CH546250A - Triazolobenzodiazepine derivs - with anticonvulsant, cns depressant and muscle-relaxant activity - Google Patents
Triazolobenzodiazepine derivs - with anticonvulsant, cns depressant and muscle-relaxant activityInfo
- Publication number
- CH546250A CH546250A CH546250DA CH546250A CH 546250 A CH546250 A CH 546250A CH 546250D A CH546250D A CH 546250DA CH 546250 A CH546250 A CH 546250A
- Authority
- CH
- Switzerland
- Prior art keywords
- muscle
- triazolobenzodiazepine
- derivs
- anticonvulsant
- oxides
- Prior art date
Links
- 239000001961 anticonvulsive agent Substances 0.000 title abstract 2
- 229960003965 antiepileptics Drugs 0.000 title abstract 2
- 239000003158 myorelaxant agent Substances 0.000 title abstract 2
- 230000001773 anti-convulsant effect Effects 0.000 title 1
- 239000003874 central nervous system depressant Substances 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- KYTREVLPRJOBEM-UHFFFAOYSA-N triazolo[4,5-i][1,2]benzodiazepine Chemical compound C1=CC2=CC=CN=NC2=C2C1=NN=N2 KYTREVLPRJOBEM-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 230000003556 anti-epileptic effect Effects 0.000 abstract 1
- 229940035363 muscle relaxants Drugs 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940125723 sedative agent Drugs 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Title cpds. of formula (I): (where R1 is H or 1-3C alkyl; R2 is 1-4C alkyl or R2--R2 is a satd. divalent 2-5C aliphatic hydrocarbon residue, and rings A and B can be substd. by F, Cl, Br, CF3, NO2 or 1-6C alkyl or alkoxy) and their 5-oxides and acid addn. salts, can be used as tranquillisers, sedatives, muscle relaxants and anti-epileptics; the 5-oxides are also of use as inters. for further pharmacologically active cpds. Cpds. (I) are e.g. prepd. by (a) reacting a 2-X-3-R1-5-phenyl-3H-1,4-benzodiazepine (where X is SH, lower alkoxy or alkylthio opt. activated by a substituent, or opt. mono- or disubstd. amino) with (R2O)2CHCONHNH2. The 5-oxides are obtd. by oxidn.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1212873 | 1971-04-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH546250A true CH546250A (en) | 1974-02-28 |
Family
ID=4380132
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH546250D CH546250A (en) | 1971-04-08 | 1971-04-08 | Triazolobenzodiazepine derivs - with anticonvulsant, cns depressant and muscle-relaxant activity |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH546250A (en) |
-
1971
- 1971-04-08 CH CH546250D patent/CH546250A/en not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased |