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C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
C07D487/04—Ortho-condensed systems
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Chemical & Material Sciences
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Organic Chemistry
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Pharmaceuticals Containing Other Organic And Inorganic Compounds
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Abstract
Title cpds. of formula (I): (where R1 is H or 1-3C alkyl; R2 is 1-4C alkyl or R2--R2 is a satd. divalent 2-5C aliphatic hydrocarbon residue, and rings A and B can be substd. by F, Cl, Br, CF3, NO2 or 1-6C alkyl or alkoxy) and their 5-oxides and acid addn. salts, can be used as tranquillisers, sedatives, muscle relaxants and anti-epileptics; the 5-oxides are also of use as inters. for further pharmacologically active cpds. Cpds. (I) are e.g. prepd. by (a) reacting a 2-X-3-R1-5-phenyl-3H-1,4-benzodiazepine (where X is SH, lower alkoxy or alkylthio opt. activated by a substituent, or opt. mono- or disubstd. amino) with (R2O)2CHCONHNH2. The 5-oxides are obtd. by oxidn.
CH546250D1971-04-081971-04-08Triazolobenzodiazepine derivs - with anticonvulsant, cns depressant and muscle-relaxant activity
CH546250A
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