CH621803A5 - - Google Patents

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Publication number
CH621803A5
CH621803A5 CH1085574A CH1085574A CH621803A5 CH 621803 A5 CH621803 A5 CH 621803A5 CH 1085574 A CH1085574 A CH 1085574A CH 1085574 A CH1085574 A CH 1085574A CH 621803 A5 CH621803 A5 CH 621803A5
Authority
CH
Switzerland
Prior art keywords
androstane
process according
formula
pyridazinyl
hydroxyl group
Prior art date
Application number
CH1085574A
Other languages
English (en)
Italian (it)
Inventor
Inventore Rinuncia Menzionato
Original Assignee
Siphar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siphar Sa filed Critical Siphar Sa
Priority to CH1085574A priority Critical patent/CH621803A5/it
Priority to GB31789/75A priority patent/GB1484655A/en
Priority to US05/600,485 priority patent/US4000125A/en
Priority to DE19752534981 priority patent/DE2534981A1/de
Priority to CA233,045A priority patent/CA1049499A/en
Priority to SE7508908A priority patent/SE418401B/xx
Priority to JP50095475A priority patent/JPS5141372A/ja
Priority to FR7524701A priority patent/FR2281124A1/fr
Priority to AR259928A priority patent/AR217617A1/es
Priority to DK358875AA priority patent/DK139101B/da
Priority to ES440110A priority patent/ES440110A1/es
Priority to BE159066A priority patent/BE832271A/xx
Publication of CH621803A5 publication Critical patent/CH621803A5/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CH1085574A 1974-08-08 1974-08-08 CH621803A5 (me)

Priority Applications (12)

Application Number Priority Date Filing Date Title
CH1085574A CH621803A5 (me) 1974-08-08 1974-08-08
GB31789/75A GB1484655A (en) 1974-08-08 1975-07-29 Cardiotonic steroids process for their preparation and therapeutical use
US05/600,485 US4000125A (en) 1974-08-08 1975-07-30 Novel cardiotonic steroids, process for their preparation and therapeutical use
DE19752534981 DE2534981A1 (de) 1974-08-08 1975-08-05 Kardiotonische steroidverbindungen, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
CA233,045A CA1049499A (en) 1974-08-08 1975-08-07 Cardiotonic steroids, process for their preparation and therapeutical use
SE7508908A SE418401B (sv) 1974-08-08 1975-08-07 Sett att framstella kardiotona steroidforeningar innehallande en pyridazinring och glykosidderivat derav
JP50095475A JPS5141372A (me) 1974-08-08 1975-08-07
FR7524701A FR2281124A1 (fr) 1974-08-08 1975-08-07 Nouveaux steroides cardiotoniques, leur procede de preparation, et leur utilisation therapeutique
AR259928A AR217617A1 (es) 1974-08-08 1975-08-07 Procedimiento para la preparacion de nuevos compuestos esteroides derivados de los 14-hidroxi-17 beta-(4-piridazinil)-5 beta,14 beta-androstanos,particularmenmente utiles como agentes cardiotonicos y sus derivados glucosidos
DK358875AA DK139101B (da) 1974-08-08 1975-08-07 Analogifremgangsmåde til fremstilling af 3beta,14beta-dihydroxy-17beta-(4-pyridazinyl)-5beta-androstan-forbindelser.
ES440110A ES440110A1 (es) 1974-08-08 1975-08-08 Procedimiento para la obtencion de compuestos esteroides cardiotonicos.
BE159066A BE832271A (fr) 1974-08-08 1975-08-08 Nouveaux steroides cardiotoniques, leur procede de preparation et leur utilisation therapeutique

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1085574A CH621803A5 (me) 1974-08-08 1974-08-08

Publications (1)

Publication Number Publication Date
CH621803A5 true CH621803A5 (me) 1981-02-27

Family

ID=4367535

Family Applications (1)

Application Number Title Priority Date Filing Date
CH1085574A CH621803A5 (me) 1974-08-08 1974-08-08

