FR2310772A1 - Cell-free chickenpox virus prodn - for vaccines, by passing on human or monkey cells until attenuated then recovering the virus in presence of a stabiliser - Google Patents

Cell-free chickenpox virus prodn - for vaccines, by passing on human or monkey cells until attenuated then recovering the virus in presence of a stabiliser

Info

Publication number
FR2310772A1
FR2310772A1 FR7515400A FR7515400A FR2310772A1 FR 2310772 A1 FR2310772 A1 FR 2310772A1 FR 7515400 A FR7515400 A FR 7515400A FR 7515400 A FR7515400 A FR 7515400A FR 2310772 A1 FR2310772 A1 FR 2310772A1
Authority
FR
France
Prior art keywords
virus
attenuated
prodn
stabiliser
vaccines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7515400A
Other languages
French (fr)
Other versions
FR2310772B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Priority to FR7515400A priority Critical patent/FR2310772A1/en
Publication of FR2310772A1 publication Critical patent/FR2310772A1/en
Application granted granted Critical
Publication of FR2310772B1 publication Critical patent/FR2310772B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/245—Herpetoviridae, e.g. herpes simplex virus
    • A61K39/25—Varicella-zoster virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16734—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16761—Methods of inactivation or attenuation
    • C12N2710/16764—Methods of inactivation or attenuation by serial passage

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Cell-free, live but attenuated chickenpox virus for use in vaccine prodn., is prepd. by passaging virulent virus at 30-38 degrees C. on cultures of either human or animal diploid cells or on primary monkey cells, until attenuated, then the attenuated virus is recovered from the infected cells in the presence of a stabiliser. Vaccines prepd. from this attenuated virus are also claimed.
FR7515400A 1975-05-16 1975-05-16 Cell-free chickenpox virus prodn - for vaccines, by passing on human or monkey cells until attenuated then recovering the virus in presence of a stabiliser Granted FR2310772A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7515400A FR2310772A1 (en) 1975-05-16 1975-05-16 Cell-free chickenpox virus prodn - for vaccines, by passing on human or monkey cells until attenuated then recovering the virus in presence of a stabiliser

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7515400A FR2310772A1 (en) 1975-05-16 1975-05-16 Cell-free chickenpox virus prodn - for vaccines, by passing on human or monkey cells until attenuated then recovering the virus in presence of a stabiliser

Publications (2)

Publication Number Publication Date
FR2310772A1 true FR2310772A1 (en) 1976-12-10
FR2310772B1 FR2310772B1 (en) 1978-11-10

Family

ID=9155357

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7515400A Granted FR2310772A1 (en) 1975-05-16 1975-05-16 Cell-free chickenpox virus prodn - for vaccines, by passing on human or monkey cells until attenuated then recovering the virus in presence of a stabiliser

Country Status (1)

Country Link
FR (1) FR2310772A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0043847A1 (en) * 1980-01-25 1982-01-20 The Wistar Institute Of Anatomy And Biology Highly attenuated varicella virus vaccine and production thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0043847A1 (en) * 1980-01-25 1982-01-20 The Wistar Institute Of Anatomy And Biology Highly attenuated varicella virus vaccine and production thereof
EP0043847A4 (en) * 1980-01-25 1982-07-06 Wistar Inst Highly attenuated varicella virus vaccine and production thereof.

Also Published As

Publication number Publication date
FR2310772B1 (en) 1978-11-10

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Legal Events

Date Code Title Description
ST Notification of lapse