GB2077590A - Highly attenuated varicella virus vaccine and production thereof - Google Patents

Highly attenuated varicella virus vaccine and production thereof

Info

Publication number
GB2077590A
GB2077590A GB8123471A GB8123471A GB2077590A GB 2077590 A GB2077590 A GB 2077590A GB 8123471 A GB8123471 A GB 8123471A GB 8123471 A GB8123471 A GB 8123471A GB 2077590 A GB2077590 A GB 2077590A
Authority
GB
United Kingdom
Prior art keywords
varicella virus
virus vaccine
production
highly attenuated
attenuated varicella
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB8123471A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wistar Institute of Anatomy and Biology
Original Assignee
Wistar Institute of Anatomy and Biology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wistar Institute of Anatomy and Biology filed Critical Wistar Institute of Anatomy and Biology
Publication of GB2077590A publication Critical patent/GB2077590A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/245—Herpetoviridae, e.g. herpes simplex virus
    • A61K39/25—Varicella-zoster virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16734—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16761—Methods of inactivation or attenuation
    • C12N2710/16764—Methods of inactivation or attenuation by serial passage

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

A live attenuated varicella virus vaccine, capable of inducing immunity in humans against varicella without spread to contacts, is prepared by serially passaging virulent varicella virus in human diploid lung fibroblasts.
GB8123471A 1980-01-25 1981-01-21 Highly attenuated varicella virus vaccine and production thereof Withdrawn GB2077590A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11543780A 1980-01-25 1980-01-25

Publications (1)

Publication Number Publication Date
GB2077590A true GB2077590A (en) 1981-12-23

Family

ID=22361396

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8123471A Withdrawn GB2077590A (en) 1980-01-25 1981-01-21 Highly attenuated varicella virus vaccine and production thereof

Country Status (5)

Country Link
EP (1) EP0043847A4 (en)
JP (1) JPS57500149A (en)
GB (1) GB2077590A (en)
IT (1) IT8147637A0 (en)
WO (1) WO1981002107A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6181782A (en) * 1984-09-28 1986-04-25 Teijin Ltd Mouse-human hybridoma producing antivirus human antibody, its production and use

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7103524A (en) * 1970-04-28 1971-11-01
DE2201877A1 (en) * 1972-01-15 1973-07-19 Steyr Daimler Puch Ag VENTILATION DEVICE FOR THE CRANKCASE OF VALVE CONTROLLED COMBUSTION MACHINES
JPS5119018B2 (en) * 1972-06-10 1976-06-14
JPS5341202B2 (en) * 1974-03-12 1978-11-01
US4000256A (en) * 1975-04-30 1976-12-28 Merck & Co., Inc. Varicella vaccine and process for its preparation
GB1481650A (en) * 1975-05-06 1977-08-03 Merck & Co Inc Chemical processes and products
BE828941A (en) * 1975-05-12 1975-11-12 VACCINE AND PROCEDURE FOR PREPARING IT
FR2310772A1 (en) * 1975-05-16 1976-12-10 Merck & Co Inc Cell-free chickenpox virus prodn - for vaccines, by passing on human or monkey cells until attenuated then recovering the virus in presence of a stabiliser
CH624430A5 (en) * 1975-05-16 1981-07-31 Merck & Co Inc Process for the production of a chicken pox virus preparation
NL7506620A (en) * 1975-06-04 1976-12-07 Merck & Co Inc Cell-free chickenpox virus prodn - for vaccines, by passing on human or monkey cells until attenuated then recovering the virus in presence of a stabiliser
US4008317A (en) * 1975-12-29 1977-02-15 Recherche Et Industrie Therapeutiques (R.I.T.) Varicella-zoster virus vaccine and preparation thereof

Also Published As

Publication number Publication date
WO1981002107A1 (en) 1981-08-06
EP0043847A1 (en) 1982-01-20
EP0043847A4 (en) 1982-07-06
IT8147637A0 (en) 1981-01-26
JPS57500149A (en) 1982-01-28

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)