CH310715A - Process for the preparation of a penicillin salt. - Google Patents

Process for the preparation of a penicillin salt.

Info

Publication number
CH310715A
CH310715A CH310715DA CH310715A CH 310715 A CH310715 A CH 310715A CH 310715D A CH310715D A CH 310715DA CH 310715 A CH310715 A CH 310715A
Authority
CH
Switzerland
Prior art keywords
preparation
salt
penicillin
penicillin salt
morpholino
Prior art date
Application number
Other languages
German (de)
Inventor
Farbwerke Hoechst Akt Bruening
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of CH310715A publication Critical patent/CH310715A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Description

  

      Verfahren        zur        Herstellung    eines     Penicillinsalzes.       Gegenstand des vorliegenden Zusatz  patentes ist ein Verfahren zur Herstellung  des bisher nicht bekannten     Penicillin-G-Salzes     von     1,1-Diphenyl-3-morpholino-propan,    wel  ches dadurch     gekennzeichnet    ist, dass man       1,1-Diphenyl-3-morpholino-propan    oder ein  Salz desselben und     Penicillin-G    oder ein Salz  desselben aufeinander     einwirken    lässt.  



  Das als     Depotpenicillinpräparat    verwend  bare Verfahrensprodukt besteht aus in Wasser       schwerlöslichen    Kristallen vom Schmelz  punkt 148'     (Zers.)     <I>Beispiel:</I>  Zu einer Lösung von 2,8 g     1,1-Diphenyl-3-          morpholino-propanhydrochlorid    in 30     cm3     Methanol gibt man eine Lösung von 3,6 g       Penicillin-G-Natrium    in 10     cm3    Wasser.

   Beim    Abkühlen kristallisiert aus dem Reaktions  gemisch in guter Ausbeute das     Penicilhnsalz     aus, das abgesaugt und     mit    wenig Methanol  gewaschen wird.     Fp.    = 148       (Zers.).  



      Process for the preparation of a penicillin salt. The subject of the present additional patent is a process for the production of the previously unknown penicillin G salt of 1,1-diphenyl-3-morpholino-propane, which is characterized in that 1,1-diphenyl-3-morpholino- propane or a salt thereof and penicillin-G or a salt thereof to act on each other.



  The process product which can be used as a depot penicillin preparation consists of crystals which are sparingly soluble in water and have a melting point of 148 '(decomp.) A solution of 3.6 g penicillin G sodium in 10 cm3 water is added to 30 cm3 of methanol.

   On cooling, the Penicilhnsalz crystallizes out of the reaction mixture in good yield, which is filtered off with suction and washed with a little methanol. M.p. = 148 (dec.).

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung des Penicillin- 0-Salzes von 1,1-Diphenyl-3-morpholino-pro- pan, dadurch gekennzeichnet, dass man 1,1- Diphenyl-3-morpholino-propan oder ein Salz desselben und Penicillin-G oder ein Salz des selben aufeinander einwirken lässt. PATENT CLAIM: Process for the preparation of the penicillin 0 salt of 1,1-diphenyl-3-morpholino-propane, characterized in that 1,1-diphenyl-3-morpholino-propane or a salt thereof and penicillin-G or let a salt of the same act on each other. Das als Depotpenlcillinpräparat verwend bare Verfahrensprodukt besteht aus in Wasser schwerlöslichen Kristallen vorn Schmelz punkt 148' (Zers. ). The process product which can be used as a depot penlcillin preparation consists of crystals which are sparingly soluble in water and have a melting point of 148 '(decomposition).
CH310715D 1951-07-27 1952-07-25 Process for the preparation of a penicillin salt. CH310715A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE310715X 1951-07-27
CH307806T 1952-07-25

Publications (1)

Publication Number Publication Date
CH310715A true CH310715A (en) 1955-10-31

Family

ID=25735453

Family Applications (1)

Application Number Title Priority Date Filing Date
CH310715D CH310715A (en) 1951-07-27 1952-07-25 Process for the preparation of a penicillin salt.

Country Status (1)

Country Link
CH (1) CH310715A (en)

Similar Documents

Publication Publication Date Title
CH310715A (en) Process for the preparation of a penicillin salt.
DE447352C (en) Process for the preparation of complex antimony compounds
DE867989C (en) Process for the production of calcium nitrite
DE936508C (en) Process for the preparation of anhydrous 4-benzoylamino-salicylic acid calcium
DE586446C (en) Process for the preparation of guanidine salts
DE399741C (en) Process for the preparation of pure 1-nitro-2-methylanthraquinone
DE339947C (en) Process for the preparation of aminosulfonic acids from hydrogenated china alkaloids
DE802880C (en) Process for the manufacture of sodium penicillin
DE1172267B (en) Process for the preparation of the bis-guaiacol-sulfonic acid salt of morphine-ª ‰ -morpholyl-ethyl-ether
DE588650C (en) Process for the preparation of oxydiphenyl ether carboxylic acids
DE892290C (en) Process for the production of reaction products of rutin
DE749080C (en) Process for the production of tanning solutions
CH279100A (en) Process for the preparation of a B-pyridyl-carbinol salt.
CH311595A (en) Process for making a new salt.
CH304880A (en) Process for the production of a sparingly soluble penicillin compound.
CH307479A (en) Process for the preparation of a penicillin compound.
CH227919A (en) Process for the preparation of benzenesulfonylurea.
CH110109A (en) Process for the preparation of pure 1-nitro-2-methylanthraquinone.
CH312528A (en) Process for the preparation of a new pyridine derivative.
KR830007504A (en) Method for preparing 3,3&#39;-dichloro-4,4&#39;-diamino-biphenyl-dihydrochloride
CH120430A (en) Process for the preparation of a new sulfur- and nitrogen-containing condensation product from the action product of chlorosulfur on a-naphthylamine.
CH210965A (en) Process for the preparation of a urea derivative.
CH312529A (en) Process for the preparation of a new pyridine derivative.
CH287779A (en) Process for the production of an organic mercury compound.
CH224316A (en) Process for the preparation of an asymmetric arsenobenzene.