CH409967A - Process for making novel cephalosporin compounds - Google Patents

Process for making novel cephalosporin compounds

Info

Publication number
CH409967A
CH409967A CH682262A CH682262A CH409967A CH 409967 A CH409967 A CH 409967A CH 682262 A CH682262 A CH 682262A CH 682262 A CH682262 A CH 682262A CH 409967 A CH409967 A CH 409967A
Authority
CH
Switzerland
Prior art keywords
balance
rods
plate
intended
steel
Prior art date
Application number
CH682262A
Other languages
German (de)
French (fr)
Inventor
Harold Flynn Edwin
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CH409967A publication Critical patent/CH409967A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Shafts, Cranks, Connecting Bars, And Related Bearings (AREA)
  • Fertilizing (AREA)

Description

  

  
 



  Axe de balancier pour pièce d'horlogerie
 On a déjà proposé un axe de balancier pour pièce d'horlogerie, en acier tenace à haute résistance, de forme cylindrique, destiné à recevoir la virole et le plateau,   et.   



  entre eux, un balancier à goutte; les extrémités de l'axe sont terminées chacune par un pivot conique. Cet axe lisse présente l'inconvénient qu'il est très difficile de fixer la position en hauteur des pièces qui sont chassées sur lui.



   Dans une autre construction connue, I'axe de balancier présente la forme classique, c'est-à-dire qu'il comprend une assiette de grand diamètre, deux tiges de diamètres différents, situées de part et d'autre de l'assiette, chaque tige étant suivie d'un tigeron terminé par un pivot conique. Cet axe est fait en acier ordinaire. Si   l'on    voulait usiner un axe de cette forme dans un acier tenace à haute résistance, cela entraînerait des difficultés considérables; de plus,   I'assiette    ayant un grand diamètre, la consommation de matière serait trop grande.



   L'invention remédie aux inconvénients susmentionnés, en fournissant un axe de balancier très résistant, de faible prix de revient et permettant de fixer exactement et facilement la position en hauteur des pièces (plateau et virole) qui sont chassées sur lui.



   L'axe de balancier selon l'invention est fait en acier tenace à haute résistance et comporte deux tiges cylindriques de même diamètre, destinées à recevoir respectivement la virole et le plateau et terminées chacune par un pivot conique. Il est caractérisé par une partie cylindrique de plus grand diamètre, disposée entre les deux tiges susdites et sur laquelle est chassé un balancier à goutte.



   Le dessin annexé représente, à titre d'exemple, une forme d'exécution de l'objet de l'invention.



   La figure unique est une vue en coupe axiale de cette forme d'exécution.



   L'axe de balancier représenté sur le dessin est fait en un acier particulièrement tenace par exemple en l'acier portant la désignation   P4XV    ,    qui est deux fois plus résistant que l'acier ordinaire. Un tel acier est très difficile à usiner et c'est pourquoi l'axe de balancier suivant l'invention a une forme particulièrement simple.



   L'axe de balancier comporte deux tiges cylindriques
I et 2 de même diamètre, la tige 1 étant légèrement plus courte que la tige 2. La tige 1 est destinée à recevoir, chassée sur elle, la virole 3 servant à la fixation de l'extrémité intérieure du spiral (non représenté), tandis que la tige 2 est destinée à recevoir un canon 4 constituant le plateau d'échappement et présentant deux saillies 5 et 6 assurant respectivement les fonctions de grand et de petit plateau, le canon 4 étant chassé sur la tige 2.



  La cheville de plateau ou ellipse 7 est ajustée dans un trou de la saillie 5, tandis que la saillie 6 présente une encoche 8, destinée à coopérer avec le dard de l'ancre (également non représentée). La tige 1 est terminée par un pivot conique 9, tandis que la tige 2 est terminée par un pivot conique 10. L'axe de balancier comporte en outre une partie cylindrique 11 dont le diamètre est plus grand que celui des tiges I et 2. Dans l'exemple représenté, le diamètre de la partie 11 est environ le double de celui des tiges 1 et 2. Sur cette partie 11 est chassé un balancier à goutte 12, c'est-à-dire un balancier dont le moyeu 13 présente un prolongement axial en forme de collerette. Le balancier est ainsi ajusté sur une surface assez longue de l'axe de balancier et sa fixation est bien assurée.

