CH484084A - Verfahren zur Herstellung eines neuen östrogen hochwirksamen Steroids - Google Patents

Verfahren zur Herstellung eines neuen östrogen hochwirksamen Steroids

Info

Publication number
CH484084A
CH484084A CH1594563A CH1594563A CH484084A CH 484084 A CH484084 A CH 484084A CH 1594563 A CH1594563 A CH 1594563A CH 1594563 A CH1594563 A CH 1594563A CH 484084 A CH484084 A CH 484084A
Authority
CH
Switzerland
Prior art keywords
production
new highly
estrogenic steroid
highly estrogenic
steroid
Prior art date
Application number
CH1594563A
Other languages
English (en)
Inventor
Georg Dr Anner
Jaroslav Dr Kalvoda
Peter Dr Wieland
Original Assignee
Ciba Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to NL125069D priority Critical patent/NL125069C/xx
Priority to NL125071D priority patent/NL125071C/xx
Application filed by Ciba Geigy filed Critical Ciba Geigy
Priority to CH1594563A priority patent/CH484084A/de
Priority to CH1906763A priority patent/CH473109A/de
Priority to CH1886763A priority patent/CH473100A/de
Priority to CH1936763A priority patent/CH487877A/de
Priority to CH1926763A priority patent/CH487876A/de
Priority to CH1946763A priority patent/CH484085A/de
Priority to CH1916763A priority patent/CH473101A/de
Priority to CH1896763A priority patent/CH473102A/de
Priority claimed from CH641464A external-priority patent/CH437219A/de
Priority to DE1443681A priority patent/DE1443681C3/de
Priority to DE1443682A priority patent/DE1443682C3/de
Priority to FR999102A priority patent/FR1434172A/fr
Priority to FR999101A priority patent/FR1418540A/fr
Priority to DE1443684A priority patent/DE1443684C3/de
Priority to DEC34698A priority patent/DE1244777B/de
Priority to DE1443683A priority patent/DE1443683C3/de
Priority to US420185A priority patent/US3318928A/en
Priority to US420186A priority patent/US3318929A/en
Priority to US420146A priority patent/US3318925A/en
Priority to US420164A priority patent/US3318926A/en
Priority to US420147A priority patent/US3318927A/en
Priority to SE15536/64A priority patent/SE324565B/xx
Priority to SE15537/64A priority patent/SE316769B/xx
Priority to ES0307438A priority patent/ES307438A1/es
Priority to SE13291/68A priority patent/SE335528B/xx
Priority to ES0307439A priority patent/ES307439A1/es
Priority to GB52080/64A priority patent/GB1087320A/en
Priority to FR999487A priority patent/FR1434174A/fr
Priority to GB52076/64A priority patent/GB1087316A/en
Priority to GB52078/64A priority patent/GB1087318A/en
Priority to SE15534/64A priority patent/SE325026B/xx
Priority to ES0307440A priority patent/ES307440A1/es
Priority to FR999489A priority patent/FR1434176A/fr
Priority to SE13290/68A priority patent/SE335338B/xx
Priority to ES0307442A priority patent/ES307442A1/es
Priority to FR999488A priority patent/FR1434175A/fr
Priority to GB52079/64A priority patent/GB1087319A/en
Priority to SE13289/68A priority patent/SE335337B/xx
Priority to ES0307441A priority patent/ES307441A1/es
Priority to SE15535/64A priority patent/SE324564B/xx
Priority to GB52077/64A priority patent/GB1087317A/en
Priority to NL6415018A priority patent/NL6415018A/xx
Priority to AT1089164A priority patent/AT253704B/de
Priority to AT1089264A priority patent/AT266337B/de
Priority to NL6415019A priority patent/NL6415019A/xx
Priority to AT561465A priority patent/AT267082B/de
Priority to NL6415016A priority patent/NL6415016A/xx
Priority to NL6415015A priority patent/NL6415015A/xx
Priority to AT1089564A priority patent/AT263226B/de
Priority to NL6415017A priority patent/NL6415017A/xx
Priority to BR165649/64A priority patent/BR6465649D0/pt
Priority to BR165650/64A priority patent/BR6465650D0/pt
Priority to BR165648/64A priority patent/BR6465648D0/pt
Priority to BR165651/64A priority patent/BR6465651D0/pt
Priority to FR9360A priority patent/FR6478M/fr
Priority to FR9724Q priority patent/FR6479M/fr
Priority to DE19651442586 priority patent/DE1442586A1/de
Priority to BE673226D priority patent/BE673226A/fr
Publication of CH484084A publication Critical patent/CH484084A/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J3/00—Processes of utilising sub-atmospheric or super-atmospheric pressure to effect chemical or physical change of matter; Apparatus therefor
    • B01J3/02—Feed or outlet devices therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Steroid Compounds (AREA)
  • Filling Or Emptying Of Bunkers, Hoppers, And Tanks (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CH1594563A 1963-12-24 1963-12-24 Verfahren zur Herstellung eines neuen östrogen hochwirksamen Steroids CH484084A (de)

