CH97979A - Process for the preparation of triallyl xanthine. - Google Patents

Process for the preparation of triallyl xanthine.

Info

Publication number
CH97979A
CH97979A CH97979DA CH97979A CH 97979 A CH97979 A CH 97979A CH 97979D A CH97979D A CH 97979DA CH 97979 A CH97979 A CH 97979A
Authority
CH
Switzerland
Prior art keywords
xanthine
triallyl
preparation
ether
alcohol
Prior art date
Application number
Other languages
German (de)
Inventor
Gesellschaft Fuer Chemis Basel
Original Assignee
Chem Ind Basel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chem Ind Basel filed Critical Chem Ind Basel
Publication of CH97979A publication Critical patent/CH97979A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)

Description

  

  Verfahren zur Darstellung von     Triallylganthin.       Es wurde gefunden,     dass    man in glatter  Weise zu dem bisher unbekannten     Triallyl-          xanthin    gelangen kann, wenn man     Diallyl-          xanthin    mit     allylierenden    Mitteln in alkali  scher Lösung     behandelt.     



  Die neue Verbindung, welche .das     Allyl-          homologe    des     Coffeins    darstellt, soll zu     the-          rapeutischen    Zwecken verwendet werden..  



  <I>Beispiel:</I>  1     Mol.        Diallylxanthin    wird mit 1     Mol.          Allylbromid    und 1     Mol.    alkoholischer Kali  lauge auf .dem     Wasserbade    bei<B>80'</B> während  6 Stunden     erwärmt.    Hierauf destilliert man  den Alkohol ab, macht den Rückstand alka  lisch und extrahiert denselben mit Äther.  Der Ätherextrakt wird über Pottasche ge  trocknet und destilliert.    Das     Triallylxanthin    siedet bei<B>176'</B> (0,05  mm), schmilzt     äci    57 bis 58  und ist in Was  ser unlöslich, in. Äther, Alkohol und den üb  rigen üblichen organischen Lösungsmitteln  löslich.



  Process for the preparation of triallylganthine. It has been found that the hitherto unknown triallyl xanthine can be obtained smoothly if one treats diallyl xanthine with allylating agents in an alkaline solution.



  The new compound, which represents the allyl homologue of caffeine, is to be used for therapeutic purposes.



  <I> Example: </I> 1 mol. Diallylxanthine is heated with 1 mol. Allyl bromide and 1 mol. Alcoholic potassium hydroxide on the water bath at <B> 80 '</B> for 6 hours. The alcohol is then distilled off, the residue is made alkaline and extracted with ether. The ether extract is dried over potash and distilled. The triallyl xanthine boils at <B> 176 '</B> (0.05 mm), melts from 57 to 58 and is insoluble in water, soluble in ether, alcohol and the other common organic solvents.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung -von Triallyl- xanthin, .dadurch gekennzeichnet, dass man Diallylxanthin in alkalischer Lösung mit allylierenden Mitteln behandelt. Das Triallyl- xanthin siedet bei 176 (0,05 mm), schmilzt bei 5 7 bis 58 und ist in Wasser unlöslich, in Äther, Alkohol und den übrigen üblichen organischen Lösungsmitteln löslich. PATENT CLAIM: Process for the preparation of triallyl xanthine, characterized in that diallyl xanthine is treated in alkaline solution with allylating agents. The triallyl xanthine boils at 176 (0.05 mm), melts at 57 to 58 and is insoluble in water, soluble in ether, alcohol and the other common organic solvents.
CH97979D 1921-10-07 1921-10-07 Process for the preparation of triallyl xanthine. CH97979A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH97979T 1921-10-07

Publications (1)

Publication Number Publication Date
CH97979A true CH97979A (en) 1923-02-16

Family

ID=4355744

Family Applications (1)

Application Number Title Priority Date Filing Date
CH97979D CH97979A (en) 1921-10-07 1921-10-07 Process for the preparation of triallyl xanthine.

Country Status (1)

Country Link
CH (1) CH97979A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2420346A1 (en) * 1977-04-02 1979-10-19 Hoechst Ag MEDICINAL PRODUCTS CONTAINING ALCENYLXANTHINS AND THEIR PREPARATION PROCESS
US4207321A (en) 1977-04-02 1980-06-10 Hoechst Aktiengesellschaft Pharmaceutical compositions containing xanthines

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2420346A1 (en) * 1977-04-02 1979-10-19 Hoechst Ag MEDICINAL PRODUCTS CONTAINING ALCENYLXANTHINS AND THEIR PREPARATION PROCESS
US4207321A (en) 1977-04-02 1980-06-10 Hoechst Aktiengesellschaft Pharmaceutical compositions containing xanthines

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