2017123809A1 (en) * 2016-01-12 2017-07-20 Taipei Medical University Compounds for inhibiting cancer and virus
CN107849074A (zh) * 2016-01-19 2018-03-27 四川海思科制药有限公司 一种核苷类似物的烷氧烷基酯前药及其应用
WO2017155082A1 (ja) * 2016-03-11 2017-09-14 国立大学法人鹿児島大学 抗肝腫瘍ウイルス剤
CA3022119A1 (en) 2016-04-28 2017-11-02 Emory University Alkyne containing nucleotide and nucleoside therapeutic compositions and uses related thereto
US20210030785A1 (en) * 2016-05-05 2021-02-04 Starpharma Pty Ltd. Method of prophylaxis of zika virus infection
WO2018017426A1 (en) * 2016-07-16 2018-01-25 Florida State University Research Foundation, Inc. Compounds and methods for treatment and prevention of flavivirus infection
WO2018022868A1 (en) * 2016-07-27 2018-02-01 Lowe Henry C Pi 4-kinase inhibitor as a therapeutic for viral hepatitis, cancer, malaria. autoimmune disorders and inflammation, and a radiosensitizer and immunosuppressant
JP6902336B2 (ja) * 2016-08-01 2021-07-14 永展国際有限公司Ｆｏｒｅｖｅｒ Ｃｈｅｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｌｉｍｉｔｅｄ ５−［２−［（６−アミノ）−９ｈ−プリン−９−イル］エチルアミノ］−１−ペンタノール多結晶体
EP3555293A4 (en) * 2016-12-15 2020-08-12 Meharry Medical College ANTIVIRAL AGENTS
WO2018140858A1 (en) 2017-01-30 2018-08-02 Western New England University Thiol isomerases inhibitors and use thereof
US10682368B2 (en) 2017-03-14 2020-06-16 Gilead Sciences, Inc. Methods of treating feline coronavirus infections
AU2018262501B2 (en) 2017-05-01 2020-12-10 Gilead Sciences, Inc. Crystalline forms of (S) 2 ethylbutyl 2 (((S) (((2R,3S,4R,5R) 5 (4 aminopyrrolo[2,1-f] [1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2 yl)methoxy)(phenoxy) phosphoryl)amino)propanoate
CN111093627B (zh) 2017-07-11 2024-03-08 吉利德科学公司 用于治疗病毒感染的包含rna聚合酶抑制剂和环糊精的组合物
US10555942B2 (en) 2017-10-10 2020-02-11 Florida State University Research Foundation, Inc. Emetine compounds for treatment and prevention of flavivirus infection
WO2019180708A1 (en) 2018-03-22 2019-09-26 Hadasit Medical Research Services And Development Ltd. Methods and synergic compositions for treating viral infections
CN108310387A (zh) * 2018-03-23 2018-07-24 昆药集团股份有限公司 一种用于预防和/或治疗脑缺血的组合产品及其应用
GB201805665D0 (en) * 2018-04-05 2018-05-23 Univ Nottingham Antiviral Compounds And Methods
US20200323830A1 (en) * 2019-04-09 2020-10-15 Tremeau Pharmaceuticals, Inc. Treatment of viral hemorrhagic fevers with etoricoxib
CN110559291A (zh) * 2019-06-28 2019-12-13 武汉威立得生物医药有限公司 联苯苄唑在制备治疗或预防流感病毒感染的药物中的应用
WO2021035068A2 (en) * 2019-08-20 2021-02-25 New York Blood Center, Inc. Inhibitors of zika virus infection
WO2021043234A1 (en) * 2019-09-04 2021-03-11 City University Of Hong Kong Use of berbamine or its analogue for preventing or treating rna virus infection
CN110623968A (zh) * 2019-10-23 2019-12-31 武汉威立得生物医药有限公司 伊文思蓝在制备药物中的用途及药物组合物
TWI789695B (zh) 2020-01-27 2023-01-11 美商基利科學股份有限公司 治療sars cov-2感染之方法
CN113265433B (zh) * 2020-02-17 2023-12-26 中国科学院分子植物科学卓越创新中心 双功能碳苷糖基转移酶及其应用
AU2021234308C1 (en) 2020-03-12 2024-02-22 Gilead Sciences, Inc. Methods of preparing 1'-cyano nucleosides
WO2021207049A1 (en) 2020-04-06 2021-10-14 Gilead Sciences, Inc. Inhalation formulations of 1'-cyano substituted carbanucleoside analogs
US20230285441A1 (en) * 2020-04-15 2023-09-14 Georgia State University Research Foundation, Inc. Treatment of coronavirus infections with auranofin
CN113797334A (zh) * 2020-05-28 2021-12-17 中国科学院理化技术研究所 青蒿素&吲哚菁绿/超薄水滑石纳米片复合材料及其制备与应用
TW202203941A (zh) 2020-05-29 2022-02-01 美商基利科學股份有限公司 瑞德西韋之治療方法
CN115996928A (zh) 2020-06-24 2023-04-21 吉利德科学公司 1’-氰基核苷类似物及其用途
TW202233204A (zh) 2020-08-27 2022-09-01 美商基利科學股份有限公司 用於治療病毒感染之化合物及方法
TWI755187B (zh) * 2020-12-07 2022-02-11 義守大學 葉綠素酯的抗病毒感染用途
CN114533740B (zh) * 2022-02-10 2024-04-12 广州威生医药科技有限公司 一种公猪气味剂组合物及其应用
WO2023167944A1 (en) 2022-03-02 2023-09-07 Gilead Sciences, Inc. Compounds and methods for treatment of viral infections
