CH637962A5 - N-Alkyl-N-iminomethyl derivatives of thienamycin - Google Patents

N-Alkyl-N-iminomethyl derivatives of thienamycin Download PDF

Info

Publication number
CH637962A5
CH637962A5 CH484078A CH484078A CH637962A5 CH 637962 A5 CH637962 A5 CH 637962A5 CH 484078 A CH484078 A CH 484078A CH 484078 A CH484078 A CH 484078A CH 637962 A5 CH637962 A5 CH 637962A5
Authority
CH
Switzerland
Prior art keywords
carbon atoms
radical
group
alkyl
methyl
Prior art date
Application number
CH484078A
Other languages
German (de)
English (en)
Inventor
Burton Grant Christensen
William Joseph Leanza
Kenneth James Wildonger
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of CH637962A5 publication Critical patent/CH637962A5/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D477/00Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20Sulfur atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72Hydrazones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CH484078A 1977-05-05 1978-05-03 N-Alkyl-N-iminomethyl derivatives of thienamycin CH637962A5 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US79397577A 1977-05-05 1977-05-05

Publications (1)

Publication Number Publication Date
CH637962A5 true CH637962A5 (en) 1983-08-31

Family

ID=25161306

Family Applications (1)

Application Number Title Priority Date Filing Date
CH484078A CH637962A5 (en) 1977-05-05 1978-05-03 N-Alkyl-N-iminomethyl derivatives of thienamycin

Country Status (13)

Country Link
JP (1) JPS53137993A (fi)
BE (1) BE866661A (fi)
CH (1) CH637962A5 (fi)
DE (1) DE2819453A1 (fi)
DK (1) DK170778A (fi)
ES (1) ES469426A1 (fi)
FR (1) FR2389626B1 (fi)
GB (1) GB1604275A (fi)
IE (1) IE46873B1 (fi)
IT (1) IT1104190B (fi)
LU (1) LU79598A1 (fi)
NL (1) NL7804229A (fi)
SE (1) SE436569B (fi)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT73791B (en) * 1980-10-17 1983-10-14 Merck & Co Inc Process for preparing 2-carbamimidoyl-6-substituted-1- -carbadethiapen-2-em-3-carboxylic acids

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3950357A (en) * 1974-11-25 1976-04-13 Merck & Co., Inc. Antibiotics
IL50911A (en) * 1975-11-21 1981-01-30 Merck & Co Inc Substituted n-methylene derivatives of thienamycin

Also Published As

Publication number Publication date
ES469426A1 (es) 1980-02-01
NL7804229A (nl) 1978-11-07
IE780849L (en) 1978-11-05
DE2819453A1 (de) 1978-11-09
FR2389626A1 (fi) 1978-12-01
DK170778A (da) 1979-01-15
FR2389626B1 (fi) 1980-06-20
BE866661A (fr) 1978-11-03
LU79598A1 (fr) 1979-02-02
SE7804447L (sv) 1978-11-06
IE46873B1 (en) 1983-10-19
GB1604275A (en) 1981-12-09
DE2819453C2 (fi) 1993-02-25
SE436569B (sv) 1985-01-07
IT1104190B (it) 1985-10-21
IT7849176A0 (it) 1978-05-03
JPH0260678B2 (fi) 1990-12-17
JPS53137993A (en) 1978-12-01

Similar Documents

Publication Publication Date Title
DE3587126T2 (de) Carbapenem-Derivate und sie enthaltende Zusammensetzung.
US4309438A (en) N-Alkyl-N-iminomethyl derivatives of thienamycin
DE2819479A1 (de) N-alkyl-n-acylderivate von thienamycin
DE3321864C2 (fi)
US4235920A (en) N-Alkylated derivatives of thienamycin
DE2356388A1 (de) Cephalosporine und verfahren zu ihrer herstellung
US4150145A (en) N-alkylated derivatives of thienamycin sulfoxide and sulfone
US4226870A (en) O-, N- and carboxyl derivatives of thienamycin
DE2652676A1 (de) N-alkylierte derivate von thienamycin, verfahren zu deren herstellung und diese enthaltende arzneimittel
US4172144A (en) Schiff's base derivatives of thienamycin
US4397861A (en) N- And carboxyl derivatives of thienamycin
US4196211A (en) 6-(α-Hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid and derivatives thereof
CH659072A5 (de) Penemderivate.
CH640236A5 (en) 3-(2-Aminoethylthio)-6-ethyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2 -carboxylic acid and process for its preparation
DE2652679C2 (fi)
CH637962A5 (en) N-Alkyl-N-iminomethyl derivatives of thienamycin
DE2652680A1 (de) O-, n- und carboxylderivate von thienamycin, verfahren zu deren herstellung und diese enthaltende arzneimittel
DE2448582A1 (de) Verfahren zur herstellung von cephalosporinen
AT395151B (de) Verfahren zur herstellung von neuen carbapenemderivaten
CH671020A5 (fi)
EP0001264A1 (en) Substituted N-methylene derivatives of thienamycin sulfoxide and sulfone and their preparation
DE2652675A1 (de) N-acylderivate von thienamycin, verfahren zu deren herstellung und diese enthaltende arzneimittel
US4208330A (en) O-Derivatives of thienamycin
CH669381A5 (fi)
DE2724560A1 (de) O-derivate von thienamycin

Legal Events

Date Code Title Description
PL Patent ceased