CH307479A - Process for the preparation of a penicillin compound. - Google Patents
Process for the preparation of a penicillin compound.Info
- Publication number
- CH307479A CH307479A CH307479DA CH307479A CH 307479 A CH307479 A CH 307479A CH 307479D A CH307479D A CH 307479DA CH 307479 A CH307479 A CH 307479A
- Authority
- CH
- Switzerland
- Prior art keywords
- preparation
- penicillin
- compound
- penicillin compound
- diphenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Description
Verfahren zur Herstellung einer Penicillinverhindung. Vorliegende Erfindung betrifft ein Ver fahren zur Herstellung einer Penicillinverbin- dung mit einem Amin.
Das Verfahren ist dadurch gekennzeichnet, dass ein Penicillin-G-Salz mit a,ss-Diphenyl-ss- hydroxy-N-methyl-äthylamin umgesetzt wird. Die so hergestellte Verbindung schmilzt bei 150-158 C.
Das gemäss der Erfindung hergestellte Penicillin-Amin-Salz besitzt während längerer Dauer anhaltende antibiotische Wirksamkeit. <I>Beispiel:</I> Zu 0,46 g a,ss-Diphenyl-ss-hydroxy-N-me- thyl-äthylamin-hydrochlorid, in 5,5 ml Wasser gelöst, wird eine Lösung von 1 g Natriumpeni- cillin G in 4 ml Wasser zugegeben. Das aus geschiedene öl lässt sich durch Anreiben und Rühren in Kristalle verwandeln. Die Kristalle ,verden abfiltriert und im Vakuum getrocknet. Die erhaltene Verbindung entspricht der For mel
EMI0001.0014
Sie schmilzt bei 150-158 C.
Ihre antibio tische Wirksamkeit beträgt 945 Einheiten pro mg; ihre Wasserlöslichkeit 4110 Einheiten pro ml.
Process for the preparation of a penicillin prevention. The present invention relates to a method for producing a penicillin compound with an amine.
The process is characterized in that a penicillin G salt is reacted with α, β-diphenyl-β-hydroxy-N-methyl-ethylamine. The compound created in this way melts at 150-158 C.
The penicillin-amine salt produced according to the invention has long-lasting antibiotic activity. <I> Example: </I> A solution of 1 g of sodium penicillin is added to 0.46 ga, ß-diphenyl-ß-hydroxy-N-methyl-ethylamine hydrochloride, dissolved in 5.5 ml of water G added in 4 ml of water. The separated oil can be transformed into crystals by grinding and stirring. The crystals are filtered off and dried in vacuo. The compound obtained corresponds to the formula
EMI0001.0014
It melts at 150-158 C.
Their antibiotic effectiveness is 945 units per mg; their water solubility 4110 units per ml.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US307479XA | 1951-02-16 | 1951-02-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH307479A true CH307479A (en) | 1955-05-31 |
Family
ID=21855813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH307479D CH307479A (en) | 1951-02-16 | 1951-09-05 | Process for the preparation of a penicillin compound. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH307479A (en) |
-
1951
- 1951-09-05 CH CH307479D patent/CH307479A/en unknown
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