Priority Applications (59)

Application Number Priority Date Filing Date Title
NL125069D NL125069C (de) 1963-12-24
NL125071D NL125071C (de) 1963-12-24
CH1594563A CH484084A (de) 1963-12-24 1963-12-24 Verfahren zur Herstellung eines neuen östrogen hochwirksamen Steroids
CH1906763A CH473109A (de) 1963-12-24 1963-12-24 Verfahren zur Herstellung neuer östrogen hochwirksamer Steroide
CH1886763A CH473100A (de) 1963-12-24 1963-12-24 Verfahren zur Herstellung neuer östrogen hochwirksamer Steroide
CH1936763A CH487877A (de) 1963-12-24 1963-12-24 Verfahren zur Herstellung neuer östrogen wirksamer Steroide
CH1926763A CH487876A (de) 1963-12-24 1963-12-24 Verfahren zur Herstellung neuer östrogen wirksamer Steroide
CH1946763A CH484085A (de) 1963-12-24 1963-12-24 Verfahren zur Herstellung eines neuen östrogen wirksamen Steroids
CH1916763A CH473101A (de) 1963-12-24 1963-12-24 Verfahren zur Herstellung neuer östrogen hochwirksamer Steroide
CH1896763A CH473102A (de) 1963-12-24 1963-12-24 Verfahren zur Herstellung neuer östrogen hochwirksamer Steroide
DE1443681A DE1443681C3 (de) 1963-12-24 1964-12-16 7 Methyl östron und sein 3 Methyl ather, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate
DE1443682A DE1443682C3 (de) 1963-12-24 1964-12-17 7 alpha, 17 alpha-Dimethyl-östradiol und sein 3-Methyläther, Verfahren zu deren Herstellung und diese enthaltende pharma zeutische Präparate
FR999102A FR1434172A (fr) 1963-12-24 1964-12-18 Procédé de préparation de nouvelles oestrones substituées
FR999101A FR1418540A (fr) 1963-12-24 1964-12-18 Procédé de préparation d'un nouveau stéroïde à haute activité oestrogène
DE1443684A DE1443684C3 (de) 1963-12-24 1964-12-19 7alpha Methyl östradiol, Verfahren zu dessen Herstellung und dieses enthal tende pharmazeutische Präparate
DEC34698A DE1244777B (de) 1963-12-24 1964-12-19 Verfahren zur Herstellung von 7alpha-Methyl-16alpha-hydroxy-oestron bzw. -3, 16-diacetat
DE1443683A DE1443683C3 (de) 1963-12-24 1964-12-19 7alpha Methyl 17alpha athinyl östradiol und sein 3 Methylather, Ver fahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate
US420185A US3318928A (en) 1963-12-24 1964-12-21 7alpha-alkyl-17alpha-alkinyl-estradiols
US420186A US3318929A (en) 1963-12-24 1964-12-21 7alpha, 17alpha-alkyl estradiols
US420146A US3318925A (en) 1963-12-24 1964-12-21 Methylated estrones
US420164A US3318926A (en) 1963-12-24 1964-12-21 7alpha-methyl-16alpha-hydroxy-estrones
US420147A US3318927A (en) 1963-12-24 1964-12-21 Alkylated estradiol
SE15536/64A SE324565B (de) 1963-12-24 1964-12-22
SE15537/64A SE316769B (de) 1963-12-24 1964-12-22
ES0307438A ES307438A1 (es) 1963-12-24 1964-12-22 Procedimiento para la obtencion de un esteroide de alta eficacia ostrogenica.
SE13291/68A SE335528B (de) 1963-12-24 1964-12-22
ES0307439A ES307439A1 (es) 1963-12-24 1964-12-22 Procedimiento para la obtencion de un esteroide de alta eficacia ostrogenica.
