CH312529A - Process for the preparation of a new pyridine derivative. - Google Patents

Process for the preparation of a new pyridine derivative.

Info

Publication number
CH312529A
CH312529A CH312529DA CH312529A CH 312529 A CH312529 A CH 312529A CH 312529D A CH312529D A CH 312529DA CH 312529 A CH312529 A CH 312529A
Authority
CH
Switzerland
Prior art keywords
preparation
pyridine derivative
new pyridine
new
isonicotinyl
Prior art date
Application number
Other languages
German (de)
Inventor
F Hoffmann- Aktiengesellschaft
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CH312529A publication Critical patent/CH312529A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/86—Hydrazides; Thio or imino analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Description

  

      Verfahren    zur     Herstellung    eines neuen     Pyridinderivates.       Gegenstand des vorliegenden Patentes ist  ein Verfahren zur Herstellung von     1-Isonico-          tinyl-2-dw        -undecenoyl-hydrazin,    das dadurch       gekennzeichnet    ist, dass     Isonicotinylhydrazin     mit     df-Undecenoylchlorid    umgesetzt     wird.     



  Die neue     Verbindung    soll als     Therapeuti-          cum,    besonders zur Bekämpfung der Tuberku  lose, Verwendung finden.    <I>Beispiel:</I>    Man setzt tropfenweise 20,2 g     dw-Undece-          noylchlorid    einer Lösung von 13,7     g        Isonico-          tinylhydrazin    in 100     cm3    Siedenein     Pyridin    in  einer solchen Geschwindigkeit zu,

   dass die     1VIi-          sehung    trotz Entfernung der     äussern    Wärme-    quelle unter     Rückfluss        weitersiedet.    Nach be  endetem Zusatz wird die Mischung während  weiteren 10 Minuten im Sieden gehalten.     Man     setzt nun 100     em3    Wasser zu, worauf sich  beim Abkühlen     1-Isonicotinoyl-2-undecenoyl.-          hydrazin    abscheidet. Die aus     einem        Wasser-          Propanol=Gemisch    umkristallisierten weissen  Flocken schmelzen bei 111,5  C.



      Process for the preparation of a new pyridine derivative. The present patent relates to a process for the preparation of 1-isonicotinyl-2-dw -undecenoylhydrazine, which is characterized in that isonicotinylhydrazine is reacted with df-undecenoyl chloride.



  The new compound is intended to be used as a therapeutic agent, particularly to combat tuberculosis. <I> Example: </I> 20.2 g of dw-undecanoyl chloride are added dropwise to a solution of 13.7 g of isonicotinyl hydrazine in 100 cm3 of boiling point in pyridine at a rate such that

   that the vision continues to boil under reflux despite the removal of the external heat source. After the addition has ended, the mixture is kept boiling for a further 10 minutes. 100 cubic meters of water are then added, whereupon 1-isonicotinoyl-2-undecenoyl.hydrazine separates out on cooling. The white flakes recrystallized from a water-propanol mixture melt at 111.5 ° C.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung von 1-Isonico- tinyl-2-'w-midecenoyl-hydrazin, dadurch ge kennzeichnet, dass Isonicotinylhydrazin mit Undecenoylchlorid umgesetzt wird. Die neue Verbindung schmilzt bei 111,5 C. PATENT CLAIM: Process for the production of 1-isonicotinyl-2-'w-midecenoylhydrazine, characterized in that isonicotinylhydrazine is reacted with undecenoyl chloride. The new compound melts at 111.5 C.
CH312529D 1951-11-03 1952-10-16 Process for the preparation of a new pyridine derivative. CH312529A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US312529XA 1951-11-03 1951-11-03
CH309035T 1952-10-16

Publications (1)

Publication Number Publication Date
CH312529A true CH312529A (en) 1955-12-31

Family

ID=25735568

Family Applications (1)

Application Number Title Priority Date Filing Date
CH312529D CH312529A (en) 1951-11-03 1952-10-16 Process for the preparation of a new pyridine derivative.

Country Status (1)

Country Link
CH (1) CH312529A (en)

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