CH644451A5 - CUFFET WREATH FOR ANALYZER. - Google Patents

Description

The invention relates to a cuvette ring for an analyzable thermoplastic, the lower device, which has several compartments molded into it under the centrifugal principle under a photometric disk, and the upper shear measurement of the sample to be analyzed, where the 40 disk is glued onto the lower one or is welded on and covers the wreath from an arrangement of several wreath-promoting at least a part of each compartment. Cuvettes arranged in a cuvette made of thermoplastic vignette arrangements of this type form an inseparable single plastic, the individual cuvette of which consists of three units which, although also having good mechanical stability, has communicating chambers, namely one in which it is not possible to form individual cuvettes remove the sample chamber, a reagent chamber and a photometric unit and destroy them separately.

see measuring chamber, the main axes of the sample and the invention is based on the task, annular

The reagent chambers are perpendicular to the circulation level and to further simplify the cuvette arrangements of the type described in the “Cobas-Bio” -Pro main axis of the measuring chamber together with the circulation level and thereby reduce the cost. The simplification should make it possible to

According to the centrifugal principle and under the photometric so retaining ring, without, however, the advantage of measuring the analysis of the sample to be analyzed, the analysis, which lies in the separation of individual cuvettes.

Sen devices are known. According to the invention, this object is preferably achieved by

sets, where very small amounts of sample are analyzed in a short time, that each cuvette has to protrude laterally at the upper edge and where, according to the nature of the tongue to be performed, the neighboring cuvette has the ability to use photometric methods in whole or in part for analysis and attached to it. Zen is particularly advantageous. This is particularly the field of clinical chemistry if the tongue is attached to the upper edge of the next but one side analysis, where the task frequently arises, for example by attaching the neighboring cuvette, preferably with this glucose, urea, uric acid, cholesterol or else Is welded. With this arrangement it is achieved that velvet protein, albumin, bilirubin or metal ions in blood, the cuvette ring is sufficiently dimensionally stable and solid to contain sera, plasmas and urine as well as puncturing liquids, e.g. Li- 60 to determine the normal handling as well as the claims, or similar biological solutions. withstand centrifugation. It was determined - The amount of test material available means that the required strength can also be achieved - is often only a few microliters and that for those who can, if the tongue is only available to carry out the analysis in the radial direction standing time is part of the neighboring cuvette, the front one is often limited to a few minutes. In such cases, «Part offers free. This is advantageous in order to make it easier to insert automatically working analyzers into the individual cuvettes with the cuvette ring stationary, which work according to the centrifugal method mentioned. to achieve.

The devices have an annular cuvette ring. In a further embodiment of the invention, it is proposed

3,644,451

If each cuvette hurls above the connection opening, the liquids filled into the reagent chamber and the sample and reagent chamber on the one hand and the measuring chamber on the other hand have a web along the inclined chamber. This web can be walls upwards and enter the measurement with mixing so that it has thickenings at its ends chamber 4.

and that the thickenings with their lateral end faces 5 According to the invention, each cuvette 1 has the upper edge 6

abut and if necessary connected to each other a laterally projecting tongue 7, which are the neighboring cuvette. The webs prevent the sample or cuvette ring from being completely or partially covered and on

Reagent liquid is carefully attached to the more sensitive of these. A preferred embodiment is shown in FIG.

Parts of the centrifugal analyzer can reach. form shown, in which the tongue 7 at the top 8 of the

In addition, the crosspieces serve to be attached due to the mutual side wall 9 of the adjacent cuvette 1 '

Support to further increase the strength of the kitchens, preferably by welding. Through this

vette wreath. In addition, the overall arrangement of the webs ensures, on the one hand, that the device provides a practical handle for convenient handling of the reagent and sample chambers which are open at the top

Arrangement. Despite the considerable radial strength protruding tongue achieved in this way, and on the other hand that the cuvette rim as a whole gains greater stability as a result of the stresses during centrifugation,

By far enough, it is possible to separate cells from the top edges of the chamber walls against the surface.

Break out the wreath in order to fit them as sub-segments with a smaller tongue area.

Insert the scope of the analysis into the analyzer.

