CH634589A5 - Process for the preparation of an aqueous dispersion or solution of a protein bonded to a urethane polymer - Google Patents
Process for the preparation of an aqueous dispersion or solution of a protein bonded to a urethane polymer Download PDFInfo
- Publication number
- CH634589A5 CH634589A5 CH1515877A CH1515877A CH634589A5 CH 634589 A5 CH634589 A5 CH 634589A5 CH 1515877 A CH1515877 A CH 1515877A CH 1515877 A CH1515877 A CH 1515877A CH 634589 A5 CH634589 A5 CH 634589A5
- Authority
- CH
- Switzerland
- Prior art keywords
- protein
- prepolymer
- bound
- water
- polymer
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title claims description 79
- 108090000623 proteins and genes Proteins 0.000 title claims description 79
- 229920000642 polymer Polymers 0.000 title claims description 40
- 238000000034 method Methods 0.000 title claims description 24
- 239000006185 dispersion Substances 0.000 title claims description 23
- JOYRKODLDBILNP-UHFFFAOYSA-N urethane group Chemical group NC(=O)OCC JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 title claims description 7
- 238000002360 preparation method Methods 0.000 title claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 43
- 102000004190 Enzymes Human genes 0.000 claims description 35
- 108090000790 Enzymes Proteins 0.000 claims description 35
- IQPQWNKOIGAROB-UHFFFAOYSA-N isocyanate group Chemical group [N-]=C=O IQPQWNKOIGAROB-UHFFFAOYSA-N 0.000 claims description 27
- 239000007788 liquid Substances 0.000 claims description 26
- 229920005862 polyol Polymers 0.000 claims description 25
- 239000004814 polyurethane Substances 0.000 claims description 25
- -1 oxyethylene, oxypropylene Chemical group 0.000 claims description 24
- 229920002635 polyurethane Polymers 0.000 claims description 24
- 150000003077 polyols Chemical class 0.000 claims description 23
- 229920001730 Moisture cure polyurethane Polymers 0.000 claims description 19
- 239000000047 product Substances 0.000 claims description 14
- 238000006243 chemical reaction Methods 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 11
- 239000007795 chemical reaction product Substances 0.000 claims description 9
- 125000006353 oxyethylene group Chemical group 0.000 claims description 7
- 229920001223 polyethylene glycol Polymers 0.000 claims description 6
- 239000004094 surface-active agent Substances 0.000 claims description 6
- 239000000427 antigen Substances 0.000 claims description 5
- 102000036639 antigens Human genes 0.000 claims description 5
- 108091007433 antigens Proteins 0.000 claims description 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 5
- 239000002202 Polyethylene glycol Substances 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 4
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- 150000001413 amino acids Chemical class 0.000 claims description 2
- 230000000890 antigenic effect Effects 0.000 claims description 2
- 230000009257 reactivity Effects 0.000 claims description 2
- 229920005830 Polyurethane Foam Polymers 0.000 claims 3
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- 150000001412 amines Chemical class 0.000 claims 2
- 238000004925 denaturation Methods 0.000 claims 2
- 230000036425 denaturation Effects 0.000 claims 2
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- 238000001179 sorption measurement Methods 0.000 claims 1
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- 239000000463 material Substances 0.000 description 6
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- 108010073038 Penicillin Amidase Proteins 0.000 description 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 4
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 3
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- WERYXYBDKMZEQL-UHFFFAOYSA-N butane-1,4-diol Chemical compound OCCCCO WERYXYBDKMZEQL-UHFFFAOYSA-N 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
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- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 3
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 3
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
- C12Y305/01011—Penicillin amidase (3.5.1.11), i.e. penicillin-amidohydrolase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
- C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- C12N11/093—Polyurethanes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/38—Albumins