GB52080/64A GB1087320A (en) 1963-12-24 1964-12-22 New, highly active estrogenic 16-oxygenated estrones and process for their manufacture
FR999487A FR1434174A (fr) 1963-12-24 1964-12-22 Procédé de préparation de nouveaux stéroïdes de la série de l'oestrane
GB52076/64A GB1087316A (en) 1963-12-24 1964-12-22 7ª‡-methyl-oestratrienes
GB52078/64A GB1087318A (en) 1963-12-24 1964-12-22 17ª‡-ethynyl-estradiols and process for their manufacture
SE15534/64A SE325026B (de) 1963-12-24 1964-12-22
ES0307440A ES307440A1 (es) 1963-12-24 1964-12-22 Procedimiento para la obtencion de un esteroide de efecto ostrogenico.
FR999489A FR1434176A (fr) 1963-12-24 1964-12-22 Procédé de préparation d'une nouvelle oestrone
SE13290/68A SE335338B (de) 1963-12-24 1964-12-22
ES0307442A ES307442A1 (es) 1963-12-24 1964-12-22 Procedimiento para la obtencion de un esteroide de efecto ostrogenico.
FR999488A FR1434175A (fr) 1963-12-24 1964-12-22 Procédé de préparation de nouveaux stéroïdes appartenant à la série de l'oestrane
GB52079/64A GB1087319A (en) 1963-12-24 1964-12-22 17ª‡-methyl-estradiols and process for their manufacture
SE13289/68A SE335337B (de) 1963-12-24 1964-12-22
ES0307441A ES307441A1 (es) 1963-12-24 1964-12-22 Procedimiento para la obtencion de un esteroide de efecto ostrogenico.
SE15535/64A SE324564B (de) 1963-12-24 1964-12-22
GB52077/64A GB1087317A (en) 1963-12-24 1964-12-22 New, highly active estrogenic 17-oxo-steroids and process for their manufacture
NL6415018A NL6415018A (de) 1963-12-24 1964-12-23
AT1089164A AT253704B (de) 1963-12-24 1964-12-23 Verfahren zur Herstellung des neuen 7α-Methyl-16α-hydroxy-östrons und seines 3, 16-Diacetates
AT1089264A AT266337B (de) 1963-12-24 1964-12-23 Verfahren zur Herstellung des neuen 7α-Methyl-östrons oder seines 3-Methyläthers
NL6415019A NL6415019A (de) 1963-12-24 1964-12-23
AT561465A AT267082B (de) 1963-12-24 1964-12-23 Verfahren zur Herstellung des neuen 7α-Methyl-östrons oder seines 3-Methyläthers
NL6415016A NL6415016A (de) 1963-12-24 1964-12-23
NL6415015A NL6415015A (de) 1963-12-24 1964-12-23
AT1089564A AT263226B (de) 1963-12-24 1964-12-23 Verfahren zur Herstellung des neuen 7α-Methyl-17α-äthinyl-östradiols oder seines 3-Methyläthers
NL6415017A NL6415017A (de) 1963-12-24 1964-12-23
BR165649/64A BR6465649D0 (pt) 1963-12-24 1964-12-24 Processo para a fabricacao de novos 17-alcovil estradiois estrogenios altamente ativos
BR165650/64A BR6465650D0 (pt) 1963-12-24 1964-12-24 Processo para a fabricacao de novas estronas 16-oxigenadas estrogenicas altamente ativas
BR165648/64A BR6465648D0 (pt) 1963-12-24 1964-12-24 Processo para a fabricacao de novos f-alfa metil 17 alfa etinil estradiois estrogenios altamente ativos
BR165651/64A BR6465651D0 (pt) 1963-12-24 1964-12-24 Processo para a fabricacao de 7-alfa-metil estradiol
FR9360A FR6478M (de) 1963-12-24 1965-03-16
FR9724Q FR6479M (de) 1963-12-24 1965-03-18
DE19651442586 DE1442586A1 (de) 1963-12-24 1965-04-10 Zellenschleuse
BE673226D BE673226A (de) 1963-12-24 1965-12-02