CN114671761B (zh) * 2022-04-18 2024-05-31 中国农业科学院烟草研究所(中国烟草总公司青州烟草研究所) 一种制备β-紫罗兰酮半抗原的方法、人工抗原和抗体
CN115969828B (zh) * 2022-09-27 2024-02-06 中国人民解放军海军军医大学 替拉曲可在制备预防和/或治疗黄热病毒感染的药物中的应用

Family Cites Families (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1796977A (en) * 1931-03-17 Sigkjeents
US2870151A (en) * 1959-01-20 Mqrpholine -ethers
US2233970A (en) * 1941-03-04 Quinoline compound and process of
US2145579A (en) * 1934-04-17 1939-01-31 Schering Kahlbaum Ag Heterocyclic azo derivatives
US2464203A (en) * 1943-05-21 1949-03-15 Boots Pure Drug Co Ltd Manufacture of dienoestrol
US2465505A (en) * 1944-12-05 1949-03-29 Hoffmann La Roche Process for the manufacture of 3, 4-di-(p-hydroxy-phenyl)-hexadiene-2, 4
BE522523A (es) * 1952-10-25
NL108827C (es) * 1956-04-09
US2970139A (en) * 1958-05-20 1961-01-31 Duschinsky Robert 5-fluorouracil nucleotides and preparation thereof
DE1122944B (de) * 1960-04-06 1962-02-01 Schering Ag Verfahren zur Herstellung von 1ª‡-Methyl-3-ketosteroiden
US3310553A (en) * 1962-09-25 1967-03-21 Pfizer & Co C Alkylated thioxathenesulfonamides
GB991651A (en) * 1963-02-20 1965-05-12 Dumex Ltd As Dibenzocycloheptadiene derivatives
GB1177525A (en) * 1967-04-13 1970-01-14 Leo Ab New Heterocyclic Aminoketones of Therapeutic Interest
US3553192A (en) * 1968-07-15 1971-01-05 Robugen Gmbh Substituted (2'-deoxyribosyl) uracil compounds, compositions containing same and process of making and using same
DE1909065A1 (de) * 1969-02-18 1970-08-20 Goldschmidt Ag Th N-substituierte Diaminopyridine und ihre Verwendung als Biocide
US4250094A (en) * 1971-04-28 1981-02-10 The Upjohn Company 1-(Aminoalkyl) substituted-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines
BE794742A (fr) * 1972-02-01 1973-07-30 Bayer Ag Nouveaux di-n-oxydes (1,4) de benzo-1,2,4-triazine, leur procede de preparation et leur application comme medicaments et additifs de nutrition
GB1490852A (en) * 1974-09-12 1977-11-02 Leo Pharm Prod Ltd Fusidic acid derivatives
US4279817A (en) * 1975-05-30 1981-07-21 The United States Of America As Represented By The Department Of Health & Human Services Method for producing dimer alkaloids
US4190594A (en) * 1975-11-03 1980-02-26 Johnson & Johnson Retinoic acid derivatives
FR2330383A1 (fr) * 1975-11-06 1977-06-03 Synthelabo Nouveaux ethers de phenols substitues, leurs sels, leur preparation et les medicaments qui les renferment
IE44263B1 (en) * 1975-12-03 1981-09-23 Leo Pharm Prod Ltd New fusidic acid derivatives
US4080455A (en) * 1975-12-16 1978-03-21 Taisho Pharmaceutical Company Limited 5-Fluoropyrimidin-4-one compositions
CH619468A5 (es) * 1976-01-12 1980-09-30 Sandoz Ag
US4144346A (en) * 1977-01-31 1979-03-13 Janssen Pharmaceutica N.V. Novel 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles
US4141907A (en) * 1977-10-20 1979-02-27 Eli Lilly And Company Deoxynarasin antibiotics
US4136174A (en) * 1978-01-18 1979-01-23 E. R. Squibb & Sons, Inc. Benzimidazolecarbamates and method
SE7903361L (sv) * 1978-04-20 1979-10-21 Johnson Matthey Co Ltd Kompositioner innehallande platina
IT1094864B (it) * 1978-05-29 1985-08-10 Tosi Franco Ist Derivati della bromexina e procedimento per la loro preparazione
US4192803A (en) * 1978-09-15 1980-03-11 American Cyanamid Company 5H-Pyrrolo[2,1-c][1,4]benzodiazepine derivatives
US4254129A (en) * 1979-04-10 1981-03-03 Richardson-Merrell Inc. Piperidine derivatives
US4254130A (en) * 1979-04-10 1981-03-03 Richardson-Merrell Inc. Piperidine derivatives
US4319039A (en) * 1979-06-15 1982-03-09 Merck & Co., Inc. Preparation of ammonium salt of hypocholesteremic fermentation product
US4316885A (en) * 1980-08-25 1982-02-23 Ayerst, Mckenna And Harrison, Inc. Acyl derivatives of rapamycin
US4376863A (en) * 1981-08-21 1983-03-15 Merck & Co., Inc. Hypocholesterolemic fermentation products
US4507311A (en) * 1981-12-07 1985-03-26 Ciba-Geigy Corporation Imidazo[1,2-c][1,3]benzodiazepines