- A61K38/385—Serum albumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4826—Trypsin (3.4.21.4) Chymotrypsin (3.4.21.1)
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
- C08G18/40—High-molecular-weight compounds
- C08G18/64—Macromolecular compounds not provided for by groups C08G18/42 - C08G18/63
- C08G18/6415—Macromolecular compounds not provided for by groups C08G18/42 - C08G18/63 having nitrogen
- C08G18/6446—Proteins and derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21004—Trypsin (3.4.21.4)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Polymers & Plastics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Polyurethanes Or Polyureas (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/749,430 US4094744A (en) | 1976-11-18 | 1976-12-10 | Water-dispersible protein/polyurethane reaction product |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH634589A5 true CH634589A5 (en) | 1983-02-15 |
Family
ID=25013731
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH1515877A CH634589A5 (en) | 1976-12-10 | 1977-12-09 | Process for the preparation of an aqueous dispersion or solution of a protein bonded to a urethane polymer |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS5379094A (enrdf_load_stackoverflow) |
| AT (1) | AT356620B (enrdf_load_stackoverflow) |
| BE (1) | BE861602A (enrdf_load_stackoverflow) |
| CH (1) | CH634589A5 (enrdf_load_stackoverflow) |
| DE (1) | DE2755053A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2393005B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1574508A (enrdf_load_stackoverflow) |
| MX (1) | MX4534E (enrdf_load_stackoverflow) |
| NL (1) | NL187585C (enrdf_load_stackoverflow) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4226935A (en) * | 1978-08-07 | 1980-10-07 | W. R. Grace & Co. | Enzymatic diagnostic composition |
| US4652524A (en) * | 1980-10-02 | 1987-03-24 | Ivan E. Modrovich | Soluble stabilized enzymes |
| US4732851A (en) * | 1982-03-16 | 1988-03-22 | Purification Engineering, Inc. | Immobilization of cells with a polyazetidine prepolymer |
| DE3705687A1 (de) * | 1987-02-23 | 1988-09-01 | Boehringer Mannheim Gmbh | Polyurethanmodifizierte enzyme |
| MXPA04000736A (es) * | 2001-07-24 | 2005-02-17 | Univ Pittsburgh | Inmovilizacion irreversible de diisopropilfluorofosfatasa en recubrimientos de poliuretano. |
| US7335400B2 (en) | 2001-07-24 | 2008-02-26 | University Of Pittsburgh | Irreversible immobilization of enzymes into polyurethane coatings |
| US9121016B2 (en) * | 2011-09-09 | 2015-09-01 | Toyota Motor Engineering & Manufacturing North America, Inc. | Coatings containing polymer modified enzyme for stable self-cleaning of organic stains |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3672955A (en) * | 1970-05-20 | 1972-06-27 | Us Agriculture | Preparation of an insoluble active enzyme |
| US3929574A (en) * | 1972-05-03 | 1975-12-30 | Grace W R & Co | Use of enzymes bound to polyurethane |
-
1977
- 1977-12-07 BE BE183252A patent/BE861602A/xx not_active IP Right Cessation
- 1977-12-07 DE DE19772755053 patent/DE2755053A1/de active Granted
- 1977-12-08 FR FR7737083A patent/FR2393005B1/fr not_active Expired
- 1977-12-08 GB GB51208/77A patent/GB1574508A/en not_active Expired
- 1977-12-08 NL NLAANVRAGE7713584,A patent/NL187585C/xx not_active IP Right Cessation
- 1977-12-09 AT AT883577A patent/AT356620B/de not_active IP Right Cessation
- 1977-12-09 JP JP14728177A patent/JPS5379094A/ja active Granted
- 1977-12-09 MX MX776679U patent/MX4534E/es unknown
- 1977-12-09 CH CH1515877A patent/CH634589A5/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| GB1574508A (en) | 1980-09-10 |
| JPH0233356B2 (enrdf_load_stackoverflow) | 1990-07-26 |
| NL7713584A (nl) | 1978-06-13 |
| DE2755053A1 (de) | 1978-06-22 |
| JPS5379094A (en) | 1978-07-13 |
| ATA883577A (de) | 1979-10-15 |
| FR2393005A1 (fr) | 1978-12-29 |
| BE861602A (fr) | 1978-03-31 |
| DE2755053C2 (enrdf_load_stackoverflow) | 1989-11-09 |
| NL187585B (nl) | 1991-06-17 |
| NL187585C (nl) | 1991-11-18 |
| FR2393005B1 (fr) | 1982-11-12 |
| AT356620B (de) | 1980-05-12 |
| MX4534E (es) | 1982-06-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PFA | Name/firm changed |
Owner name: W. R. GRACE & CO.-CONN. (A CONNECTICUT CORP.) |
|
| PL | Patent ceased | ||
| PL | Patent ceased |