GB1481650A - Chemical processes and products - Google Patents

Chemical processes and products

Info

Publication number
GB1481650A
GB1481650A GB18978/75A GB1897875A GB1481650A GB 1481650 A GB1481650 A GB 1481650A GB 18978/75 A GB18978/75 A GB 18978/75A GB 1897875 A GB1897875 A GB 1897875A GB 1481650 A GB1481650 A GB 1481650A
Authority
GB
United Kingdom
Prior art keywords
virus
cell
attenuated
preparing
glutamic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB18978/75A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Priority to GB18978/75A priority Critical patent/GB1481650A/en
Publication of GB1481650A publication Critical patent/GB1481650A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/245—Herpetoviridae, e.g. herpes simplex virus
    • A61K39/25—Varicella-zoster virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16734—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16761—Methods of inactivation or attenuation
    • C12N2710/16764—Methods of inactivation or attenuation by serial passage

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

1481650 Preparing an attenuated cell-free varicella virus MERCK & CO INC 6 May 1975 18978/75 Heading A5B A method of preparing a live attenuated, cell-free varicella virus useful as an antigen in a vaccine comprises serially passaging the virulent virus at 30‹-38‹C in a tissue culture preparation selected from human and animal diploid cell strains and primary cells of simian origin a sufficient number of times to attenuate the virus followed by release of the attenuated virus from the infected cell by sonication in the presence of a stabiliser comprising sucrose, albumin and phosphate together with glutamine, glutamic acid or a salt of glutamic acid.
GB18978/75A 1975-05-06 1975-05-06 Chemical processes and products Expired GB1481650A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB18978/75A GB1481650A (en) 1975-05-06 1975-05-06 Chemical processes and products

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB18978/75A GB1481650A (en) 1975-05-06 1975-05-06 Chemical processes and products

Publications (1)

Publication Number Publication Date
GB1481650A true GB1481650A (en) 1977-08-03

Family

ID=10121704

Family Applications (1)

Application Number Title Priority Date Filing Date
GB18978/75A Expired GB1481650A (en) 1975-05-06 1975-05-06 Chemical processes and products

Country Status (1)

Country Link
GB (1) GB1481650A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0043847A1 (en) * 1980-01-25 1982-01-20 The Wistar Institute Of Anatomy And Biology Highly attenuated varicella virus vaccine and production thereof
EP0290197A2 (en) * 1987-05-04 1988-11-09 Merck & Co. Inc. Stable lyophilized live herpes virus vaccine
WO1993024616A1 (en) * 1992-06-04 1993-12-09 Merck & Co., Inc. Process for attenuated varicella zoster virus vaccine production
US5360736A (en) * 1992-06-04 1994-11-01 Merck & Co., Inc. Process for attenuated varicella zoster virus vaccine production

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0043847A1 (en) * 1980-01-25 1982-01-20 The Wistar Institute Of Anatomy And Biology Highly attenuated varicella virus vaccine and production thereof
EP0043847A4 (en) * 1980-01-25 1982-07-06 Wistar Inst Highly attenuated varicella virus vaccine and production thereof.
EP0290197A2 (en) * 1987-05-04 1988-11-09 Merck & Co. Inc. Stable lyophilized live herpes virus vaccine
EP0290197A3 (en) * 1987-05-04 1989-10-18 Merck & Co. Inc. Stable lyophilized live herpes virus vaccine
WO1993024616A1 (en) * 1992-06-04 1993-12-09 Merck & Co., Inc. Process for attenuated varicella zoster virus vaccine production
US5360736A (en) * 1992-06-04 1994-11-01 Merck & Co., Inc. Process for attenuated varicella zoster virus vaccine production
US5607852A (en) * 1992-06-04 1997-03-04 Merch & Co., Inc. Process for attenuated varicella zoster virus vaccine production

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee