CH575762A5

CH575762A5 - Rapid-acting oil-in-water disinfectant compsn - is operative at mild pH values

Info

Publication number: CH575762A5
Application number: CH509174A
Authority: CH
Original assignee: Herzog Paul
Priority date: 1974-04-11
Filing date: 1974-04-11
Publication date: 1976-05-31

Abstract

A disinfectant of an oil-in-water, type has an oil phase contg. 80-320 pts. wt. monostearic glyceride, 80-320 pts. wt. paraffin oil, 80-320 pts. wt. cetyl alcohol, 150-600 pts. wt. vaseline, 10-200 pts. wt. of, esp., polyoxyethylene sorbitan mono-oleate and, opt., 0.5-2 pts. wt. preservative (esp. ethyl p-hydroxybenzoate) and an aqs. phase (3-7 1 per 1 oil phase) contg. 0.4-5 g of, esp., guajazulene, 100-450 g H2O2 and, opt., a stabiliser for the peroxide (e.g. urea) and has a pH of 5-8, esp. 5-6.5 (obtd. by adding the rel. amts. of alkaline substances). This pH range affords a more rapid disinfecting action than in the parent patent and the compsn. may be used, e.g., by doctors.

Description

  

  
 



   Das Hauptpatent betrifft ein Desinfektionsmittel, das durch eine wässrige Emulsion von Wasserstoffperoxid gekennzeichnet ist. Diese Emulsion ist vom Öl-in-Wasser-Typ.



   Ein besonders vorteilhaftes Desinfektionsmittel nach dem Hauptpatent ist ein solches, bei welchem die Ölphase der Emulsion 80 bis 320   Gewichtsteilessonostearinglycerid,    80 bis 320 Gewichtsteile Paraffinöl,   80 6is320      Gsswichtsteile    Cetylalkohol, 150 bis 600 Gewichtsteile Vaselin, 10 bis 200 Gewichtsteile Polyoxyäthylenderivate von Sorbitanhydriden, die teilweise mit einer Fettsäure verestert sind, insbesondere Polyoxyäthylensorbitanmonoleat, sowie gegebenenfalls 0,5 bis 2 Gewichtsteile eines Konservierungsmittels, insbesondere p Hydroxybenzoesäureäthylester enthält.



   Ganz besonders vorteilhaft ist ein solches Desinfektionsmittel, welches pro Liter der genannten Ölphase 3 bis 7 Liter Wasser enthält, in welchem 0,4 bis 5 g eines Azulens, insbesondere Guajazulen, und 100 bis 450 g Wasserstoffperoxid gelöst sind, sowie gegebenenfalls einen Stabilisator wie beispielsweise Harnstoff für das Wasserstoffperoxid.



   Bei der Herstellung solcher Desinfektionsmittel verwendet man zweckmässig eine handelsübliche wässrige Lösung, die   30 %    Wasserstoffperoxid enthält. Solche handelsübliche Lösungen sind sauer und weisen einen pH-Wert zwischen etwa 1 und 3 auf. Das ist insofern günstig, als auf diese Weise Desinfektionsmittel hergestellt werden können, deren pH-Wert ohne besondere Massnahmen etwa zwischen 2,7 und 4,7 liegt.



  Bei diesen sauren pH-Werten ist nicht nur das Wasserstoffperoxid stabil, sondern die menschliche Haut verträgt die Berührung mit dem Desinfektionsmittel gut. Oberhalb pH 5 ist die Verträglichkeit nicht mehr so gut. Es kann jedoch erwünscht sein, den pH-Wert des Desinfektionsmittels zu erhöhen, und zwar vor allem deshalb, um eine raschere Desinfektionswirkung zu erzielen. Bei höheren pH-Werten ist das Wasserstoffperoxid nicht mehr so stabil und zerfällt rascher, so dass eine gute Desinfektionswirkung, beispielsweise auf den Händen von Ärzten, sehr rasch erzielt werden kann. Allzu hohe pH-Werte sind aber nicht erwünscht, da sonst die Haut zu stark angegriffen werden kann.



   Das erfindungsgemässe Desinfektionsmittel, welches in allen übrigen Teilen demjenigen des Hauptpatentes entspricht, ist dadurch gekennzeichnet, dass es einen pH-Wert zwischen 5 und 8, insbesondere zwischen 5 und 7 und vorzugsweise zwischen 5 und 6,5   aufweiset.   



   Diese pH-Werte können in einfacher Weise dadurch erreicht werden, dass man den Mitteln, welche dem Hauptpatent entsprechen, gewisse Mengen alkalisierender Zusätze beimischt.

 

   Wünscht man beispielsweise ein pH von 5,5, so kann man dem Desinfektionsmittel pro Kilogramm 15,6 g   NaH2P04    2H2O + 2,2 g Na2HPO4   12H2O    beimischen.



   Um ein pH von 6,1 zu erreichen, kann man einem Kilogramm des Desinfektionsmittels 15,6 g NaH2PO4    2H2O    + 9 g Na2HPO4   12H2O    beimischen.



   Anstelle dieser Phosphate kann man auch entsprechende Mengen von Alkaliboraten, Alkaliacetaten oder Alkalihydroxiden verwenden.



   PATENTANSPRUCH



   Desinfektionsmittel nach dem Patentanspruch des Hauptpatentes, gekennzeichnet durch einen pH-Wert von 5 bis 8.



   UNTERANSPRUCH
Mittel nach Patentanspruch, gekennzeichnet durch einen pH-Wert von 5 bis 7, insbesondere von 5 bis 6,5.

**WARNUNG** Ende DESC Feld konnte Anfang CLMS uberlappen**.



   



  
 



   The main patent relates to a disinfectant which is characterized by an aqueous emulsion of hydrogen peroxide. This emulsion is of the oil-in-water type.



   A particularly advantageous disinfectant according to the main patent is one in which the oil phase of the emulsion contains 80 to 320 parts by weight of monostearing glyceride, 80 to 320 parts by weight of paraffin oil, 80 to 320 parts by weight of cetyl alcohol, 150 to 600 parts by weight of vaseline, 10 to 200 parts by weight of polyoxyethylene derivatives of sorbitol anhydrides, some of which contain are esterified with a fatty acid, in particular polyoxyethylene sorbitan monoleate, and optionally 0.5 to 2 parts by weight of a preservative, in particular p-hydroxybenzoic acid ethyl ester.



   A disinfectant of this type is particularly advantageous which contains 3 to 7 liters of water per liter of the oil phase mentioned, in which 0.4 to 5 g of an azulene, in particular guaiacol, and 100 to 450 g of hydrogen peroxide are dissolved, and optionally a stabilizer such as, for example Urea for the hydrogen peroxide.



   In the production of such disinfectants, it is advisable to use a commercially available aqueous solution containing 30% hydrogen peroxide. Such commercially available solutions are acidic and have a pH value between approximately 1 and 3. This is beneficial in that disinfectants can be produced in this way with a pH value between 2.7 and 4.7 without special measures.



  At these acidic pH values, not only is the hydrogen peroxide stable, but the human skin also tolerates contact with the disinfectant. Above pH 5, the tolerance is no longer so good. However, it may be desirable to increase the pH of the disinfectant, primarily in order to achieve a faster disinfecting effect. At higher pH values, the hydrogen peroxide is no longer as stable and breaks down more quickly, so that a good disinfecting effect, for example on the hands of doctors, can be achieved very quickly. However, pH values that are too high are not desirable, as otherwise the skin can be attacked too severely.



   The disinfectant according to the invention, which corresponds in all other parts to that of the main patent, is characterized in that it has a pH value between 5 and 8, in particular between 5 and 7 and preferably between 5 and 6.5.