Country Status (12)

Country Link
US (1) US4000125A (me)
JP (1) JPS5141372A (me)
AR (1) AR217617A1 (me)
BE (1) BE832271A (me)
CA (1) CA1049499A (me)
CH (1) CH621803A5 (me)
DE (1) DE2534981A1 (me)
DK (1) DK139101B (me)
ES (1) ES440110A1 (me)
FR (1) FR2281124A1 (me)
GB (1) GB1484655A (me)
SE (1) SE418401B (me)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1144136B (it) * 1980-03-05 1986-10-29 Zenyaku Kogyo Kk Glucosidi di condurango agenti antitumorali che li comprendono e procedimento per la loro preparazione
US5373095A (en) * 1985-10-18 1994-12-13 The Upjohn Company Steroid compounds
IT1262931B (it) * 1992-01-16 1996-07-22 Zambon Spa Composti steroidei 17(piridazin-n-ossido)-sostituiti attivi sul sistema cardiovascolare
DE4227616C2 (de) * 1992-08-20 1995-04-13 Sigma Tau Ind Farmaceuti 17-(3-Furyl)-und 17-(4-Pyridazinyl)-5beta, 14beta-androstanderivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammemsetzungen
AU2006218711B2 (en) * 2005-03-02 2010-11-11 University Of Maryland, Baltimore Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activities, pharmacokinetics and antitumor activity
WO2009114658A2 (en) * 2008-03-12 2009-09-17 University Of Maryland, Baltimore Androgen receptor inactivation contributes to antitumor efficacy of cyp17 inhibitors in prostate cancer
US20100048914A1 (en) 2008-03-14 2010-02-25 Angela Brodie Novel C-17-Heteroaryl Steroidal Cyp17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
US20110118219A1 (en) * 2008-03-25 2011-05-19 University Of Maryland, Baltimore Novel prodrugs of c-17-heteroaryl steroidal cyp17 inhibitors/antiandrogens: synthesis, in vitro biological activities, pharmacokinetics and antitumor activity
WO2009129208A2 (en) * 2008-04-14 2009-10-22 University Of Maryland, Baltimore Compositions and methods of inducing endoplasmic reticulum stress reponse
EP3023433A1 (en) 2009-02-05 2016-05-25 Tokai Pharmaceuticals, Inc. Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens
WO2010091303A1 (en) 2009-02-05 2010-08-12 Tokai Pharmaceuticals Novel steroidal cyp17 inhibitors/antiandrogens
AU2010279398A1 (en) * 2009-08-07 2012-03-08 Tokai Pharmaceuticals, Inc. Treatment of prostate cancer
MX2015012274A (es) 2013-03-14 2016-06-02 Univ Maryland Agentes de sub-regulacion del receptor de androgeno y uso de los mismos.
KR20160058774A (ko) 2013-08-12 2016-05-25 토카이 파마슈티컬, 아이엔씨. 안드로겐-표적 치료제를 이용하는 종양 질환 치료를 위한 바이오마커
EP3313858B1 (en) * 2015-06-29 2019-09-25 Universiteit Gent Methods for the site-selective coupling of a first agent to a second agent

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3838163A (en) * 1968-11-22 1974-09-24 Hoffmann La Roche Substituted isoxazole derivatives as steroid intermediates

Also Published As

Publication number Publication date
SE418401B (sv) 1981-05-25
JPS5141372A (me) 1976-04-07
ES440110A1 (es) 1977-02-16
DK358875A (me) 1976-02-09
DK139101C (me) 1979-05-21
SE7508908L (sv) 1976-02-09
FR2281124A1 (fr) 1976-03-05
AR217617A1 (es) 1980-04-15
CA1049499A (en) 1979-02-27
GB1484655A (en) 1977-09-01
FR2281124B1 (me) 1980-05-16
DK139101B (da) 1978-12-18
BE832271A (fr) 1975-12-01
US4000125A (en) 1976-12-28
DE2534981A1 (de) 1976-02-19

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