EP0043847A4 - Highly attenuated varicella virus vaccine and production thereof. - Google Patents

Highly attenuated varicella virus vaccine and production thereof.

Info

Publication number
EP0043847A4
EP0043847A4 EP19810900474 EP81900474A EP0043847A4 EP 0043847 A4 EP0043847 A4 EP 0043847A4 EP 19810900474 EP19810900474 EP 19810900474 EP 81900474 A EP81900474 A EP 81900474A EP 0043847 A4 EP0043847 A4 EP 0043847A4
Authority
EP
European Patent Office
Prior art keywords
production
virus vaccine
highly attenuated
varicella virus
attenuated varicella
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19810900474
Other languages
German (de)
French (fr)
Other versions
EP0043847A1 (en
Inventor
Stanley A Plotkin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wistar Institute of Anatomy and Biology
Original Assignee
Wistar Institute of Anatomy and Biology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wistar Institute of Anatomy and Biology filed Critical Wistar Institute of Anatomy and Biology
Publication of EP0043847A1 publication Critical patent/EP0043847A1/en
Publication of EP0043847A4 publication Critical patent/EP0043847A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/245—Herpetoviridae, e.g. herpes simplex virus
    • A61K39/25—Varicella-zoster virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16734—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16761—Methods of inactivation or attenuation
    • C12N2710/16764—Methods of inactivation or attenuation by serial passage

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
EP19810900474 1980-01-25 1981-01-21 Highly attenuated varicella virus vaccine and production thereof. Withdrawn EP0043847A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11543780A 1980-01-25 1980-01-25
US115437 1980-01-25

Publications (2)

Publication Number Publication Date
EP0043847A1 EP0043847A1 (en) 1982-01-20
EP0043847A4 true EP0043847A4 (en) 1982-07-06

Family

ID=22361396

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19810900474 Withdrawn EP0043847A4 (en) 1980-01-25 1981-01-21 Highly attenuated varicella virus vaccine and production thereof.

Country Status (5)

Country Link
EP (1) EP0043847A4 (en)
JP (1) JPS57500149A (en)
GB (1) GB2077590A (en)
IT (1) IT8147637A0 (en)
WO (1) WO1981002107A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6181782A (en) * 1984-09-28 1986-04-25 Teijin Ltd Mouse-human hybridoma producing antivirus human antibody, its production and use

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7103524A (en) * 1970-04-28 1971-11-01
DE2201877A1 (en) * 1972-01-15 1973-07-19 Steyr Daimler Puch Ag VENTILATION DEVICE FOR THE CRANKCASE OF VALVE CONTROLLED COMBUSTION MACHINES
FR2201877A1 (en) * 1972-06-10 1974-05-03 Univ Osaka Res Found Live varicella vaccine - produced using rabbit kidney cells
BE828941A (en) * 1975-05-12 1975-11-12 VACCINE AND PROCEDURE FOR PREPARING IT
US3985615A (en) * 1974-03-12 1976-10-12 Research Foundation For Microbial Diseases Of Osaka University Process for preparing live varicella vaccines
NL7506620A (en) * 1975-06-04 1976-12-07 Merck & Co Inc Cell-free chickenpox virus prodn - for vaccines, by passing on human or monkey cells until attenuated then recovering the virus in presence of a stabiliser
FR2310772A1 (en) * 1975-05-16 1976-12-10 Merck & Co Inc Cell-free chickenpox virus prodn - for vaccines, by passing on human or monkey cells until attenuated then recovering the virus in presence of a stabiliser
US4000256A (en) * 1975-04-30 1976-12-28 Merck & Co., Inc. Varicella vaccine and process for its preparation
FR2336944A1 (en) * 1975-12-29 1977-07-29 Rit Rech Ind Therapeut LIVE VARICELLA AND ZONA VACCINES
GB1481650A (en) * 1975-05-06 1977-08-03 Merck & Co Inc Chemical processes and products
CH624430A5 (en) * 1975-05-16 1981-07-31 Merck & Co Inc Process for the production of a chicken pox virus preparation