   These pH values can be achieved in a simple manner by adding certain amounts of alkalizing additives to the agents which correspond to the main patent.

 

   For example, if you want a pH of 5.5, you can add 15.6 g NaH2P04 2H2O + 2.2 g Na2HPO4 12H2O per kilogram to the disinfectant.



   To achieve a pH of 6.1, one kilogram of disinfectant can be mixed with 15.6 g NaH2PO4 2H2O + 9 g Na2HPO4 12H2O.



   Instead of these phosphates, it is also possible to use corresponding amounts of alkali borates, alkali acetates or alkali hydroxides.



   PATENT CLAIM



   Disinfectant according to the claim of the main patent, characterized by a pH value of 5 to 8.



   SUBClaim
Agent according to patent claim, characterized by a pH value of 5 to 7, in particular 5 to 6.5.

** WARNING ** End of DESC field could overlap beginning of CLMS **.

Claims

** WARNING ** Beginning of CLMS field could overlap end of DESC **.

The main patent relates to a disinfectant which is characterized by an aqueous emulsion of hydrogen peroxide. This emulsion is of the oil-in-water type.

A particularly advantageous disinfectant according to the main patent is one in which the oil phase of the emulsion contains 80 to 320 parts by weight of monostearing glyceride, 80 to 320 parts by weight of paraffin oil, 80 to 320 parts by weight of cetyl alcohol, 150 to 600 parts by weight of vaseline, 10 to 200 parts by weight of polyoxyethylene derivatives of sorbitol anhydrides, some of which contain are esterified with a fatty acid, in particular polyoxyethylene sorbitan monoleate, and optionally 0.5 to 2 parts by weight of a preservative, in particular p-hydroxybenzoic acid ethyl ester.

A disinfectant of this type is particularly advantageous which contains 3 to 7 liters of water per liter of the oil phase mentioned, in which 0.4 to 5 g of an azulene, in particular guaiacol, and 100 to 450 g of hydrogen peroxide are dissolved, and optionally a stabilizer such as, for example Urea for the hydrogen peroxide.

In the production of such disinfectants, it is advisable to use a commercially available aqueous solution containing 30% hydrogen peroxide. Such commercially available solutions are acidic and have a pH value between approximately 1 and 3. This is beneficial in that disinfectants can be produced in this way with a pH value between 2.7 and 4.7 without special measures.

At these acidic pH values, not only is the hydrogen peroxide stable, but the human skin also tolerates contact with the disinfectant. Above pH 5, the tolerance is no longer so good. However, it may be desirable to increase the pH of the disinfectant, primarily in order to achieve a faster disinfecting effect. At higher pH values, the hydrogen peroxide is no longer as stable and breaks down more quickly, so that a good disinfecting effect, for example on the hands of doctors, can be achieved very quickly. However, pH values that are too high are not desirable, as otherwise the skin can be attacked too severely.

The disinfectant according to the invention, which corresponds in all other parts to that of the main patent, is characterized in that it has a pH value between 5 and 8, in particular between 5 and 7 and preferably between 5 and 6.5.

These pH values can be achieved in a simple manner by adding certain amounts of alkalizing additives to the agents which correspond to the main patent.

For example, if you want a pH of 5.5, you can add 15.6 g NaH2P04 2H2O + 2.2 g Na2HPO4 12H2O per kilogram to the disinfectant.

To achieve a pH of 6.1, one kilogram of disinfectant can be mixed with 15.6 g NaH2PO4 2H2O + 9 g Na2HPO4 12H2O.

Instead of these phosphates, it is also possible to use corresponding amounts of alkali borates, alkali acetates or alkali hydroxides.

PATENT CLAIM

Disinfectant according to the claim of the main patent, characterized by a pH value of 5 to 8.

SUBClaim Agent according to patent claim, characterized by a pH value of 5 to 7, in particular 5 to 6.5.