US4503072A (en) * 1982-12-22 1985-03-05 Merck & Co., Inc. Antihypercholesterolemic compounds
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
US4894366A (en) * 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
US4729999A (en) * 1984-10-12 1988-03-08 Bcm Technologies Antiestrogen therapy for symptoms of estrogen deficiency
GB8517360D0 (en) * 1985-07-09 1985-08-14 Erba Farmitalia Substituted androsta-1,4-diene-3,17-diones
US4725622A (en) * 1986-01-23 1988-02-16 Syntex (U.S.A.) Inc. Mycophenolic acid derivatives in the treatment of rheumatoid arthritis
US4753935A (en) * 1987-01-30 1988-06-28 Syntex (U.S.A.) Inc. Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions
US4727069A (en) * 1987-01-30 1988-02-23 Syntex (U.S.A.) Inc. Heterocyclic aminoalkyl esters of mycophenolic acid, derivatives thereof and pharmaceutical compositions
US4719229A (en) * 1987-05-13 1988-01-12 Merck & Co., Inc. Antihypercholesterolemic agents
US5091378A (en) * 1987-05-22 1992-02-25 E. R. Squibb & Sons, Inc. Phosphorus-containing HMG-CoA reductase inhibitors, new intermediates and method
US4798823A (en) * 1987-06-03 1989-01-17 Merck & Co., Inc. New cyclosporin analogs with modified "C-9 amino acids"
FI95572C (fi) * 1987-06-22 1996-02-26 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
US5382600A (en) * 1988-01-22 1995-01-17 Pharmacia Aktiebolag 3,3-diphenylpropylamines and pharmaceutical compositions thereof
US4804770A (en) * 1988-04-29 1989-02-14 E. R. Squibb & Sons, Inc. Process for preparing a keto-phosphonate intermediate useful in preparing HMG-CoA reductase inhibitors
US5284826A (en) * 1989-07-24 1994-02-08 Sandoz Ltd. 0-hydroxyethyl and acyloxyethyl derivatives of [ser]8 cyclosporins
US5275693A (en) * 1990-03-30 1994-01-04 Yamato Kako Kabushiki Kaisha Film forming process
US5112857A (en) * 1990-09-04 1992-05-12 Merck & Co., Inc. Hmg-coa reductase inhibitor metabolites
US5380916A (en) * 1990-11-02 1995-01-10 University Of Florida Method for the isolation and purification of taxane derivatives
US5177080A (en) * 1990-12-14 1993-01-05 Bayer Aktiengesellschaft Substituted pyridyl-dihydroxy-heptenoic acid and its salts
US5714512A (en) * 1991-07-08 1998-02-03 Rhone-Poulenc Rorer, S.A. Compositions containing taxane derivatives
US5189042A (en) * 1991-08-22 1993-02-23 Merck & Co. Inc. Fluoromacrolides having immunosuppressive activity
US6028205A (en) * 1991-09-23 2000-02-22 Florida State University C2 tricyclic taxanes
US5284865A (en) * 1991-09-23 1994-02-08 Holton Robert A Cyclohexyl substituted taxanes and pharmaceutical compositions containing them
US6018073A (en) * 1991-09-23 2000-01-25 Florida State University Tricyclic taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
US5489601A (en) * 1991-09-23 1996-02-06 Florida State University Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them
US5714513A (en) * 1991-09-23 1998-02-03 Florida State University C10 taxane derivatives and pharmaceutical compositions
US5430160A (en) * 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
US5721268A (en) * 1991-09-23 1998-02-24 Florida State University C7 taxane derivatives and pharmaceutical compositions containing them
US5283253A (en) * 1991-09-23 1994-02-01 Florida State University Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
US6011056A (en) * 1991-09-23 2000-01-04 Florida State University C9 taxane derivatives and pharmaceutical compositions containing them
US5710287A (en) * 1991-09-23 1998-01-20 Florida State University Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them
US5284840A (en) * 1992-06-12 1994-02-08 Merck & Co., Inc. Alkylidene macrolides having immunosuppressive activity
FR2698363B1 (fr) * 1992-11-23 1994-12-30 Rhone Poulenc Rorer Sa Nouveaux dérivés du taxane, leur préparation et les compositions qui les contiennent.
