CH610347A5 - Process for the preparation of a strain of influenza virus and use of this strain for the production of live viral vaccines against influenza - Google Patents

Process for the preparation of a strain of influenza virus and use of this strain for the production of live viral vaccines against influenza

Info

Publication number
CH610347A5
CH610347A5 CH747577A CH747577A CH610347A5 CH 610347 A5 CH610347 A5 CH 610347A5 CH 747577 A CH747577 A CH 747577A CH 747577 A CH747577 A CH 747577A CH 610347 A5 CH610347 A5 CH 610347A5
Authority
CH
Switzerland
Prior art keywords
strain
influenza
influenza virus
preparation
production
Prior art date
Application number
CH747577A
Inventor
Julien Peetermans
Original Assignee
Rit Rech Ind Therapeut
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from BE168041A external-priority patent/BE843094R/en
Application filed by Rit Rech Ind Therapeut filed Critical Rit Rech Ind Therapeut
Publication of CH610347A5 publication Critical patent/CH610347A5/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The strain P/76/7 of influenza virus, resistant to serum inhibitors, is obtained by recombining the strains A/PR8/34 and A/Victoria/3/75 of influenza virus with each other and by subjecting the strain resulting from the recombination to three passages through the allantoic cavity of embryonated eggs in the presence of normal guinea-pig serum. A live anti-influenza vaccine is obtained by incubating this serum inhibitor-resistant strain in the allantoic cavity of embryonated eggs, by harvesting the viral material and by freeze-drying it.
CH747577A 1976-06-18 1977-06-17 Process for the preparation of a strain of influenza virus and use of this strain for the production of live viral vaccines against influenza CH610347A5 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BE168041A BE843094R (en) 1976-06-18 1976-06-18 LIVE VIRAL INFLUENZA VACCINES AND THEIR MANUFACTURING PROCESS

Publications (1)

Publication Number Publication Date
CH610347A5 true CH610347A5 (en) 1979-04-12

Family

ID=3842893

Family Applications (1)

Application Number Title Priority Date Filing Date
CH747577A CH610347A5 (en) 1976-06-18 1977-06-17 Process for the preparation of a strain of influenza virus and use of this strain for the production of live viral vaccines against influenza

Country Status (5)

Country Link
AU (1) AU513734B2 (en)
CH (1) CH610347A5 (en)
FR (1) FR2354778A2 (en)
GB (1) GB1582763A (en)
NL (1) NL7706710A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4318903A (en) * 1978-07-12 1982-03-09 Smithkline-Rit Live influenza virus vaccine and the preparation thereof
US4278662A (en) * 1979-10-16 1981-07-14 Smith Kline - Rit Attenuated influenza type A virus vaccine

Also Published As

Publication number Publication date
AU513734B2 (en) 1980-12-18
GB1582763A (en) 1981-01-14
AU2611577A (en) 1978-12-21
NL7706710A (en) 1977-12-20
FR2354778B2 (en) 1980-01-18
FR2354778A2 (en) 1978-01-13

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Legal Events

Date Code Title Description
PL Patent ceased