CH519516A - Cephalosporin derivatives - Google Patents

Cephalosporin derivatives

Info

Publication number
CH519516A
CH519516A CH1659168A CH1659168A CH519516A CH 519516 A CH519516 A CH 519516A CH 1659168 A CH1659168 A CH 1659168A CH 1659168 A CH1659168 A CH 1659168A CH 519516 A CH519516 A CH 519516A
Authority
CH
Switzerland
Prior art keywords
group
substd
opt
desacetyl
beta
Prior art date
Application number
CH1659168A
Other languages
German (de)
Inventor
Rolf Dr Bosshardt
Bruno Dr Fechtig
Johannes Dr Mueller
Heinrich Dr Peter
Hans Dr Bickel
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Priority to CH1659168A priority Critical patent/CH519516A/en
Priority to CH9571A priority patent/CH523915A/en
Priority to US867863A priority patent/US3706746A/en
Priority to IE1461/69A priority patent/IE33355B1/en
Priority to FR6936926A priority patent/FR2024808B1/fr
Priority to SU1774526A priority patent/SU427515A3/en
Priority to DE19691954516 priority patent/DE1954516A1/en
Priority to SU1377102A priority patent/SU406363A3/ru
Priority to GB53698/69A priority patent/GB1287786A/en
Priority to ES373176A priority patent/ES373176A1/en
Priority to SE15152/69A priority patent/SE367422B/xx
Priority to AT638971A priority patent/AT303969B/en
Priority to BE741381D priority patent/BE741381A/xx
Priority to AT1044269A priority patent/AT300191B/en
Priority to BR21395769A priority patent/BR6913957D0/en
Priority to NL6916775A priority patent/NL6916775A/xx
Priority to JP44089029A priority patent/JPS4928200B1/ja
Publication of CH519516A publication Critical patent/CH519516A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/32—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by an araliphatic carboxylic acid, which is substituted on the aliphatic radical by hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

O-DESACETYL-7-N-ACYLAMINO-CEPHALOSPO ACIDS. M3A. are new compounds of formula: (R1 is an acyl group of an alkanoic acid substd. by a cyclic group having a free amino group attached to an aliphatic or cycloaliphatic. C atom, R2 is H or opt. substd. hydrocarbyl, n = 0 or 1), including salts of I. Cyclic substituents in R1 may be cycloalkyl (C3-C8) opt. substd. by alkyl, alkoxy, OH, CF3, NO2 halogen and opt. containing a double bond, phenyl, pyridyl, thienyl or furyl which may be similarly substituted the NH2 group is in the alpha- or beta-position relative to the CO group. Specific compounds claimed include O-desacetyl-O-(beta-chloroethyl-carbamoyl)-7-N- D-(-)-alpha-pheny- lglycyl aminocaphalosporanic acid. Use as long acting broad spectrum antibiotics active against Gram-ve and Gram-ve organisms esp. pencillium resistant Staph. aureus, E. coli, Kl. pneumoniae Salm. typhosa, Pseudomonas, B. protens. Also used in animal foodstuffs and as disinfectants or preservatives.
CH1659168A 1968-11-07 1968-11-07 Cephalosporin derivatives CH519516A (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
CH1659168A CH519516A (en) 1968-11-07 1968-11-07 Cephalosporin derivatives
CH9571A CH523915A (en) 1968-11-07 1968-11-07 Cephalosporin derivatives
US867863A US3706746A (en) 1968-11-07 1969-10-20 O-desacetyl derivatives of 7-n-acylamino-cephalosphoranic acids
IE1461/69A IE33355B1 (en) 1968-11-07 1969-10-27 O-desacetyl-7-n-acylamino-cephalosporanic acids and process for their manufacture
FR6936926A FR2024808B1 (en) 1968-11-07 1969-10-28
SU1774526A SU427515A3 (en) 1968-11-07 1969-10-29 METHOD OF OBTAINING O-DEZETSETIL-7 - \ - ACYLAMINO-CEPHALOSPORANIC ACIDS
DE19691954516 DE1954516A1 (en) 1968-11-07 1969-10-29 Process for the preparation of new O-deacetyl-7-N-acylamino-cephalosporanic acids
SU1377102A SU406363A3 (en) 1968-11-07 1969-10-29
GB53698/69A GB1287786A (en) 1968-11-07 1969-11-03 O-desacetyl-7-n-acylamino-cephalosporanic acids and process for their manufacture
ES373176A ES373176A1 (en) 1968-11-07 1969-11-05 Procedure for the obtaining of acid - o - desacetil-7n-acilamino-cefaloesporaicos. (Machine-translation by Google Translate, not legally binding)
SE15152/69A SE367422B (en) 1968-11-07 1969-11-05
AT638971A AT303969B (en) 1968-11-07 1969-11-06 Process for the preparation of new O-deacetyl-7-N-acylamino-cephalosporanic acids
BE741381D BE741381A (en) 1968-11-07 1969-11-06
AT1044269A AT300191B (en) 1968-11-07 1969-11-06 Process for the preparation of new O-deacetyl-7-N-acylamino-cephalosporanic acids
BR21395769A BR6913957D0 (en) 1968-11-07 1969-11-06 PROCESS FOR THE MANUFACTURE OF NEW O-DESACETYL-7-N-ACYLAMINE-CEPHALOSPORAMIC ACIDS
NL6916775A NL6916775A (en) 1968-11-07 1969-11-06
JP44089029A JPS4928200B1 (en) 1968-11-07 1969-11-07

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1659168A CH519516A (en) 1968-11-07 1968-11-07 Cephalosporin derivatives

Publications (1)

Publication Number Publication Date
CH519516A true CH519516A (en) 1972-02-29

Family

ID=4418617

Family Applications (2)

Application Number Title Priority Date Filing Date
CH1659168A CH519516A (en) 1968-11-07 1968-11-07 Cephalosporin derivatives
CH9571A CH523915A (en) 1968-11-07 1968-11-07 Cephalosporin derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
CH9571A CH523915A (en) 1968-11-07 1968-11-07 Cephalosporin derivatives

Country Status (4)

Country Link
AT (2) AT303969B (en)
BR (1) BR6913957D0 (en)
CH (2) CH519516A (en)
SU (2) SU427515A3 (en)

Also Published As

Publication number Publication date
BR6913957D0 (en) 1973-05-03
AT303969B (en) 1972-12-27
CH523915A (en) 1972-06-15
SU427515A3 (en) 1974-05-05
AT300191B (en) 1972-07-10
SU406363A3 (en) 1973-11-05

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Legal Events

Date Code Title Description
PL Patent ceased