US5380751A (en) * 1992-12-04 1995-01-10 Bristol-Myers Squibb Company 6,7-modified paclitaxels
US5484926A (en) * 1993-10-07 1996-01-16 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
US5973160A (en) * 1992-12-23 1999-10-26 Poss; Michael A. Methods for the preparation of novel sidechain-bearing taxanes
TW467896B (en) * 1993-03-19 2001-12-11 Bristol Myers Squibb Co Novel β-lactams, methods for the preparation of taxanes and sidechain-bearing taxanes
US5380738A (en) * 1993-05-21 1995-01-10 Monsanto Company 2-substituted oxazoles further substituted by 4-fluorophenyl and 4-methylsulfonylphenyl as antiinflammatory agents
US5380897A (en) * 1993-05-25 1995-01-10 Hoeschele; James D. Tri(platinum) complexes
US5393790A (en) * 1994-02-10 1995-02-28 G.D. Searle & Co. Substituted spiro compounds for the treatment of inflammation
US5380879A (en) * 1994-02-18 1995-01-10 Syntex (U.S.A.) Inc. Derivatives of mycophenolic acid
US5493030A (en) * 1994-02-18 1996-02-20 Syntex (U.S.A.) Inc. 5-substituted derivatives of mycophenolic acid
US5384332A (en) * 1994-05-11 1995-01-24 Eli Lilly And Company Methods for inhibiting aortal smooth muscle cell proliferation and restenosis with 1,1,2-triphenylbut-1-ene derivatives
US5486534A (en) * 1994-07-21 1996-01-23 G. D. Searle & Co. 3,4-substituted pyrazoles for the treatment of inflammation
US5596008A (en) * 1995-02-10 1997-01-21 G. D. Searle & Co. 3,4-Diaryl substituted pyridines for the treatment of inflammation
RU2200158C2 (ru) * 1995-02-13 2003-03-10 Джи.Ди.Сирл энд Ко. Замещенные изоксазолы, фармацевтические композиции на их основе и способ подавления воспалений
EP0828718A1 (en) * 1995-06-02 1998-03-18 G.D. SEARLE & CO. Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
US6177456B1 (en) * 1995-10-02 2001-01-23 Xechem International, Inc. Monohalocephalomannines having anticancer and antileukemic activity and method of preparation therefor
US5709797A (en) * 1996-06-05 1998-01-20 Poli Industria Chimica S.P.A. Method of isolating cyclosporins
US6017935A (en) * 1997-04-24 2000-01-25 Bristol-Myers Squibb Company 7-sulfur substituted paclitaxels
US6342507B1 (en) * 1997-09-05 2002-01-29 Isotechnika, Inc. Deuterated rapamycin compounds, method and uses thereof
US6506766B1 (en) * 1998-02-13 2003-01-14 Abbott Laboratories Glucocortiocoid-selective antinflammatory agents
EP1231919B1 (en) * 1999-09-08 2015-09-30 Sloan-Kettering Institute For Cancer Research Derivatives of 1-amino-1-(hetero)arylaminocarbonyl-6-hydroxyaminocarbonylhexane useful in the treatment of tumors
US6290445B1 (en) * 2000-04-18 2001-09-18 Avibank Mfg., Inc. Non-removable structural threaded fastener with threads of lesser outer diameter than the shank and method of forming same
US20020013334A1 (en) * 2000-06-15 2002-01-31 Robl Jeffrey A. HMG-CoA reductase inhibitors and method
US6541510B2 (en) * 2000-09-28 2003-04-01 Immugen Pharmaceuticals, Inc. Antiviral methods and compounds
US6673818B2 (en) * 2001-04-20 2004-01-06 Pharmacia Corporation Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation
PL373523A1 (en) * 2002-04-22 2005-09-05 Pfizer Products Inc. Indol-2-ones as selective inhibitors of cyclooxygenase-2
KR100478467B1 (ko) * 2002-06-24 2005-03-23 씨제이 주식회사 피라졸-3-온 유도체, 그 제조방법 및 약제학적 조성물
AU2003248748A1 (en) * 2002-06-28 2004-01-19 Idenix (Cayman) Limited 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