   Lorsqu'on chasse la virole 3 sur la tige 1 et le canon 4 sur la tige 2, ces éléments viennent buter contre l'une ou l'autre des portées de la partie cylindrique 11, de sorte que leur position axiale est bien   determinée.    Le moyeu 13 de l'axe de balancier est relié par un organe élastique 14 de type connu à la serge 15 du balancier.



  Du fait que l'axe de balancier est fait en un acier très tenace, les pivots 9 et 10 sont plus résistants que ceux d'un axe ordinaire, et c'est la raison pour   laquelle    il est possible de simplifier l'organe élastique 14 (par exemple,  si cet organe élastique comporte des bras, on peut réduire la longueur de ces bras). 



  
 



  Balance axis for timepiece
 A balance shaft for a timepiece has already been proposed, made of tough high-strength steel, of cylindrical shape, intended to receive the ferrule and the plate, and.



  between them, a drop pendulum; the ends of the axis are each terminated by a conical pivot. This smooth axis has the drawback that it is very difficult to fix the height position of the parts which are driven onto it.



   In another known construction, the balance axle has the conventional shape, that is to say it comprises a plate of large diameter, two rods of different diameters, located on either side of the plate. , each rod being followed by a tigeron terminated by a conical pivot. This axis is made of ordinary steel. If one wanted to machine an axle of this shape in tough, high strength steel, it would cause considerable difficulty; moreover, the plate having a large diameter, the consumption of material would be too great.



   The invention overcomes the aforementioned drawbacks, by providing a very strong balance pin, of low cost price and making it possible to fix exactly and easily the height position of the parts (plate and ferrule) which are driven on it.



   The balance axle according to the invention is made of tenacious high-strength steel and comprises two cylindrical rods of the same diameter, intended to receive the ferrule and the plate respectively and each terminated by a conical pivot. It is characterized by a cylindrical part of larger diameter, arranged between the two aforementioned rods and on which is driven a drop balance.



   The appended drawing represents, by way of example, an embodiment of the object of the invention.



   The single figure is an axial sectional view of this embodiment.



   The balance shaft shown in the drawing is made of a particularly tough steel, for example steel bearing the designation P4XV, which is twice as strong as ordinary steel. Such a steel is very difficult to machine and this is why the balance axis according to the invention has a particularly simple shape.



   The balance axis has two cylindrical rods
I and 2 of the same diameter, the rod 1 being slightly shorter than the rod 2. The rod 1 is intended to receive, driven onto it, the ferrule 3 serving for fixing the inner end of the balance spring (not shown), while the rod 2 is intended to receive a barrel 4 constituting the exhaust plate and having two projections 5 and 6 respectively ensuring the functions of large and small plate, the barrel 4 being driven out on the rod 2.



  The plate pin or ellipse 7 is fitted in a hole of the projection 5, while the projection 6 has a notch 8, intended to cooperate with the stinger of the anchor (also not shown). The rod 1 ends with a conical pivot 9, while the rod 2 ends with a conical pivot 10. The balance axle further comprises a cylindrical part 11, the diameter of which is greater than that of the rods I and 2. In the example shown, the diameter of part 11 is approximately twice that of rods 1 and 2. On this part 11 is driven a drip balance 12, that is to say a balance whose hub 13 has an axial extension in the form of a collar. The balance is thus adjusted over a fairly long surface of the balance axis and its fixing is well assured.

   When the ferrule 3 is driven off the rod 1 and the barrel 4 on the rod 2, these elements abut against one or the other of the bearing surfaces of the cylindrical part 11, so that their axial position is well determined. The hub 13 of the balance shaft is connected by an elastic member 14 of known type to the rim 15 of the balance.



  Because the balance axle is made of a very tough steel, the pivots 9 and 10 are stronger than those of an ordinary axle, and this is the reason why it is possible to simplify the elastic member 14 (for example, if this elastic member has arms, the length of these arms can be reduced).