In the following, the invention will be explained with reference to the attached drawing. The drawing further shows that in the present

Drawing explained for example. The following example shows the tongue 7 only in the centrifugal direction

Fig. 1 covers a perspective view of a design rear part of the respective neighboring cuvette.

in the form of a single cuvette of a cuvette according to the invention.

ring, that each cuvette 1 above the connection opening 10

2 is a plan view of a section of a first between sample and reagent chamber on the one hand and measuring

for the cuvette ring. 25 chamber on the other hand has a web 11. These bridges

The single cuvette shown in FIG. 1 as a whole is preferably thickened 12 at its ends, thereby

1 designated. The cuvette consists of a total of three cells - on the one hand increased stability can be achieved and

the reagent chamber 2, the sample chamber 3, on the other hand, the possibility is opened that the webs with their

with the photometric measuring chamber 4. The main axes ren butt end faces 13 and

the reagent and sample chamber are connected to the circulation plane 30 if necessary. The analyzer can connect vertically; the main axis of the measuring chamber is also done by welding or gluing. The bridges

4 lies in the circulation level. Fig. 1 also shows that they form a handle for handling the cuvette - the rear wall of the reagent chamber in the centrifugal direction. Wreath relieved.

is slanted. The cuvette ring is preferably made of crystal-clear,

speaking wall of the sample chamber is also inclined. 35 unstabilized polymethyl methacrylate (PMMA)

If the cuvette ring and thus every single cuvette is placed.

C.

2 sheets of drawings

Claims (6)

644451 2 PATENT CLAIMS in which a predetermined number of individual cuvettes 1. Cuvette ring for an analysis device that is summarized according to the. The individual cuvettes each have little centrifugal principle with photometric measurement of the at least three chambers, namely a sample chamber, an analyzing sample works, the ring consisting of a reagent chamber and a photometric measuring chamber. The arrangement of several individual cells arranged in the shape of a ring, 5 the sample as well as the reagent, in the case of stationary cells, consists of thermoplastic material, each of which fills three interconnecting chambers into the chamber of the single cell cell provided for this purpose, the first of all two liquids, namely a sample chamber, a reagent remain separate from each other. After filling the cuvette chamber and a photometric measuring chamber, the analyzer is put into operation, with the main axes of the sample and reagent chambers first rotating around the centrifuge at high speed. Standing vertically under the influence of the running plane and the main axis of the measurement of the centrifugal force, both the sample chamber to be analyzed and the circulation plane coincide, as a result, as does the reagent liquid from the two chambers, in that each cuvette (1) at the upper edge (6) one that they were initially filled in, expelled and has under the laterally protruding tongue (7) that the neighboring union is lifted into the photometric measuring chamber, completely or partially covered and attached to it. 15 After a predetermined time has elapsed, 2. cuvette ring according to claim 1, characterized gekennzeich- metric scanning of the individual measuring chambers that the tongue (7) at the upper edge (8) of the next but one, usually the speed of rotation of the zen side wall (9) of the adjacent cuvette (1st ') attached, preferred centrifugal part of the analyzer is reduced. Which is welded from the way of measurement. Extinction is registered after evaluation by a 3. cuvette ring according to claim 1 or 2, characterized geo 2o computer as a rule immediately identified as the analysis result that the tongue (7) only prints the centrifugal. Towards the rear of the neighboring cell. Known centrifugal analyzers of this type, like them 4. Cell wreath according to one of the preceding claims, for example in the prospectus sheet published in 1978, characterized in that each cell (1) above “Cobas-Bio” from F. Hoffmann-La Roche & Co., Basel half a connection opening (10) between the sample and 25 are described, a large number of individual cuvettes reagent chamber on the one hand and measuring chamber on the other hand, which has a separate cuvette ring to erSteg (11). mentioned cuvette ring are summarized. The cuvette 5. cuvette ring according to claim 4, characterized marked ring has numerous radial slots into which the cuvettes with net that the web (11) at its ends thickened (12) inserted their elongated measuring chambers and thus has. 30 are held. The arrangement has the advantage that after 6. cuvette ring according to claim 4 or 5, thereby used single cuvettes thrown away and indicated that the webs (11) of adjacent cuvettes can be destroyed with if necessary. The latter is butted against one another and joined against the side faces 13 of the ana. lysis of pathogenic liquids is particularly important. are also connected to each other. From DE-OS 27 26 219 a cuvette arrangement for 35 centrifugal analyzers with a different structure are known. According to this prior publication, the cuvette arrangement consists of two disks made of flexible