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
CH1594563A CH484084A (de) 1963-12-24 1963-12-24 Verfahren zur Herstellung eines neuen östrogen hochwirksamen Steroids
CH641464A CH437219A (de) 1964-05-15 1964-05-15 Zellenschleuse
CH691464 1964-05-27
CH1565664 1964-12-03
CH1565564 1964-12-03
CH1565364 1964-12-03
CH1565464 1964-12-03
CH1589664 1964-12-09

Publications (1)

Publication Number Publication Date
CH484084A true CH484084A (de) 1970-01-15

Family

ID=27570366

Family Applications (1)

Application Number Title Priority Date Filing Date
CH1594563A CH484084A (de) 1963-12-24 1963-12-24 Verfahren zur Herstellung eines neuen östrogen hochwirksamen Steroids

Country Status (8)

Country Link
US (5) US3318928A (de)
BR (4) BR6465648D0 (de)
CH (1) CH484084A (de)
DE (6) DE1443681C3 (de)
FR (2) FR6478M (de)
GB (5) GB1087319A (de)
NL (7) NL6415019A (de)
SE (7) SE335528B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3507888A (en) * 1966-08-30 1970-04-21 Searle & Co Process and intermediates for manufacture of 17-oxygenated estr-4-en-3-ones
US3511860A (en) * 1966-09-26 1970-05-12 Syntex Corp Synthesis of 19-nor and ring a aromatic steroids and intermediates therefor
US3626061A (en) * 1967-09-08 1971-12-07 Upjohn Co Compositions comprising 7{60 -methyl-17{60 -lkylated estradiols
US3627894A (en) * 1967-09-08 1971-12-14 Upjohn Co Pharmaceutical compositions comprising 72-methyl estrone and methods for using same
US3626062A (en) * 1967-09-08 1971-12-07 Upjohn Co Composition comprising 7{60 -methyl estradiol 3,17-bistrimethyl silyl ethers
DD145919B1 (de) * 1978-06-28 1982-06-30 Kurt Ponsold Verfahren zur herstellung von 14,1 -methylenderivaten der oestranreihe
US5227375A (en) * 1990-02-08 1993-07-13 Endorecherche, Inc. Aromatase inhibitors
US6054446A (en) 1997-12-24 2000-04-25 Sri International Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use
US6548491B2 (en) 1997-12-24 2003-04-15 Sri International Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use
US6503896B1 (en) 1997-12-24 2003-01-07 Sri International Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use
PL356465A1 (en) * 2002-10-04 2004-04-05 ANPHARM Przedsiębiorstwo Farmaceutyczne S.A. METHOD OF MANUFACTURE OF 17beta-HYDROXY-7alpha-METHYL-19-NOR-17alpha-PREGN-5(10)-ENE-20-YNE-3-ONE
PE20050677A1 (es) * 2003-12-22 2005-10-04 Akzo Nobel Nv Esteroides con perfil androgenico y progestagenico mixto
US8022053B2 (en) * 2004-11-02 2011-09-20 Bayer Schering Pharma Aktiengesellschaft Oral solid dosage forms containing a low dose of estradiol
UY29185A1 (es) * 2004-11-02 2006-05-31 Schering Ag Formas de dosificación oral sólidas que contienen una dosis baja de estradiol

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2225419A (en) * 1937-03-01 1940-12-17 Schering Corp Process for the conversion of 17-cisalcohols of the cyclopentanopolyhydrophenanthrene series into the corresponding 17-trans-alcohols
US2584271A (en) * 1948-06-19 1952-02-05 Searle & Co Steroid derivatives and method for producing the same
GB723697A (en) * 1952-06-17 1955-02-09 Alberto Ercoli Improvements in the preparation of 3:17-diols of the cyclopentanopolyhydrophenanthrene series

Also Published As

Publication number Publication date
US3318927A (en) 1967-05-09
NL125069C (de)
BR6465651D0 (pt) 1973-08-02
NL6415017A (de) 1965-06-25
DE1443684B2 (de) 1973-04-19
DE1443683A1 (de) 1969-11-27
BR6465650D0 (pt) 1973-08-02
DE1443682B2 (de) 1973-05-17
DE1443682A1 (de) 1969-11-13
US3318926A (en) 1967-05-09
US3318925A (en) 1967-05-09
GB1087319A (en) 1967-10-18
SE316769B (de) 1969-11-03
SE325026B (de) 1970-06-22
US3318928A (en) 1967-05-09
BR6465649D0 (pt) 1973-08-02
SE335338B (de) 1971-05-24
DE1443683B2 (de) 1973-04-19
DE1443684A1 (de) 1969-11-13
GB1087317A (en) 1967-10-18
DE1443681B2 (de) 1973-05-03
NL6415015A (de) 1965-06-25
FR6479M (de) 1968-11-25
SE324564B (de) 1970-06-08
GB1087320A (en) 1967-10-18
GB1087318A (en) 1967-10-18
SE324565B (de) 1970-06-08
DE1443682C3 (de) 1973-12-20
DE1443683C3 (de) 1973-11-08
DE1244777B (de) 1967-07-20
DE1442586A1 (de) 1968-11-21
NL125071C (de)
SE335528B (de) 1971-06-01
NL6415018A (de) 1965-06-25
DE1443684C3 (de) 1973-11-08
BR6465648D0 (pt) 1973-08-02
DE1443681A1 (de) 1969-11-13
US3318929A (en) 1967-05-09
DE1443681C3 (de) 1973-11-22
SE335337B (de) 1971-05-24
NL6415016A (de) 1965-06-25
NL6415019A (de) 1965-06-25
FR6478M (de) 1968-11-25
GB1087316A (en) 1967-10-18

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