Patent Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2120426A1 (en) * 1970-04-28 1971-11-11 Merck & Co., Inc., Rahway, N.J. (V.StA.) Varicellavaccine
FR2092100A1 (en) * 1970-04-28 1972-01-21 Merck & Co Inc
GB1293310A (en) * 1970-04-28 1972-10-18 Merck & Co Inc Vaccine
NL7103524A (en) * 1970-04-28 1971-11-01
DE2201877A1 (en) * 1972-01-15 1973-07-19 Steyr Daimler Puch Ag VENTILATION DEVICE FOR THE CRANKCASE OF VALVE CONTROLLED COMBUSTION MACHINES
FR2201877A1 (en) * 1972-06-10 1974-05-03 Univ Osaka Res Found Live varicella vaccine - produced using rabbit kidney cells
US3985615A (en) * 1974-03-12 1976-10-12 Research Foundation For Microbial Diseases Of Osaka University Process for preparing live varicella vaccines
US4000256A (en) * 1975-04-30 1976-12-28 Merck & Co., Inc. Varicella vaccine and process for its preparation
GB1481650A (en) * 1975-05-06 1977-08-03 Merck & Co Inc Chemical processes and products
BE828941A (en) * 1975-05-12 1975-11-12 VACCINE AND PROCEDURE FOR PREPARING IT
FR2310772A1 (en) * 1975-05-16 1976-12-10 Merck & Co Inc Cell-free chickenpox virus prodn - for vaccines, by passing on human or monkey cells until attenuated then recovering the virus in presence of a stabiliser
CH624430A5 (en) * 1975-05-16 1981-07-31 Merck & Co Inc Process for the production of a chicken pox virus preparation
NL7506620A (en) * 1975-06-04 1976-12-07 Merck & Co Inc Cell-free chickenpox virus prodn - for vaccines, by passing on human or monkey cells until attenuated then recovering the virus in presence of a stabiliser
FR2336944A1 (en) * 1975-12-29 1977-07-29 Rit Rech Ind Therapeut LIVE VARICELLA AND ZONA VACCINES

Also Published As

Publication number Publication date
WO1981002107A1 (en) 1981-08-06
JPS57500149A (en) 1982-01-28
EP0043847A1 (en) 1982-01-20
IT8147637A0 (en) 1981-01-26
GB2077590A (en) 1981-12-23

Similar Documents

Publication Publication Date Title
JPS5663995A (en) Nontransit virus
ZA829386B (en) Modified vaccinia virus and methods for making and using the same
EP0083286A3 (en) Modified vaccinia virus and methods for making and using the same
ZA794416B (en) Pasteurellois vaccines
AU4131578A (en) Dual induction and e.g.r. system
JPS57118794A (en) Imunosome and preparation thereof
JPS57106535A (en) Peralumina-nepheline/kalcilite glass-ceramic and manufacture thereof
JPS5612319A (en) Cholera vaccine
JPS5716868A (en) 1-hydroxyethyl-azole derivative,manufacture and use
ZA811662B (en) Vaccine
JPS5756478A (en) Triazinylaminotriazines, manufacture and use
AU546515B2 (en) Bovinc leukemia virus vaccine
ZA815022B (en) Burner system
JPS56164191A (en) Theophyllinylmethyldioxolane derivative, its manufacture and medicine
MW1681A1 (en) 2-nitroimidazoles and preparation thereof
ZA811919B (en) Veterinary vaccines
JPS5748993A (en) N-phosphonylcarbonyl-carbamates, manufacture and use
GB2083477B (en) Endoproteinase-lys-c and process for the preparation thereof
JPS5732227A (en) Hydrophobia vaccine
AU547725B1 (en) Brucellosis vaccine
ZA815084B (en) Nasal preparations and process for the manufacture thereof
GB2038179B (en) Meningo-encephalitis virus vacines
EP0043847A4 (en) Highly attenuated varicella virus vaccine and production thereof.
ZA796820B (en) Vaccines
JPS57122077A (en) Dihydropyranes, manufacture and use

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19811003

AK Designated contracting states

Designated state(s): FR

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19830615

RIN1 Information on inventor provided before grant (corrected)

Inventor name: PLOTKIN, STANLEY A.