Claims (1)

REVENDICATION CLAIM Axe de balancier pour pièce d'horlogerie, fait en acier tenace à haute résistance et comportant deux tiges cylindriques de même diamètre, destinées à recevoir respectivement la virole et le plateau et terminées chacune par un pivot conique, caractérisé par une partie cylindrique de plus grand diamètre, disposée entre les deux tiges susdites et sur laquelle est chassé un balancier à goutte, les portées de ladite partie cylindrique permettant de fixer exactement en hauteur la position de la virole et du plateau. Balance shaft for a timepiece, made of tough high-strength steel and comprising two cylindrical rods of the same diameter, intended to receive the ferrule and the plate respectively and each terminated by a conical pivot, characterized by a cylindrical part of larger diameter, disposed between the two aforementioned rods and on which is driven a drop balance, the bearing surfaces of said cylindrical part making it possible to fix the position of the shell and the plate exactly in height. SOUS-REVENDICATIONS I. Axe de balancier selon la revendication, caractérisé en ce qu'il est fait en un acier deux fois plus résistant que l'acier ordinaire. SUB-CLAIMS I. Balance wheel axis according to claim, characterized in that it is made of a steel twice as strong as ordinary steel. 2. Axe de balancier selon la revendication, caractérisé en ce que la tige destinée à porter la virole est légèrement plus courte que celle destinée à porter le plateau. 2. Balance axle according to claim, characterized in that the rod intended to carry the ferrule is slightly shorter than that intended to carry the plate. 3. Axe de balancier selon la revendication, caractérisé en ce que le diamètre de ladite partie cylindrique est environ le double de celui desdites tiges 3. Balance axle according to claim, characterized in that the diameter of said cylindrical part is approximately twice that of said rods.
CH682262A 1961-06-08 1962-06-06 Process for making novel cephalosporin compounds CH409967A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11561261A 1961-06-08 1961-06-08

Publications (1)

Publication Number Publication Date
CH409967A true CH409967A (en) 1966-03-31

Family

ID=22362437

Family Applications (1)

Application Number Title Priority Date Filing Date
CH682262A CH409967A (en) 1961-06-08 1962-06-06 Process for making novel cephalosporin compounds

Country Status (14)

Country Link
BE (1) BE618663A (en)
BR (1) BR6239733D0 (en)
CA (1) CA984379A (en)
CH (1) CH409967A (en)
DE (2) DE1445684A1 (en)
DK (1) DK129199B (en)
ES (1) ES277871A1 (en)
FI (1) FI43597C (en)
FR (1) FR2899M (en)
GB (1) GB982252A (en)
LU (1) LU41846A1 (en)
NO (2) NO122749B (en)
OA (1) OA02701A (en)
SE (2) SE322513B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1082943A (en) * 1963-03-27 1967-09-13 Glaxo Lab Ltd Derivatives of 7-aminocephalosporanic acid
US3492297A (en) * 1965-07-01 1970-01-27 Merck & Co Inc Guanidino cephalosporins
GB1195203A (en) * 1966-06-24 1970-06-17 Glaxo Lab Ltd Cephalosporins

Also Published As

Publication number Publication date
NO122749B (en) 1971-08-09
NO133074B (en) 1975-11-24
GB982252A (en) 1965-02-03
NO133074C (en) 1976-03-03
OA02701A (en) 1970-12-15
DK129199B (en) 1974-09-09
DE1445684A1 (en) 1968-12-05
BR6239733D0 (en) 1973-06-14
LU41846A1 (en) 1962-12-07
DK129199C (en) 1975-01-27
FR2899M (en) 1964-11-09
FI43597C (en) 1971-05-10
ES277871A1 (en) 1962-12-01
CA984379A (en) 1976-02-24
DE1445701A1 (en) 1969-08-28
SE357204B (en) 1973-06-18
BE618663A (en) 1962-12-14
SE322513B (en) 1970-04-13
FI43597B (en) 1971-02-01

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