KR100470075B1 (ko) * 2002-11-21 2005-02-05 씨제이 주식회사 1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물
JP4767848B2 (ja) * 2003-07-11 2011-09-07 ユニヴァーシティ オブ ケンタッキー リサーチ ファウンデーション パルテノライド誘導体を抗白血病薬及び細胞毒性薬として使用する方法
US20060039890A1 (en) * 2004-08-20 2006-02-23 Renshaw Perry F Treatment of psychological and cognitive disorders using a cholesterol -lowering agent in combination with an antidepressant

Also Published As

Publication number Publication date
WO2008033466A3 (en) 2008-12-11
AR062794A1 (es) 2008-12-03
WO2008033466A2 (en) 2008-03-20
TW200831112A (en) 2008-08-01
US20080161324A1 (en) 2008-07-03

Similar Documents

Publication Publication Date Title
CL2007002678A1 (es) Composicion que comprende a) un primer agente seleccionado de loratadina, bifonazol, sertralina, ritonavir y atorvastatina, entre otros; y b) un segundo agente seleccionado de amprenavir, nevirapina y rosiglitazona, entre otros; kit farmaceutico, uti
EP1904052A4 (en) LIQUID PHARMACEUTICAL COMPOSITIONS OF DOCATEXEL
NO345139B1 (no) Florizinanaloger som inhibitorer av glukosekotransportør 2 og farmasøytisk sammensetning derav
DK1962807T3 (da) Film-coatet og/eller granuleret calcium-indeholdende forbindelser og anvendelse deraf i farmaceutiske sammensætninger
IL192613A (en) Cycloalkylamines and their pharmaceutical compositions
CL2007002910A1 (es) Composicion farmaceutica que comprende compuestos derivados de anillos monociclicos, biciclicos o triciclicos, inhibidores de amidohidrolasa de acidos grasos; complejo que comprende al compuesto; y uso en el tratamiento de enfermedades tales como dol
IL194460A0 (en) Deazapurine derivatives and pharmaceutical compositions containing the same
IL183372A (en) Pharmaceuticals containing azalastine
CL2007001325A1 (es) Compuestos derivados de biciclos, inhibidores de cept; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar hiperlipidemia, arterioesclerosis, entre otras enfermedades.
IL193776A0 (en) A pharmaceutical composition containing an aminosalicylate active agent
FI20050808A0 (fi) Värikoostumus ja happi-indikaattori
IL183689A0 (en) Pharmaceutical compositions and kits for improving the structure and function of arterioles
ZA200809998B (en) Stable pharmaceutical composition containing docetaxel and a method of manufacturing the same
DK2033629T3 (da) Fast farmaceutisk sammensætning omfattende valsartan
BRPI0719877A2 (pt) Elementos de engaxetamento randômicos e coluna contendo os mesmos
DK1968990T3 (da) Vandopløselig benzoazepinforbindelse og farmaceutisk sammensætning deraf
BRPI0716495A2 (pt) (r,r)-fenoterol e análogos de (r,r)- ou (r,s)-fenoterol, uso dos mesmos na preparação de composição farmacêutica e composição farmacêutica compreendendo o referidos compostos.
BRPI0717369A2 (pt) Composto, medicamento, composição farmacêutica que o contém e uso do composto.
EP1819323A4 (en) PHARMACEUTICAL COMPOSITION WITH ANTI-SKIN COMPOSER
BRPI0716698A2 (pt) Composto, composição farmacêutica e uso de um composto
BRPI0611748A2 (pt) composto, composição farmacêutica, e, uso de uma composição farmacêutica
IL186102A0 (en) Alpha ketoamide derivatives and pharmaceutical compositions containing the same
BRPI0720684A2 (pt) composto, medicamento, composição farmacêutica que contém e uso do composto
IL197273A0 (en) Pharmaceutical and sunscreen compositions comprising caspase-14
PL1791530T3 (pl) Kompozycja farmaceutyczna zawierająca psychostymulant